L Gandini

Summary

Affiliation: University of Rome La Sapienza
Country: Italy

Publications

  1. ncbi request reprint Effect of chemo- or radiotherapy on sperm parameters of testicular cancer patients
    Loredana Gandini
    Laboratory of Seminology and Immunology of Human Reproduction, Department of Medical Pathophysiology, Policlinico Umberto I, University of Rome La Sapienza, Rome, Italy
    Hum Reprod 21:2882-9. 2006
  2. ncbi request reprint Full-term pregnancies achieved with ICSI despite high levels of sperm chromatin damage
    L Gandini
    Department of Medical Pathophysiology, University of Rome, Rome, Italy
    Hum Reprod 19:1409-17. 2004
  3. ncbi request reprint Lipoperoxidation damage of spermatozoa polyunsaturated fatty acids (PUFA): scavenger mechanisms and possible scavenger therapies
    A Lenzi
    Department of Medical Physiopathology, Laboratory of Seminology and Immunology of Reproduction, University of Rome La Sapienza, Rome, Italy
    Front Biosci 5:E1-E15. 2000
  4. doi request reprint Hormone and genetic study in male to female transsexual patients
    F Lombardo
    Department of Experimental Medicine, Policlinico Umberto I, University of Rome La Sapienza, Viale del Policlinico 155, 00161, Rome, Italy
    J Endocrinol Invest 36:550-7. 2013
  5. doi request reprint Protamine-1 and -2 polymorphisms and gene expression in male infertility: an Italian study
    D Grassetti
    Department of Experimental Medicine, University of Rome La Sapienza, Viale del Policlinico 155, 00161 Rome, Italy
    J Endocrinol Invest 35:882-8. 2012
  6. ncbi request reprint Might erectile dysfunction be due to the thermolabile variant of methylenetetrahydrofolate reductase?
    F Lombardo
    Unit of Seminology and Immunology of Reproduction, Department of Medical Physiopathology, University of Rome La Sapienza, Rome, Italy
    J Endocrinol Invest 27:883-5. 2004
  7. ncbi request reprint Control and impairment of immune privilege in the testis and in semen
    A Filippini
    Department of Histology and Medical Embryology, University of Rome La Sapienza, Italy
    Hum Reprod Update 7:444-9. 2001
  8. doi request reprint Testicular cancer and sperm DNA damage: short- and long-term effects of antineoplastic treatment
    D Paoli
    Laboratory of Seminology Sperm Bank, Department of Experimental Medicine, University of Rome La Sapienza, Rome, Italy
    Andrology 3:122-8. 2015
  9. ncbi request reprint Androgens and fertility
    F Lombardo
    Department of Medical Pathophysiology, 1st University of Rome La Sapienza, Rome, Italy
    J Endocrinol Invest 28:51-5. 2005
  10. ncbi request reprint Presence of membrane and soluble forms of Fas ligand and of matrilysin (MMP-7) activity in normal and abnormal human semen
    A Riccioli
    Department of Histology and Medical Embryology, Istituto Pasteur Fondazione Cenci Bolognetti, University of Rome La Sapienza, Italy
    Hum Reprod 20:2814-20. 2005

Collaborators

Detail Information

Publications53

  1. ncbi request reprint Effect of chemo- or radiotherapy on sperm parameters of testicular cancer patients
    Loredana Gandini
    Laboratory of Seminology and Immunology of Human Reproduction, Department of Medical Pathophysiology, Policlinico Umberto I, University of Rome La Sapienza, Rome, Italy
    Hum Reprod 21:2882-9. 2006
    ....
  2. ncbi request reprint Full-term pregnancies achieved with ICSI despite high levels of sperm chromatin damage
    L Gandini
    Department of Medical Pathophysiology, University of Rome, Rome, Italy
    Hum Reprod 19:1409-17. 2004
    ..It has been reported that sperm chromatin structure assay (SCSA) identified thresholds for negative pregnancy outcome after ART when the DNA fragmentation index (DFI), previously known as COMPalphat, was >30%...
