Davide Gibellini

Summary

Affiliation: University of Bologna
Country: Italy

Publications

  1. ncbi Inhibition of HIV-1 Tat activity correlates with down-regulation of bcl-2 and results in reduction of angiogenesis and oncogenicity
    Alfredo Corallini
    Department of Experimental and Diagnostic Medicine, Section of Microbiology, Center of Biotechnology, University of Ferrara, I 44100 Ferrara, Italy
    Virology 299:1-7. 2002
  2. ncbi HIV-1 negatively affects the survival/maturation of cord blood CD34(+) hematopoietic progenitor cells differentiated towards megakaryocytic lineage by HIV-1 gp120/CD4 membrane interaction
    Davide Gibellini
    Department of Clinical and Experimental Medicine, Microbiology Section, University of Bologna, Bologna, Italy
    J Cell Physiol 210:315-24. 2007
  3. ncbi Antiretroviral molecules and cardiovascular diseases
    Davide Gibellini
    Department of Haematology and Oncological Sciences, University of Bologna, Bologna, Italy
    New Microbiol 35:359-75. 2012
  4. pmc Prospective evaluation of bone markers, parathormone and 1,25-(OH)₂ vitamin D in HIV-positive patients after the initiation of tenofovir/emtricitabine with atazanavir/ritonavir or efavirenz
    Emanuele Focà
    Infectious Diseases Department, University of Brescia, Brescia, Italy
    BMC Infect Dis 12:38. 2012
  5. doi Guidelines for the qualitative detection of viral genomes in dried blood spots
    Davide Gibellini
    Microbiology Section, Department of Haematology and Oncological Sciences, University of Bologna, Bologna, Italy
    Methods Mol Biol 903:21-34. 2012
  6. doi Analysis of the effects of HIV-1 Tat on the survival and differentiation of vessel wall-derived mesenchymal stem cells
    Davide Gibellini
    Microbiology Section, Department of Haematology and Oncological Sciences, University of Bologna, Bologna, Italy
    J Cell Biochem 113:1132-41. 2012
  7. doi HIV-1 Tat protein enhances RANKL/M-CSF-mediated osteoclast differentiation
    Davide Gibellini
    Department of Haematology and Oncological Sciences, Microbiology Section, University of Bologna, Italy
    Biochem Biophys Res Commun 401:429-34. 2010
  8. doi HIV-1 infection of a nurse from a newborn with an unknown HIV infection: a case report
    Davide Gibellini
    Section of Microbiology of the Department of Hematology and Oncologic Science, University of Bologna, Bologna, Italy
    J Clin Virol 46:374-7. 2009
  9. doi HIV-1 triggers apoptosis in primary osteoblasts and HOBIT cells through TNFalpha activation
    Davide Gibellini
    Department of Clinical and Experimental Medicine, Microbiology Section, University of Bologna, Bologna, Italy
    J Med Virol 80:1507-14. 2008
  10. pmc HIV-1 and recombinant gp120 affect the survival and differentiation of human vessel wall-derived mesenchymal stem cells
    Davide Gibellini
    Department of Haematology and Oncological Sciences, Microbiology Section, University of Bologna, Italy
    Retrovirology 8:40. 2011

Collaborators

Detail Information

Publications47

  1. ncbi Inhibition of HIV-1 Tat activity correlates with down-regulation of bcl-2 and results in reduction of angiogenesis and oncogenicity
    Alfredo Corallini
    Department of Experimental and Diagnostic Medicine, Section of Microbiology, Center of Biotechnology, University of Ferrara, I 44100 Ferrara, Italy
    Virology 299:1-7. 2002
    ....
  2. ncbi HIV-1 negatively affects the survival/maturation of cord blood CD34(+) hematopoietic progenitor cells differentiated towards megakaryocytic lineage by HIV-1 gp120/CD4 membrane interaction
    Davide Gibellini
    Department of Clinical and Experimental Medicine, Microbiology Section, University of Bologna, Bologna, Italy
    J Cell Physiol 210:315-24. 2007
    ..This long-term inhibitory effect is also correlated to specific cytokines regulation and it may represent an additional mechanism to explain the TP occurring in HIV-1 patients...
  3. ncbi Antiretroviral molecules and cardiovascular diseases
    Davide Gibellini
    Department of Haematology and Oncological Sciences, University of Bologna, Bologna, Italy
    New Microbiol 35:359-75. 2012
    ..Here, we discuss the interaction between antiretroviral therapy and cardiovascular system in HIV-positive patients focusing on the antiretroviral-related mechanisms involved in cardiovascular alterations...
