A Izzotti

Summary

Affiliation: University of Genoa
Country: Italy

Publications

  1. ncbi request reprint Effects of oral administration of N-acetyl-L-cysteine: a multi-biomarker study in smokers
    Frederik Jan van Schooten
    Department of Health Risk Analysis and Toxicology, Maastricht University, The Netherlands
    Cancer Epidemiol Biomarkers Prev 11:167-75. 2002
  2. ncbi request reprint Molecular Damage in Glaucoma: from Anterior to Posterior Eye Segment. The MicroRNA Role
    Alberto Izzotti
    Department of Health Sciences, University of Genoa, Via A Pastore 1, 16132 Genoa, Italy
    Microrna 4:3-17. 2015
  3. doi request reprint Genomic and post-genomic effects of anti-glaucoma drugs preservatives in trabecular meshwork
    Alberto Izzotti
    Mutagenesis Unit, IRCCS AOU San Martino IST, Genova, Italy Department of Health Sciences, University of Genoa, Via A Pastore 1, 16132 Genoa, Italy Electronic address
    Mutat Res 772:1-9. 2015
  4. doi request reprint The effects of environmental chemical carcinogens on the microRNA machinery
    A Izzotti
    Department of Health Sciences, University of Genoa, Italy Mutagenesis Unit, IRCCS University Hospital San Martino IST National Research Cancer Institute, Genoa, Italy Electronic address
    Int J Hyg Environ Health 217:601-27. 2014
  5. doi request reprint Molecular medicine and the development of cancer chemopreventive agents
    Alberto Izzotti
    Department of Health Sciences, Faculty of Medicine, University of Genoa, Genoa, Italy
    Ann N Y Acad Sci 1259:26-32. 2012
  6. doi request reprint Molecular diagnostics of ocular diseases: the application of antibody microarray
    Alberto Izzotti
    Department of Health Sciences, Section of Hygiene and Preventive Medicine, University of Genoa, Genoa, Italy
    Expert Rev Mol Diagn 12:629-43. 2012
  7. doi request reprint Different mutations in three prime repair exonuclease 1 and ribonuclease H2 genes affect clinical features in Aicardi-Goutieres syndrome
    Alberto Izzotti
    Department of Health Sciences, University of Genoa, Genoa, 16132, Italy
    J Child Neurol 27:51-60. 2012
  8. ncbi request reprint Survival of atherosclerotic patients as related to oxidative stress and gene polymorphisms
    Alberto Izzotti
    Department of Health Sciences, University of Genoa, Via A Pastore 1, I 16132 Genoa, Italy
    Mutat Res 621:119-28. 2007
  9. doi request reprint Brain damage as detected by cDNA-microarray in the spinal fluid of patients with Aicardi-Goutieres syndrome
    A Izzotti
    Department of Health Sciences, University of Genoa, Via Pastore 1, 16132, Genoa, Italy
    Neurology 71:610-2. 2008
  10. ncbi request reprint Modulation of multigene expression and proteome profiles by chemopreventive agents
    Alberto Izzotti
    Department of Health Sciences, University of Genoa, Via A Pastore 1, I 16132 Genoa, Italy
    Mutat Res 591:212-23. 2005

Collaborators

Detail Information

Publications80

  1. ncbi request reprint Effects of oral administration of N-acetyl-L-cysteine: a multi-biomarker study in smokers
    Frederik Jan van Schooten
    Department of Health Risk Analysis and Toxicology, Maastricht University, The Netherlands
    Cancer Epidemiol Biomarkers Prev 11:167-75. 2002
    ..1) but not on BAL fluid antioxidant scavenging capacity. We conclude that NAC has the potential to impact upon tobacco smoke carcinogenicity in humans because it can modulate certain cancer-associated biomarkers in specific organs...
  2. ncbi request reprint Molecular Damage in Glaucoma: from Anterior to Posterior Eye Segment. The MicroRNA Role
    Alberto Izzotti
    Department of Health Sciences, University of Genoa, Via A Pastore 1, 16132 Genoa, Italy
    Microrna 4:3-17. 2015
    ....
  3. doi request reprint Genomic and post-genomic effects of anti-glaucoma drugs preservatives in trabecular meshwork
    Alberto Izzotti
    Mutagenesis Unit, IRCCS AOU San Martino IST, Genova, Italy Department of Health Sciences, University of Genoa, Via A Pastore 1, 16132 Genoa, Italy Electronic address
    Mutat Res 772:1-9. 2015
    ..Presented data indicates the delicate balance between efficacy and safety of drug preservatives as not yet optimized. ..
