Silvia Martini

Summary

Affiliation: University of Siena
Country: Italy

Publications

  1. ncbi request reprint Solution behavior of a sugar-based carborane for boron neutron capture therapy: a nuclear magnetic resonance investigation
    Claudia Bonechi
    Dipartimento di Scienze e Tecnologie Chimiche e dei Biosistemi, Universita di Siena, Via A Moro 2, 53100 Siena, Italy
    Biophys Chem 125:320-7. 2007
  2. ncbi request reprint Solution structure of rifaximin and its synthetic derivative rifaximin OR determined by experimental NMR and theoretical simulation methods
    Silvia Martini
    Department of Chemical and Biosystem Sciences, University of Siena, Via Aldo Moro, 2 53100 Siena, Italy
    Bioorg Med Chem 12:2163-72. 2004
  3. ncbi request reprint Drug-protein recognition processes investigated by NMR relaxation data. A study on corticosteroid-albumin interactions
    Silvia Martini
    Department of Chemical and Biosystem Sciences, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy
    Biochem Pharmacol 71:858-64. 2006
  4. doi request reprint Antimicrobial activity against Helicobacter pylori strains and antioxidant properties of blackberry leaves (Rubus ulmifolius) and isolated compounds
    Silvia Martini
    Dipartimento Farmaco Chimico Tecnologico, Universita di Siena, Via Aldo Moro 2, 53100 Siena, Italy
    Int J Antimicrob Agents 34:50-9. 2009
  5. doi request reprint Interaction of quercetin and its conjugate quercetin 3-O-beta-D-glucopyranoside with albumin as determined by NMR relaxation data
    Silvia Martini
    Department of Chemical and Biosystem Sciences, University of Siena, Via Aldo Moro, 2 53100 Siena, Italy
    J Nat Prod 71:175-8. 2008
  6. ncbi request reprint Antibacterial activity of grape extracts on cagA-positive and -negative Helicobacter pylori clinical isolates
    S Martini
    Dipartimento de Farmaco Chimico Tecnologico, Università degli Studi de Siena, Siena, Italy
    J Chemother 21:507-13. 2009
  7. doi request reprint Increasing photostability and water-solubility of carotenoids: synthesis and characterization of β-carotene-humic acid complexes
    Silvia Martini
    Department of Pharmaceutical and Applied Chemistry, University of Siena, 53100 Siena, Italy
    J Photochem Photobiol B 101:355-61. 2010
  8. doi request reprint Interaction between vine pesticides and bovine serum albumin studied by nuclear spin relaxation data
    Silvia Martini
    Department of Pharmaceutical and Applied Chemistry, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy
    J Agric Food Chem 58:10705-9. 2010
  9. ncbi request reprint In vivo NMR study of yeast fermentative metabolism in the presence of ferric irons
    Maso Ricci
    Department of Pharmaceutical and Applied Chemistry, University of Siena, Via Aldo Moro, 2 53100 Siena, Italy
    J Biosci 36:97-103. 2011
  10. ncbi request reprint Metabolic response to exogenous ethanol in yeast: an in vivo NMR and mathematical modelling approach
    Silvia Martini
    Dipartimento di Scienze e Tecnologie Chimiche e dei Biosistemi, Università di Siena Via Aldo Moro, 2 53100 Siena, Italy
    Biophys Chem 120:135-42. 2006

