Piero Marchetti

Summary

Affiliation: University of Pisa
Country: Italy

Publications

  1. doi request reprint Metabolic and cardiovascular effects of beta cell replacement in type 1 diabetes
    Piero Marchetti
    Department of Clinical and Experimental Medicine, University of Pisa, Cisanello AOUP University Hospital, Pisa, Italy
    Intern Emerg Med 8:S55-6. 2013
  2. ncbi request reprint The pancreatic beta cells in human type 2 diabetes
    Piero Marchetti
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    Adv Exp Med Biol 771:288-309. 2012
  3. doi request reprint A local glucagon-like peptide 1 (GLP-1) system in human pancreatic islets
    P Marchetti
    Department of Endocrinology and Metabolism, University of Pisa, Via Paradisa 2, Pisa, Italy
    Diabetologia 55:3262-72. 2012
  4. pmc From genotype to human β cell phenotype and beyond
    Piero Marchetti
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    Islets 4:323-32. 2012
  5. doi request reprint Long-term (5 years) efficacy and safety of pancreas transplantation alone in type 1 diabetic patients
    Ugo Boggi
    Division of General and Transplant Surgery in Uremic and Diabetic Patients, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy
    Transplantation 93:842-6. 2012
  6. ncbi request reprint Efficacy and safety of basiliximab in kidney transplantation
    Ugo Boggi
    Division of Surgery in Uremic and Diabetic Patients General and Transplant Surgery, Department of Oncology, Transplants and Advanced Technologies in Medicine, University of Pisa, Pisa, Italy
    Expert Opin Drug Saf 4:473-90. 2005
  7. ncbi request reprint Histopathology and ex vivo insulin secretion of pancreatic islets in gestational diabetes: A case report
    Mariella Tancredi
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    Islets 3:231-3. 2011
  8. ncbi request reprint Functional and molecular defects of pancreatic islets in human type 2 diabetes
    Silvia Del Guerra
    Department of Endocrinology and Metabolism, Metabolic Unit, Ospedale Cisanello, Via Paradisa 2, 56124 Pisa, Italy
    Diabetes 54:727-35. 2005
  9. ncbi request reprint Pancreatic islets from type 2 diabetic patients have functional defects and increased apoptosis that are ameliorated by metformin
    Piero Marchetti
    Department of Endocrinology and Metabolism and Diabetes, Transplant Unit, University of Pisa, Italy
    J Clin Endocrinol Metab 89:5535-41. 2004
  10. ncbi request reprint The beneficial effects of pancreas transplant alone on diabetic nephropathy
    Alberto Coppelli
    Department of Endocrinology and Metabolism, Metabolic Unit, Ospedale Cisanello, Via Paradisa 2, 56100 Pisa, Italy
    Diabetes Care 28:1366-70. 2005

Collaborators

Detail Information

Publications52

  1. doi request reprint Metabolic and cardiovascular effects of beta cell replacement in type 1 diabetes
    Piero Marchetti
    Department of Clinical and Experimental Medicine, University of Pisa, Cisanello AOUP University Hospital, Pisa, Italy
    Intern Emerg Med 8:S55-6. 2013
    ....
  2. ncbi request reprint The pancreatic beta cells in human type 2 diabetes
    Piero Marchetti
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    Adv Exp Med Biol 771:288-309. 2012
    ..Continuous improvements in our knowledge of the beta cells in human Type 2 diabetes will lead to more targeted and effective strategies for the prevention and treatment of the disease...
  3. doi request reprint A local glucagon-like peptide 1 (GLP-1) system in human pancreatic islets
    P Marchetti
    Department of Endocrinology and Metabolism, University of Pisa, Via Paradisa 2, Pisa, Italy
    Diabetologia 55:3262-72. 2012
    ..We performed comprehensive morphological, functional and molecular studies to evaluate the presence and various features of a local GLP-1 system in human pancreatic islet cells, including those from type 2 diabetic patients...
  4. pmc From genotype to human β cell phenotype and beyond
    Piero Marchetti
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    Islets 4:323-32. 2012
    ....
