Genomes and Genes
Affiliation: University of Rome Tor Vergata
- L-dopa modulates motor cortex excitability in Alzheimer's disease patientsAlessandro Martorana
Dipartimento di Neuroscienze, Clinica Neurologica, Universita di Roma, Tor Vergata, Via Montpellier, 1, 00133 Rome, Italy
J Neural Transm (Vienna) 115:1313-9. 2008..In addition, considering that L-dopa showed a pharmacological profile similar to the one of cholinomimetics, L-dopa might represent a reliable tool to study new therapeutic perspective and strategies for AD...
- Dopamine modulates cholinergic cortical excitability in Alzheimer's disease patientsAlessandro Martorana
Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Roma, Italy
Neuropsychopharmacology 34:2323-8. 2009..These alterations might be responsible, at least in part, for the progressive cognitive decline observed in AD patients...
- Insulin and the Future Treatment of Alzheimer's DiseaseRoberta Semprini
Centro Alzheimer UOC Neurologia, Dipartimento Medicina dei Sistemi Università di Roma Tor Vergata
CNS Neurol Disord Drug Targets 15:660-4. 2016..Here we review most of the available data regarding relationship between Alzheimer's disease and insulin and propose new direction to deepen our understanding about insulin involvement in the pathogenesis of Alzheimer's dementia. ..
- Apathy as marker of frail statusRoberta Semprini
Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Via Montpellier, 00133 Rome, Italy
J Aging Res 2012:436251. 2012..Unfortunately available literature largely underestimates the presence of these factors. Thus to better identify markers of frailty, a good neuropsychological assessment and the evaluation of behavioural disturbances are suggested...
- Dopamine D₂-agonist rotigotine effects on cortical excitability and central cholinergic transmission in Alzheimer's disease patientsAlessandro Martorana
Clinica Neurologica, Dipartimento di Neuroscienze, Centro di Riferimento per la Malattia di Alzheimer, Universita di Roma Tor Vergata, Viale Oxford 81, 00133 Roma, Italy
Neuropharmacology 64:108-13. 2013..This article is part of a Special Issue entitled 'Cognitive Enhancers'...
- Plasmin system of Alzheimer's disease patients: CSF analysisAlessandro Martorana
Department of Neuroscience, University of Rome Tor Vergata, 1 Montpellier Street, 00133, Rome, Italy
J Neural Transm (Vienna) 119:763-9. 2012..Unfortunately, the CSF detection of plasmin system could not be a useful biomarker for either AD diagnosis or disease progression. However, these findings do not exclude the possible involvement of the plasmin system in AD...
- Cerebrospinal fluid levels of Aβ42 relationship with cholinergic cortical activity in Alzheimer's disease patientsAlessandro Martorana
Dipartimento di Neuroscienze, Universita di Roma Torvergata, Viale Oxford 81, 00133, Rome, Italy
J Neural Transm (Vienna) 119:771-8. 2012..We suggest that coupling of CSF biomarkers with neurophysiological parameters of central cholinergic function could be important to better detect ongoing mechanisms of neural degeneration in vivo...
- Beyond the cholinergic hypothesis: do current drugs work in Alzheimer's disease?Alessandro Martorana
Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Rome, Italy
CNS Neurosci Ther 16:235-45. 2010....
- Altered dopamine modulation of LTD-like plasticity in Alzheimer's disease patientsGiacomo Koch
Stroke Unit, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Rome, Italy
Clin Neurophysiol 122:703-7. 2011..Mechanisms of synaptic plasticity like long term depression (LTD) are altered in experimental models of Alzheimer's disease (AD). LTD-like plasticity mechanisms has not been yet fully investigated in AD patients...
- CSF tau levels influence cortical plasticity in Alzheimer's disease patientsGiacomo Koch
Dipartimento di Neuroscienze, Policlinico Tor Vergata, Universita di Roma Tor Vergata, Rome, Italy
J Alzheimers Dis 26:181-6. 2011..These data could be interpreted as the consequence of CSF t-Tau mediated abnormal excitatory activity and could suggest that CSF t-Tau may impact mechanisms of cortical plasticity...
