Daniela Furlan

Summary

Affiliation: University of Insubria
Country: Italy

Publications

  1. ncbi request reprint The high frequency of de novo promoter methylation in synchronous primary endometrial and ovarian carcinomas
    Daniela Furlan
    Anatomic Pathology Unit, Department of Human Morphology, University of Insubria, Varese, Italy
    Clin Cancer Res 12:3329-36. 2006
  2. doi request reprint Diagnostic utility of MS-MLPA in DNA methylation profiling of adenocarcinomas and neuroendocrine carcinomas of the colon-rectum
    Daniela Furlan
    Department of Surgical and Morphological Sciences, Anatomic Pathology Unit, University of Insubria and Ospedale di Circolo, Via O Rossi, 9, 21100, Varese, Italy
    Virchows Arch 462:47-56. 2013
  3. doi request reprint Hierarchical clustering analysis of pathologic and molecular data identifies prognostically and biologically distinct groups of colorectal carcinomas
    Daniela Furlan
    Department of Human Morphology, Section of Anatomic Pathology, Centro Insubre di Biotecnologie per la Salute Umana, University of Insubria and Ospedale di Circolo, Varese, Italy
    Mod Pathol 24:126-37. 2011
  4. ncbi request reprint Up-regulation and stabilization of HIF-1alpha in colorectal carcinomas
    Daniela Furlan
    Department of Human Morphology, Anatomic Pathology Unit, University of Insubria, Via O Rossi, 9, 21100 Varese, Italy
    Surg Oncol 16:S25-7. 2007
  5. ncbi request reprint Allelotypes and fluorescence in situ hybridization profiles of poorly differentiated endocrine carcinomas of different sites
    Daniela Furlan
    Department of Human Morphology, Anatomic Pathology Unit, University of Insubria, Ospedale di Circolo, Viale Borri 57, 21100 Varese, Italy
    Clin Cancer Res 11:1765-75. 2005
  6. doi request reprint Up-regulation of the hypoxia-inducible factor-1 transcriptional pathway in colorectal carcinomas
    Daniela Furlan
    Department of Human Morphology, Anatomic Pathology Unit, University of Insubria, Varese, Italy
    Hum Pathol 39:1483-94. 2008
  7. ncbi request reprint Microallelotyping defines the monoclonal or the polyclonal origin of mixed and collision endocrine-exocrine tumors of the gut
    Daniela Furlan
    Department of Clinical and Biological Sciences, University of Insubria, Varese, Italy
    Lab Invest 83:963-71. 2003
  8. ncbi request reprint Intratumour T cells, their activation status and survival in gastric carcinomas characterised for microsatellite instability and Epstein-Barr virus infection
    Anna Maria Chiaravalli
    Department of Human Morphology, Section of Anatomic Pathology, University of Insubria and Ospedale di Circolo, Varese, Italy
    Virchows Arch 448:344-53. 2006
  9. doi request reprint APC alterations are frequently involved in the pathogenesis of acinar cell carcinoma of the pancreas, mainly through gene loss and promoter hypermethylation
    Daniela Furlan
    Department of Surgical and Morphological Sciences, University of Insubria, Varese, Italy
    Virchows Arch 464:553-64. 2014
  10. ncbi request reprint Histidine decarboxylase, DOPA decarboxylase, and vesicular monoamine transporter 2 expression in neuroendocrine tumors: immunohistochemical study and gene expression analysis
    Silvia Uccella
    Section of Anatomic Pathology, Dept of Human Morphology, University of Insubria and Ospedale di Circolo, Via Ottorino Rossi, 9 I 21100 Varese, Italy
    J Histochem Cytochem 54:863-75. 2006