  4. doi request reprint The effects of environmental chemical carcinogens on the microRNA machinery
    A Izzotti
    Department of Health Sciences, University of Genoa, Italy Mutagenesis Unit, IRCCS University Hospital San Martino IST National Research Cancer Institute, Genoa, Italy Electronic address
    Int J Hyg Environ Health 217:601-27. 2014
    ..On the whole, reported findings provide evidence that microRNA analysis is a molecular toxicology tool that can elucidate the pathogenic mechanisms activated by environmental carcinogens. ..
  5. doi request reprint Molecular medicine and the development of cancer chemopreventive agents
    Alberto Izzotti
    Department of Health Sciences, Faculty of Medicine, University of Genoa, Genoa, Italy
    Ann N Y Acad Sci 1259:26-32. 2012
    ..Therefore, microRNAs are reliable biomarkers for evaluating chemoprevention efficacy and may be used to counteract carcinogenesis...
  6. doi request reprint Molecular diagnostics of ocular diseases: the application of antibody microarray
    Alberto Izzotti
    Department of Health Sciences, Section of Hygiene and Preventive Medicine, University of Genoa, Genoa, Italy
    Expert Rev Mol Diagn 12:629-43. 2012
    ..Future development is addressed to improve antibody microarray specificity and to set up minimally invasive procedures for aqueous humor sampling...
  7. doi request reprint Different mutations in three prime repair exonuclease 1 and ribonuclease H2 genes affect clinical features in Aicardi-Goutieres syndrome
    Alberto Izzotti
    Department of Health Sciences, University of Genoa, Genoa, 16132, Italy
    J Child Neurol 27:51-60. 2012
    ....
  8. ncbi request reprint Survival of atherosclerotic patients as related to oxidative stress and gene polymorphisms
    Alberto Izzotti
    Department of Health Sciences, University of Genoa, Via A Pastore 1, I 16132 Genoa, Italy
    Mutat Res 621:119-28. 2007
    ..Survival was significantly affected not only by traditional risk factors for atherosclerosis but also by molecular end-points and adverse gene polymorphisms, and by their combinations...
  9. doi request reprint Brain damage as detected by cDNA-microarray in the spinal fluid of patients with Aicardi-Goutieres syndrome
    A Izzotti
    Department of Health Sciences, University of Genoa, Via Pastore 1, 16132, Genoa, Italy
    Neurology 71:610-2. 2008
  10. ncbi request reprint Modulation of multigene expression and proteome profiles by chemopreventive agents
    Alberto Izzotti
    Department of Health Sciences, University of Genoa, Via A Pastore 1, I 16132 Genoa, Italy
    Mutat Res 591:212-23. 2005
    ..OPZ was poorly effective in lung and considerably altered the basal gene expression in liver. NAC had a medium efficacy and was the safest agent, as also supported by the analysis of 518 proteins in rat lung...
  11. ncbi request reprint The role of oxidative stress in glaucoma
    Alberto Izzotti
    Department of Health Sciences, University of Genoa, Via A Pastore 1, I 16132 Genoa, Italy
    Mutat Res 612:105-14. 2006
    ....
  12. ncbi request reprint DNA damage and alterations of gene expression in chronic-degenerative diseases
    Alberto Izzotti
    Department of Health Sciences, University of Genoa, Genoa, Italy
    Acta Biochim Pol 50:145-54. 2003
    ..These four experimental studies suggest that DNA damage may result in different CDD (cancer, growth retardation, glaucoma) depending on the replication rate of the target cell population...
  13. doi request reprint Genomic biomarkers and clinical outcomes of physical activity
    Alberto Izzotti
    Department of Health Sciences, Faculty of Medicine, University of Genoa, Genoa, Italy
    Ann N Y Acad Sci 1229:103-14. 2011
    ..6-fold in case they performed physical activity. These findings indicate that the preventive effect of physical activity undergoes interindividual variation affected by genetic polymorphisms...
  14. doi request reprint Interferon-related transcriptome alterations in the cerebrospinal fluid cells of Aicardi-Goutières patients
    Alberto Izzotti
    Department of Health Sciences, University of Genoa, Genoa, Italy
    Brain Pathol 19:650-60. 2009
    ..These gene-expression signature parallels a progressive attenuation of clinical symptoms with age. Obtained results provide evidence that exposure to IFN-alpha is harmful for developing brain...
