Nicola Martinelli

Summary

Affiliation: University of Verona
Country: Italy

Publications

  1. ncbi Paraoxonases: ancient substrate hunters and their evolving role in ischemic heart disease
    Nicola Martinelli
    Department of Medicine, Section of Internal Medicine, University of Verona, Verona, Italy
    Adv Clin Chem 59:65-100. 2013
  2. doi An integrated genomic-transcriptomic approach supports a role for the proto-oncogene BCL3 in atherosclerosis
    Giovanna Marchetti
    Nicola Martinelli, Department of Medicine, University of Verona, 37134 Verona, Italy, E mail
    Thromb Haemost 113:655-63. 2015
  3. doi Air particulate matter and cardiovascular disease: a narrative review
    Nicola Martinelli
    Department of Medicine, Section of Internal Medicine B, University of Verona, Italy
    Eur J Intern Med 24:295-302. 2013
  4. doi Novel serum paraoxonase activity assays are associated with coronary artery disease
    Nicola Martinelli
    Department of Clinical and Experimental Medicine, University of Verona, Verona, Italy
    Clin Chem Lab Med 47:432-40. 2009
  5. pmc Additive effect of LRP8/APOER2 R952Q variant to APOE epsilon2/epsilon3/epsilon4 genotype in modulating apolipoprotein E concentration and the risk of myocardial infarction: a case-control study
    Nicola Martinelli
    Department of Clinical and Experimental Medicine, University of Verona, Verona, Italy
    BMC Med Genet 10:41. 2009
  6. doi Polymorphisms at LDLR locus may be associated with coronary artery disease through modulation of coagulation factor VIII activity and independently from lipid profile
    Nicola Martinelli
    Department of Medicine, University of Verona, Verona, Italy
    Blood 116:5688-97. 2010
  7. pmc Low levels of serum paraoxonase activities are characteristic of metabolic syndrome and may influence the metabolic-syndrome-related risk of coronary artery disease
    Nicola Martinelli
    Department of Medicine, University of Verona, Policlinico G B Rossi, Italy
    Exp Diabetes Res 2012:231502. 2012
  8. ncbi The -1131 T>C and S19W APOA5 gene polymorphisms are associated with high levels of triglycerides and apolipoprotein C-III, but not with coronary artery disease: an angiographic study
    Nicola Martinelli
    University of Verona, Department of Clinical and Experimental Medicine, Italy
    Atherosclerosis 191:409-17. 2007
  9. pmc Combined effect of hemostatic gene polymorphisms and the risk of myocardial infarction in patients with advanced coronary atherosclerosis
    Nicola Martinelli
    Department of Clinical and Experimental Medicine, University of Verona, Verona, Italy
    PLoS ONE 3:e1523. 2008
  10. pmc Factor II activity is similarly increased in patients with elevated apolipoprotein CIII and in carriers of the factor II 20210A allele
    Oliviero Olivieri
    Department of Medicine, Unit of Internal Medicine, University of Verona, Verona, Italy
    J Am Heart Assoc 2:e000440. 2013

Collaborators

Detail Information

Publications49

  1. ncbi Paraoxonases: ancient substrate hunters and their evolving role in ischemic heart disease
    Nicola Martinelli
    Department of Medicine, Section of Internal Medicine, University of Verona, Verona, Italy
    Adv Clin Chem 59:65-100. 2013
    ..In this review, we examine the biochemical pathways impacted by these unique enzymes and investigate the potential use of PON as diagnostic tools and their impact on development of future therapeutic strategies...
  2. doi An integrated genomic-transcriptomic approach supports a role for the proto-oncogene BCL3 in atherosclerosis
    Giovanna Marchetti
    Nicola Martinelli, Department of Medicine, University of Verona, 37134 Verona, Italy, E mail
    Thromb Haemost 113:655-63. 2015
    ..Our integrated approach suggests a role for BCL3 in cardiovascular diseases. ..
  3. doi Air particulate matter and cardiovascular disease: a narrative review
    Nicola Martinelli
    Department of Medicine, Section of Internal Medicine B, University of Verona, Italy
    Eur J Intern Med 24:295-302. 2013
    ....