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Solution behavior of a sugar-based carborane for boron neutron capture therapy: a nuclear magnetic resonance investigation
    Claudia Bonechi
    Dipartimento di Scienze e Tecnologie Chimiche e dei Biosistemi, Universita di Siena, Via A Moro 2, 53100 Siena, Italy
    Biophys Chem 125:320-7. 2007
    ..At the same time, inter-molecular specific CH()O interactions do not seem effective in the aggregate formation process, which appears to take place only on non-specific hydrophobic basis...
  2. ncbi request reprint Solution structure of rifaximin and its synthetic derivative rifaximin OR determined by experimental NMR and theoretical simulation methods
    Silvia Martini
    Department of Chemical and Biosystem Sciences, University of Siena, Via Aldo Moro, 2 53100 Siena, Italy
    Bioorg Med Chem 12:2163-72. 2004
    ..Although no dramatic structural rearrangements were detected, the aliphatic chain moved toward CH(3)(14), causing a reduction of the aromatic shielding contribution in particular on CH(3)(34)...
  3. ncbi request reprint Drug-protein recognition processes investigated by NMR relaxation data. A study on corticosteroid-albumin interactions
    Silvia Martini
    Department of Chemical and Biosystem Sciences, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy
    Biochem Pharmacol 71:858-64. 2006
    ..This approach allowed the comparison of the binding ability of prednisolone and prednisone towards albumin...
  4. doi request reprint Antimicrobial activity against Helicobacter pylori strains and antioxidant properties of blackberry leaves (Rubus ulmifolius) and isolated compounds
    Silvia Martini
    Dipartimento Farmaco Chimico Tecnologico, Universita di Siena, Via Aldo Moro 2, 53100 Siena, Italy
    Int J Antimicrob Agents 34:50-9. 2009
    ..A relationship between antimicrobial activity and antioxidant capacity was found only for H. pylori strain G21 CagA(-) strain...
  5. doi request reprint Interaction of quercetin and its conjugate quercetin 3-O-beta-D-glucopyranoside with albumin as determined by NMR relaxation data
    Silvia Martini
    Department of Chemical and Biosystem Sciences, University of Siena, Via Aldo Moro, 2 53100 Siena, Italy
    J Nat Prod 71:175-8. 2008
    ..The calculated values of the affinity indexes and thermodynamic equilibrium constants suggested a much stronger capacity of 1 to interact with BSA when compared with its glucosylated derivative, 2...
  6. ncbi request reprint Antibacterial activity of grape extracts on cagA-positive and -negative Helicobacter pylori clinical isolates
    S Martini
    Dipartimento de Farmaco Chimico Tecnologico, Università degli Studi de Siena, Siena, Italy
    J Chemother 21:507-13. 2009
    ..pylori isolates, which are endowed with cancer promoter activity, this observation may help explain why the organisms expressing CagA are more closely associated with atrophic gastritis and gastric carcinoma development...
  7. doi request reprint Increasing photostability and water-solubility of carotenoids: synthesis and characterization of β-carotene-humic acid complexes
    Silvia Martini
    Department of Pharmaceutical and Applied Chemistry, University of Siena, 53100 Siena, Italy
    J Photochem Photobiol B 101:355-61. 2010
    ..This work provides a useful tool to avoid antioxidants photodegradation and oxidation by radicals, thus maintaining their biological activity...
  8. doi request reprint Interaction between vine pesticides and bovine serum albumin studied by nuclear spin relaxation data
    Silvia Martini
    Department of Pharmaceutical and Applied Chemistry, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy
    J Agric Food Chem 58:10705-9. 2010
    ..These results indicate that myclobutanil and triadimenol, despite their structure similarity, may have very different residence times in the plasma and rates of clearance...
  9. ncbi request reprint In vivo NMR study of yeast fermentative metabolism in the presence of ferric irons
    Maso Ricci
    Department of Pharmaceutical and Applied Chemistry, University of Siena, Via Aldo Moro, 2 53100 Siena, Italy
    J Biosci 36:97-103. 2011
    ..The developed mathematical model was able to simulate the cellular activity, the metabolic yield and the main metabolic fluxes occurring during fermentation and to describe how these are modulated by the presence of ferric ions...
  10. ncbi request reprint Metabolic response to exogenous ethanol in yeast: an in vivo NMR and mathematical modelling approach
    Silvia Martini
    Dipartimento di Scienze e Tecnologie Chimiche e dei Biosistemi, Università di Siena Via Aldo Moro, 2 53100 Siena, Italy
    Biophys Chem 120:135-42. 2006
    ..The robustness and flexibility of the model enables it to work correctly at different initial exogenous ethanol concentrations...
  11. ncbi request reprint Synthetic polymers as biomacromolecular models for studying ligand-protein interactions: a nuclear spin relaxation approach
    Gianfranco Corbini
    Department of Pharmaceutical Chemistry, University of Siena, Via Aldo Moro, 2, Siena 53100, Italy
    J Pharm Biomed Anal 40:113-21. 2006
    ....
  12. doi request reprint Interaction study of bioactive molecules with fibrinogen and human platelets determined by 1H NMR relaxation experiments
    Claudia Bonechi
    Department of Chemical and Biosystem Sciences and CSGI, University of Siena, Siena, Italy
    Bioorg Med Chem 17:1630-5. 2009
    ..In this paper, we applied this methodology to investigate the affinity of epinephrine and isoproterenol towards two different systems: fibrinogen and platelets...
  13. doi request reprint Study of bradykinin conformation in the presence of model membrane by Nuclear Magnetic Resonance and molecular modelling
