Annalisa Marcuzzi

Summary

Affiliation: University of Trieste
Country: Italy

Publications

  1. pmc Genetic and functional profiling of Crohn's disease: autophagy mechanism and susceptibility to infectious diseases
    Annalisa Marcuzzi
    Institute for Maternal and Child Health IRCCS Burlo Garofolo of Trieste, Via dell Istria 65 1, 34137 Trieste, Italy
    Biomed Res Int 2013:297501. 2013
  2. pmc Clinical genetic testing of periodic fever syndromes
    Annalisa Marcuzzi
    Laboratory of Immunopathology, Institute for Maternal and Child Health IRCCS Burlo Garofolo, 34137 Trieste, Italy
    Biomed Res Int 2013:501305. 2013
  3. doi request reprint Presence of IL-9 in paired samples of human colostrum and transitional milk
    Annalisa Marcuzzi
    Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste, Italy
    J Hum Lact 29:26-31. 2013
  4. doi request reprint Lovastatin-induced apoptosis is modulated by geranylgeraniol in a neuroblastoma cell line
    Annalisa Marcuzzi
    Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy
    Int J Dev Neurosci 30:451-6. 2012
  5. doi request reprint Decreased cholesterol levels reflect a consumption of anti-inflammatory isoprenoids associated with an impaired control of inflammation in a mouse model of mevalonate kinase deficiency
    Annalisa Marcuzzi
    Paediatric Division, Institute of Child Health, IRCCS Burlo Garofolo, Via dell Istria 65 1, 34137, Trieste, Italy
    Inflamm Res 59:335-8. 2010
  6. doi request reprint The farnesyltransferase inhibitors tipifarnib and lonafarnib inhibit cytokines secretion in a cellular model of mevalonate kinase deficiency
    Annalisa Marcuzzi
    Medical Genetic Service, Institute for Maternal and Child Health Burlo Garofolo, Trieste 34134, Italy
    Pediatr Res 70:78-82. 2011
  7. ncbi request reprint Geraniol rescues inflammation in cellular and animal models of mevalonate kinase deficiency
    Annalisa Marcuzzi
    Medical Genetic Service, Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste, Italy
    In Vivo 25:87-92. 2011
  8. doi request reprint Natural isoprenoids inhibit LPS-induced-production of cytokines and nitric oxide in aminobisphosphonate-treated monocytes
    Annalisa Marcuzzi
    Department of Reproductive and Developmental Sciences, University of Trieste, Italy
    Int Immunopharmacol 10:639-42. 2010
  9. doi request reprint Defect in mevalonate pathway induces pyroptosis in Raw 264.7 murine monocytes
    Annalisa Marcuzzi
    Medical Genetic Service, Institute for Maternal and Child Health Burlo Garofolo, Trieste, Italy
    Apoptosis 16:882-8. 2011
  10. doi request reprint The effect of clodronate on a mevalonate kinase deficiency cellular model
    Valentina Zanin
    Institute for Maternal and Child Health IRCCS Burlo Garofolo, Via dell Istria 65 1, 34137 Trieste, Italy
    Inflamm Res 61:1363-7. 2012