  4. pmc Prospective evaluation of bone markers, parathormone and 1,25-(OH)₂ vitamin D in HIV-positive patients after the initiation of tenofovir/emtricitabine with atazanavir/ritonavir or efavirenz
    Emanuele Focà
    Infectious Diseases Department, University of Brescia, Brescia, Italy
    BMC Infect Dis 12:38. 2012
    ..Lastly, the effect of tenofovir on 1,25-(OH)₂ vitamin D is uncertain...
  5. doi Guidelines for the qualitative detection of viral genomes in dried blood spots
    Davide Gibellini
    Microbiology Section, Department of Haematology and Oncological Sciences, University of Bologna, Bologna, Italy
    Methods Mol Biol 903:21-34. 2012
    ....
  6. doi Analysis of the effects of HIV-1 Tat on the survival and differentiation of vessel wall-derived mesenchymal stem cells
    Davide Gibellini
    Microbiology Section, Department of Haematology and Oncological Sciences, University of Bologna, Bologna, Italy
    J Cell Biochem 113:1132-41. 2012
    ..The Tat-related impairment of MSC survival and differentiation might play an important role in vessel damage and formation of the atherosclerotic lesions observed in HIV-infected patients...
  7. doi HIV-1 Tat protein enhances RANKL/M-CSF-mediated osteoclast differentiation
    Davide Gibellini
    Department of Haematology and Oncological Sciences, Microbiology Section, University of Bologna, Italy
    Biochem Biophys Res Commun 401:429-34. 2010
    ....
  8. doi HIV-1 infection of a nurse from a newborn with an unknown HIV infection: a case report
    Davide Gibellini
    Section of Microbiology of the Department of Hematology and Oncologic Science, University of Bologna, Bologna, Italy
    J Clin Virol 46:374-7. 2009
    ..HIV infection of healthcare workers by injury is an important issue in the management and prophylaxis of HIV-related disease...
  9. doi HIV-1 triggers apoptosis in primary osteoblasts and HOBIT cells through TNFalpha activation
    Davide Gibellini
    Department of Clinical and Experimental Medicine, Microbiology Section, University of Bologna, Bologna, Italy
    J Med Virol 80:1507-14. 2008
    ..As a whole, these results indicate that HIV-1 may impair bone mass structure homeostasis by TNFalpha regulated osteoblast apoptosis...
  10. pmc HIV-1 and recombinant gp120 affect the survival and differentiation of human vessel wall-derived mesenchymal stem cells
    Davide Gibellini
    Department of Haematology and Oncological Sciences, Microbiology Section, University of Bologna, Italy
    Retrovirology 8:40. 2011
    ..This paper investigated the interaction between HIV-1 and vascular wall resident human mesenchymal stem cells (MSCs)...
  11. doi HIV-1 DNA load analysis in peripheral blood lymphocytes and monocytes from naïve and HAART-treated individuals
    Davide Gibellini
    Department of Clinical and Experimental Medicine, Microbiology Section, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy
    J Infect 56:219-25. 2008
    ..To evaluate HIV-1 DNA load in PBLs and monocytes from both long-term HAART-treated and antiretroviral naïve HIV-1 infected patients...
  12. ncbi RANKL/OPG/TRAIL plasma levels and bone mass loss evaluation in antiretroviral naive HIV-1-positive men
    Davide Gibellini
    Department of Clinical and Experimental Medicine, Microbiology Section, University of Bologna, Bologna, Italy
    J Med Virol 79:1446-54. 2007
    ....
  13. ncbi Simultaneous detection of HCV and HIV-1 by SYBR Green real time multiplex RT-PCR technique in plasma samples
    Davide Gibellini
    Department of Clinical and Experimental Medicine, Microbiology Section, University of Bologna, St Orsola Hospital, Via Massarenti 9, 40138 Bologna, Italy
    Mol Cell Probes 20:223-9. 2006
    ..This method may represent a useful alternative method for the detection of HIV-1/HCV co-infection, reliable for a rapid and relatively inexpensive screening of blood donors...
  14. ncbi HIV-1 tat protein and cell proliferation and survival: a brief review
    Davide Gibellini
    Department of Clinical and Experimental Medicine, Microbiology Section, University of Bologna, Italy
    New Microbiol 28:95-109. 2005
    ..This review focuses on some aspects of Tat biological activity with particular regard to effects of Tat on cell proliferation and survival regulation...