  15. doi request reprint Mitochondrial damage in the trabecular meshwork of patients with glaucoma
    Alberto Izzotti
    Department of Health Sciences, University of Genoa, Genoa, Italy
    Arch Ophthalmol 128:724-30. 2010
    ..Oxidative damage plays a major role in glaucoma pathogenesis. Since no environmental risk factor for glaucoma is recognized, we focused our attention on mitochondria, the main endogenous source of reactive oxygen species...
  16. doi request reprint Sensitivity of ocular anterior chamber tissues to oxidative damage and its relevance to the pathogenesis of glaucoma
    Alberto Izzotti
    Department of Health Sciences, Faculty of Medicine, University of Genoa, Genoa, Italy
    Invest Ophthalmol Vis Sci 50:5251-8. 2009
    ..This study was conducted to comparatively evaluate the sensitivity to oxidative stress of anterior chamber tissues including the cornea, iris, and trabecular meshwork...
  17. doi request reprint Inhibition of the de-myelinating properties of Aicardi-Goutières syndrome lymphocytes by cathepsin D silencing
    A Pulliero
    Department of Health Sciences, University of Genoa, Italy
    Biochem Biophys Res Commun 430:957-62. 2013
    ..These results suggest a new strategy for repairing AGS lymphocytes in vitro by inhibiting their ability to induce astrocyte damage and leukodystrophy...
  18. ncbi request reprint Modulation of biomarkers by chemopreventive agents in smoke-exposed rats
    A Izzotti
    Department of Health Sciences, University of Genoa, Italy
    Cancer Res 61:2472-9. 2001
    ....
  19. doi request reprint Increased resistance to oxidative DNA damage of trabecular meshwork cells by E. coli FPG gene transfection
    M Foresta
    Molecular Mutagenesis and DNA Repair Unit, Istituto Nazionale Ricerca Cancro, Genoa, Italy
    Free Radic Res 45:751-8. 2011
    ..These findings bear relevance for primary and secondary prevention of degenerative glaucomas and other degenerative diseases where oxidative damage plays a pathogenic role...
  20. doi request reprint Proteome alterations in primary open angle glaucoma aqueous humor
    A Izzotti
    Department of Health Sciences, Faculty of Medicine, University of Genoa, and Department of Head Neck Pathologies, St Martino Hospital, Ophthalmology Unit, Genoa, Italy
    J Proteome Res 9:4831-8. 2010
    ..Furthermore, this study allows a better understanding of mechanisms involved in the pathogenesis of POAG, the main cause of irreversible blindness worldwide...
  21. doi request reprint Aqueous humor oxidative stress proteomic levels in primary open angle glaucoma
    A Bagnis
    University of Genova, Eye Clinic, Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Genoa, Italy
    Exp Eye Res 103:55-62. 2012
    ..Based on our results, GS, NOS2, SOD and GST as measured by antibody microarray technology may be useful oxidative markers in aqueous humor of glaucomatous patients...
  22. ncbi request reprint DNA adducts and chronic degenerative disease. Pathogenetic relevance and implications in preventive medicine
    S De Flora
    Institute of Hygiene and Preventive Medicine, University of Genoa, Italy
    Mutat Res 366:197-238. 1996
    ..The efficacy of chemopreventive agents can be assessed by evaluating inhibition of nuclear DNA or mitochondrial DNA adduct formation in vitro, in animal models, and in phase II clinical trials in high-risk individuals...
  23. ncbi request reprint Genomic and transcriptional alterations in mouse fetus liver after transplacental exposure to cigarette smoke
    Alberto Izzotti
    Department of Health Sciences, University of Genoa, Via A Pastore 1, I 16132, Italy
    FASEB J 17:1127-9. 2003
    ..Moreover, hypoxia-related genes and several oncogenes and receptors involved in proliferation and differentiation of leukocytes were induced in the fetal liver, which also bears hematopoietic functions...
  24. doi request reprint The Aicardi-Goutières syndrome. Molecular and clinical features of RNAse deficiency and microRNA overload
    A Pulliero
    Department of Health Sciences, University of Genoa, Genoa, Italy
    Mutat Res 717:99-108. 2011
    ..Thus, evidence exists that mutations silencing intracellular RNases affect microRNA turnover resulting in the severe clinical consequences in the brain characterizing the clinical feature of AGS...