Collaborators

Detail Information

Publications33

  1. pmc Genetic and functional profiling of Crohn's disease: autophagy mechanism and susceptibility to infectious diseases
    Annalisa Marcuzzi
    Institute for Maternal and Child Health IRCCS Burlo Garofolo of Trieste, Via dell Istria 65 1, 34137 Trieste, Italy
    Biomed Res Int 2013:297501. 2013
    ..The major expectation for the near future is to be able to anticipate the possible consequences of the disease already in childhood, thus preventing associated complications, and to choose the best treatment for each patient...
  2. pmc Clinical genetic testing of periodic fever syndromes
    Annalisa Marcuzzi
    Laboratory of Immunopathology, Institute for Maternal and Child Health IRCCS Burlo Garofolo, 34137 Trieste, Italy
    Biomed Res Int 2013:501305. 2013
    ..In our opinion, however, to obtain the best from this new development a rule should always be kept well in mind: use genetics only to answer specific clinical questions...
  3. doi request reprint Presence of IL-9 in paired samples of human colostrum and transitional milk
    Annalisa Marcuzzi
    Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste, Italy
    J Hum Lact 29:26-31. 2013
    ..Human colostrum and breast milk are known to contain high levels of cytokines, cytokine receptors, and chemokines...
  4. doi request reprint Lovastatin-induced apoptosis is modulated by geranylgeraniol in a neuroblastoma cell line
    Annalisa Marcuzzi
    Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy
    Int J Dev Neurosci 30:451-6. 2012
    ....
  5. doi request reprint Decreased cholesterol levels reflect a consumption of anti-inflammatory isoprenoids associated with an impaired control of inflammation in a mouse model of mevalonate kinase deficiency
    Annalisa Marcuzzi
    Paediatric Division, Institute of Child Health, IRCCS Burlo Garofolo, Via dell Istria 65 1, 34137, Trieste, Italy
    Inflamm Res 59:335-8. 2010
    ..The aim of this study was to evaluate, in a mouse model of mevalonate kinase deficiency (MKD), the possible link between inflammatory symptoms and serum cholesterol levels...
  6. doi request reprint The farnesyltransferase inhibitors tipifarnib and lonafarnib inhibit cytokines secretion in a cellular model of mevalonate kinase deficiency
    Annalisa Marcuzzi
    Medical Genetic Service, Institute for Maternal and Child Health Burlo Garofolo, Trieste 34134, Italy
    Pediatr Res 70:78-82. 2011
    ..The effect of GOH and Tip was successfully replicated in MKD patients' monocytes. Tip and Lon showed a dramatic anti-inflammatory effect in monocytes where mevalonate pathway was chemically or genetically impaired...
  7. ncbi request reprint Geraniol rescues inflammation in cellular and animal models of mevalonate kinase deficiency
    Annalisa Marcuzzi
    Medical Genetic Service, Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste, Italy
    In Vivo 25:87-92. 2011
    ....
  8. doi request reprint Natural isoprenoids inhibit LPS-induced-production of cytokines and nitric oxide in aminobisphosphonate-treated monocytes
    Annalisa Marcuzzi
    Department of Reproductive and Developmental Sciences, University of Trieste, Italy
    Int Immunopharmacol 10:639-42. 2010
    ..These natural isoprenoids could be proposed as novel therapeutic approach for the still orphan drug MKD, but also considered for the evaluation of possible inflammatory side effects of aminobisphosphonates...
  9. doi request reprint Defect in mevalonate pathway induces pyroptosis in Raw 264.7 murine monocytes
    Annalisa Marcuzzi
    Medical Genetic Service, Institute for Maternal and Child Health Burlo Garofolo, Trieste, Italy
    Apoptosis 16:882-8. 2011
    ..The involvement of pyroptosis is a novel hit in our cell model and opens discussions about its role in inflammatory cells with chemical or genetic inhibition of mevalonate pathway...
  10. doi request reprint The effect of clodronate on a mevalonate kinase deficiency cellular model
    Valentina Zanin
    Institute for Maternal and Child Health IRCCS Burlo Garofolo, Via dell Istria 65 1, 34137 Trieste, Italy
    Inflamm Res 61:1363-7. 2012
    ....
  11. doi request reprint Targeting farnesyl-transferase as a novel therapeutic strategy for mevalonate kinase deficiency: in vitro and in vivo approaches
