A R Genazzani

Summary

Affiliation: University of Pisa
Country: Italy

Publications

  1. ncbi request reprint Long-term low-dose dehydroepiandrosterone replacement therapy in aging males with partial androgen deficiency
    A R Genazzani
    Department of Reproductive Medicine and Child Development, Division of Gynecology and Obstetrics, University of Pisa, Pisa, Italy
    Aging Male 7:133-43. 2004
  2. ncbi request reprint Drospirenone increases central and peripheral beta-endorphin in ovariectomized female rats
    Andrea Riccardo Genazzani
    Department of Reproductive Medicine and Child Development, Division of Gynecology and Obstetrics, University of Pisa, Pisa, Italy
    Menopause 14:63-73. 2007
  3. ncbi request reprint Effect of tibolone administration on central and peripheral levels of allopregnanolone and beta-endorphin in female rats
    Andrea R Genazzani
    Department of Reproductive Medicine and Child Development, Division of Gynecology and Obstetrics, University of Pisa, Italy
    Menopause 13:57-64. 2006
  4. ncbi request reprint Endocrinology of menopausal transition and its brain implications
    Andrea Riccardo Genazzani
    Department of Reproductive Medicine and Child Development, Division of Gynecology and Obstetrics, University of Pisa, Pisa, Italy
    CNS Spectr 10:449-57. 2005
  5. ncbi request reprint Estrogen, cognition and female ageing
    Andrea Riccardo Genazzani
    Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Pisa, Italy
    Hum Reprod Update 13:175-87. 2007
  6. ncbi request reprint Long-term low-dose oral administration of dehydroepiandrosterone modulates adrenal response to adrenocorticotropic hormone in early and late postmenopausal women
    Andrea R Genazzani
    Department of Reproductive Medicine and Child Development, Division of Gynecology and Obstetrics, University of Pisa, Pisa, Italy
    Gynecol Endocrinol 22:627-35. 2006
  7. ncbi request reprint Androgens and the brain
    Andrea R Genazzani
    Department of Reproductive Medicine and Child Development, Section of Gynecology and Obstetrics, University of Pisa, Pisa, Italy
    Maturitas 57:27-30. 2007
  8. ncbi request reprint Conjugated equine estrogens reverse the effects of aging on central and peripheral allopregnanolone and beta-endorphin levels in female rats
    Andrea R Genazzani
    Department of Reproductive Medicine and Child Development, P Fioretti Division of Obstetrics and Gynecology, University of Pisa, Via Roma 35, 56100 Pisa, Italy
    Fertil Steril 81:757-66. 2004
  9. ncbi request reprint "Controversial issues in climacteric medicine" series 3rd Pisa workshop "HRT in climacteric and aging brain". Pisa, Italy, 15-18 March 2003
    Andrea R Genazzani
    Department of Reproductive Medicine and Child Development, University of Pisa, Italy
    Maturitas 46:7-26. 2003
  10. ncbi request reprint Tibolone, transdermal estradiol or oral estrogen-progestin therapies: effects on circulating allopregnanolone, cortisol and dehydroepiandrosterone levels
    N Pluchino
    Division of Obstetrics and Gynecology, University of Pisa, Italy
    Gynecol Endocrinol 20:144-9. 2005

Detail Information

Publications173 found, 100 shown here

  1. ncbi request reprint Long-term low-dose dehydroepiandrosterone replacement therapy in aging males with partial androgen deficiency
    A R Genazzani
    Department of Reproductive Medicine and Child Development, Division of Gynecology and Obstetrics, University of Pisa, Pisa, Italy
    Aging Male 7:133-43. 2004
    ..Restoring DHEA levels to young adult values seems to benefit the age-related decline in physiological functions but, however promising, placebo-controlled trials are required to confirm these preliminary results...
  2. ncbi request reprint Drospirenone increases central and peripheral beta-endorphin in ovariectomized female rats
    Andrea Riccardo Genazzani
    Department of Reproductive Medicine and Child Development, Division of Gynecology and Obstetrics, University of Pisa, Pisa, Italy
    Menopause 14:63-73. 2007
    ....
  3. ncbi request reprint Effect of tibolone administration on central and peripheral levels of allopregnanolone and beta-endorphin in female rats
    Andrea R Genazzani
    Department of Reproductive Medicine and Child Development, Division of Gynecology and Obstetrics, University of Pisa, Italy
    Menopause 13:57-64. 2006
    ....
  4. ncbi request reprint Endocrinology of menopausal transition and its brain implications
    Andrea Riccardo Genazzani
    Department of Reproductive Medicine and Child Development, Division of Gynecology and Obstetrics, University of Pisa, Pisa, Italy
    CNS Spectr 10:449-57. 2005
    ..These findings open new perspectives in the study of the effects of sex steroids on the central nervous system and on the possible use of alternative and/or auxiliary HRT...
  5. ncbi request reprint Estrogen, cognition and female ageing
    Andrea Riccardo Genazzani
    Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Pisa, Italy
    Hum Reprod Update 13:175-87. 2007
    ..A critical update of HRT use in women and a discussion of possible prospectives for steroid use are subsequently proposed...
  6. ncbi request reprint Long-term low-dose oral administration of dehydroepiandrosterone modulates adrenal response to adrenocorticotropic hormone in early and late postmenopausal women
    Andrea R Genazzani
    Department of Reproductive Medicine and Child Development, Division of Gynecology and Obstetrics, University of Pisa, Pisa, Italy
    Gynecol Endocrinol 22:627-35. 2006
    ..The present study aimed to evaluate the effects of a long-term (12 months) oral DHEA administration (25 mg/day) on adrenal function, before and after 3, 6 and 12 months of treatment...