  15. ncbi Quantitative detection of human immunodeficiency virus type 1 (HIV-1) proviral DNA in peripheral blood mononuclear cells by SYBR green real-time PCR technique
    Davide Gibellini
    Department of Clinical and Experimental Medicine, Microbiology Section, University of Bologna, St Orsola Hospital, Via Massarenti 9, 40138 Bologna, Italy
    J Clin Virol 29:282-9. 2004
    ..Moreover, the detection of HIV-1 proviral DNA is an important diagnostic marker in the evaluation of HIV-1 infection of newborns of HIV-1 seropositive women...
  16. ncbi HIV-1 Tat protein concomitantly down-regulates apical caspase-10 and up-regulates c-FLIP in lymphoid T cells: a potential molecular mechanism to escape TRAIL cytotoxicity
    Davide Gibellini
    Department of Clinical and Experimental Medicine, Microbiology Section, University of Bologna, Bologna, Italy
    J Cell Physiol 203:547-56. 2005
    ..Taken together, these results provide a molecular basis to explain the resistance of tat-expressing Jurkat cells to apoptosis induced by TRAIL and, possibly, to other death-inducing ligands...
  17. ncbi Quantitative detection of human immunodeficiency virus type 1 (HIV-1) viral load by SYBR green real-time RT-PCR technique in HIV-1 seropositive patients
    Davide Gibellini
    Department of Clinical and Experimental Medicine, Microbiology Section, University of Bologna, St Orsola Hospital, Via Massarenti 9, 40138, Bologna, Italy
    J Virol Methods 115:183-9. 2004
    ..The SYBR green real-time RT-PCR represents a good alternative to b-DNA assay in HIV-1 viral load determination especially during the monitoring of HAART treatment...
  18. ncbi Quantitative DNA proviral detection in HIV-1 patients treated with antiretroviral therapy
    Francesca Vitone
    Department of Clinical and Experimental Medicine, Microbiology Section, University of Bologna, St Orsola Hospital, Via Massarenti 9, Bologna 40138, Italy
    J Clin Virol 33:194-200. 2005
    ....
  19. doi Prevalence of R5 strains in multi-treated HIV subjects and impact of new regimens including maraviroc in a selected group of patients with CCR5-tropic HIV-1 infection
    Isabella Bon
    Department of Experimental, Diagnostic and Specialty Medicine, School of Medicine, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy
    Int J Infect Dis 17:e875-82. 2013
    ....
  20. pmc Human T-lymphotropic virus type 1 (HTLV-1) prevalence and quantitative detection of DNA proviral load in individuals with indeterminate/positive serological results
    Francesca Vitone
    Department of Clinical and Experimental Medicine, University of Bologna, 47900 Rimini, Italy
    BMC Infect Dis 6:41. 2006
    ..We subsequently applied a real time PCR on peripheral blood mononuclear cells from subjects with positive or indeterminate serological results...
  21. doi Incomplete IgG response to HIV-1 proteins and low avidity levels in recently converted HIV patients treated with early antiretroviral therapy
    Maria Carla Re
    Microbiology Section of the Department of Hematology and Oncologic Sciences, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy
    Int J Infect Dis 14:e1008-12. 2010
    ....
  22. ncbi Genotypic resistance in plasma and peripheral blood lymphocytes in a group of naive HIV-1 patients
    Isabella Bon
    Section of Microbiology, Department of Clinical and Experimental Medicine, University of Bologna, Via Massarenti, 9, 40138 Bologna, Italy
    J Clin Virol 38:313-20. 2007
    ....
  23. ncbi Recent and long-lasting infections: the need for avidity testing in HIV-1 infected subjects
    Maria Carla Re
    Department of Haematology and Oncologic Sciences, University of Bologna, Bologna, Italy
    New Microbiol 35:407-14. 2012
    ....
  24. pmc Different patterns of HIV-1 DNA after therapy discontinuation
    Maria Carla Re
    Department of Clinical and Experimental Medicine, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy
    BMC Infect Dis 5:69. 2005
    ....
  25. ncbi Low avidity antibody: a reliable method to diagnose a recent HIV-1 infection
    Maria Carla Re
    Section of Microbiology and Section of Infectious Diseases, Department of Clinical and Experimental Medicine, University of Bologna, Bologna, Italy
    New Microbiol 31:19-26. 2008
    ..Avidity index levels might distinguish between acute and chronic infection. The method is semi-automated, inexpensive and easy to perform, and estimates the time elapsed from seroconversion, thereby identifying a recent infection...