  4. doi Novel serum paraoxonase activity assays are associated with coronary artery disease
    Nicola Martinelli
    Department of Clinical and Experimental Medicine, University of Verona, Verona, Italy
    Clin Chem Lab Med 47:432-40. 2009
    ..The aim of this study was to evaluate for the first time TBBLase and DEPCyMCase activity in patients with coronary artery disease (CAD)...
  5. pmc Additive effect of LRP8/APOER2 R952Q variant to APOE epsilon2/epsilon3/epsilon4 genotype in modulating apolipoprotein E concentration and the risk of myocardial infarction: a case-control study
    Nicola Martinelli
    Department of Clinical and Experimental Medicine, University of Verona, Verona, Italy
    BMC Med Genet 10:41. 2009
    ....
  6. doi Polymorphisms at LDLR locus may be associated with coronary artery disease through modulation of coagulation factor VIII activity and independently from lipid profile
    Nicola Martinelli
    Department of Medicine, University of Verona, Verona, Italy
    Blood 116:5688-97. 2010
    ..67 with 95% confidence interval, 1.10-2.54). Haplotype analysis confirmed such results. Our data suggest that polymorphisms at LDLR locus modulate FVIII:c levels and may be associated with CAD risk independently from plasma lipids...
  7. pmc Low levels of serum paraoxonase activities are characteristic of metabolic syndrome and may influence the metabolic-syndrome-related risk of coronary artery disease
    Nicola Martinelli
    Department of Medicine, University of Verona, Policlinico G B Rossi, Italy
    Exp Diabetes Res 2012:231502. 2012
    ..45 with 95% CI 0.47-4.46). Our results suggest that low PON1 concentrations are typical in MS and may modulate the MS-related risk of CAD...
  8. ncbi The -1131 T>C and S19W APOA5 gene polymorphisms are associated with high levels of triglycerides and apolipoprotein C-III, but not with coronary artery disease: an angiographic study
    Nicola Martinelli
    University of Verona, Department of Clinical and Experimental Medicine, Italy
    Atherosclerosis 191:409-17. 2007
    ..Different genotypes, i.e., APOA5 and APOC3 variants, may lead to similar biochemical phenotypes, namely hypertriglyceridemia, but to contrasting clinical phenotypes such as the presence of angiographically proven CAD...
  9. pmc Combined effect of hemostatic gene polymorphisms and the risk of myocardial infarction in patients with advanced coronary atherosclerosis
    Nicola Martinelli
    Department of Clinical and Experimental Medicine, University of Verona, Verona, Italy
    PLoS ONE 3:e1523. 2008
    ..The aim of this study was to evaluate the combined effect of ten common prothrombotic polymorphisms as a determinant of MI...
  10. pmc Factor II activity is similarly increased in patients with elevated apolipoprotein CIII and in carriers of the factor II 20210A allele
    Oliviero Olivieri
    Department of Medicine, Unit of Internal Medicine, University of Verona, Verona, Italy
    J Am Heart Assoc 2:e000440. 2013
    ..Few studies have so far investigated the relationship between apolipoprotein CIII (Apo CIII) and coagulation pathway in subjects with or without coronary artery disease (CAD)...
  11. ncbi FADS genotypes and desaturase activity estimated by the ratio of arachidonic acid to linoleic acid are associated with inflammation and coronary artery disease
    Nicola Martinelli
    Department of Clinical and Experimental Medicine and the Section of Biology and Genetics, University of Verona, Verona, Italy
    Am J Clin Nutr 88:941-9. 2008
    ..Single-nucleotide polymorphisms (SNPs) in FADS1 and FADS2 have been associated with different concentrations of AA and LA, and those associations have possible functional consequences for desaturase activity...
  12. ncbi ALOX5AP gene variants and risk of coronary artery disease: an angiography-based study
    Domenico Girelli
    Department of Clinical and Experimental Medicine, University of Verona, Verona, Italy
    Eur J Hum Genet 15:959-66. 2007
    ..Our angiography-based study suggests a possible modest role of ALOX5AP in the development of the atheroma rather than in its late thrombotic complications such as MI...