  25. doi request reprint Glaucoma and Helicobacter pylori infection: correlations and controversies
    A Izzotti
    Department of Health Sciences, Faculty of Medicine, University of Genoa, Genoa, Italy
    Br J Ophthalmol 93:1420-7. 2009
    ..Systemic H pylori-induced oxidative damage may be the mechanism which links oxidative stress, H pylori infection and the damage to the trabecular meshwork and optical nerve head that results in glaucoma...
  26. ncbi request reprint Modulation of apoptosis by cigarette smoke and cancer chemopreventive agents in the respiratory tract of rats
    R M Balansky
    Department of Health Sciences, University of Genoa, Via A. Pastore 1, I-16132 Genoa, Italy
    Carcinogenesis 22:375-80. 2001
    ..Thus, it is important to discriminate between whether the opposite modulation of apoptosis is per se a protective mechanism or the beneficial outcome of other mechanisms inhibiting genotoxicity...
  27. ncbi request reprint Gene expression in the lung of p53 mutant mice exposed to cigarette smoke
    Alberto Izzotti
    Department of Health Sciences, University of Genoa, Genoa, Italy
    Cancer Res 64:8566-72. 2004
    ..Taken together, these findings may explain the increased susceptibility of p53 mutant mice to smoke-related alterations of intermediate biomarkers and lung carcinogenesis...
  28. doi request reprint Exposure of mice to cigarette smoke and/or light causes DNA alterations in heart and aorta
    Alberto Izzotti
    Department of Health Sciences, University of Genoa, Genoa, Italy
    Mutat Res 644:38-42. 2008
    ..Although the pathogenetic meaning is uncertain, DNA damage in heart and aorta may tentatively be related to cardiomyopathies and to the atherogenesis process, respectively...
  29. ncbi request reprint Systemic genotoxic effects produced by light, and synergism with cigarette smoke in the respiratory tract of hairless mice
    Roumen M Balansky
    Department of Health Sciences, University of Genoa, Via A Pastore 1, I 16132 Genoa, Italy
    Carcinogenesis 24:1525-32. 2003
    ..This damage may mechanistically be involved in light-related hematopoietic malignancies. In addition, the light displayed an insofar unsuspected synergism with smoke in the induction of DNA damage in the respiratory tract...
  30. doi request reprint Modulation by phenethyl isothiocyanate and budesonide of molecular and histopathologic alterations induced by environmental cigarette smoke in mice
    Francesco D'Agostini
    Department of Health Sciences, University of Genoa, Genoa, Italy
    Cancer Prev Res (Phila) 2:546-56. 2009
    ..Thus, although not as efficiently as the bioassay in mainstream cigarette smoke-exposed mice, the model in neonatal mice is suitable to evaluate both ECS carcinogenicity and its modulation by chemopreventive agents...
  31. doi request reprint Gene-environment interactions in ocular diseases
    S C Sacca
    Ophthalmology Division, St Martino Hospital, Genoa, Italy
    Mutat Res 667:98-117. 2009
    ..Whenever these factors target individuals who are susceptible due their genetic assets the results is the onset of a specific eye disease depending on the affected ocular tissue...
  32. ncbi request reprint Formation of DNA adducts in the aorta of smoke-exposed rats, and modulation by chemopreventive agents
    A Izzotti
    Department of Health Sciences, University of Genoa, Via Pastore 1, I-16132, Genoa, Italy
    Mutat Res 494:97-106. 2001
    ....
  33. doi request reprint Inhibition of neuroblastoma cell growth by TREX1-mutated human lymphocytes
    A Pulliero
    Department of Health Sciences, University of Genoa, I 16132 Genoa, Italy
    Oncol Rep 27:1689-94. 2012
    ..The results obtained provide evidence that mutations of the TREX1 gene increase the capability of T-lymphocytes to inhibit growth of neoplastic neuronal cells and related angiogenesis...
  34. pmc Chemoprevention of cigarette smoke-induced alterations of MicroRNA expression in rat lungs
    Alberto Izzotti
    Department of Health Sciences, University of Genoa, Italy
    Cancer Prev Res (Phila) 3:62-72. 2010
    ..Therefore, microRNA analysis may provide a new tool for predicting at early carcinogenesis stages both the potential safety and efficacy of cancer chemopreventive agents...
  35. ncbi request reprint Early loss of Fhit in the respiratory tract of rodents exposed to environmental cigarette smoke
    Francesco D'Agostini
    Department of Health Sciences, University of Genoa, Via A Pastore 1, I 16132 Genoa, Italy
    Cancer Res 66:3936-41. 2006
    ..In conclusion, there is unequivocal evidence that Fhit is an early, critical target in smoke-related lung carcinogenesis in rodents, and that certain chemopreventive agents can attenuate the occurrence of this gene alteration...