  26. ncbi Meaning of DNA detection during the follow-up of HIV-1 infected patients: a brief review
    Maria Carla Re
    Department of Clinical and Experimental Medicine, Section of Microbiology, University of Bologna, St Orsola Hospital, Massarenti, 9, 40138 Bologna, Italy
    New Microbiol 29:81-8. 2006
    ....
  27. doi HIV-related mechanisms in atherosclerosis and cardiovascular diseases
    Davide Gibellini
    aMicrobiology Section, Department of Haematology and Oncological Sciences bInfectious Diseases Section, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna cDepartment of Life Sciences, University of Trieste, Trieste dInteruniversity Consortium, National Institute Biostructure and Biosystems, Rome, Italy
    J Cardiovasc Med (Hagerstown) 14:780-90. 2013
    ..In this review, we discuss these major HIV-related mechanisms able to promote atherosclerosis and cardiovascular diseases in HIV-positive patients. ..
  28. ncbi Analysis of the effects of specific protease inhibitors on OPG/RANKL regulation in an osteoblast-like cell line
    Davide Gibellini
    Microbiology Section, Department of Haematology and Oncologic Sciences, University of Bologna, Italy
    New Microbiol 33:109-15. 2010
    ..Instead, cell cultures treated by the highest concentrations of tipranavir or darunavir showed a change in cell survival or an increase in RANKL, with a negative effect on the OPG/RANKL balance...
  29. ncbi Differentially expressed genes in HIV-1 tat-expressing CD4(+) T-cell line
    Davide Gibellini
    Department of Clinical and Experimental Medicine, St Orsola Hospital, University of Bologna, Via Massarenti 9, 40138, Bologna, Italy
    Virus Res 90:337-45. 2002
    ....
  30. ncbi Calcaneal quantitative ultrasound (QUS) and dual X-ray absorptiometry (DXA) bone analysis in adult HIV-positive patients
    Alberto Clo
    Department of Experimental, Diagnostic, and Specialty Medicine, University of Bologna, Microbiology Unit, S Orsola Malpighi Hospital, Bologna, Italy
    New Microbiol 38:345-56. 2015
    ..QUS can be used as an additional tool for analyzing bone density in HIV-positive patients and its case of use and low cost make it especially suitable for resource-limited settings where DXA is not employed. ..
  31. ncbi Prevalence of sub-clinical vertebral fractures in HIV-infected patients
    Marco Borderi
    Infectious Disease Unit, Department of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy
    New Microbiol 37:25-32. 2014
    ....
  32. pmc Peptide-derivatized SB105-A10 dendrimer inhibits the infectivity of R5 and X4 HIV-1 strains in primary PBMCs and cervicovaginal histocultures
    Isabella Bon
    Department of Experimental, Diagnostic and Specialty Medicine DIMES, Microbiology Section, University of Bologna, Bologna, Italy
    PLoS ONE 8:e76482. 2013
    ..These results demonstrated the strong antiviral activity of SB105-A10 and suggest a potential microbicide use of this dendrimer to prevent the heterosexual transmission of HIV-1. ..
  33. doi HIV-1 subtype C transmission network: the phylogenetic reconstruction strongly supports the epidemiological data
    Isabella Bon
    Microbiology Section of the Department of Haematology and Oncologic Sciences, University of Bologna, Via Massarenti, 9 40138 Bologna, Italy
    J Clin Virol 48:212-4. 2010
    ....
  34. ncbi Bone alterations during HIV infection
    Elisa De Crignis
    Department of Clinical and Experimental Medicine, University of Bologna, Bologna, Italy
    New Microbiol 31:155-64. 2008
    ....
  35. ncbi Effects of Antiretroviral Molecules on Survival and Gene Expression of An Osteoblast-like Cell Line
    Anna Miserocchi
    Microbiology Section, Retrovirus Laboratory, St Orsola Hospital, Department of Experimental, Diagnostic and Specialty Medicine, School of Medicine, University of Bologna, Italy, Massarenti 9 40138 Bologna, Italy
    Curr HIV Res 14:497-505. 2016
    ..The advent of combined antiretroviral therapy effectively undermined the evolution of HIV disease. Nevertheless, clinical observations indicated a clear association between therapy and the impairment of bone mineral density...
  36. ncbi HIV-1 gp120 impairs the differentiation and survival of cord blood CD34+ HPCs induced to the erythroid lineage
    Silvia Morini
    Microbiology Section of the Department of Experimental, Diagnostic and Specialty Medicine, School of Medicine, University of Bologna, Italy
    New Microbiol 39:13-23. 2016
    ....