  13. ncbi Apolipoprotein C-III, metabolic syndrome, and risk of coronary artery disease
    Oliviero Olivieri
    Unit of Internal Medicine, Department of Clinical and Experimental Medicine, University of Verona, Verona, Italy
    J Lipid Res 44:2374-81. 2003
    ..6% vs. 34.8%, P < 0.05). In conclusion, apoC-III-rich lipoprotein metabolism and the APOC3 polymorphism have relevant impacts on the CAD risk of MS patents...
  14. pmc Gene sequence variations of the platelet P2Y12 receptor are associated with coronary artery disease
    Ugo Cavallari
    Department of Mother and Child and of Biology Genetics, Section of Biology and Genetics, University of Verona, Verona, Italy
    BMC Med Genet 8:59. 2007
    ..No data are available on its association with coronary artery disease (CAD)...
  15. pmc Serum levels of the hepcidin-20 isoform in a large general population: the Val Borbera study
    Natascia Campostrini
    Department of Medicine, Section of Internal Medicine, University of Verona, Italy
    J Proteomics 76:28-35. 2012
    ..This article is part of a Special Issue entitled: Integrated omics...
  16. pmc Global DNA hypomethylation in peripheral blood mononuclear cells as a biomarker of cancer risk
    Simonetta Friso
    Corresponding Author Simonetta Friso, Department of Medicine, University of Verona School of Medicine, Policlinico G B Rossi, P le L A Scuro, 10, 37134 Verona, Italy
    Cancer Epidemiol Biomarkers Prev 22:348-55. 2013
    ..Whether methylation measured in peripheral blood mononuclear cells (PBMCs) DNA is a clinically reliable biomarker for early detection or cancer risk assessment is to be established...
  17. doi Promoter methylation in coagulation F7 gene influences plasma FVII concentrations and relates to coronary artery disease
    Simonetta Friso
    Department of Medicine, University of Verona School of Medicine, Verona, Italy
    J Med Genet 49:192-9. 2012
    ..Transcriptional regulation of F7 by epigenetic features is, however, still unknown as is the inter-relationship of genetic and epigenetic modifications at the promoter site...
  18. ncbi Increased factor VIII coagulant activity levels in male carriers of the factor V R2 polymorphism
    Nicola Martinelli
    Department of Clinical and Experimental Medicine, University of Verona, Italy
    Blood Coagul Fibrinolysis 18:125-9. 2007
    ..The report concomitantly addresses the relationship between factor V and factor VIII levels and supports the hypothesis of a mild prothrombotic role of FVHR2 by means of increased factor VIII levels...
  19. pmc Hyperhomocysteinemia and mortality after coronary artery bypass grafting
    Domenico Girelli
    Department of Clinical and Experimental Medicine, University of Verona, Italy
    PLoS ONE 1:e83. 2006
    ..No previous study specifically has addressed the relationship between HHcy and mortality after coronary artery bypass grafting (CABG) surgery. The aim of this study is to evaluate the prognostic impact of HHcy after CABG surgery...
  20. ncbi Apolipoprotein C-III, n-3 polyunsaturated fatty acids, and "insulin-resistant" T-455C APOC3 gene polymorphism in heart disease patients: example of gene-diet interaction
    Oliviero Olivieri
    Unit of Internal Medicine, Department of Clinical and Experimental Medicine, University of Verona, Verona, Italy
    Clin Chem 51:360-7. 2005
    ..The T-455C polymorphism in the insulin-responsive element of the APOC3 gene influences TG and apo C-III concentrations. Long-chain n-3 polyunsaturated fatty acids (PUFAs) contained in fish have well-known apo C-III-lowering properties...
  21. ncbi On the association of the oxidised LDL receptor 1 (OLR1) gene in patients with acute myocardial infarction or coronary artery disease
    Elisabetta Trabetti
    Department of Mother and Child and of Biology Genetics, Section of Biology and Genetics, University of Verona, Verona, Italy
    Eur J Hum Genet 14:127-30. 2006
    ..Even if the OLR1 genotype frequency distribution data in CAD or AMI subjects here reported do not fully confirm the positive results of some other association studies, an association with a marker of CAD severity was observed...