Collaborators

Detail Information

Publications25

  1. ncbi request reprint The high frequency of de novo promoter methylation in synchronous primary endometrial and ovarian carcinomas
    Daniela Furlan
    Anatomic Pathology Unit, Department of Human Morphology, University of Insubria, Varese, Italy
    Clin Cancer Res 12:3329-36. 2006
    ....
  2. doi request reprint Diagnostic utility of MS-MLPA in DNA methylation profiling of adenocarcinomas and neuroendocrine carcinomas of the colon-rectum
    Daniela Furlan
    Department of Surgical and Morphological Sciences, Anatomic Pathology Unit, University of Insubria and Ospedale di Circolo, Via O Rossi, 9, 21100, Varese, Italy
    Virchows Arch 462:47-56. 2013
    ..Aberrant gene methylation is a common abnormality in CRC initiation and may be observed in tumors with very different genetic and clinicopathological profiles...
  3. doi request reprint Hierarchical clustering analysis of pathologic and molecular data identifies prognostically and biologically distinct groups of colorectal carcinomas
    Daniela Furlan
    Department of Human Morphology, Section of Anatomic Pathology, Centro Insubre di Biotecnologie per la Salute Umana, University of Insubria and Ospedale di Circolo, Varese, Italy
    Mod Pathol 24:126-37. 2011
    ..Hierarchical clustering seems to be a useful, promising and powerful tool for further translational studies and should lead us to define a diagnostic and prognostic signature for different carcinomas...
  4. ncbi request reprint Up-regulation and stabilization of HIF-1alpha in colorectal carcinomas
    Daniela Furlan
    Department of Human Morphology, Anatomic Pathology Unit, University of Insubria, Via O Rossi, 9, 21100 Varese, Italy
    Surg Oncol 16:S25-7. 2007
    ..The lack of prognostic impact of HIF-1 in this site could be explained by an intricate interaction between the survival program mediated by HIF-1 and the genetic background of tumors cells in which its activation occurs...
  5. ncbi request reprint Allelotypes and fluorescence in situ hybridization profiles of poorly differentiated endocrine carcinomas of different sites
    Daniela Furlan
    Department of Human Morphology, Anatomic Pathology Unit, University of Insubria, Ospedale di Circolo, Viale Borri 57, 21100 Varese, Italy
    Clin Cancer Res 11:1765-75. 2005
    ....
  6. doi request reprint Up-regulation of the hypoxia-inducible factor-1 transcriptional pathway in colorectal carcinomas
    Daniela Furlan
    Department of Human Morphology, Anatomic Pathology Unit, University of Insubria, Varese, Italy
    Hum Pathol 39:1483-94. 2008
    ..Mechanisms leading to increased synthesis of hypoxia-inducible factor-1alpha mRNA via autocrine growth factor loops may play a crucial role in invasive growth in this site...
  7. ncbi request reprint Microallelotyping defines the monoclonal or the polyclonal origin of mixed and collision endocrine-exocrine tumors of the gut
    Daniela Furlan
    Department of Clinical and Biological Sciences, University of Insubria, Varese, Italy
    Lab Invest 83:963-71. 2003
    ....
  8. ncbi request reprint Intratumour T cells, their activation status and survival in gastric carcinomas characterised for microsatellite instability and Epstein-Barr virus infection
    Anna Maria Chiaravalli
    Department of Human Morphology, Section of Anatomic Pathology, University of Insubria and Ospedale di Circolo, Varese, Italy
    Virchows Arch 448:344-53. 2006
    ..In conclusion, our study demonstrates that a high number of CD3+ and CD8+ TILs is a characteristic of MSI- and EBV-associated GCs and represents a favourable prognostic factor, independently of the pathogenesis of GCs...
  9. doi request reprint APC alterations are frequently involved in the pathogenesis of acinar cell carcinoma of the pancreas, mainly through gene loss and promoter hypermethylation
    Daniela Furlan
    Department of Surgical and Morphological Sciences, University of Insubria, Varese, Italy