  7. ncbi request reprint Androgens and the brain
    Andrea R Genazzani
    Department of Reproductive Medicine and Child Development, Section of Gynecology and Obstetrics, University of Pisa, Pisa, Italy
    Maturitas 57:27-30. 2007
    ..The present short review will focus on the neuroactive effect of androgen with particular regard to the Delta4 and Delta5 androgen replacement therapy...
  8. ncbi request reprint Conjugated equine estrogens reverse the effects of aging on central and peripheral allopregnanolone and beta-endorphin levels in female rats
    Andrea R Genazzani
    Department of Reproductive Medicine and Child Development, P Fioretti Division of Obstetrics and Gynecology, University of Pisa, Via Roma 35, 56100 Pisa, Italy
    Fertil Steril 81:757-66. 2004
    ..To compare beta-endorphin and allopregnanolone levels and their response to a 2-week oral estrogen treatment with conjugated equine estrogens (CEE) in young ovariectomized (ovx) and in healthy aged female rats...
  9. ncbi request reprint "Controversial issues in climacteric medicine" series 3rd Pisa workshop "HRT in climacteric and aging brain". Pisa, Italy, 15-18 March 2003
    Andrea R Genazzani
    Department of Reproductive Medicine and Child Development, University of Pisa, Italy
    Maturitas 46:7-26. 2003
  10. ncbi request reprint Tibolone, transdermal estradiol or oral estrogen-progestin therapies: effects on circulating allopregnanolone, cortisol and dehydroepiandrosterone levels
    N Pluchino
    Division of Obstetrics and Gynecology, University of Pisa, Italy
    Gynecol Endocrinol 20:144-9. 2005
    ..Unlike estrogen-based therapy, tibolone treatment did not reduce the DHEA milieu in the menopause, and thus did not enhance the androgen deficiency syndrome in postmenopausal women...
  11. ncbi request reprint Neuroendocrine effects of different estradiol-progestin regimens in postmenopausal women
    M Stomati
    Department of Obstetrics and Gynecology, University of Pisa, Italy
    Maturitas 28:127-35. 1997
    ..Vasomotor and behavioral effects were evaluated by using the Kupperman score, while changes in plasma endorphin (beta-END) levels were used as marker of neuroendocrine effects...
  12. ncbi request reprint Adrenal response to adrenocorticotropic hormone stimulation in patients with premenstrual syndrome
    I Lombardi
    Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Pisa, Italy
    Gynecol Endocrinol 18:79-87. 2004
    ..Considering the specific actions of these hormones on the control of mood and behavior, this specific hormonal milieu may contribute to the cyclic occurrence of anxiety, aggressiveness and irritability reported by PMS patients...
  13. doi request reprint Advances in neurosteroids: role in clinical practice
    N Pluchino
    Division of Obstetrics and Gynecology, University of Pisa, Italy
    Climacteric 16:8-17. 2013
    ..The brain metabolism of synthetic progestins and the implications of DHEA treatment in postmenopausal women will also be discussed...
  14. doi request reprint Effect of 1-year, low-dose DHEA therapy on climacteric symptoms and female sexuality
    A R Genazzani
    Department of Reproductive Medicine and Child Development, Division of Gynecology and Obstetrics, University of Pisa
    Climacteric 14:661-8. 2011
    ..Sexual desire is affected by endocrine and psychosocial factors. Menopausal hormonal changes are relevant to the causes of sexual dysfunction during reproductive aging...
  15. doi request reprint Central modifications of allopregnanolone and beta-endorphin following subcutaneous administration of Nestorone
    E Lenzi
    Department of Reproductive Medicine and Child Development, Division of Gynaecology and Obstetrics, University of Pisa, Via Roma 35, 56100 Pisa, Italy
    J Steroid Biochem Mol Biol 116:15-20. 2009
    ..This suggests that Nestorone at the antiovulatory dose levels may not alter the positive effects of estrogen treatment on mood and behaviour...
  16. doi request reprint Clinical and metabolic effects of drospirenone-estradiol in menopausal women: a prospective study
    M Gambacciani
    Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology Piero Fioretti, Pisa University Hospital, University of Pisa, Via Roma 67, Pisa, Italy
    Climacteric 14:18-24. 2011
    ..To describe the effects of low-dose hormonal replacement therapy (HRT) on quality of life, metabolic parameters and blood pressure in postmenopausal women...
  17. doi request reprint Evaluation of brain-derived neurotrophic factor in menstrual blood and its identification in human endometrium
    N Russo
    Department of Reproductive Medicine and Child Development, Division of Gynecology and Obstetrics, University of Pisa, Pisa, Italy
    Gynecol Endocrinol 28:492-5. 2012
    ..The detection of BDNF in the human menstrual blood and endometrium further supports the role of this neurotrophin in female reproductive function...
  18. doi request reprint Daily variation of brain-derived neurotrophic factor and cortisol in women with normal menstrual cycles, undergoing oral contraception and in postmenopause
    N Pluchino
    Department of Reproductive Medicine and Child Development, Division of Gynecology and Obstetrics, University of Pisa, Via Roma 35, 56100 Pisa, Italy
    Hum Reprod 24:2303-9. 2009
    ..We aimed to investigate whether BDNF circadian rhythms exist in women and if there is a relationship with cortisol circadian rhythmicity. Moreover, we aimed to establish whether the hormonal status influences BDNF diurnal variations...