  22. ncbi Antibodies against cyclic citrullinated peptides in patients affected by rheumatoid arthritis before and after infliximab treatment
    Paola Caramaschi
    Dipartimento di Medicina Clinica e Sperimentale, Istituto Medicina Interna B, Universita di Verona, Policlinico G B Rossi, P le Scuro, 37134, Verona, Italy
    Rheumatol Int 26:58-62. 2005
    ....
  23. ncbi Influence of polymorphisms in the factor VII gene promoter on activated factor VII levels and on the risk of myocardial infarction in advanced coronary atherosclerosis
    Claudia Bozzini
    Department of Clinical and Experimental Medicine, University of Verona, Policlinico G B Rossi, 37134 Verona, Italy
    Thromb Haemost 92:541-9. 2004
    ..This study highlights a "within-gene" interaction, and the need to explore polymorphisms in candidate gene(s) in detail...
  24. ncbi Prevalence of body iron excess in the metabolic syndrome
    Claudia Bozzini
    Department of Clinical and Experimental Medicine, University of Verona, Policlinico G B Rossi, 37134 Verona, Italy
    Diabetes Care 28:2061-3. 2005
  25. doi SNPs of the FADS gene cluster are associated with polyunsaturated fatty acids in a cohort of patients with cardiovascular disease
    Giovanni Malerba
    Department of Mother and Child, and Biology Genetics, Section of Biology and Genetics, University of Verona, Verona, Italy
    Lipids 43:289-99. 2008
    ....
  26. doi A score of risk factors associated with ischemic digital ulcers in patients affected by systemic sclerosis treated with iloprost
    Paola Caramaschi
    Dipartimento di Medicina Clinica e Sperimentale, Universita di Verona, Policlinico G B Rossi, Piazzale Scuro, 37134, Verona, Italy
    Clin Rheumatol 28:807-13. 2009
    ..A score reflecting the sum of these factors may be useful to predict the risk of developing ischemic DUs...
  27. doi Detection of a large deletion in the P-selectin (SELP) gene
    Alessandra Pasquali
    Department of Mother and Child, and Biology Genetics, University of Verona, Strada Le Grazie 8, Verona, Italy
    Mol Cell Probes 24:161-5. 2010
    ..Re-genotyping of 1023 apparent homozygotes indicated an overall allele frequency of 0.27%. The inclusion of this allelic variant in genetic association studies will avoid genotyping errors and marginally improve the sensitivity...
  28. ncbi Low plasma vitamin B-6 concentrations and modulation of coronary artery disease risk
    Simonetta Friso
    Department of Clinical and Experimental Medicine, University of Verona School of Medicine, Verona, Italy
    Am J Clin Nutr 79:992-8. 2004
    ..Both low PLP and elevated inflammatory markers, such as high-sensitivity CRP (hs-CRP) and fibrinogen, are related to higher risk of coronary artery disease (CAD)...
  29. ncbi Folic acid effects on s-adenosylmethionine, s-adenosylhomocysteine, and DNA methylation in patients with intermediate hyperhomocysteinemia
    Francesca Pizzolo
    Department of Medicine, University of Verona School of Medicine, Verona, Italy
    J Am Coll Nutr 30:11-8. 2011
    ..The purpose of this study was to investigate the effects of FA supplementation on AdoMet, AdoHcy, and genomic DNA methylation in hyperhomocysteinemic subjects without end-stage renal disease...
  30. pmc Evaluation of hepcidin isoforms in hemodialysis patients by a proteomic approach based on SELDI-TOF MS
    Natascia Campostrini
    Department of Medicine, University of Verona, 37134 Verona, Italy
    J Biomed Biotechnol 2010:329646. 2010
    ..Measurement of hepcidin isoforms through MS-based techniques can be a useful tool for better understanding of their biological role in hemodialysis patients and other clinical conditions...
  31. ncbi The interaction between MTHFR 677 C-->T genotype and folate status is a determinant of coronary atherosclerosis risk
    Domenico Girelli
    Department of Clinical and Experimental Medicine, Institute of Biology and Genetics, University of Verona, Policlinico G B Rossi, 37134 Verona, Italy
    J Nutr 133:1281-5. 2003
    ..8, 95% CI, 1.03-3.15). A gene-nutrient interaction that defines a higher risk for CAD is determined by folate levels below specific thresholds, which differ depending on the MTHFR 677 C-->T genotype...