    Virchows Arch 464:553-64. 2014
    ..In conclusion, ACCs do not show extensive global gene hypermethylation. APC alterations are frequently involved in the pathogenesis of ACCs mainly through gene loss and promoter hypermethylation, along with reduction of APC mRNA levels...
  10. ncbi request reprint Histidine decarboxylase, DOPA decarboxylase, and vesicular monoamine transporter 2 expression in neuroendocrine tumors: immunohistochemical study and gene expression analysis
    Silvia Uccella
    Section of Anatomic Pathology, Dept of Human Morphology, University of Insubria and Ospedale di Circolo, Via Ottorino Rossi, 9 I 21100 Varese, Italy
    J Histochem Cytochem 54:863-75. 2006
    ..HDC should not be considered as a general endocrine marker and HDC IR in bronchial carcinoids and PDNECs of the lung can probably be attributed to a cross-reaction with DDC...
  11. doi request reprint TP53 alterations in pancreatic acinar cell carcinoma: new insights into the molecular pathology of this rare cancer
    Stefano La Rosa
    Department of Pathology, Ospedale di Circolo, Viale Borri 57, 21100, Varese, Italy
    Virchows Arch 468:289-96. 2016
    ..The molecular alterations correlated well with the immunohistochemical findings. A statistically significant association was found between the combination of mutation of one allele and loss of the other allele of TP53 and worse survival...
  12. ncbi request reprint Different molecular profiles characterize well-differentiated endocrine tumors and poorly differentiated endocrine carcinomas of the gastroenteropancreatic tract
    Daniela Furlan
    Department of Human Morphology, University of Insubria and Ospedale di Circolo, Viale Borri 57, 21100 Varese, Italy
    Clin Cancer Res 10:947-57. 2004
    ..The purpose of this work was a molecular characterization of 38 gastroenteropancreatic ETs with respect to the primary site and to the morphofunctional profile, pointing out useful diagnostic or prognostic molecular markers...
  13. doi request reprint Prognostic relevance of aberrant DNA methylation in g1 and g2 pancreatic neuroendocrine tumors
    Michele Stefanoli
    Section of Anatomic Pathology, Department of Surgical and Morphological Sciences, University of Insubria and Ospedale di Circolo, Varese, Italy
    Neuroendocrinology 100:26-34. 2014
    ..We evaluated the frequency of both epigenetic alterations in PanNETs to assess the relationship between methylation profiles and chromosomal instability, tumour phenotypes and prognosis...
  14. doi request reprint Colorectal poorly differentiated neuroendocrine carcinomas and mixed adenoneuroendocrine carcinomas: insights into the diagnostic immunophenotype, assessment of methylation profile, and search for prognostic markers
    Stefano La Rosa
    Department of Pathology, Ospedale di Circolo, Varese, Italy
    Am J Surg Pathol 36:601-11. 2012
    ....
  15. doi request reprint Identification of the first case of germline duplication of BRCA1 exon 13 in an Italian family
    Roberta Cerutti
    Department of Human Morphology, Anatomic Pathology Unit, Centro Insubre di Biotecnologie per la Salute Umana, Ospedale di Circolo, University of Insubria, Via O Rossi, 9, 21100, Varese, Italy
    Fam Cancer 9:275-82. 2010
    ....
  16. doi request reprint Microsatellite unstable gastrointestinal neuroendocrine carcinomas: a new clinicopathologic entity
    Nora Sahnane
    Section of Anatomic PathologyDepartment of Surgical and Morphological Sciences, University of Insubria, Via O Rossi, 9, 21100 Varese, ItalyCRIBI Biotechnology CenterUniversity of Padova, Padova, ItalyDepartment of Molecular MedicineInstitute of Pathology, University of Pavia, IRCCS Policlinico San Matteo, Pavia, ItalyDepartment of PathologyOspedale di Circolo, Varese, Italy
    Endocr Relat Cancer 22:35-45. 2015
    ..MSI-NEC/MANECs resemble MSI-gastrointestinal adenocarcinomas for frequency, molecular profile and pathogenetic mechanisms. ..