  19. doi request reprint Differential actions of estrogen and SERMs in regulation of the actin cytoskeleton of endometrial cells
    M I Flamini
    Molecular and Cellular Gynecological Endocrinology Laboratory, Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Via Roma, 57, 56100 Pisa, Italy
    Mol Hum Reprod 15:675-85. 2009
    ....
  20. ncbi request reprint Longitudinal evaluation of perimenopausal femoral bone loss: effects of a low-dose oral contraceptive preparation on bone mineral density and metabolism
    M Gambacciani
    Department of Obstetrics and Gynecology, University of Pisa, Italy
    Osteoporos Int 11:544-8. 2000
    ..05) increase in femoral bone density. It is concluded that perimenopausal OC administration can avoid the increase in bone turnover and the decrease in femoral bone density due to the perimenopausal impairment of ovarian function...
  21. ncbi request reprint p53 status is neither a predictive nor a prognostic variable in patients with advanced ovarian cancer treated with a paclitaxel-based regimen
    A Gadducci
    Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Via Roma 56, Pisa, 56127, Italy
    Anticancer Res 20:4793-9. 2000
    ..The aim of this study was to assess the relationship between p53 status and the clinical outcome of patients with advanced ovarian cancer treated with a paclitaxel-based regimen...
  22. ncbi request reprint Surgical cytoreduction during second-look laparotomy in patients with advanced ovarian cancer
    A Gadducci
    Department of Procreative Medicine, University of Pisa, Italy
    Anticancer Res 20:1959-64. 2000
    ..The impact of surgical cytoreduction performed during second-look on the survival of patients with advanced ovarian cancer is still under debate...
  23. doi request reprint A review of the cardiovascular and breast actions of drospirenone in preclinical studies
    T Simoncini
    Molecular and Cellular Gynecological Endocrinology Laboratory, Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Pisa, Italy
    Climacteric 13:22-33. 2010
    ..This literature-based review explores differences in the preclinical and clinical profiles of the progestins used in hormone therapy, focusing on their effects on the cardiovascular system and breast...
  24. doi request reprint Progestogens and brain: an update
    N Pluchino
    Department of Reproductive Medicine and Child Development, Division of Gynaecology and Obstetrics, University of Pisa, Via Roma 35, Pisa, Italy
    Maturitas 62:349-55. 2009
    ..The aim of the present paper is to briefly review and compare neuroendocrine effects of progestogens with special reference to P metabolism into neuroactive steroids and the opioids system...
  25. ncbi request reprint An intensive follow-up does not change survival of patients with clinical stage I endometrial cancer
    A Gadducci
    Department of Procreative Medicine, University of Pisa, Italy
    Anticancer Res 20:1977-84. 2000
    ..The clinical benefit of an intensive follow-up protocol in endometrial cancer patients is still uncertain...
  26. ncbi request reprint Prospective evaluation of body weight and body fat distribution in early postmenopausal women with and without hormonal replacement therapy
    M Gambacciani
    Department of Obstetrics and Gynecology Piero Fioretti, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    Maturitas 39:125-32. 2001
    ....
  27. ncbi request reprint Effects of low-dose continuous combined conjugated estrogens and medroxyprogesterone acetate on menopausal symptoms, body weight, bone density, and metabolism in postmenopausal women
    M Gambacciani
    Department of Obstetrics and Gynecology, University of Pisa, Italy
    Am J Obstet Gynecol 185:1180-5. 2001
    ....
  28. ncbi request reprint Adrenal function under long-term raloxifene administration
    A R Genazzani
    Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Pisa, Italy
    Gynecol Endocrinol 17:159-68. 2003
    ....
  29. ncbi request reprint Nongenomic mechanisms of endothelial nitric oxide synthase activation by the selective estrogen receptor modulator raloxifene
    Tommaso Simoncini
    Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Italy
    Circulation 105:1368-73. 2002
    ..The selective estrogen receptor modulator (SERM) raloxifene is effective for the treatment of postmenopausal osteoporosis, but its ability to activate eNOS via PI3K is unknown...
  30. pmc Brain derived neurotrophic factor circulating levels in patients undergoing IVF
    P Monteleone
    Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Via Roma 67, 56126 Pisa, Italy
    J Assist Reprod Genet 24:477-80. 2007
    ....
  31. ncbi request reprint Effect of different hormonal replacement therapies on circulating allopregnanolone and dehydroepiandrosterone levels in postmenopausal women
    F Bernardi
    Department of Reproductive Medicine and Child Development, University of Pisa, Pisa, Italy
    Gynecol Endocrinol 17:65-77. 2003
    ..In conclusion, HRT strongly modifies circulating neurosteroid levels in postmenopausal women...
  32. ncbi request reprint Effects of combined low dose of the isoflavone derivative ipriflavone and estrogen replacement on bone mineral density and metabolism in postmenopausal women
    M Gambacciani
    Department of Obstetrics and Gynecology, University of Pisa, Italy
    Maturitas 28:75-81. 1997
    ..To assess the pattern of biochemical markers of bone metabolism and vertebral bone mineral density in early postmenopausal women treated with combined ipriflavone and low dose conjugated estrogens...
  33. ncbi request reprint Disadaptive disorders in women: allopregnanolone, a sensitive steroid
    F Bernardi
    Department of Reproductive Medicine and Child Development, Division of Gynecology and Obstetrics, University of Pisa, Pisa, Italy
    Gynecol Endocrinol 19:344-53. 2004
    ....