  3. ncbi request reprint Lipoperoxidation damage of spermatozoa polyunsaturated fatty acids (PUFA): scavenger mechanisms and possible scavenger therapies
    A Lenzi
    Department of Medical Physiopathology, Laboratory of Seminology and Immunology of Reproduction, University of Rome La Sapienza, Rome, Italy
    Front Biosci 5:E1-E15. 2000
    ..Scavengers, such as GSH, can be used to treat these cases as they can restore the physiological constitution of PUFA in the cell membrane. The results of GSH therapy are presented and discussed...
  4. doi request reprint Hormone and genetic study in male to female transsexual patients
    F Lombardo
    Department of Experimental Medicine, Policlinico Umberto I, University of Rome La Sapienza, Viale del Policlinico 155, 00161, Rome, Italy
    J Endocrinol Invest 36:550-7. 2013
    ..Data of the literature demonstrated controversial results of a correlation between transsexualism and genetic mutations...
  5. doi request reprint Protamine-1 and -2 polymorphisms and gene expression in male infertility: an Italian study
    D Grassetti
    Department of Experimental Medicine, University of Rome La Sapienza, Viale del Policlinico 155, 00161 Rome, Italy
    J Endocrinol Invest 35:882-8. 2012
    ..There are two types of protamines: protamine 1 (P1) and the protamine 2 family (P2, P3, and P4), coded by the genes PRM1 and PRM2...
  6. ncbi request reprint Might erectile dysfunction be due to the thermolabile variant of methylenetetrahydrofolate reductase?
    F Lombardo
    Unit of Seminology and Immunology of Reproduction, Department of Medical Physiopathology, University of Rome La Sapienza, Rome, Italy
    J Endocrinol Invest 27:883-5. 2004
    ..Furthermore, careful attention should be given to the risk of ED when dealing with this metabolic disturbance...
  7. ncbi request reprint Control and impairment of immune privilege in the testis and in semen
    A Filippini
    Department of Histology and Medical Embryology, University of Rome La Sapienza, Italy
    Hum Reprod Update 7:444-9. 2001
    ....
  8. doi request reprint Testicular cancer and sperm DNA damage: short- and long-term effects of antineoplastic treatment
    D Paoli
    Laboratory of Seminology Sperm Bank, Department of Experimental Medicine, University of Rome La Sapienza, Rome, Italy
    Andrology 3:122-8. 2015
    ..Our results thus indicate that post-treatment DNA damage is influenced both by the type and intensity of the therapy and by the pathological and clinical stage of the disease. ..
  9. ncbi request reprint Androgens and fertility
    F Lombardo
    Department of Medical Pathophysiology, 1st University of Rome La Sapienza, Rome, Italy
    J Endocrinol Invest 28:51-5. 2005
    ..Abuse of anabolic steroids is a frequent cause of male infertility, and substances such as endocrine disruptors can alter male fertility through an anti androgenic action...
  10. ncbi request reprint Presence of membrane and soluble forms of Fas ligand and of matrilysin (MMP-7) activity in normal and abnormal human semen
    A Riccioli
    Department of Histology and Medical Embryology, Istituto Pasteur Fondazione Cenci Bolognetti, University of Rome La Sapienza, Italy
    Hum Reprod 20:2814-20. 2005
    ....
  11. ncbi request reprint Diagnosing erectile dysfunction: instruments for endocrine diagnosis
    F Lombardo
    Department of Medical Pathophysiology, Laboratory of Seminology and Immunology of Reproduction, Policlinico Umberto I, 1st University of Rome La Sapienza, Rome, Italy
    Int J Androl 28:53-5. 2005
    ....
  12. doi request reprint Androgen receptor polymorphisms and testicular cancer risk
    D Grassetti
    Laboratory of Seminology Sperm Bank, Department of Experimental Medicine, University of Rome La Sapienza, Rome, Italy
    Andrology 3:27-33. 2015
    ..Finally, stage II patients were more likely to have a CAG repeat number <21 or >24 than stage I patients. ..
  13. ncbi request reprint Cryopreservation and sperm DNA integrity
    L Gandini
    Laboratory of Seminology and Reproductive Immunology, Department of Medical Pathophysiology, University of Rome La Sapienza, 00100, Rome, Italy
    Cell Tissue Bank 7:91-8. 2006
    ..Overall sperm quality was found to deteriorate after cryopreservation. When thawed spermatozoa were subjected to an extra swim-up round, a general improvement in nuclear maturity was seen in post-rise spermatozoa...