  5. doi request reprint Long-term (5 years) efficacy and safety of pancreas transplantation alone in type 1 diabetic patients
    Ugo Boggi
    Division of General and Transplant Surgery in Uremic and Diabetic Patients, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy
    Transplantation 93:842-6. 2012
    ....
  6. ncbi request reprint Efficacy and safety of basiliximab in kidney transplantation
    Ugo Boggi
    Division of Surgery in Uremic and Diabetic Patients General and Transplant Surgery, Department of Oncology, Transplants and Advanced Technologies in Medicine, University of Pisa, Pisa, Italy
    Expert Opin Drug Saf 4:473-90. 2005
    ..However, life-threatening reactions were reported following re-exposure to basiliximab in recipients who lost graft function early after transplantation and, therefore, discontinued all immunosuppressive agents...
  7. ncbi request reprint Histopathology and ex vivo insulin secretion of pancreatic islets in gestational diabetes: A case report
    Mariella Tancredi
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    Islets 3:231-3. 2011
    ..These findings suggest that in this case of human GD there might mainly be a defect of β-cell amount, not due to increased apoptosis, but possibly to insufficient regeneration...
  8. ncbi request reprint Functional and molecular defects of pancreatic islets in human type 2 diabetes
    Silvia Del Guerra
    Department of Endocrinology and Metabolism, Metabolic Unit, Ospedale Cisanello, Via Paradisa 2, 56124 Pisa, Italy
    Diabetes 54:727-35. 2005
    ..In this regard, it is suggested that reducing islet cell oxidative stress is a potential target of human type 2 diabetes therapy...
  9. ncbi request reprint Pancreatic islets from type 2 diabetic patients have functional defects and increased apoptosis that are ameliorated by metformin
    Piero Marchetti
    Department of Endocrinology and Metabolism and Diabetes, Transplant Unit, University of Pisa, Italy
    J Clin Endocrinol Metab 89:5535-41. 2004
    ..Thus, T2D islets have several functional and survival defects, which can be ameliorated by metformin; the beneficial effects of the drug are mediated, at least in part, by a reduction of oxidative stress...
  10. ncbi request reprint The beneficial effects of pancreas transplant alone on diabetic nephropathy
    Alberto Coppelli
    Department of Endocrinology and Metabolism, Metabolic Unit, Ospedale Cisanello, Via Paradisa 2, 56100 Pisa, Italy
    Diabetes Care 28:1366-70. 2005
    ..We evaluated whether restoration of long-lasting normoglycemia by pancreas transplant alone might have beneficial action on diabetic nephropathy...
  11. ncbi request reprint The direct effects of the angiotensin-converting enzyme inhibitors, zofenoprilat and enalaprilat, on isolated human pancreatic islets
    Roberto Lupi
    Metabolic Unit, Department of Endocrinology and Metabolism, University of Pisa, Ospedale Cisanello, Via Paradisa 2, 56100 Pisa, Italy
    Eur J Endocrinol 154:355-61. 2006
    ....
  12. ncbi request reprint Pancreas transplant alone determines early improvement of cardiovascular risk factors and cardiac function in type 1 diabetic patients
    Alberto Coppelli
    Department of Endocrinology and Metabolism, Metabolic Unit, Cisanello Hospital Pisa University, Pisa, Italy
    Transplantation 76:974-6. 2003
    ..The effects of pancreas transplant alone (PTA) on cardiovascular risk factors (CRF) and cardiac function in type 1 diabetes mellitus (T1DM) patients are still unsettled...
  13. ncbi request reprint Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated
    Roberto Lupi
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    Diabetes 51:1437-42. 2002
    ..The cytostatic action is likely to be due to the FFA-induced reduction of intraislet glucose metabolism, and the proapoptotic effects are mostly caspase mediated, partially dependent on ceramide pathway, and possibly Bcl-2 regulated...