    Luigina De Leo
    Department of Reproductive and Developmental Sciences, and Public Healthcare, University of Trieste, Italy
    Pharmacol Res 61:506-10. 2010
    ....
  12. pmc Temperature and drug treatments in mevalonate kinase deficiency: an ex vivo study
    Paola Maura Tricarico
    Department of Medical, Surgical and Health Sciences, University of Trieste, 34127 Trieste, Italy
    Biomed Res Int 2013:715465. 2013
    ..We evidenced the role of temperature in the modulation of the inflammatory events and suggested strongly considering this variable in future researches aimed at finding a treatment for MKD. ..
  13. doi request reprint Putative modifier genes in mevalonate kinase deficiency
    Annalisa Marcuzzi
    Department of Advanced Diagnostic and Clinical Trials, Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste I 34137, Italy
    Mol Med Rep 13:3181-9. 2016
    ..As MVK mutations may be associated with MKD, the identification of specific modifier genes may assist in providing an earlier diagnosis...
  14. pmc Innovative Target Therapies Are Able to Block the Inflammation Associated with Dysfunction of the Cholesterol Biosynthesis Pathway
    Annalisa Marcuzzi
    Department of Medicine, Surgery and Health Sciences, University of Trieste, Piazzale Europa 1, Trieste 34128, Italy
    Int J Mol Sci 17:. 2015
    ..In this review we will focus in particular on inhibitors of cholesterol synthesis, mitochondria-targeted drugs and inhibitors of the inflammasome. ..
  15. doi request reprint Natural isoprenoids are able to reduce inflammation in a mouse model of mevalonate kinase deficiency
    Annalisa Marcuzzi
    Department of Reproductive and Developmental Sciences, University of Trieste, Trieste, Italy
    Pediatr Res 64:177-82. 2008
    ..All these compounds were effective in preventing the inflammation induced by alendronate-muramyldipeptide, suggesting a possible role for these compounds in the treatment of MKD in humans...
  16. doi request reprint Inflammation profile of four early onset Crohn patients
    Annalisa Marcuzzi
    Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste, Italy
    Gene 493:282-5. 2012
    ..Further studies to determine its pathogenic effect should be performed. In addition IL-10 mediated inhibition of LPS-induced TNFα expression was measured in patient's monocytes...
  17. doi request reprint A common genetic background could explain early-onset Crohn's disease
    Anna Monica Bianco
    Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste, Italy
    Med Hypotheses 78:520-2. 2012
    ....
  18. ncbi request reprint Systemic and neuronal inflammatory markers in a mouse model of mevalonate kinase deficiency: a strain-comparative study
    Giulio Kleiner
    Institute for Maternal and Child Health IRCCS Burlo Garofolo, Via dell Istria, 65 1 34137 Trieste, Italy
    In Vivo 27:715-22. 2013
    ..This study aims to assess the role played in pathology by the inflammasome and the reliability of this model...
  19. doi request reprint Mouse model of mevalonate kinase deficiency: comparison of cytokine and chemokine profile with that of human patients
    Annalisa Marcuzzi
    Health Genetics Unit, Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste, Italy
    Pediatr Res 74:266-71. 2013
    ..The pathogenic mechanism originating an immune response in MKD patients has not been clearly understood...
  20. pmc Geranylgeraniol and Neurological Impairment: Involvement of Apoptosis and Mitochondrial Morphology
    Annalisa Marcuzzi
    Piazzale Europa 1, University of Trieste, Trieste 34127, Italy
    Int J Mol Sci 17:365. 2016
    ....
  21. pmc Ex vivo response to mucosal bacteria and muramyl dipeptide in inflammatory bowel disease
    Claudia Loganes
    Claudia Loganes, Elisa Marini, Samuele Naviglio, Tarcisio Not, Annalisa Marcuzzi, Department of Medicine, Surgery, and Health Sciences, University of Trieste, Strada di Fiume, 447 Trieste, Italy
    World J Gastroenterol 22:9734-9743. 2016
    ..To evaluate how mucosal bacteria impact on the spontaneous and muramyl dipeptide (MDP)-induced inflammation in Crohn's disease (CD) and ulcerative colitis (UC)...
  22. pmc Alendronate, a double-edged sword acting in the mevalonate pathway