  32. pmc Relationship between human leucocyte antigen class I and class II and chronic idiopathic urticaria associated with aspirin and/or NSAIDs hypersensitivity
    Maria Luisa Pacor
    Dipartimento de Medicina Clinica e Sperimentale, Policlinico G B Rossi, Universita di Verona, Italy
    Mediators Inflamm 2006:62489. 2006
    ..HLA genes play a role in the predisposition of several diseases. The aim was to analyze the prevalence of HLA class I phenotypes and HLA-DRB1* genotype in patients with CIU associated with ASA and NSAIDs hypersensitivity (AICU)...
  33. ncbi Evaluation of finger skin temperature in scleroderma patients cyclically treated with iloprost
    Paola Caramaschi
    Dipartimento di Medicina Clinica e Sperimentale, Policlinico G B Rossi, Verona, Italy
    Joint Bone Spine 73:57-61. 2006
    ..To evaluate by computerized digital thermometry (CDT) the effect of cyclic iloprost infusions on finger skin temperature (FST) in scleroderma patients...
  34. pmc A novel molecular diagnostic marker for familial and early-onset coronary artery disease and myocardial infarction in the LRP8 gene
    Gong Qing Shen
    From the Department of Molecular Cardiology, Center for Cardiovascular Genetics, Lerner Research Institute, Cleveland Clinic, OH G Q S, L L, S R, S A, Q C, Q K W Department of Medicine, University of Verona, Verona, Italy D G, O O, N M Samsung Medical Center, Sungkyunkwan University, Seoul, South Korea J E P The Scripps Research Institute, Scripps Clinic, La Jolla, CA E J T and Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, China Q K W
    Circ Cardiovasc Genet 7:514-20. 2014
    ....
  35. doi A 'desaturase hypothesis' for atherosclerosis: Janus-faced enzymes in omega-6 and omega-3 polyunsaturated fatty acid metabolism
    Nicola Martinelli
    Department of Clinical and Experimental Medicine, University of Verona, Policlinico G B Rossi, Piazzale L A Scuro 10, Verona, Italy
    J Nutrigenet Nutrigenomics 2:129-39. 2009
    ..For these reasons, carriers of specific FADS haplotypes may be predisposed to more pronounced vascular inflammatory damage, but also to an increased beneficial effect with omega-3 PUFA supplementation...
  36. pmc Reduced serum hepcidin levels in patients with chronic hepatitis C
    Domenico Girelli
    Department of Clinical and Experimental Medicine, University of Verona, Policlinico G B Rossi, Verona, Italy
    J Hepatol 51:845-52. 2009
    ....
  37. doi Comparative effect of tacrolimus 0.1% ointment and clobetasol 0.05% ointment in patients with oral lichen planus
    Giovanni Corrocher
    Dipartimento di Scienze Morfologico Biomediche, Sezione di Chirurgia Maxillo Faciale e Odontostomatologia, Universita di Verona, Verona, Italy
    J Clin Periodontol 35:244-9. 2008
    ..Oral lichen planus (OLP) is considered to be an autoimmune disease of unknown aetiology that affects the mucosae, especially the oral cavity...
  38. pmc The RFC1 80G>A, among Common One-Carbon Polymorphisms, Relates to Survival Rate According to DNA Global Methylation in Primary Liver Cancers
    Sara Moruzzi
    Department of Medicine, University of Verona School of Medicine, Verona, Italy
    PLoS ONE 11:e0167534. 2016
    ....
  39. doi Delta-5 and delta-6 desaturases: crucial enzymes in polyunsaturated fatty acid-related pathways with pleiotropic influences in health and disease
    Federica Tosi
    Department of Medicine, University of Verona, Piazzale Luduvico Antonio Scuro, 10, 37134, Verona, Italy
    Adv Exp Med Biol 824:61-81. 2014
    ..Moreover, we focus also on the potentially useful therapeutic application of D5D/D6D activity modulation, as suggested by anti-inflammatory and tumor-suppressing effects of D6D inhibition in mice models. ..
  40. pmc Paraoxonase-1 status in patients with hereditary hemochromatosis
    Nicola Martinelli
    Department of Medicine, Hospital of Verona, Policlinico G B Rossi, Verona, Italy
    J Lipid Res 54:1484-92. 2013
    ..Our study provides preliminary evidence that PON1 may play a role in protecting against iron-induced oxidative stress in hereditary hemochromatosis...