  14. doi request reprint Microarray analysis of isolated human islet transcriptome in type 2 diabetes and the role of the ubiquitin-proteasome system in pancreatic beta cell dysfunction
    Marco Bugliani
    Department of Clinical and Experimental Medicine, Islet Cell Laboratory, University of Pisa, Pisa 56124, Italy
    Mol Cell Endocrinol 367:1-10. 2013
    ..These results show the presence of many changes in islet transcriptome in T2D islets and underline the importance of the association between UPS alterations and beta cell dysfunction in human T2D...
  15. ncbi request reprint Beneficial effect of the nonpeptidyl low molecular weight radical scavenger IAC on cultured human islet function
    Rita Mancarella
    Department of Endocrinology and Metabolism, Metabolic Unit, University of Pisa, Pisa, Italy
    Cell Transplant 17:1271-6. 2008
    ..We found that IAC markedly reduced oxidative stress and ameliorated islets function. These results suggest that the use of IAC could be an interesting pharmacological approach for the treatment of the islets before transplantation...
  16. ncbi request reprint Effects of pancreas-kidney transplantation on diabetic retinopathy
    Rosa Giannarelli
    Department of Endocrinology and Metabolism Metabolic Unit, University of Pisa, I 56121, Pisa, Italy
    Transpl Int 18:619-22. 2005
    ..In conclusion, despite a relatively short follow-up period, successful PTx in our cohort of patients was associated with improvement and/or stabilization of DR in the majority of recipients...
  17. doi request reprint The direct effects of tacrolimus and cyclosporin A on isolated human islets: A functional, survival and gene expression study
    Marco Bugliani
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    Islets 1:106-10. 2009
    ..In conclusion, Tac and CsA affect features of beta-cell differently, with several changes occurring at the molecular level...
  18. ncbi request reprint Effects of prolonged in vitro exposure to sulphonylureas on the function and survival of human islets
    Silvia Del Guerra
    Metabolic Unit, Department of Endocrinology and Metabolism, Cisanello Hospital Pisa, Pisa 56100, Italy
    J Diabetes Complications 19:60-4. 2005
    ..In conclusion, prolonged exposure of human islets to different sulphonylureas causes different disturbances of islet cell function, with glimepiride showing milder effects, as compared with chlorpropamide and glibenclamide...
  19. ncbi request reprint Reduction of oxidative stress by a new low-molecular-weight antioxidant improves metabolic alterations in a nonobese mouse diabetes model
    Michela Novelli
    Dipartimento di Patologia Sperimentale, University of Pisa, Pisa, Italy
    Pancreas 35:e10-7. 2007
    ....
  20. doi request reprint Transplantation of the pancreas
    Ugo Boggi
    Division of General and Transplant Surgery, Azienda Ospedaliera Universitaria Pisana, Universita di Pisa, Via Paradisa 2, 56124, Pisa, Italy
    Curr Diab Rep 12:568-79. 2012
    ..Refinements in graft preservation, surgical techniques, immunosuppression, and prophylactic treatments are expected to further improve the results of pancreas transplantation...
  21. ncbi request reprint Effects of C-peptide on isolated human pancreatic islet cells
    Marco Bugliani
    Department of Endocrinology and Metabolism Metabolic Unit, University of Pisa, Pisa, Italy
    Diabetes Metab Res Rev 23:215-9. 2007
    ..Recent data have demonstrated that pro-insulin-derived C-peptide can affect the function of several different cell types. We hypothesized that C-peptide might have an influence on the function and survival of isolated human islets...
  22. ncbi request reprint Improved insulin secretory function and reduced chemotactic properties after tissue culture of islets from type 1 diabetic patients
    Roberto Lupi
    Department of Endocrinology and Metabolism, Metabolic Unit, University of Pisa, Pisa, Italy
    Diabetes Metab Res Rev 20:246-51. 2004
    ..Type 1 diabetes results from the destruction of pancreatic beta-cell as a consequence of an autoimmune process. To date, information on the properties of islets isolated from type 1 diabetic patients is very scant...