  14. ncbi request reprint HIV-1 viral DNA is present in ejaculated abnormal spermatozoa of seropositive subjects
    B Muciaccia
    Department of Histology and Medical Embryology, Sapienza University of Rome, Rome, Italy
    Hum Reprod 22:2868-78. 2007
    ..However, the presence of HIV-1 in spermatozoa has been a matter of debate, since the sperm cell fraction may contain somatic infected cells that jeopardize the attribution of the detected virus to the spermatozoa...
  15. doi request reprint Exposure to polychlorinated biphenyls and hexachlorobenzene, semen quality and testicular cancer risk
    D Paoli
    Laboratory of Seminology Sperm Bank, Department of Experimental Medicine, University of Rome La Sapienza, Viale del Policlinico 155, 00161, Rome, Italy
    J Endocrinol Invest 38:745-52. 2015
    ..We carried out a case-control study to investigate the possible role of occupational and environmental exposure to endocrine disruptors in the onset of testicular cancer (TC)...
  16. doi request reprint Spermatogenesis in Hodgkin's lymphoma patients: a retrospective study of semen quality before and after different chemotherapy regimens
    D Paoli
    Laboratory of Seminology Sperm Bank, Department of Experimental Medicine, University of Rome La Sapienza, Italy
    Hum Reprod 31:263-72. 2016
    ..Is spermatogenesis impairment caused by Hodgkin's lymphoma (HL) itself or by the various treatments?..
  17. pmc Acute endothelial response to testosterone gel administration in men with severe hypogonadism and its relationship to androgen receptor polymorphism: a pilot study
    D Francomano
    Department of Experimental Medicine, Endocrinology and Food and Science Section, Sapienza University of Rome, 00161, Rome, Italy
    J Endocrinol Invest 39:265-71. 2016
    ..Testosterone (T) exerts different effects on the cardiovascular system. Despite this knowledge, the acute vascular effect of androgen remains still poorly understood...
  18. doi request reprint Effects of a dietary supplement on cholesterol in subjects with moderate hypercholesterolemia
    F Lombardo
    Department of Experimental Medicine, Policlinico Umberto I, University Sapienza, Rome, Italy
    Clin Ter 164:e147-50. 2013
    ....
  19. ncbi request reprint Testicular function in boys previously treated with recombinant-human growth hormone for non-growth hormone-deficient short stature
    A F Radicioni
    Chair of Endocrinology, Department of Medical Pathophysiology, 1st University of Rome La Sapienza, Rome, Italy
    J Endocrinol Invest 30:931-6. 2007
    ..This study suggests that recombinant hGH treatment has no detrimental effects on the development and maturation of male gonadal function in non- GH deficient short stature young patients...
  20. ncbi request reprint Therapy of immunologic infertility
    F Dondero
    Laboratory of Seminology and Immunology of Reproduction 5th Medical Clinic, University of Rome, La Sapienza, Italy
    Acta Eur Fertil 22:139-45. 1991
    ..In this paper we review the various classic and up-to-date methods of management of immunologic infertility...
  21. ncbi request reprint Antisperm immunity in natural and assisted reproduction
    F Lombardo
    Department of Medical Physiopathology, University of Rome La Sapienza, Italy
    Hum Reprod Update 7:450-6. 2001
    ..ASA evaluation in all couples who undergo the various techniques of insemination or IVF is imperative...
  22. doi request reprint Strategies and advantages of early diagnosis in Klinefelter's syndrome
    A F Radicioni
    Department of Medical Pathophysiology, Sapienza University of Rome, Rome, Italy
    Mol Hum Reprod 16:434-40. 2010
    ..To achieve this, it is crucial to increase both medical and general awareness of the disease, including through use of the media and patients' associations...
  23. ncbi request reprint Endocrinological diagnosis in sexology
    F Lombardo
    University Laboratory of Seminology and Immunology of Reproduction, Department of Medical Pathophysiology, 1st University of Rome La Sapienza, Rome, Italy
    J Endocrinol Invest 26:112-4. 2003
    ..It is therefore necessary that the diagnostic process for sexual dysfunctions of an endocrine nature be as integrated and wide as possible, especially as such pathologies are usually extremely responsive to medical or surgical therapy...