  34. doi request reprint Progestogens regulate endothelial actin cytoskeleton and cell movement via the actin-binding protein moesin
    Xiao Dong Fu
    Molecular and Cellular Gynecological Endocrinology Laboratory, Department of Reproductive Medicine and Child Development, University of Pisa, Pisa 56100, Italy
    Mol Hum Reprod 14:225-34. 2008
    ..These findings provide new information on the biological actions of progestins on human endothelial cells that are relevant for vascular function...
  35. ncbi request reprint Conjugated equine estrogens, estrone sulphate and estradiol valerate oral administration in ovariectomized rats: effects on central and peripheral allopregnanolone and beta-endorphin
    Massimo Stomati
    Department of Reproductive Medicine and Child Development, Division of Gynecology and Obstetrics P Fioretti, University of Pisa, Via Roma 35, 56100, Pisa, Italy
    Maturitas 43:195-206. 2002
    ....
  36. doi request reprint Endothelial regulation of eNOS, PAI-1 and t-PA by testosterone and dihydrotestosterone in vitro and in vivo
    L Goglia
    Department of Reproductive Medicine and Child Development, Molecular and Cellular Gynecological Endocrinology Laboratory MCGEL, University of Pisa, Pisa, Italy
    Mol Hum Reprod 16:761-9. 2010
    ..Physiological, but not higher amounts are associated with enhanced NO synthesis and an increased t-PA/PAI-1 ratio. These findings are useful to understand the impact of androgens in ageing individuals...
  37. ncbi request reprint Androgen replacement therapy and cardiovascular function
    A R Genazzani
    Department of Reproductive Medicine and Child Development, Section of Gynecology and Obstetrics, University of Pisa, Pisa, Italy
    Climacteric 12:102-7. 2009
    ..The present short review examines the effect of androgen on the cardiovascular system, with particular regard to dehydroepiandrosterone and testosterone replacement in postmenopausal women...
  38. ncbi request reprint CNS: sex steroids and SERMs
    F Bernardi
    Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology P Fioretti, University of Pisa, Via Roma 35, 56100 Pisa, Italy
    Ann N Y Acad Sci 997:378-88. 2003
    ..The effects of raloxifene on mood and cognition encourage the efforts in the research of an ideal estrogen replacement therapy, showing all the positive effects of estrogens and fewer side effects...
  39. ncbi request reprint Progesterone and progestins: effects on brain, allopregnanolone and beta-endorphin
    N Pluchino
    Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynaecology, University of Pisa, Pisa, Italy
    J Steroid Biochem Mol Biol 102:205-13. 2006
    ..This may have far-reaching implications for the clinical effects and related indications of each compound...
  40. ncbi request reprint Postmenopausal osteoporosis: therapeutic options
    A R Genazzani
    Department of Gynecology and Obstetrics, University of Pisa, Italy
    Climacteric 8:99-109. 2005
  41. doi request reprint Polycystic ovary syndrome: brain-derived neurotrophic factor (BDNF) plasma and follicular fluid levels
    N Russo
    Department of Reproductive Medicine and Child Development, Division of Gynaecology and Obstetrics, University of Pisa, Pisa, Italy
    Gynecol Endocrinol 28:241-4. 2012
    ..Therefore we can hypothsize that high levels of luteinizing hormone, probably increase the secretion of BDNF in PCOS patients...
  42. ncbi request reprint The clinical relevance of serum CYFRA 21-1 assay in patients with ovarian cancer
    A Gadducci
    Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Pisa, Italy
    Int J Gynecol Cancer 11:277-82. 2001
    ..Moreover, the serial measurement of CYFRA 21-1 levels might have a potential clinical relevance for the assessment of disease status in patients followed after surgery and chemotherapy...
  43. ncbi request reprint Correlation of recurrence rates and times with posttreatment human papillomavirus status in patients treated with loop electrosurgical excision procedure conization for cervical squamous intraepithelial lesions
    B Prato
    Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Pisa, Italy
    Int J Gynecol Cancer 18:90-4. 2008
    ..The combined evaluation of surgical margin status and posttreatment HPV testing could allow to subdivide patients treated with LEEP into categories at different risk of recurrence, requiring new tailored surveillance procedures...
  44. ncbi request reprint Malnutrition and cachexia in ovarian cancer patients: pathophysiology and management
    A Gadducci
    Department of Procreative Medicine, University of Pisa, Italy
    Anticancer Res 21:2941-7. 2001
    ..Krebs' and Goplerud's score (based on age, nutritional status, tumor status, ascites, previous chemotherapy and irradiation) seems to offer reliable eligibility criteria for those patients who can benefit from surgery...
  45. ncbi request reprint Hormone replacement therapy: the benefits in tailoring the regimen and dose
    M Gambacciani
    Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology Piero Fioretti, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    Maturitas 40:195-201. 2001
    ..Low dose regimens should be considered as a starting dose to minimize the occurrence of side effects, improving compliance and, therefore, HRT effects on the prevention of long-term consequences of estrogen deprivation...
  46. pmc Evaluation of FHIT gene alterations in ovarian cancer
    F Buttitta
    Department of Oncology, University of Pisa, Italy
    Br J Cancer 77:1048-51. 1998
    ..In none of these cases was the FHITgene found to be altered. Our results indicate that FHITplays a role in a small proportion of ovarian carcinomas...