  36. pmc Relationships of microRNA expression in mouse lung with age and exposure to cigarette smoke and light
    Alberto Izzotti
    Department of Health Sciences, University of Genoa, Genoa, Italy
    FASEB J 23:3243-50. 2009
    ..Both gender and age affected smoke-related microRNA dysregulation in mice. The data presented provide supporting evidence that microRNAs play a fundamental role in both physiological and pathological changes occurring in mouse lung...
  37. ncbi request reprint Mechanisms of N-acetylcysteine in the prevention of DNA damage and cancer, with special reference to smoking-related end-points
    S De Flora
    Department of Health Sciences, Section of Hygiene and Preventive Medicine, University of Genoa, Via A Pastore 1, I 16132 Genoa, Italy
    Carcinogenesis 22:999-1013. 2001
    ..On the whole, there is overwhelming evidence that NAC has the ability to modulate a variety of DNA damage- and cancer-related end-points...
  38. doi request reprint Oxidative stress and glaucoma: injury in the anterior segment of the eye
    S C Sacca
    Division of Ophthalmology, St Martino Hospital, Genoa, Italy
    Prog Brain Res 173:385-407. 2008
    ..On the whole, these findings support the hypothesis that oxidative damage is an important step in the pathogenesis of primary open-angle glaucoma and might be a relevant target for both prevention and therapy...
  39. doi request reprint Degenerative periodontal-diseases and oral osteonecrosis: the role of gene-environment interactions
    D Baldi
    Department of Medical, Biophysical, and Dentistry Sciences and Technologies, University of Genoa, Italy
    Mutat Res 667:118-31. 2009
    ..This issue warrants future investigations aimed at improving oral health and preventing oral degenerative diseases using molecular and experimental approaches currently utilized in mutagenicity studies...
  40. ncbi request reprint Proteomic analysis as related to transcriptome data in the lung of chromium(VI)-treated rats
    Alberto Izzotti
    Department of Health Sciences, University of Genoa, I 16132 Genoa, Italy
    Int J Oncol 24:1513-22. 2004
    ..However, this parallelism is re-established when the cell undergoes genotoxic damage...
  41. ncbi request reprint Selective induction of gene expression in rat lung by hexavalent chromium
    Alberto Izzotti
    Department of Health Sciences, University of Genoa, Italy
    Mol Carcinog 35:75-84. 2002
    ....
  42. ncbi request reprint Alterations of gene expression in skin and lung of mice exposed to light and cigarette smoke
    Alberto Izzotti
    Department of Health Sciences, University of Genoa, Genoa, Italy
    FASEB J 18:1559-61. 2004
    ..These results provide a mechanistic insight explaining the systemic alterations induced by both light and smoke in mouse skin and lungs...
  43. ncbi request reprint Oxidative DNA damage in the human trabecular meshwork: clinical correlation in patients with primary open-angle glaucoma
    Sergio Claudio Saccà
    Department of Neurosciences, Clinica Oculistica, University of Genoa, I 16132 Genoa, Italy
    Arch Ophthalmol 123:458-63. 2005
    ..To evaluate the intensity of oxidative molecular damage and its clinical correlations: visual field damage, intraocular pressure, age, and disease duration...
  44. ncbi request reprint Birth-related genomic and transcriptional changes in mouse lung. Modulation by transplacental N-acetylcysteine
    Alberto Izzotti
    Department of Health Sciences, University of Genoa, Via A Pastore 1, Genoa I 16132, Italy
    Mutat Res 544:441-9. 2003
    ..It therefore appears that administration of NAC during pregnancy is beneficial not only to counteract the adverse effects of toxic agents, as supported by previous studies, but also to attenuate birth-related DNA alterations...
  45. ncbi request reprint Induction of apoptosis in the lung but not in the liver of rats receiving intra-tracheal instillations of chromium(VI)
    Francesco D'Agostini
    Department of Health Sciences, University of Genoa, Via A Pastore 1, I 16132 Genoa, Italy
    Carcinogenesis 23:587-93. 2002
    ..Therefore, apoptosis is likely to provide a protective mechanism at a post-genotoxic stage of Cr(VI) carcinogenesis...
  46. ncbi request reprint Increased DNA alterations in atherosclerotic lesions of individuals lacking the GSTM1 genotype
    A Izzotti
    Department of Health Sciences, University of Genoa, Italy
    FASEB J 15:752-7. 2001
    ....