  37. ncbi Durable viral suppression in an HIV-infected patient in the absence of antiretroviral therapy
    Isabella Bon
    Microbiology Section of the Department of Experimental, Diagnostic and Specialty Medicine, School of Medicine, University of Bologna, Italy
    New Microbiol 38:289-92. 2015
    ..The patient's clinical and virological history showed a peculiar evolution of HIV infection, with an MDR HIV-1 in CSF and a wild HIV strain in PBMCs. The patient's PBMC showed a rapid shift from a wild type to an MDR strain in few days. ..
  38. ncbi Overexpression of MLH-1 and psoriasin genes in cutaneous angiofibromas from tuberous sclerosis complex patients
    Michelangelo La Placa
    Department of Clinical and Experimental Medicine, Dermatology Section, University of Bologna, Bologna, Italy
    J Cutan Pathol 33:608-13. 2006
    ....
  39. ncbi A rapid hemi-nested PCR for HTLV-I detection
    Davide Gibellini
    Section of Microbiology, Department of Clinical and Experimental Medicine, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy
    J Clin Virol 28:341-3. 2003
    ....
  40. pmc IFI16 Expression Is Related to Selected Transcription Factors during B-Cell Differentiation
    Pier Paolo Piccaluga
    Department of Experimental, Diagnostic, and Specialty Medicine, Bologna University Medical School Unit of Hematopathology, S Orsola Malpighi Hospital, 40138 Bologna, Italy
    J Immunol Res 2015:747645. 2015
    ..In addition, analysis of the CD40 signaling pathway showed that IFI16 gene expression directly correlated with NF-κB activation, indicating that IFI16 could be considered an upstream modulator of NF-κB in human B-cells. ..
  41. ncbi Serum antibody reactivity to human intracisternal A-type particle retrovirus proteins in systemic sclerosis patients
    Michelangelo La Placa
    Department of Clinical and Experimental Medicine, University of Bologna, Bologna, Italy
    Acta Derm Venereol 84:177-80. 2004
    ....
  42. ncbi Impaired dendritic cell immunophenotype and function in heart transplant patients undergoing active cytomegalovirus infection
    Stefania Varani
    Department of Clinical and Experimental Medicine, Section of Microbiology, University of Bologna, Bologna, Italy
    Transplantation 79:219-27. 2005
    ..Human cytomegalovirus (HCMV) infects dendritic cells (DCs) in vitro and inhibits their maturation properties and their ability to stimulate T-cell proliferation and cytotoxicity. This study analyzed HCMV infection of DCs in vivo...
  43. ncbi Role of CREB transcription factor in c-fos activation in natural killer cells
    Cristina Ponti
    Department of Anatomical Sciences, Cellular Signalling Laboratory, University of Bologna, Bologna, Italy
    Eur J Immunol 32:3358-65. 2002
    ....
  44. pmc Virus-encoded microRNA contributes to the molecular profile of EBV-positive Burkitt lymphomas
    Pier Paolo Piccaluga
    Hematopathology Section, Department of Experimental, Diagnostic, and Experimental Medicine, S Orsola Malpighi Hospital, Bologna University School of Medicine, Bologna, Italy
    Oncotarget 7:224-40. 2016
    ..In conclusion, our data indicated significant differences in the transcriptional profiles of EBV-positive and EBV-negative BL and highlight the role of virus encoded miRNA. ..
  45. ncbi Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) and TNF-alpha promote the NF-kappaB-dependent maturation of normal and leukemic myeloid cells
    Paola Secchiero
    Department of Morphology and Embryology, Human Anatomy Section, St Anna Hospital, University of Ferrara, Italy
    J Leukoc Biol 74:223-32. 2003
    ..These findings demonstrate that NF-kappaB is essential for monocytic maturation and is activated via distinct pathways, involving or not involving caspases, by the related cytokines TRAIL and TNF-alpha...
  46. ncbi Serum antibodies against human intracisternal A-type particle (HIAP) endogenous retrovirus in Alopecia areata patients: a hallmark of autoimmune disease?
    Michelangelo La Placa
    J Invest Dermatol 123:407-9. 2004
  47. ncbi Dendritic cell function in cytomegalovirus-infected patients with mononucleosis
    Giada Frascaroli
    Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden
    J Leukoc Biol 79:932-40. 2006
    ..During symptomatic HCMV infection in the immunocompetent host, DCs exhibit an impaired immunophenotype and function. These effects may contribute to the viral-induced immunomodulation, which is often observed in HCMV-infected patients...