  47. ncbi request reprint Vascular endothelial growth factor and interleukin-8 in ovarian cystic pathology
    A Fasciani
    Department of Reproductive Medicine and Child Development, Division of Gynaecology and Obstetrics, University of Pisa, Pisa, Italy
    Fertil Steril 75:1218-21. 2001
    ..To determine the levels of the angiogenic factors vascular endothelial growth factor (VEGF) and interleukin (IL-8) in ovarian cysts...
  48. pmc Extra-nuclear signaling of progesterone receptor to breast cancer cell movement and invasion through the actin cytoskeleton
    Xiao Dong Fu
    Molecular and Cellular Gynecological Endocrinology Laboratory, Department of Reproductive Medicine and Child Development, University of Pisa, Pisa, Italy
    PLoS ONE 3:e2790. 2008
    ..These results provide original mechanistic explanations for the effects of progestins on breast cancer progression and highlight potential targets to treat endocrine-sensitive breast cancers...
  49. doi request reprint One-year therapy with 10mg/day DHEA alone or in combination with HRT in postmenopausal women: effects on hormonal milieu
    Nicola Pluchino
    Department of Reproductive Medicine and Child Development, Division of Gynecology and Obstetrics, University of Pisa, Pisa, Italy
    Maturitas 59:293-303. 2008
    ..However, the aging process and the number of years since menopause may further modulate the effects of hormone therapy on hormonal milieu...
  50. ncbi request reprint Drospirenone increases endothelial nitric oxide synthesis via a combined action on progesterone and mineralocorticoid receptors
    T Simoncini
    Molecular and Cellular Gynecological Endocrinology Laboratory MCGEL, Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Via Roma 57, Pisa 56100, Italy
    Hum Reprod 22:2325-34. 2007
    ..Drospirenone (DRSP) is a progestin that uniquely interferes with the signaling of the mineralocorticoid receptor (MR). Hormone therapy containing DRSP results in blood pressure reduction in hypertensive post-menopausal women...
  51. ncbi request reprint Hormone replacement therapy in climacteric and aging brain. International Menopause Society Expert Workshop, 15-18 March 2003, Pisa, Italy
    A R Genazzani
    Department of Gynecology and Obstetrics, University of Pisa, Via Roma 35, 56126 Italy
    Climacteric 6:188-203. 2003
  52. ncbi request reprint A longitudinal evaluation of the effect of two doses of tibolone on bone density and metabolism in early postmenopausal women
    M Gambacciani
    Department of Obstetrics and Gynecology Piero Fioretti, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    Gynecol Endocrinol 18:9-16. 2004
    ..It is concluded that tibolone is effective, even at lower doses, in relieving climacteric symptoms and preventing a decrease in spine and femur BMD in early postmenopausal women...
  53. doi request reprint DHEA therapy in postmenopausal women: the need to move forward beyond the lack of evidence
    A R Genazzani
    Department of Reproductive Medicine and Child Development, Division of Gynecology and Obstetrics, University of Pisa, Pisa, Italy
    Climacteric 13:314-6. 2010
    ....
  54. ncbi request reprint Controversial issues in climacteric medicine II. Hormone replacement therapy and cancer. International Menopause Society Expert Workshop. 9-12 June 2001, Opera del Duomo, Pisa, Italy
    A R Genazzani
    Department of Gynecology and Obstetrics, University of Pisa, Via Roma 35, 56126 Italy
    Climacteric 4:181-93. 2001
    ..This issue is considered as an important area for future evaluation and research. The International Menopause Society is in the process of drawing up specific recommendations for further research in the field of HRT and cancer...
  55. ncbi request reprint Menopause and aging, quality of life and sexuality
    A R Genazzani
    Department of Reproductive Medicine and Child Development, University of Pisa, Pisa, Italy
    Climacteric 10:88-96. 2007
  56. ncbi request reprint Analysis of the pattern of hypersensitivity reactions in patients receiving carboplatin retreatment for recurrent ovarian cancer
    A Gadducci
    Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Pisa, Italy
    Int J Gynecol Cancer 18:615-20. 2008
    ....
  57. ncbi request reprint Selective estrogen receptor modulators: different actions on vascular cell adhesion molecule-1 (VCAM-1) expression in human endothelial cells
    T Simoncini
    Department of Reproductive Medicine and Child Development, University of Pisa, Italy
    J Clin Endocrinol Metab 84:815-8. 1999
    ..Therefore, only some SERMs have potential anti-atherogenic actions exerted directly at the vascular level through the regulation of endothelial cell adhesion molecules expression and of endothelial-leukocyte interactions...
  58. doi request reprint One-year randomized study of the endometrial safety and bleeding pattern of 0.25 mg drospirenone/0.5 mg 17β-estradiol in postmenopausal women
    A R Genazzani
    Department of Obstetrics and Gynecology, University of Pisa, Pisa, Italy
    Climacteric 16:490-8. 2013
    ..To investigate the long-term endometrial safety and bleeding pattern of the 0.25 mg drospirenone/0.5 mg 17β-estradiol (DRSP/E2) dose combination compared with 0.5 mg norethisterone acetate (NETA)/1.0 mg E2, in postmenopausal women...
  59. doi request reprint Steroid hormones and BDNF
    N Pluchino
    Division of Obstetrics and Gynecology, University of Pisa, Pisa, Italy
    Neuroscience 239:271-9. 2013
    ....