  47. ncbi request reprint Oxidative deoxyribonucleic acid damage in the eyes of glaucoma patients
    Alberto Izzotti
    Department of Health Sciences, University of Genoa, Via A Pastore 1, I 16132 Genoa, Italy
    Am J Med 114:638-46. 2003
    ..Some investigators have hypothesized that oxidative damage may be involved. We evaluated oxidative deoxyribonucleic acid (DNA) damage, in terms of 8-hydroxy-2'-deoxyguanosine (8-OH-dG), in the eyes of glaucoma patients...
  48. pmc Modulation of microRNA expression by budesonide, phenethyl isothiocyanate and cigarette smoke in mouse liver and lung
    Alberto Izzotti
    Department of Health Sciences, University of Genoa, Via A Pastore 1, I 16132 Genoa, Italy
    Carcinogenesis 31:894-901. 2010
    ..PEITC and BUD protected the lung from ECS-induced alterations of miRNA expression but exhibited some adverse effects in liver...
  49. pmc Influence of FHIT on benzo[a]pyrene-induced tumors and alopecia in mice: chemoprevention by budesonide and N-acetylcysteine
    Roumen Balansky
    Department of Health Sciences, University of Genoa, Via A Pastore 1, I 16132 Genoa, Italy
    Proc Natl Acad Sci U S A 103:7823-8. 2006
    ..In conclusion, heterozygosity for FHIT affects susceptibility of mice to spontaneous alopecia areata and B[a]P-induced preneoplastic lesions of the uterus and does not alter responsiveness to budesonide and NAC...
  50. ncbi request reprint Interplay between Helicobacter pylori and host gene polymorphisms in inducing oxidative DNA damage in the gastric mucosa
    Alberto Izzotti
    Department of Health Sciences, University of Genoa, Via A Pastore 1, I 16132, Genoa, Italy
    Carcinogenesis 28:892-8. 2007
    ..The interplay between bacterial and host gene polymorphisms may explain why gastric cancer only occurs in a small fraction of H.pylori-infected individuals...
  51. ncbi request reprint Multiple points of intervention in the prevention of cancer and other mutation-related diseases
    S De Flora
    Department of Health Sciences, University of Genoa, Genoa, Italy
    Mutat Res 480:9-22. 2001
    ....
  52. ncbi request reprint Induction by 7,12-dimethylbenz(a)anthracene of molecular and biochemical alterations in transformed human mammary epithelial stem cells, and protection by N-acetylcysteine
    Silvio De Flora
    Department of Health Sciences, Section of Hygiene and Preventive Medicine, University of Genoa, I 16132 Genoa, Italy
    Int J Oncol 29:521-9. 2006
    ..Thus, the immortal cell line derived from the normal human adult breast stem cell without further tumorigenic progression is the most susceptible both to DMBA-related alterations and to the protective effects of NAC...
  53. ncbi request reprint Chemoprevention of genome, transcriptome, and proteome alterations induced by cigarette smoke in rat lung
    Alberto Izzotti
    Department of Health Sciences, University of Genoa, Via A Pastore 1, I 16132 Genoa, Italy
    Eur J Cancer 41:1864-74. 2005
    ....
  54. ncbi request reprint Molecular and cytogenetical alterations induced by environmental cigarette smoke in mice heterozygous for Fhit
    Silvio De Flora
    Department of Health Sciences, University of Genoa, Via A Pastore 1, I 16132 Genoa, Italy
    Cancer Res 67:1001-6. 2007
    ....
  55. ncbi request reprint Induction and modulation of lung tumors: genomic and transcriptional alterations in cigarette smoke-exposed mice
    Silvio De Flora
    Department of Health Sciences, University of Genoa, Genoa, Italy
    Exp Lung Res 31:19-35. 2005
    ..Smoke-induced genomic and transcriptional alterations were suitable for evaluating their modulation by chemopreventive agent, as shown in studies using the thiol N-acetylcysteine and the nonsteroidal anti-inflammatory drug sulindac...
  56. ncbi request reprint Mutagenesis and cardiovascular diseases Molecular mechanisms, risk factors, and protective factors
    Silvio De Flora
    Department of Health Sciences, University of Genoa, Via A Pastore 1, I 16132 Genoa, Italy
    Mutat Res 621:5-17. 2007
    ..Prevention of both cancer and atherosclerosis is based on avoidance of exposure to risk factors and on fortification of the host defense mechanisms by means of dietary principles and chemopreventive drugs...