- In vivo electrophysiology of dopamine-denervated striatum: focus on the nitric oxide/cGMP signaling pathwaySalvatore Galati
Division of Neurology, Department of Neuroscience, University of Rome Tor Vergata, Rome, Italy
Synapse 62:409-20. 2008..In addition, these findings suggest a functional cross-talk between NO, spontaneously active interneurons, and projection neurons that becomes critical in the parkinsonian state...
- Neurotensin effects on N-type calcium currents among rat pallidal neurons: an electrophysiological and immunohistochemical studyAlessandro Martorana
Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Italy
Synapse 60:371-83. 2006..This hypothesis might have implications on both sensori-motor and associative functions of the GP and should be tested in DA-denervated disease models...
- Abeta1-42 Detection in CSF of Alzheimer's disease is influenced by temperature: indication of reversible Abeta1-42 aggregation?Giulia M Sancesario
Clinical Biochemistry and Molecular Biology, Rome, Italy
Exp Neurol 223:371-6. 2010..Moreover, our study suggests that low temperature could induce Abeta1-42 conformational changes and multimeric aggregates in probable AD, but, more importantly, Abeta1-42 aggregation could be reversible...
- CSF markers in Alzheimer disease patients are not related to the different degree of cognitive impairmentAlessandro Stefani
IRCCS Fondazione S Lucia, Rome, Italy
J Neurol Sci 251:124-8. 2006..Conversely, t-tau concentration correlates with the transition towards marked cognitive impairment...
- Distribution of TRPC1 receptors in dendrites of rat substantia nigra: a confocal and electron microscopy studyAlessandro Martorana
Santa Lucia Foundation IRCCS Hospital, Laboratory of Neuroanatomy, Via del Fosso Fiorano 64, Rome, Italy
Eur J Neurosci 24:732-8. 2006..Such observation reinforces the concept of an involvement of TRPC1 in mGluR1-mediated excitatory inputs in rat dopamine neurons...
- Frailty among Alzheimer's disease patientsGiacomo Koch
Department of Neuroscience, University of Rome Tor Vergata, 1 Montpellier Street 00133 Rome, Italy
CNS Neurol Disord Drug Targets 12:507-11. 2013..In the absence of other indices we conclude that patients with these features could well be considered "frail" among AD. ..
- AD with subcortical white matter lesions and vascular dementia: CSF markers for differential diagnosisAlessandro Stefani
CERC IRCCS Fondazione Santa Lucia, Rome, Italy
J Neurol Sci 237:83-8. 2005..VD. In conclusion, Abeta1-42 proved to be a valuable tool to discriminate AD vs. VD patients and possibly to improve diagnostic accuracy in clinical forms, improperly classified as "mixed dementia" based on radiological vascular lesions...
- Co-localization of brain-derived neurotrophic factor (BDNF) and wild-type huntingtin in normal and quinolinic acid-lesioned rat brainFrancesca R Fusco
Basal Ganglia Unit, Laboratory of Experimental Neurorehabilitation, Santa Lucia Foundation IRCCS, Via Ardeatina 306, Rome 00179, Italy
Eur J Neurosci 18:1093-102. 2003....
- Comparison between Early-Onset and Late-Onset Alzheimer's Disease Patients with Amnestic Presentation: CSF and (18)F-FDG PET StudyAgostino Chiaravalloti
Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy
Dement Geriatr Cogn Dis Extra 6:108-19. 2016..To investigate the differences in brain glucose consumption between patients with early onset of Alzheimer's disease (EOAD, aged ≤65 years) and patients with late onset of Alzheimer's disease (LOAD, aged >65 years)...
- Inflammation triggers synaptic alteration and degeneration in experimental autoimmune encephalomyelitisDiego Centonze
Neurologic Clinic, Department of Neuroscience, Tor Vergata University, 00133 Rome, Italy
J Neurosci 29:3442-52. 2009..Our data establish a link between neuroinflammation and synaptic degeneration and calls for early neuroprotective therapies in chronic inflammatory diseases of the CNS...
- Long-term potentiation-like cortical plasticity is disrupted in Alzheimer's disease patients independently from age of onsetFrancesco Di Lorenzo
Non Invasive Brain Stimulation Unit Department of Behavioral and Clinical Neurology, Santa Lucia Foundation IRCCS, Rome, Italy
Ann Neurol 80:202-10. 2016..We used transcranial magnetic stimulation tools to investigate the mechanisms of cortical plasticity and sensory-motor integration in AD patients with a wide range of disease onset...