  24. doi request reprint Semen quality in men with Y chromosome aberrations
    A Antonelli
    Department of Cellular Biotechnology and Haematology, University of Rome La Sapienza, Rome, Italy
    Int J Androl 34:453-60. 2011
    ..The failure of meiosis and, in consequence, spermatogenesis may be a result of the failure to inactivate the X chromosome in the meiotic prophase, which is necessary for normal male spermatogenesis to take place...
  25. ncbi request reprint Polyunsaturated fatty acids of germ cell membranes, glutathione and blutathione-dependent enzyme-PHGPx: from basic to clinic
    A Lenzi
    Laboratory of Seminology and Immunology of Human Reproduction, Department of Medical Pathophysiology, University of Rome La Sapienza, Italy
    Contraception 65:301-4. 2002
    ..Scavengers, such as glutathione can be used to treat these cases as they can restore the physiological constitution of PUFA in the cell membrane...
  26. ncbi request reprint Testicular cancer and Hodgkin's disease: evaluation of semen quality
    Loredana Gandini
    University Laboratory of Seminology and Immunology of Reproduction, Department of Medical Pathophysiology, Policlinico Umberto I, University of Rome La Sapienza, 00161, Rome, Italy
    Hum Reprod 18:796-801. 2003
    ..The aim of our study was to establish whether there is a difference in semen quality between patients with testicular cancer (TC) and Hodgkin's disease (HD)...
  27. ncbi request reprint Use of carnitine therapy in selected cases of male factor infertility: a double-blind crossover trial
    Andrea Lenzi
    Outpatient Department and Laboratory of Seminology and Reproductive Immunology at the Training Center in Andrology of the European Academy of Andrology, Rome, Italy
    Fertil Steril 79:292-300. 2003
    ..To determine the efficacy of L-carnitine therapy in selected cases of male factor infertility...
  28. ncbi request reprint Clinical and laboratoristic strategy in late onset hypogonadism
    Francesco Lombardo
    Dipartimento di Fisiopatologia Medica, Universitt di Roma Sapienza
    Acta Biomed 81:85-8. 2010
    ..The exact target testosterone level is a matter of debate, but current recommendations advocate levels in the mid-lower normal adult range...
  29. doi request reprint Treatment of erectile dysfunction due to C677T mutation of the MTHFR gene with vitamin B6 and folic acid in patients non responders to PDE5i
    Francesco Lombardo
    Department of Medical Pathophysiology, University of Rome La Sapienza, Rome, Italy
    J Sex Med 7:216-23. 2010
    ..Since hyperhomocysteinemia is considered an important cardiovascular risk factor, it could also be involved in the pathogenesis of ED...
  30. ncbi request reprint Antisperm immunity in assisted reproduction
    Francesco Lombardo
    The University Laboratory of Seminology and Immunology of Reproduction, Department of Physiopathology, University of Rome La Sapienza, 00161 Rome, Italy
    J Reprod Immunol 62:101-9. 2004
    ..As immunological infertility is relatively rare, literature in the field is quite scarce and more studies need to be conducted to confirm that embryo quality is not impaired...
  31. ncbi request reprint Psychosocial factors discriminate oligozoospermic from normozoospermic men
    Luigi De Gennaro
    Department of Psychology, University of Rome La Sapienza, Rome, Italy
    Fertil Steril 79:1571-6. 2003
    ..To compare the profile of psychosocial variables in a group of oligozoospermic and normozoospermic men for assessing the hypothesis of a relationship between impaired seminal status and psychosocial factors...
  32. ncbi request reprint Sperm tail agenesis in a case of consanguinity
    Maurizio Latini
    Department of Medical Pysiopathology, University of Rome La Sapienza, Rome, Italy
    Fertil Steril 81:1688-91. 2004
    ..To report a case of 100% teratozoospermia in a patient whose family history presented a high degree of consanguinity...