  57. ncbi request reprint High susceptibility of neonatal mice to molecular, biochemical and cytogenetic alterations induced by environmental cigarette smoke and light
    Silvio De Flora
    Department of Health Sciences, University of Genoa, Via A Pastore 1, I 16132 Genoa, Italy
    Mutat Res 659:137-46. 2008
    ..The findings of these studies provide a mechanistic clue to the general concept that the neonatal period and early stages of life are critical in affecting susceptibility to carcinogens...
  58. ncbi request reprint Lack of genotoxic effects in hematopoietic and gastrointestinal cells of mice receiving chromium(VI) with the drinking water
    Silvio De Flora
    Department of Health Sciences, University of Genoa, Via A Pastore 1, I 16132 Genoa, Italy
    Mutat Res 659:60-7. 2008
    ..These results are discussed in the light of literature data, also including a recent 2-year carcinogenicity study performed by the National Toxicology Program...
  59. ncbi request reprint Molecular alterations and lung tumors in p53 mutant mice exposed to cigarette smoke
    Silvio De Flora
    Department of Health Sciences, University of Genoa, I 16132 Genoa, Italy
    Cancer Res 63:793-800. 2003
    ..These findings provide evidence that p53 mutations play a role in smoke-related carcinogenesis not only in humans but also in A/J mice...
  60. ncbi request reprint Modulation of cigarette smoke-related end-points in mutagenesis and carcinogenesis
    Silvio De Flora
    Department of Health Sciences, University of Genoa, Via A Pastore 1, I 16132 Genoa, Italy
    Mutat Res 523:237-52. 2003
    ..We are trying to develop a pharmacogenomic approach, e.g. based on genetic metabolic polymorphisms, aimed at predicting not only the risk of developing cancer but also the individual responsiveness to chemopreventive agents...
  61. doi request reprint Modulation of genomic and postgenomic alterations in noncancer diseases and critical periods of life
    Silvio De Flora
    Department of Health Sciences, University of Genoa, Via A Pastore 1, I 16132 Genoa, Italy
    Mutat Res 667:15-26. 2009
    ..The discovery that chemopreventive agents are also able to attenuate nucleotide damage in stem-derived cells warrants further studies in view of possible clinical applications...
  62. ncbi request reprint Modulation of apoptosis by cancer chemopreventive agents
    Francesco D'Agostini
    Department of Health Sciences, University of Genoa, Via A Pastore 1, I 16132 Genoa, Italy
    Mutat Res 591:173-86. 2005
    ..We suggest that stimulation of apoptosis by so many chemopreventive agents, as reported in the literature, may often reflect the occurrence of toxic effects at high doses...
  63. doi request reprint Microarray expression in peri-implant tissue next to different titanium implant surfaces predicts clinical outcomes: a split-mouth study
    M Menini
    Division of Implant Prosthodontics, Department of Surgical Sciences, University of Genoa, Genoa, Italy
    Clin Oral Implants Res . 2016
    ..This split-mouth study evaluated miRNA expression of tissues around implants with different surface treatments...
  64. ncbi request reprint Physical activity and cancer prevention: a review of current evidence and biological mechanisms
    F Anzuini
    Department of Health Sciences, University of Genova, Italy
    J Prev Med Hyg 52:174-80. 2011
    ..The main aim of this paper is to review the evidence available from the date of PubMed's inception to May 2011 for a link between cancer and physical activity (PA) in both animal models and humans...
  65. ncbi request reprint Pharmacological modulation of genome and proteome alterations in mice treated with the endocrine disruptor bisphenol A
    Alberto Izzotti
    Department of Health Sciences, University of Genoa, Via A Pastore 1, I 16132 Genoa, Italy
    Curr Cancer Drug Targets 10:147-54. 2010
    ..Therefore, the in vivo use of proteome analysis proves to be a sensitive tool for the early prediction not only of protective effects but also of adverse effects of chemopreventive agents...
  66. ncbi request reprint Upregulation of stem cell antigen-1 in the lung of neonatal mice exposed to environmental cigarette smoke
    Alberto Izzotti
    Department of Health Sciences, University of Genoa, I 16132 Genoa, Italy
    Oncol Rep 22:469-74. 2009
    ..These findings may contribute to explain the high vulnerability of mouse lung early in life...