- Down-regulation of nitrergic transmission in the rat striatum after chronic nigrostriatal deafferentationGiuseppe Sancesario
Department of Neuroscience, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
Eur J Neurosci 20:989-1000. 2004....
- The load of amyloid-β oligomers is decreased in the cerebrospinal fluid of Alzheimer's disease patientsGiulia M Sancesario
Tor Vergata General Hospital, Faculty of Medicine and Surgery, The University of Rome Tor Vergata, Rome, Italy
J Alzheimers Dis 31:865-78. 2012..The low amount of Aβ oligomers detected in native CSF of AD may be inversely related to their levels in the brain, as occurs for Aβ monomers, representing a biomarker for the amyloid pathogenic cascade...
- Altered parietal-motor connections in Alzheimer's disease patientsSonia Bonnì
IRCCS Fondazione Santa Lucia, Rome, Italy
J Alzheimers Dis 33:525-33. 2013..Our findings reveal that parieto-frontal cortico-cortical functional connectivity is altered in AD patients, providing further evidence for a disconnection-based interpretation of AD symptoms...
- Impaired LTP- but not LTD-like cortical plasticity in Alzheimer's disease patientsGiacomo Koch
Fondazione Santa Lucia IRCCS, Rome, Italy
J Alzheimers Dis 31:593-9. 2012..These results demonstrate the impairment of LTP-like together with normal LTD-like cortical plasticity in AD patients...
- Exercise attenuates the clinical, synaptic and dendritic abnormalities of experimental autoimmune encephalomyelitisSilvia Rossi
Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
Neurobiol Dis 36:51-9. 2009..Our work suggests that life style and experiences can impact the clinical course of inflammatory neurodegenerative diseases by affecting their synaptic bases...
- Reversal of LTP-Like Cortical Plasticity in Alzheimer's Disease Patients with Tau-Related Faster Clinical ProgressionGiacomo Koch
Non Invasive Brain Stimulation Unit Department of Behavioural and Clinical Neurology, Santa Lucia Foundation IRCCS, Rome, Italy
J Alzheimers Dis 50:605-16. 2016..These results suggest that more aggressive tau pathology is associated with prominent LTD-like mechanisms of cortical plasticity and faster cognitive decline. ..
- P2Y1 receptor switches to neurons from glia in juvenile versus neonatal rat cerebellar cortexSusanna Amadio
Santa Lucia Foundation, Roma, Italy
BMC Dev Biol 7:77. 2007..In the CNS, several P2 receptors for extracellular nucleotides are identified on neurons and glial cells to participate to neuron-neuron, glia-glia and glia-neuron communication...
- Effects of simvastatin on neuroprotection and modulation of Bcl-2 and BAX in the rat quinolinic acid model of Huntington's diseaseStefano Patassini
Laboratory of Neuroanatomy, Santa Lucia Foundation IRCCS, European Center for Brain Research, Rome, Italy
Neurosci Lett 448:166-9. 2008..Our findings show that statins could be explored as possible neuroprotective agents for neurodegenerative disorders such as HD...
- Cerebrospinal Fluid Aβ42 Levels: When Physiological Become Pathological StateAlessandro Martorana
Clinica Neurologica, Sytem Medicine Department, University of Rome Tor Vergata, Rome, Italy
CNS Neurosci Ther 21:921-5. 2015..Aim of this review is to discuss the role of CSF Aβ levels in light of experimental, clinical pathologic, and electrophysiological results in AD and other pathological entities to put in a correct frame the value of Aβ changes. ..
- Dopaminergic modulation of cortical plasticity in Alzheimer's disease patientsGiacomo Koch
1 Non Invasive Brain Stimulation Unit, Department of Behavioural and Clinical Neurology, Santa Lucia Foundation IRCCS, Rome, Italy 2 Department of Neuroscience, Tor Vergata University, Rome, Italy
Neuropsychopharmacology 39:2654-61. 2014..Our findings reveal that dopamine agonists may restore the altered mechanisms of LTP-like cortical plasticity in AD patients, thus providing novel implications for therapies based on dopaminergic stimulation. ..