  60. ncbi request reprint Sex-steroid hormones, gonadotropin and ovarian carcinogenesis: a review of epidemiological and experimental data
    A Gadducci
    Department of Procreative Medicine and Child Development, Division of Gynecology and Obstetrics, University of Pisa, Italy
    Gynecol Endocrinol 19:216-28. 2004
  61. ncbi request reprint The relative contributions of menopause and aging to postmenopausal reduction in intervertebral disk height
    M Gambacciani
    Department of Obstetrics and Gynecology, University of Pisa, Pisa, Italy
    Climacteric 10:298-305. 2007
    ....
  62. ncbi request reprint Hormone replacement therapy and endometrial, ovarian and colorectal cancer
    M Gambacciani
    Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, Via Roma 35, Pisa, Italy
    Best Pract Res Clin Endocrinol Metab 17:139-47. 2003
    ..The future of HRT in post-menopausal women lies in the individualization of the therapy based upon personal risk factors and characteristics...
  63. pmc p53 alterations are predictive of chemoresistance and aggressiveness in ovarian carcinomas: a molecular and immunohistochemical study
    F Buttitta
    Institute of Pathology, University of Pisa, Italy
    Br J Cancer 75:230-5. 1997
    ..Thus, a routine analysis of this gene could have profound implications for the treatment of ovarian cancer...
  64. ncbi request reprint Raloxifene acutely stimulates nitric oxide release from human endothelial cells via an activation of endothelial nitric oxide synthase
    T Simoncini
    Department of Reproductive Medicine and Child Development, University of Pisa, Italy
    J Clin Endocrinol Metab 85:2966-9. 2000
    ..In conclusion, raloxifene activates eNOS in human endothelial cells, exerting a potentially important direct vasculo-protective effect stimulating endothelial NO production...
  65. ncbi request reprint Is pretreatment hemoglobin level a predictor of complete response to salvage chemotherapy for recurrent platinum-pretreated ovarian carcinoma?
    A Gadducci
    Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Pisa, Italy
    Eur J Gynaecol Oncol 24:405-10. 2003
    ....
  66. ncbi request reprint Effects of low-dose, continuous combined hormone replacement therapy on sleep in symptomatic postmenopausal women
    Marco Gambacciani
    Department of Obstetrics and Gynecology, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    Maturitas 50:91-7. 2005
    ..Low-dose estrogen associated with low-dose micronized progesterone may especially benefit women who complain of disturbed sleep...
  67. ncbi request reprint Efficacy of a topical cosmetic slimming treatment for postmenopausal women: a randomized, double-blind, placebo controlled trial
    N Pluchino
    Division of Gynecology and Obstetrics, Department of Reproductive Medicine and Child Development, University of Pisa, Pisa, Italy
    Minerva Ginecol 65:79-88. 2013
    ....
  68. ncbi request reprint Neoadjuvant chemotherapy and concurrent chemoradiation in the treatment of advanced cervical cancer
    A Gadducci
    Department of Procreative Medicine, University of Pisa, Italy
    Anticancer Res 21:3525-33. 2001
    ..A multicenter randomized trial comparing chemo-surgical treatment with concurrent chemoradiation is warranted to better define the optimum therapeutic strategy for patients with advanced cervical cancer...
  69. ncbi request reprint The HRT misuse and osteoporosis epidemic: a possible future scenario
    M Gambacciani
    Department of Obstetrics and Gynecology, University of Pisa, Pisa, Italy
    Climacteric 10:273-5. 2007
    ....
  70. ncbi request reprint Treatment options in patients with recurrent ovarian cancer
    A Gadducci
    Department of Procreative Medicine, Pisa, Italy
    Anticancer Res 21:3557-64. 2001
    ..Secondary surgical cytoreduction may have a role in highly selected patients with good performance status, with long disease-free interval and without extra-abdominal or liver metastases...
  71. ncbi request reprint Pregnant patient with dermatomyositis successfully treated with intravenous immunoglobulin therapy
    M Mosca
    University of Pisa, Pisa, Italy
    Arthritis Rheum 53:119-21. 2005
  72. ncbi request reprint Vascular endothelial growth factor and its soluble receptor in ovarian pathology
    P G Artini
    Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, S Chiara Hospital, University of Pisa, Pisa, Italy
    Gynecol Endocrinol 21:50-6. 2005
    ..The soluble form of the vascular endothelial growth factor (VEGF) receptor, s-VEGFR-1, may negatively regulate the action of VEGF. Our purpose was to better understand the regulation of angiogenetic processes in ovarian cysts...
  73. ncbi request reprint Vascular endothelial growth factor, interleukin-6 and interleukin-2 in serum and follicular fluid of patients with ovarian hyperstimulation syndrome
    P G Artini
    Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Via Roma 35, 56100, Pisa, Italy
    Eur J Obstet Gynecol Reprod Biol 101:169-74. 2002
    ..The pathogenesis of ovarian hyperstimulation syndrome (OHSS) is not completely understood...
  74. ncbi request reprint Second trimester sonography and fetal spina bifida screening
    F A L Strigini
    Division of Obstetrics and Gynecology, University of Pisa, Pisa, Italy
    Int J Gynaecol Obstet 81:59-60. 2003
  75. doi request reprint Office vaginoscopic hysteroscopy in infertile women: effects of gynecologist experience, instrument size, and distention medium on patient discomfort
    Nicola Pluchino
    Department of Reproductive Medicine and Child Development, Division of Gynecology and Obstetrics, University of Pisa, Via Roma 35, 56100 Pisa, Italy
    J Minim Invasive Gynecol 17:344-50. 2010
    ..To assess the roles of instrument diameter (5.0- or 3.5-mm external sheath), uterine distention medium (carbon dioxide [CO(2)] or saline solution), and hysteroscopist experience in diagnostic hysteroscopy...