  33. ncbi request reprint A placebo-controlled double-blind randomized trial of the use of combined l-carnitine and l-acetyl-carnitine treatment in men with asthenozoospermia
    Andrea Lenzi
    Department of Medical Physiopathology, University of Rome La Sapienza, Rome, Italy
    Fertil Steril 81:1578-84. 2004
    ..To determine the efficacy of combined l-carnitine and l-acetyl-carnitine therapy in infertile males with oligo-astheno-teratozoospermia...
  34. ncbi request reprint Antioxidant treatment associated with sildenafil reduces monocyte activation and markers of endothelial damage in patients with diabetic erectile dysfunction: a double-blind, placebo-controlled study
    Susanna Morano
    Department of Clinical Sciences, Sapienza University, Rome, Italy
    Eur Urol 52:1768-74. 2007
    ..To investigate the synergic effect of propionyl L-carnitine (PLC) plus sildenafil in reducing monocyte oxidative activity and endothelial dysfunction markers in diabetic patients with erectile dysfunction (ED)...
  35. ncbi request reprint Circulating monocyte oxidative activity is increased in patients with type 2 diabetes and erectile dysfunction
    Susanna Morano
    Department of Clinical Sciences, University La Sapienza, Rome, Italy
    J Urol 177:655-9. 2007
    ..We investigated the relationship between oxidative stress and diabetic erectile dysfunction...
  36. doi request reprint Effects of a dietary supplement on chronic pelvic pain syndrome (Category IIIA), leucocytospermia and semen parameters
    F Lombardo
    Department of Experimental Medicine, Policlinico Umberto I, University of Rome La Sapienza, Rome, Italy
    Andrologia 44:672-8. 2012
    ..Improvements were also seen in the pain score of the NIH-Chronic Prostatitis Symptom Index (CPSI), confirming that the reduced inflammation also resulted in a reduction in pain...
  37. doi request reprint Are apolipoprotein E alleles correlated with semen quality?
    D Paoli
    Laboratory of Seminology Sperm Bank, Department of Experimental Medicine, University of Rome La Sapienza, Rome, Italy
    Int J Androl 35:714-9. 2012
    ..This demonstrates once again that the use of number of children as an index of fertility is not indicative of real male reproductive capacity...
  38. ncbi request reprint Stress, sexual dysfunctions, and male infertility
    A Lenzi
    Department of Medical Physiopathology, 1st University of Rome La Sapienza, Rome, Italy
    J Endocrinol Invest 26:72-6. 2003
    ....
  39. doi request reprint Testicular tumors as a possible cause of antisperm autoimmune response
    Donatella Paoli
    Department of Medical Pathophysiology, University of Rome La Sapienza, Rome, Italy
    Fertil Steril 91:414-9. 2009
    ..To evaluate the presence of antisperm antibodies in testicular cancer patients 1 month after orchiectomy and before radiotherapy or chemotherapy...
  40. doi request reprint Sumo1-ylation of human spermatozoa and its relationship with semen quality
    S Marchiani
    Department of Clinical Physiopathology, Sexual Medicine and Andrology Unit, Center of Excellence for Research, Transfer and High Education DENOthe, University of Florence, Florence, Italy
    Int J Androl 34:581-93. 2011
    ..By using a fluorescent probe to distinguish dead/live cells, we show that SUMO1 is mainly present in live spermatozoa. In conclusion, sumoylation of human spermatozoa may be involved in the regulation of motility...
  41. doi request reprint Epidemiology, diagnosis, and treatment of male hypogonadotropic hypogonadism
    A Lenzi
    Department of Medical Physiopathology, University of Rome La Sapienza, Rome, Italy
    J Endocrinol Invest 32:934-8. 2009
    ..This commentary aims at reviewing knowledge on the forms of male HH in order to indicate and discuss clinical context, diagnostic and therapeutic approach in the less known non-classical form, i.e. FHH...
  42. ncbi request reprint Beta-chemokine receptors 5 and 3 are expressed on the head region of human spermatozoon
    Barbara Muciaccia
    Department of Histology and Medical Embryology, and Centro di Eccellenza Biologia e Medicina Molecolare, University of Rome La Sapienza, Rome, Italy
    FASEB J 19:2048-50. 2005
    ..Finally, both CCR5 and CCR3 expressed on the sperm cell surface may be involved in HIV-1 adhesion to spermatozoa, thus allowing these cells to perform as virion cellular carriers during sexual transmission of HIV-1 infection...