    Paola Maura Tricarico
    Department of Medicine, Surgery and Health Science, University of Trieste, Trieste I 34127, Italy
    Mol Med Rep 12:4238-42. 2015
    ..Since MKD lacks specific treatments, these results may assist scientists and physicians in making the decision as to the most suitable choice of therapeutic compounds for this neglected disease...
  23. doi request reprint Microglia activation and interaction with neuronal cells in a biochemical model of mevalonate kinase deficiency
    Paola Maura Tricarico
    University of Trieste, Piazzale Europa 1, 34127, Trieste, Italy
    Apoptosis 20:1048-55. 2015
    ..We can thus hypothesise that the use of microglial activation blockers could prevent this additional neuronal death. ..
  24. doi request reprint Two‑gene mutation in a single patient: Biochemical and functional analysis for a correct interpretation of exome results
    Anna Monica Bianco
    Department of Advanced Diagnostic and Clinical Trials, Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste, Trieste 34137, Italy
    Mol Med Rep 12:6128-32. 2015
    ..Although NGS is a powerful tool to identify pathogenic mutations, the analysis of genetic data requires expert critical revision of all detected variants...
  25. pmc To Extinguish the Fire from Outside the Cell or to Shutdown the Gas Valve Inside? Novel Trends in Anti-Inflammatory Therapies
    Annalisa Marcuzzi
    Department of Medicine, Surgery and Health Sciences, University of Trieste, Piazzale Europa 1, Trieste 34128, Italy
    Int J Mol Sci 16:21277-93. 2015
    ..Autoinflammatory diseases, which have previously put anti-cytokine proteins in the limelight, can again provide a valuable model to measure the real potential of small inhibitors as anti-inflammatory agents. ..
  26. doi request reprint Database tools in genetic diseases research
    Anna Monica Bianco
    Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste, Italy Electronic address
    Genomics 101:75-85. 2013
    ....
  27. pmc Mevalonate kinase deficiency and neuroinflammation: balance between apoptosis and pyroptosis
    Paola Maura Tricarico
    Department of Medicine, Surgery and Health Sciences, University of Trieste, Piazzale Europa 1, Trieste 34128, Italy
    Int J Mol Sci 14:23274-88. 2013
    ..Targeting inflammation and degeneration in the central nervous system might help identify promising treatment approaches for mevalonic aciduria or other diseases in which these mechanisms are involved. ..
  28. pmc Cytokine levels in the serum of healthy subjects
    Giulio Kleiner
    Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Via dell Istria, 65 1, 34137 Trieste, Italy
    Mediators Inflamm 2013:434010. 2013
    ..In conclusion, we drew some kinds of guidelines about the physiological production of cytokines and chemokines, underling the difference caused by aging...
  29. doi request reprint TRAIL administration down-modulated the acute systemic inflammatory response induced in a mouse model by muramyldipeptide or lipopolysaccharide
    Annalisa Marcuzzi
    Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy
    Cytokine 60:43-6. 2012
    ..These data demonstrate for the first time that TRAIL has a potent anti-inflammatory activity, which might be beneficial for the anti-tumoral activity of TRAIL...
  30. pmc Block of the mevalonate pathway triggers oxidative and inflammatory molecular mechanisms modulated by exogenous isoprenoid compounds
    Paola Maura Tricarico
    Department of Medicine and Surgery and Health, University of Trieste, Piazzale Europa, 1, 34128 Trieste, Italy
    Int J Mol Sci 15:6843-56. 2014
    ..Moreover, although further studies are necessary, the achieved results suggest a possible role for exogenous isoprenoids in the treatment of MKD. ..
  31. doi request reprint Specific protein profile in cerebrospinal fluid from HIV-1-positive cART-treated patients affected by neurological disorders
    Valentina Zanin
    Institute for Maternal and Child Health IRCCS Burlo Garofolo, Via dell Istria 65 1, 34137 Trieste, Italy
    J Neurovirol 18:416-22. 2012
    ..05) in JCV + PML patients. This pilot study emphasized the role of immunoregulation in HIV-1-related neurological disorders during cART treatment...