  23. ncbi request reprint The role of peripheral benzodiazepine receptors on the function and survival of isolated human pancreatic islets
    Lorella Marselli
    Dipartimento di Endocrinologia e Metabolismo, Sezione Metabolismo, Universita di Pisa, Via Paradisa 2, Ospedale Cisanello, 56100 Pisa, Italy
    Eur J Endocrinol 151:207-14. 2004
    ..We hypothesized that PBRs can have a role in human islet physiopathology, and evaluated the effects of prolonged exposure to two specific PBR ligands, PK11195 and Ro5-4864 on the function and survival of isolated human islets...
  24. doi request reprint Laparoscopic robot-assisted pancreas transplantation: first world experience
    Ugo Boggi
    Division of General and Transplant Surgery, Pisa University Hospital, Pisa, Italy
    Transplantation 93:201-6. 2012
    ..The da Vinci surgical system, a computer-assisted electromechanical device, provides the unique opportunity to test whether laparoscopy can reduce the morbidity of pancreas transplantation...
  25. doi request reprint The beta-cell in human type 2 diabetes
    Piero Marchetti
    Department of Endocrinology and Metabolism, Cisanello Hospital, 56124 Pisa, Italy
    Adv Exp Med Biol 654:501-14. 2010
    ..Encouraging, although preliminary, data show that some of these defects might be directly counteracted, at least in part, by appropriate in vitro pharmacological intervention...
  26. ncbi request reprint Pancreas preservation with University of Wisconsin and Celsior solutions: a single-center, prospective, randomized pilot study
    Ugo Boggi
    Divisione di Chirurgia Generale e Trapianti, Dipartimento di Oncologia, Trapianti e Nuove Tecnologie in Medicina, Universita di Pisa, Pisa, Italy
    Transplantation 77:1186-90. 2004
    ..We report the results of a single-center, prospective, randomized pilot study specifically designed to compare the safety profile of Celsior solution with University of Wisconsin (UW) solution in clinical pancreas transplantation...
  27. doi request reprint Ultrastructural morphometric analysis of insulin secretory granules in human type 2 diabetes
    Matilde Masini
    Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Via Roma 55, Scuola Medica, 56126 Pisa, Italy
    Acta Diabetol 49:S247-52. 2012
    ..In conclusion, we detected significant changes in the intracellular distribution of insulin secretory granules within the beta cell that might be related with the alterations in insulin secretion observed in type 2 diabetes patients...
  28. ncbi request reprint A technique for retroperitoneal pancreas transplantation with portal-enteric drainage
    Ugo Boggi
    Divisione di Chirurgia Generale e Trapianti, Universita di Pisa, Ospedale di Cisanello, Pisa, Italy
    Transplantation 79:1137-42. 2005
    ..We describe a new technique that circumvents these difficulties...
  29. doi request reprint Surgical techniques for pancreas transplantation
    Ugo Boggi
    Division of General and Transplant Surgery in Uremic and Diabetic Patientss, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy
    Curr Opin Organ Transplant 15:102-11. 2010
    ..The purpose of this review is to examine recent surgical advances and discuss their contribution to improved graft function...
  30. doi request reprint A role for autophagy in β-cell life and death
    Matilde Masini
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    Islets 1:157-9. 2009
    ....
  31. pmc Current perspectives on laparoscopic robot-assisted pancreas and pancreas-kidney transplantation
    Ugo Boggi
    Division of General and Transplant Surgery, Pisa University Hospital, Via Paradisa 2, 56124 Pisa, Italy
    Rev Diabet Stud 8:28-34. 2011
    ..There is no proof that progressive graft warming produces actual damage to transplanted organs, unless exceedingly long. However, this important question is likely to elicit a vibrant discussion in the transplant community...
  32. doi request reprint Mast cells infiltrate pancreatic islets in human type 1 diabetes
    Luisa Martino
    Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Via Roma 55, 56126, Pisa, Italy
    Diabetologia 58:2554-62. 2015
    ..In this study, we explored the role of mast cells as an additional agent in the pathogenesis of type 1 diabetes insulitis...