    Claudia Bonechi
    Department of Chemical and Biosystem Sciences and CSGI, University of Siena, Via A Moro 2, 53100 Siena, Italy
    Biochim Biophys Acta 1788:708-16. 2009
    ..These structural results supported the hypothesis of the central role played by the peptide C-terminal domain in biological environments, and provided an explanation for the different biological behaviours observed for bradykinin..
  14. pmc Water-protein interactions: the secret of protein dynamics
    Silvia Martini
    Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy
    ScientificWorldJournal 2013:138916. 2013
    ..In this paper we demonstrate that Nuclear Magnetic Resonance Spectroscopy can be used to determine the dynamical contributions of proteins to the water molecules belonging to their hydration shells...
  15. ncbi request reprint Metabolic response to exogenous ethanol in yeast: an in vivo statistical total correlation NMR spectroscopy approach
    Maso Ricci
    Department of Pharmaceutical and Applied Chemistry, University of Siena, Siena, Italy
    J Biosci 37:749-55. 2012
    ....
  16. doi request reprint Stacking interaction study of trans-resveratrol (trans-3,5,4'-trihydroxystilbene) in solution by Nuclear Magnetic Resonance and Fourier Transform Infrared Spectroscopy
    Claudia Bonechi
    Department of Chemical and Biosystem Sciences, University of Siena, Via Aldo Moro, 2 53100 Siena, Italy
    Magn Reson Chem 46:625-9. 2008
    ..Moreover, the dynamics of the supramolecular aggregates were studied by nuclear spin relaxation data...
  17. pmc Using liposomes as carriers for polyphenolic compounds: the case of trans-resveratrol
    Claudia Bonechi
    Pharmaceutical and Applied Chemistry Departments and CSGI, University of Siena, Siena, Italy
    PLoS ONE 7:e41438. 2012
    ..The toxicity of all these systems was tested on stabilized cell lines (mouse fibroblast NIH-3T3 and human astrocytes U373-MG), showing that cell viability was not affected by the administration of liposomial resveratrol...
  18. doi request reprint Increased susceptibility to resveratrol of Helicobacter pylori strains isolated from patients with gastric carcinoma
    Silvia Martini
    Department of Pharmaceutical and Applied Chemistry, University of Siena, Via Aldo Moro, 2 53100 Siena, Italy
    J Nat Prod 74:2257-60. 2011
    ..Since the targets of resveratrol (1) are also the bacterial ATPases, their putative reduced expression could increase the susceptibility to this compound, so that it saturates its targets more quickly and efficiently...
  19. ncbi request reprint Fibrinogen-catecholamine interaction as observed by NMR and Fourier transform infrared spectroscopy
    Silvia Martini
    Department of Chemical and Biosystem Sciences, University of Siena, Via Aldo Moro, 2 53100 Siena, Italy
    Biomacromolecules 8:2689-96. 2007
    ..The interaction with the stress level of epinephrine leads to drastic protein conformational changes, whereas norepinephrine does not affect fibrinogen secondary structure, even at stress concentration...
  20. ncbi request reprint Comparative analysis of the effects of locally used herbicides and their active ingredients on a wild-type wine Saccharomyces cerevisiae strain
    Daniela Braconi
    Dipartimento di Biologia Molecolare, Universita degli Studi di Siena, Via Fiorentina 1, 53100, Siena, Italy
    J Agric Food Chem 54:3163-72. 2006
    ..Interestingly, we found that while pure active compounds affect cell growth and metabolism at a lower extent, commercial preparations have a significant major negative influence on yeast biology...
  21. doi request reprint Discrimination of human semen specimens by NMR data, sperm parameters, and statistical analysis
    Claudia Bonechi
    a Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro, Siena, Italy
    Syst Biol Reprod Med 61:353-9. 2015
    ..Furthermore, this methodology allows the identification of the metabolites which play the most important role in identifying differences among human seminal plasma samples. ..
  22. ncbi request reprint Boronphenylalanine insertion in cationic liposomes for Boron Neutron Capture Therapy
    Silvia Martini
    Department of Chemical and Biosystem Sciences, University of Siena Via Aldo Moro, 2, 53100 Siena, Italy
    Biophys Chem 111:27-34. 2004
    ..Further information was given by proton spin-lattice relaxation rates...
  23. ncbi request reprint In vivo 13C-NMR and modelling study of metabolic yield response to ethanol stress in a wild-type strain of Saccharomyces cerevisiae
    Silvia Martini
    Dipartimento di Scienze e Tecnologie Chimiche e dei Biosistemi, Universita di Siena, Via Aldo Moro 2, 53100 Siena, Italy
    FEBS Lett 564:63-8. 2004
    ..In particular, the ratio between the kinetic constants associated with ethanol production and glucose consumption gave the estimation of the metabolic yield of the processes in perfect agreement with experimental results...
  24. ncbi request reprint The bio-optical properties of CDOM as descriptor of lake stratification
    Luca Bracchini
    Dipartimento di Scienze e Tecnologie Chimiche e dei Biosistemi, Universita di Siena, Via A Moro, 2 53100 Siena, Italy
    J Photochem Photobiol B 85:145-9. 2006
    ..The proposed multivariate approach can be used for the analysis of different stratified aquatic ecosystems in relation to interaction between bio-optical properties and stratification of the water body...
  25. ncbi request reprint Local measures of intermolecular free energies in solution
    Ching Ling Teng
    Chemistry Department and Biophysics Program, University of Virginia, Charlottesville, Virginia 22904, USA
    J Am Chem Soc 126:15253-7. 2004
    ....