  76. ncbi request reprint Increased HLA-DR homozygosity associated with pre-eclampsia
    I de Luca Brunori
    Department of Reproductive Medicine and Child Development, Stella Maris Foundation and Institute of Immunohematology, University of Pisa, S Chiara Hospital, Italy
    Hum Reprod 15:1807-12. 2000
    ..014). From our results, it emerges that HLA-DR homozygosity and reduced antigenic disparity seem to be associated to a major risk for pre-eclampsia, which consequently appears to be a 'couple's disease'...
  77. ncbi request reprint Changes in vascular endothelial growth factor levels and the risk of ovarian hyperstimulation syndrome in women enrolled in an in vitro fertilization program
    P G Artini
    Department of Reproductive Medicine and Child Development, University of Pisa, Italy
    Fertil Steril 70:560-4. 1998
    ....
  78. ncbi request reprint HLA-DR in couples associated with preeclampsia: background and updating by DNA sequencing
    Irma de Luca Brunori
    Department of Obstetrics and Gynecology, University of Pisa, Pisa, Italy
    J Reprod Immunol 59:235-43. 2003
    ..From our results, it emerges that HLA-DR homozygosity and the reduced antigenic variety seem to be associated to a major risk for preeclampsia, which further appears to be a "couple's disease"...
  79. doi request reprint Effects of phytoestrogens derived from red clover on atherogenic adhesion molecules in human endothelial cells
    Tommaso Simoncini
    Molecular and Cellular Gynecological Endocrinology Laboratory, Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Pisa, Italy
    Menopause 15:542-50. 2008
    ..Recent evidence suggests that these compounds may act neutrally or even beneficially on surrogate cardiovascular risk markers in postmenopausal women. However, little is known of the effects of phytoestrogens on vascular cells...
  80. ncbi request reprint Differential signal transduction of progesterone and medroxyprogesterone acetate in human endothelial cells
    Tommaso Simoncini
    Molecular and Cellular Gynecological Endocrinology Laboratory, Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Pisa 56100, Italy
    Endocrinology 145:5745-56. 2004
    ..Our findings show significant differences in the signal transduction pathways recruited by P and MPA in endothelial cells, which may have relevant clinical implications...
  81. ncbi request reprint Genomic and nongenomic mechanisms of nitric oxide synthesis induction in human endothelial cells by a fourth-generation selective estrogen receptor modulator
    Tommaso Simoncini
    Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, 56100 Pisa, Italy
    Endocrinology 143:2052-61. 2002
    ..The present data show that EM-652 (acolbifene) has estrogen-like activity on the vascular wall, directly increasing NO production through genomic and nongenomic mechanisms in vitro and in vivo...
  82. doi request reprint Progesterone receptor enhances breast cancer cell motility and invasion via extranuclear activation of focal adhesion kinase
    Xiao Dong Fu
    Department of Reproductive Medicine and Child Development, University of Pisa, Italy
    Endocr Relat Cancer 17:431-43. 2010
    ..These results provide novel mechanistic views on the effects of progesterone on breast cancer progression, and may in the future be helpful to develop new strategies for the treatment of endocrine-sensitive breast cancers...
  83. ncbi request reprint P53 gene status in patients with advanced serous epithelial ovarian cancer in relation to response to paclitaxel- plus platinum-based chemotherapy and long-term clinical outcome
    Angiolo Gadducci
    Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Italy
    Anticancer Res 26:687-93. 2006
    ....
  84. ncbi request reprint Comparative effects of dydrogesterone and medroxyprogesterone acetate in critical areas: the brain and the vessels
    Tommaso Simoncini
    Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Pisa, Italy
    Gynecol Endocrinol 23:9-16. 2007
    ..The aim of the present paper is to review the comparative effects of dydrogesterone and other progestins at these sites, supporting the idea that the progestin has to be clinically selected...
  85. ncbi request reprint Effect of oral contraceptives on endothelial function in the peripheral microcirculation of healthy women
    Agostino Virdis
    Department of Internal Medicine, University of Pisa, Italy
    J Hypertens 21:2275-80. 2003
    ..We assessed whether third-generation oral contraceptive (OC) treatment (30 microg ethinylestradiol + 75 microg gestodene daily) could affect the endothelial function of healthy women...
  86. ncbi request reprint Estrogen receptor alpha interacts with Galpha13 to drive actin remodeling and endothelial cell migration via the RhoA/Rho kinase/moesin pathway
    Tommaso Simoncini
    Molecular and Cellular Gynecological Endocrinology Laboratory, Department of Reproductive Medicine and Child Development, University of Pisa, Italy
    Mol Endocrinol 20:1756-71. 2006
    ..Furthermore, exposure of this estrogen receptor-dependent, nongenomic action of estrogen on human vascular endothelial cells is especially relevant to the present interest in the role of estrogen in cardiovascular protection...
  87. ncbi request reprint Membrane integrity evaluation in rabbit spermatozoa
    Michele Ducci
    Dipartimento di Anatomia, Biochimica e Fisiologia Veterinaria, Universita di Pisa, Viale delle Piagge 2, 56124 Pisa, Italy
    Eur J Obstet Gynecol Reprod Biol 102:53-6. 2002
    ..The behaviour of head and tail sperm membrane subjected to different vitality tests was evaluated, searching for possible correlations with sperm motility...