  33. ncbi request reprint Hepatitis C virus infection and human pancreatic beta-cell dysfunction
    Matilde Masini
    Department of Endocrinology and Metabolism, Metabolic Unit, University of Pisa and Pisa University Hospital, Via Paradisa 2, 56124 Pisa, Italy
    Diabetes Care 28:940-1. 2005
  34. ncbi request reprint Insulin secretory function is impaired in isolated human islets carrying the Gly(972)-->Arg IRS-1 polymorphism
    Piero Marchetti
    Department of Endocrinology and Metabolism, Metabolic Unit, University of Pisa, Pisa, Italy
    Diabetes 51:1419-24. 2002
    ..These alterations may account for the increased predisposition to type 2 diabetes in individuals carrying the Gly(972)-->Arg amino acid polymorphism of IRS-1...
  35. pmc Palmitate activates autophagy in INS-1E β-cells and in isolated rat and human pancreatic islets
    Luisa Martino
    Department of Experimental Pathology, University of Pisa, Pisa, Italy
    PLoS ONE 7:e36188. 2012
    ....
  36. pmc Results of pancreas transplantation alone with special attention to native kidney function and proteinuria in type 1 diabetes patients
    Ugo Boggi
    Division of General and Transplant Surgery in Uremic and Diabetic Patients, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy
    Rev Diabet Stud 8:259-67. 2011
    ..Further improvements were recorded in several cardiovascular risk factors, retinopathy, and neuropathy. We conclude that PTA was an effective and reasonably safe procedure in this single-center experience...
  37. doi request reprint Zinc transporter 8 autoantibodies increase the predictive value of islet autoantibodies for function loss of technically successful solitary pancreas transplant
    Margherita Occhipinti
    Department of Endocrinology and Metabolism, Cisanello University Hospital, Pisa, Italy
    Transplantation 92:674-7. 2011
    ..Despite the success rate of solitary pancreas transplantation in type 1 diabetes with preserved kidney function has greatly improved in recent years, a residual proportion of failures persists...
  38. ncbi request reprint New-onset diabetes after liver transplantation: from pathogenesis to management
    Piero Marchetti
    Department of Endocrinology and Metabolism, Metabolic Unit, University of Pisa, Pisa, Italy
    Liver Transpl 11:612-20. 2005
    ..In conclusion, prospective trials are necessary to properly define antidiabetic therapy and immunosuppressive strategies in this population...
  39. doi request reprint Follow-up of secondary diabetic complications after pancreas transplantation
    Ugo Boggi
    Division of General and Transplant Surgery, University of Pisa, Pisa, Italy
    Curr Opin Organ Transplant 18:102-10. 2013
    ..We herein review the available literature to define the impact of pancreas transplantation on chronic complications of diabetes mellitus...
  40. ncbi request reprint An overview of pancreatic beta-cell defects in human type 2 diabetes: implications for treatment
    Piero Marchetti
    Department of Endocrinology and Metabolism, Metabolic Unit, University of Pisa, Pisa, Italy
    Regul Pept 146:4-11. 2008
    ..Interestingly, however, pharmacological intervention can improve several defects of Type 2 diabetes islet cells in vitro, suggesting that progression of the disease might not be relentless...
  41. ncbi request reprint beta-cell function and anti-diabetic pharmacotherapy
    Stefano Del Prato
    Department of Endocrinology and Metabolism, Section of Diabetes and Metabolic Diseases, University of Pisa, Pisa, Italy
    Diabetes Metab Res Rev 23:518-27. 2007
    ..Moreover, promising future approaches aiming at preserving beta-cell function and mass are discussed...
  42. ncbi request reprint Is tacrolimus associated with fewer surgical complications than ciclosporin after kidney-pancreas transplantation?
    Ugo Boggi
    Divisione di Chirurgia nell Uremico e nel Diabetico Chirurgia Generale e Trapiantologica Università di Pisa Ospedale di Cisanello, Via Paradisa 2, 56124, Pisa, Italy
    Nat Clin Pract Nephrol 1:76-7. 2005
  43. ncbi request reprint The pancreatic beta-cell in human Type 2 diabetes
    Piero Marchetti
    Department of Endocrinology and Metabolism, Metabolic Section, University of Pisa, Pisa, Italy
    Nutr Metab Cardiovasc Dis 16:S3-6. 2006
    ..There is growing evidence that the beta-cell is central to the development of Type 2 diabetes. In this brief review we discuss the factors predisposing to beta-cell dysfunction and some characteristics of islet cells in Type 2 diabetes...