  17. ncbi request reprint Prognostic factors for ampullary adenocarcinomas: tumor stage, tumor histology, tumor location, immunohistochemistry and microsatellite instability
    Fausto Sessa
    Division of Anatomic Pathology, Department of Human Morphology, University of Insubria, Varese, Italy
    Virchows Arch 451:649-57. 2007
    ....
  18. ncbi request reprint Microsatellite instability and p53 expression in gallbladder carcinomas
    Fausto Sessa
    Department of Clinical and Biological Sciences, University of Insubria, Varese, Italy
    Diagn Mol Pathol 12:96-102. 2003
    ....
  19. doi request reprint Disruption of the APC gene by t(5;7) translocation in a Turcot family
    Nora Sahnane
    Department of Surgical and Morphological Sciences, University of Insubria, via O Rossi 9, IT 21100 Varese, Italy Electronic address
    Cancer Genet 209:107-11. 2016
    ..This family suggests that clinically positive TS and FAP cases, which test negative with standard molecular analysis, could be easily and cost-effectively resolved by a classical and molecular cytogenetic approach. ..
  20. doi request reprint Pyrosequencing for EGFR mutation detection: diagnostic accuracy and clinical implications
    Nora Sahnane
    Department of Surgical and Morphological Sciences, Anatomic Pathology Unit, University of Insubria, Varese, Italy Oncology Unit, Ospedale di Circolo, Varese, Italy
    Diagn Mol Pathol 22:196-203. 2013
    ..Pyrosequencing should be used in molecular diagnostic of NSCLC to appropriately select patients who are likely to benefit from TKI therapy. ..
  21. pmc Mixed exocrine-neuroendocrine carcinoma of the nasal cavity: clinico-pathologic and molecular study of a case and review of the literature
    Stefano La Rosa
    Department of Pathology, Ospedale di Circolo, Viale Borri 57, 21100 Varese, Italy
    Head Neck Pathol 7:76-84. 2013
    ..We have also reviewed the literature on sinonasal mixed exocrine-neuroendocrine carcinomas to give to the reader a comprehensive overview of these very rare tumor types...
  22. ncbi request reprint Genetic progression in sporadic endometrial and gastrointestinal cancers with high microsatellite instability
    Daniela Furlan
    Department of Clinical and Biological Sciences, University of Insubria, Varese, Italy
    J Pathol 197:603-9. 2002
    ....
  23. pmc Durable recurrence-free survival after pneumonectomy for late lung metastasis from rectal cancer: case report with genetic and epigenetic analyses
    Andrea Imperatori
    Center for Thoracic Surgery, Department of Surgical and Morphological Sciences, University of Insubria, Ospedale di Circolo, Via Guicciardini, 9, Varese, 21100, Italy
    BMC Cancer 15:567. 2015
    ..In the few long-term survivors after pneumonectomy for late-recurrent colorectal cancer, the disease has a relatively indolent metastatic course and genetic and epigenetic profiling may provide further insight regarding tumor evolution...
  24. ncbi request reprint Two PMS2 mutations in a Turcot syndrome family with small bowel cancers
    Marco Agostini
    Department of Preclinical Research and Epidemiology, Experimental Oncology 1, Centro Riferimento Oncologico, IRCCS, Aviano, Italy
    Am J Gastroenterol 100:1886-91. 2005
    ..A recessive model of inheritance caused by compound heterozygous mutations was consistent with the observed severe clinical phenotype and has important implications for predicting cancer risk in both the proband and his relatives...
  25. ncbi request reprint Evaluation of tumor microsatellite instability using five quasimonomorphic mononucleotide repeats and pentaplex PCR
    Nirosha Suraweera
    INSERM U434, Centre d Etudes du Polymorphisme Humain, Paris, France
    Gastroenterology 123:1804-11. 2002
    ..Analysis of BAT-26 is sufficient for detecting the MSI phenotype in most, but not all, cases. Additional results with dinucleotide markers can sometimes lead to incorrect classification of MSI tumors...