  67. ncbi request reprint Antioxidant activity of timolol on endothelial cells and its relevance for glaucoma course
    A Izzotti
    Department of Health Sciences, University of Genoa, Italy
    Eye (Lond) 22:445-53. 2008
    ..We test the hypothesis that the classic beta-blocker therapy for glaucoma with timolol involves the activation of antioxidant protective mechanisms towards endothelial cells...
  68. doi request reprint Interaction between Helicobacter pylori, diet, and genetic polymorphisms as related to non-cancer diseases
    Alberto Izzotti
    Department of Health Sciences, University of Genoa, Via A Pastore, 1, 16132 Genoa, Italy
    Mutat Res 667:142-57. 2009
    ..In conclusion, there is an evidence that mutagenesis-related mechanisms play a pathogenic role in the appearance of non-cancer diseases following H. pylori infection...
  69. pmc Downregulation of microRNA expression in the lungs of rats exposed to cigarette smoke
    Alberto Izzotti
    Department of Health Sciences, University of Genoa, Via A Pastore 1, I 16132 Genoa, Italy
    FASEB J 23:806-12. 2009
    ..Five ECS-down-regulated microRNAs are known to be affected by single nucleotide polymorphisms. Thus, changes in microRNA expression are an early event following exposure to cigarette smoke...
  70. doi request reprint Molecular fingerprints of environmental carcinogens in human cancer
    C Ceccaroli
    a Department of Health Sciences, University of Genoa, Italy
    J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 33:188-228. 2015
    ..The multiple analysis of these biomarkers provides information on the carcinogenic mechanisms activated by exposure to environmental carcinogens. ..
  71. doi request reprint Environmental carcinogens and mutational pathways in atherosclerosis
    A Pulliero
    Department of Health Sciences, University of Genoa, Italy
    Int J Hyg Environ Health 218:293-312. 2015
    ..This review summarizes the experimental and clinical evidence supporting the pathogenic role of mutation-related pathway in atherosclerosis examining the underlying molecular mechanisms. ..
  72. doi request reprint Formation of adducts by bisphenol A, an endocrine disruptor, in DNA in vitro and in liver and mammary tissue of mice
    Alberto Izzotti
    Department of Health Sciences, University of Genoa, Genoa, Italy
    Mutat Res 679:28-32. 2009
    ....
  73. ncbi request reprint Mutagenicity of sediments along the Po River and genotoxicity biomarkers in fish from polluted areas
    Luigi Viganò
    Water Research Institute, CNR, I 20047 Brugherio, Milan, Italy
    Mutat Res 515:125-34. 2002
    ..söetta. Thus, certain biomarkers of exposure and effect in fish, as assessed under field conditions, correlate with the pollution of river sediments by mutagenic compounds...
  74. ncbi request reprint Glutathione S-transferase M1 and its implications in glaucoma pathogenesis: a controversial matter
    Alberto Izzotti
    Exp Eye Res 79:141-2; author reply 143. 2004
  75. ncbi request reprint [Open angle glaucoma: epidemiology, pathogenesis and prevention]
    Alberto Izzotti
    Dipartimento di Scienze della Salute, Universita, Genova
    Recenti Prog Med 97:37-45. 2006
    ....
  76. ncbi request reprint Glaucomatous outflow pathway and oxidative stress
    Sergio Claudio Saccà
    San Martino Hospital, Section of Ophthalmology, Largo Rosanna Benzi 1, 16132 Genova, Italy
    Exp Eye Res 84:389-99. 2007
    ..On the whole, these findings support the hypothesis that oxidative damage is an important step in the pathogenesis of primary open-angle glaucoma, and might be a relevant target for both prevention and therapy...
  77. ncbi request reprint DNA damage, mutagenesis and cardiovascular disease
    Frederik J Van Schooten
    Mutat Res 621:1-4. 2007
  78. ncbi request reprint K-ras mutations in lung tumors from p53 mutant mice exposed to cigarette smoke
    Ruisheng Yao
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri, USA
    Exp Lung Res 31:271-81. 2005
    ..These results suggest that tobacco smoke enhances lung tumorigenesis primarily through promoting spontaneously occurring K-ras mutations...
  79. ncbi request reprint Re: The central role of receiver operating characteristic (ROC) curves in evaluating tests for the early detection of cancer
    Stefano Parodi
    J Natl Cancer Inst 97:234-5; author reply 235. 2005
  80. ncbi request reprint Lipid peroxidation-derived etheno-DNA adducts in human atherosclerotic lesions
    Jagadeesan Nair
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Mutat Res 621:95-105. 2007
    ....