  44. ncbi request reprint Prolonged in vitro exposure to autoantibodies against CD38 impairs the function and survival of human pancreatic islets
    Piero Marchetti
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    Diabetes 51:S474-7. 2002
    ..9 +/- 0.4, P < 0.01). We conclude that prolonged exposure of human islets to sera positive for the presence of CD38Abs with [Ca(2+)](i)-mobilizing activity impairs beta-cell function and viability in cultured human pancreatic islets...
  45. pmc Evidence of β-Cell Dedifferentiation in Human Type 2 Diabetes
    Francesca Cinti
    Departments of Medicine F C, R B, J Y K M, D A and Surgery Y O, P R S, L E R, Columbia University College of Physicians and Surgeons, New York, New York 10032 Department of Clinical and Experimental Medicine F C, Universita Politecnica delle Marche, Ancona, Italy and Department of Clinical and Experimental Medicine M M, L M, M S, P M, Islet Cell Laboratory, University of Pisa, 56100 Pisa, Italy
    J Clin Endocrinol Metab 101:1044-54. 2016
    ..Diabetes is associated with a deficit of insulin-producing β-cells. Animal studies show that β-cells become dedifferentiated in diabetes, reverting to a progenitor-like stage, and partly converting to other endocrine cell types...
  46. doi request reprint Segmental live donor pancreas transplantation: review and critique of rationale, outcomes, and current recommendations
    Ugo Boggi
    Divisione di Chirurgia Generale e Trapianti nell Uremico e nel Diabetico, Università di Pisa e Azienda Ospedaliero Universitaria, Pisana, Pisa, Italy
    Clin Transplant 25:4-12. 2011
    ..Furthermore, LD allows recipient pre-conditioning and/or pair donor exchange. In conclusion, LD PTx may offer significant advantages to well-selected diabetic recipients. LDs are exposed to relatively small risks...
  47. ncbi request reprint Early improvement of unstable diabetic retinopathy after solitary pancreas transplantation
    Rosa Giannarelli
    Department of Endocrinology and Metabolism, Metabolic Unit, University of Pisa, Italy
    Diabetes Care 25:2358-9. 2002
  48. ncbi request reprint A benefit-risk assessment of basiliximab in renal transplantation
    Ugo Boggi
    Division of General Surgery and Transplants, Department of Oncology, Transplants and Advanced Technologies in Medicine, University of Pisa, Pisa, Italy
    Drug Saf 27:91-106. 2004
    ....
  49. ncbi request reprint New-onset diabetes after transplantation
    Piero Marchetti
    Dipartimento di Endocrinologia e Metabolismo, Ospedale Cisanello, Pisa, Italy
    J Heart Lung Transplant 23:S194-201. 2004
    ..These management approaches should help to lower the risk of new-onset diabetes after heart transplantation and reduce the possible long-term consequences of the condition...
  50. ncbi request reprint Lipotoxicity in human pancreatic islets and the protective effect of metformin
    Roberto Lupi
    Department of Endocrinology and Metabolism, Metabolic Unit, University of Pisa, Pisa, Italy
    Diabetes 51:S134-7. 2002
    ..Metformin prevents these deleterious effects, supporting a direct protective action on human beta-cells...
  51. ncbi request reprint Autophagy and the pancreatic beta-cell in human type 2 diabetes
    Piero Marchetti
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    Autophagy 5:1055-6. 2009
    ....
  52. doi request reprint Glucagon-like peptide 1 protects INS-1E mitochondria against palmitate-mediated beta-cell dysfunction: a proteomic study
    Federica Ciregia
    Department of Pharmacy, University of Pisa, Pisa, Italy
    Mol Biosyst 11:1696-707. 2015
    ..In summary, our results provided a snapshot of mitochondrial proteins and potential pathways affected by palmitate treatment and gave us information on the potential protective role of GLP-1. ..