- Opioid-mediated modulation of calcium currents in striatal and pallidal neurons following reserpine treatment: focus on kappa responseFrancesca Spadoni
Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Italy
Synapse 51:194-205. 2004..The suppression of the kappa response only in striatum reinforces the notion of an imbalance of endogenous opiates as relevant in extrapyramidal motor dysfunctions...
- Cellular localization of TRPC3 channel in rat brain: preferential distribution to oligodendrocytesFrancesca R Fusco
Laboratory of Experimental Neurorehabilitation, Basal Ganglia Section, Santa Lucia Foundation I R C C S, Via Ardeatina 306, 00179 Rome, Italy
Neurosci Lett 365:137-42. 2004..Res. Tech. 52 (2001) 672], we can speculate that the distribution of TRPC3 in oligodendrocytes plays a role in myelination and or demyelination processes...
- Tissue plasminogen activator is required for corticostriatal long-term potentiationDiego Centonze
Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
Eur J Neurosci 16:713-21. 2002....
- Huntingtin distribution among striatal output neurons of normal rat brainFrancesca R Fusco
Laboratory of Experimental Neurorehabilitation, Santa Lucia Foundation IRCCS, Via Ardeatina 306, 00179, Rome, Italy
Neurosci Lett 339:53-6. 2003..Our data showed that striatopallidal neurons co-containing SP and D1a [Surmeier, D.J., Song, W.J., and Yan, Z., J. Neurosci., 16 (1996) 6579-6591] co-localized with huntingtin in a higher proportion than striatonigral neurons...
- CSF and clinical hallmarks of subcortical dementias: focus on DLB and PDDAlessandro Stefani
Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Rome, Italy
J Neural Transm (Vienna) 119:861-75. 2012..However, more complete data, possibly collected in fieri during the progressive derangement of cognitive abilities, are needed to improve our ability to decipher and treat these entities...
- D2-mediated modulation of N-type calcium currents in rat globus pallidus neurons following dopamine denervationAlessandro Stefani
IRCCS Fondazione Santa Lucia, Via Ardeatina 306, 00179 Roma, Italy
Eur J Neurosci 15:815-25. 2002..A direct D2 modulation of calcium conductance in GP may alter GP firing properties and GABA release onto pallidofugal targets...
- Adult polyglucosan body disease: proton magnetic resonance spectroscopy of the brain and novel mutation in the GBE1 geneRoberto Massa
Dipartimento di Neuroscienze, Università di Roma Tor Vergata and Fondazione Santa Lucia, Roma, Italy
Muscle Nerve 37:530-6. 2008....
- Orexinergic system dysregulation, sleep impairment, and cognitive decline in Alzheimer diseaseClaudio Liguori
Neurophysiopathology Unit, Sleep Medicine Centre, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy
JAMA Neurol 71:1498-505. 2014..Orexin contributes to the regulation of the sleep-wake cycle by increasing arousal levels and maintaining wakefulness...
- Is cerebral glucose metabolism related to blood-brain barrier dysfunction and intrathecal IgG synthesis in Alzheimer disease?: A 18F-FDG PET/CT studyAgostino Chiaravalloti
aDepartment of Biomedicine and Prevention, University Tor Vergata, Rome, Italy bIRCCS Neuromed, Pozzilli, Italy cDepartment of Health Sciences, University Magna Graecia, Catanzaro, Italy dDepartment of Neurosciences, University Tor Vergata, Rome, Italy eIRCCS Santa Lucia, Rome, Italy
Medicine (Baltimore) 95:e4206. 2016..No significant relationships have been found between brain glucose consumption and IgG index. The results of our study suggest that BBB dysfunction is related to reduction of cortical activity in the left temporal cortex in AD subjects. ..
- Kyphoplasty: a new opportunity for rehabilitation of neurologic disabilitiesSalvatore Masala
Department of Diagnostics for Images and Interventional Radiology, University of Rome Tor Vergata, Policlinico Tor Vergata General Hospital, Rome, Italy
Am J Phys Med Rehabil 83:810-2. 2004....