  88. ncbi request reprint Hormonal influence on the central nervous system
    Andrea R Genazzani
    Department of Obstetrics and Gynecology, University of Pisa Via Roma 35, 56100 Pisa, Italy
    Maturitas 43:S11-7. 2002
    ..Further studies are required in order to explain the specific role of endogenous and exogenous sex steroids on the CNS...
  89. ncbi request reprint Dehydroepiandrosterone, the endothelium, and cardiovascular protection
    Tommaso Simoncini
    Molecular and Cellular Gynecological Endocrinology Laboratory MCGEL, Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Via Roma, 57, 56100 Pisa, Italy
    Endocrinology 148:3065-7. 2007
  90. ncbi request reprint A randomized control comparison study of culture media (HTF versus P1) for human in vitro fertilization
    Paolo G Artini
    Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Via Roma 35, 56100 Pisa, Italy
    Eur J Obstet Gynecol Reprod Biol 116:196-200. 2004
    ..For this reason, different studies have focused on single embryo transfer, more precisely blastocyst transfer. The aim of the study is to confirm that phosphate-free culture media can be used to generate greater quality embryos...
  91. ncbi request reprint Tibolone activates nitric oxide synthesis in human endothelial cells
    Tommaso Simoncini
    Molecular and Cellular Gynecological Endocrinology Laboratory, Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Via Roma, 57, 56100 Pisa, Italy
    J Clin Endocrinol Metab 89:4594-600. 2004
    ..These results help to understand the mechanisms of action of tibolone on the cardiovascular system and have relevant clinical implications...
  92. ncbi request reprint Activation of nitric oxide synthesis in human endothelial cells by red clover extracts
    Tommaso Simoncini
    Molecular and Cellular Gynecological Endocrinology Laboratory MCGEL, Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Via Roma, 57, 56100, Pisa, Italy
    Menopause 12:69-77. 2005
    ..This is particularly important for estrogen-like compounds such as phytoestrogens, whose mechanisms of action may significantly differ from those of other estrogenic compounds...
  93. ncbi request reprint Non-genomic actions of sex steroid hormones
    Tommaso Simoncini
    Molecular and Cellular Gynecological Endocrinology Laboratory, Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Via Roma 67, Italy
    Eur J Endocrinol 148:281-92. 2003
    ..The understanding of the molecular basis of the rapid effects of steroids is therefore important, and may in the future turn out to be of relevance for clinical purposes...
  94. ncbi request reprint Dehydroepiandrosterone modulates endothelial nitric oxide synthesis via direct genomic and nongenomic mechanisms
    Tommaso Simoncini
    Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Pisa 56100, Italy
    Endocrinology 144:3449-55. 2003
    ..Our present data suggest that DHEA may have direct genomic and nongenomic effects on the vascular wall that are not mediated by other steroid hormone receptors, leading to eNOS activation and induction...
  95. ncbi request reprint [Cardiovascular effects of selective estrogen receptor modulators. Current perspectives]
    Tommaso Simoncini
    Laboratorio di Endocrinologia Ginecologica Cellulare e Molecolare, Divisione di Ostetricia e Ginecologia, Dipartimento di Medicina della Riproduzione e dell Età Evolutiva, Universita di Pisa
    Recenti Prog Med 94:51-6. 2003
    ....
  96. ncbi request reprint Differential estrogen signaling in endothelial cells upon pulsed or continuous administration
    Tommaso Simoncini
    Molecular and Cellular Gynecological Endocrinology Laboratory MCGEL, Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Pisa 56100, Italy
    Maturitas 50:247-58. 2005
    ..We therefore, tested whether a different kinetics of exposure of endothelial cells to estrogens may alter the balance between transcriptional and non-transcriptional signaling...
  97. ncbi request reprint Effects of dydrogesterone and of its stable metabolite, 20-alpha-dihydrodydrogesterone, on nitric oxide synthesis in human endothelial cells
    Tommaso Simoncini
    Molecular and Cellular Gynecological Endocrinology Laboratory, Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Pisa, Italy
    Fertil Steril 86:1235-42. 2006
    ..The Women's Health Initiative trial reports an excess of heart disease in postmenopausal women receiving MPA...
  98. ncbi request reprint Novel non-transcriptional mechanisms for estrogen receptor signaling in the cardiovascular system. Interaction of estrogen receptor alpha with phosphatidylinositol 3-OH kinase
    Tommaso Simoncini
    Division of Obstetrics and Gynecology, University of Pisa, Via Roma, 67, 56100, Pisa, Italy
    Steroids 67:935-9. 2002
    ..This original non-transcriptional mechanism for ER signaling may play an important role in the generation of some of the rapid 'non-genomic' effects of estrogen...
  99. ncbi request reprint In-vitro evidence of autocrine secretion of vascular endothelial growth factor by endothelial cells from human placental blood vessels
    G Bocci
    Division of Pharmacology and Chemotherapy, Department of Oncology, Transplants and Advanced Technologies in Medicine, University of Pisa, Pisa, Italy
    Mol Hum Reprod 7:771-7. 2001
    ..9% respectively. In conclusion, this study reports the first evidence of autocrine secretion of VEGF by human placental endothelial cells and demonstrates the involvement of VEGF in endothelial cell growth within a fibrin gel culture...
  100. ncbi request reprint Drospirenone and its antialdosterone properties
    A R Genazzani
    Department of Obstetrics and Gynecology, University of Pisa, Pisa, Italy
    Climacteric 10:11-8. 2007
    ..The combined actions of drospirenone on sodium and water retention and cardiovascular parameters make it a more attractive therapeutic option as a component of hormone replacement therapy than other synthetic progestins...