  43. doi request reprint Expression of a truncated form of KIT tyrosine kinase in human spermatozoa correlates with sperm DNA integrity
    Barbara Muciaccia
    Department of Histology and Medical Embryology, University of Rome La Sapienza, Rome, Italy
    Hum Reprod 25:2188-202. 2010
    ....
  44. ncbi request reprint Expression of Fas and Fas ligand in human testicular germ cell tumours
    E Baldini
    Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy
    Int J Androl 32:123-30. 2009
    ....
  45. ncbi request reprint Pre-receptorial regulation of steroid hormones in bone cells: insights on glucocorticoid-induced osteoporosis
    Silvia Pierotti
    Department of Medical Pathophysiology, University of Rome La Sapienza, Viale del Policlinico 155, Rome, Italy
    J Steroid Biochem Mol Biol 108:292-9. 2008
    ..The different kinetics of 11beta-HSD1 at various stage of differentiation and the GC-dependency of enzymatic activity have been presented...
  46. ncbi request reprint PHGPx in spermatogenesis: how many functions?
    Rossella Puglisi
    Department of Histology and Medical Embryology, University of Rome La Sapienza, 00161 Rome, Italy
    Contraception 72:291-3. 2005
    ..The data are discussed in light of the idea that PHGPx is a moonlighting protein, changing roles depending on the intracellular localization, expression in a specific cell type and different partners which it interacts with...
  47. ncbi request reprint HIV-1 chemokine co-receptor CCR5 is expressed on the surface of human spermatozoa
    Barbara Muciaccia
    Department of Histology and Medical Embryology, University La Sapienza, Rome, Italy
    AIDS 19:1424-6. 2005
    ..CCR5 expressed on the sperm cell surface may allow sperm to act as virion cellular carriers during the sexual transmission of HIV-1 infection...
  48. doi request reprint HDL cholesterol is a strong determinant of endothelial progenitor cells in hypercholesterolemic subjects
    Fabio Rossi
    Dipartimento di Fisiopatologia Medica, Sapienza Università, Rome, Italy
    Microvasc Res 80:274-9. 2010
    ..Our study documented that, in hypercholesterolemic subjects, HDL-C is a strong determinant of EPC number and function, and EPC number decrease is an independent risk factor for endothelial dysfunction...
  49. ncbi request reprint Native specific activity of glutathione peroxidase (GPx-1), phospholipid hydroperoxide glutathione peroxidase (PHGPx) and glutathione reductase (GR) does not differ between normo- and hypomotile human sperm samples
    Federica Tramer
    Department of Biochemistry, Biophysics and Macromolecular Chemistry, University of Trieste, Italy
    Int J Androl 27:88-93. 2004
    ..These results are discussed and compared with recent literature data on both rescued and native PHGPx specific activity in human spermatozoa, as well as with data obtained for GPx in human seminal plasma...
  50. ncbi request reprint Mice overexpressing the mitochondrial phospholipid hydroperoxide glutathione peroxidase in male germ cells show abnormal spermatogenesis and reduced fertility
    Rossella Puglisi
    Department of Histology and Medical Embryology, Sapienza University of Rome, Via A Scarpa 14, 00161 Roma, Italy
    Endocrinology 148:4302-9. 2007
    ..Present findings in the mouse may be of interest to human male fertility...
  51. ncbi request reprint Treatment of sexual dysfunctions secondary to male infertility with sildenafil citrate
    Emmanuele A Jannini
    Fertil Steril 81:705-7. 2004
    ..Two pregnancies were obtained after sildenafil administration...
  52. ncbi request reprint Characterization of human sperm
    Andrea Lenzi
    Hum Reprod 17:842; author reply 843. 2002
  53. ncbi request reprint Enzymatic and immunochemical evaluation of phospholipid hydroperoxide glutathione peroxidase (PHGPx) in testes and epididymal spermatozoa of rats of different ages
    Federica Tramer
    Department of Biochemistry, Biophysics and Macromolecular Chemistry, University of Trieste, Trieste, Italy
    Int J Androl 25:72-83. 2002
    ..The subcellular distribution of PHGPx is qualitatively, but not quantitatively, unchanged during ageing. These different behaviours are compared and discussed...