  41. doi Genetic architecture of coronary artery disease in the genome-wide era: implications for the emerging "golden dozen" loci
    Domenico Girelli
    Department of Clinical and Experimental Medicine, Section of Internal Medicine, University of Verona, Italy
    Semin Thromb Hemost 35:671-82. 2009
    ..Although these genetic variants have little or no current predictive value of at the level of individual patients, they have the potential to disclose novel biological mechanisms involved in the pathophysiology of CAD/MI...
  42. ncbi Homocysteine plasma concentration is related to severity of lung impairment in scleroderma
    Paola Caramaschi
    Dipartmento di Medicina Clinica e Sperimentale, Policlinico GB Rossi, Verona, Italy
    J Rheumatol 30:298-304. 2003
    ..To investigate the correlation between plasma concentration of total homocysteine and pulmonary involvement in patients with limited or diffuse scleroderma (systemic sclerosis, SSc)...
  43. pmc Increased serum hepcidin levels in subjects with the metabolic syndrome: a population study
    Nicola Martinelli
    Department of Medicine, University of Verona, Verona, Italy
    PLoS ONE 7:e48250. 2012
    ..Due to recently discovered pleiotropic effects of hepcidin, this may worsen insulin resistance and contribute to the cardiovascular complications of MetS...
  44. pmc Access rate to the emergency department for venous thromboembolism in relationship with coarse and fine particulate matter air pollution
    Nicola Martinelli
    Section of Internal Medicine, Department of Medicine, University of Verona, Verona, Italy
    PLoS ONE 7:e34831. 2012
    ..247; P = 0.012). Our results suggest that short-time exposure to high concentrations of PM(10-2.5) may favour an increased rate of ED accesses for VTE through the induction of a prothrombotic state...
  45. ncbi Infective endocarditis with lung and systemic embolization in an injection drug user
    Nicola Martinelli
    Department of Clinical and Experimental Medicine, University of Verona, Policlinico G B Rossi, 37134 Verona, Italy
    Eur Heart J 27:2938. 2006
  46. doi Serum DNase I, soluble Fas/FasL levels and cell surface Fas expression in patients with SLE: a possible explanation for the lack of efficacy of hrDNase I treatment
    Elisa Tinazzi
    Department of Clinical and Experimental Medicine, Section of Internal Medicine, University of Verona, 37134 Verona, Italy
    Int Immunol 21:237-43. 2009
    ..This role may contribute to explain the inefficacy of hrDNase I in SLE, a treatment proposed for the ability of DNase I to remove DNA from auto-antigenic nucleoprotein complexes...
  47. ncbi Anti-TNFalpha therapy in rheumatoid arthritis and autoimmunity
    Paola Caramaschi
    Dipartimento di Medicina Clinica e Sperimentale, Universita di Verona, Verona, Italy
    Rheumatol Int 26:209-14. 2006
    ..Both CRP and Blys do not seem to participate in this phenomenon. Other autoantibodies were detected in a few patients, but no case of onset of new autoimmune disorders was observed...
  48. ncbi Comparison of topical tacrolimus 0.1 % in pectin ointment with clobetasol 0.5% ointment in adults with moderate to severe desquamative gingivitis: A 4-week, randomized, double-blind clinical trial
    Giovanni Corrocher
    Dipartimento di Scienze Morfologico Biomediche, Sezione di Chirurgia Maxillo Facciale e Odontostomatologia, Universita di Verona, Verona, Italy
    Clin Ther 28:1296-302. 2006
    ..The time from the development of initial signs of DG to diagnosis can vary from months to years. Based on a literature search, no data concerning patients with DG without signs of autoimmune disease were available...
  49. ncbi Long-term evaluation of lung function in patients affected by scleroderma treated with cyclic iloprost infusions
    Paola Caramaschi
    Department of Clinical and Experimental Medicine, University of Verona, Verona, Italy
    Rheumatol Int 25:250-4. 2005
    ..The aim of this study was to evaluate pulmonary function in patients suffering from scleroderma treated for 3 years with cyclic iloprost infusions...