Luigi Ferrucci

Summary

Affiliation: University of Florence
Country: Italy

Publications

  1. ncbi Biomarkers of frailty in older persons
    L Ferrucci
    Laboratory of Clinical Epidemiology, Geriatric Department, Italian National Institute of Research and Care on Aging Institute INRCA, Florence, Italy
    J Endocrinol Invest 25:10-5. 2002
  2. ncbi Does the Clock Drawing Test predict cognitive decline in older persons independent of the Mini-Mental State Examination? The FINE Study Group. Finland, Italy, The Netherlands Elderly
    L Ferrucci
    Geriatric Department, I Fraticini, National Research Institute INRCA, Florence, Italy
    J Am Geriatr Soc 44:1326-31. 1996
  3. ncbi The frailty syndrome: a critical issue in geriatric oncology
    Luigi Ferrucci
    Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA
    Crit Rev Oncol Hematol 46:127-37. 2003
  4. ncbi Treatment of isolated systolic hypertension is most effective in older patients with high-risk profile
    L Ferrucci
    Laboratory of Clinical Epidemiology, INRCA Geriatric Department, Florence, Italy
    Circulation 104:1923-6. 2001
  5. ncbi Change in muscle strength explains accelerated decline of physical function in older women with high interleukin-6 serum levels
    Luigi Ferrucci
    Laboratory of Clinical Epidemiology, INRCA Geriatric Department, Florence, Italy
    J Am Geriatr Soc 50:1947-54. 2002
  6. ncbi Preventive health care for older women: life-style recommendations and new directions
    L Ferrucci
    Dipartimento di Geriatria, INRCA
    Aging (Milano) 12:113-31. 2000
  7. ncbi Constant hierarchic patterns of physical functioning across seven populations in five countries
    L Ferrucci
    INRCA Geriatric Department I Fraticini, Firenze, Italy
    Gerontologist 38:286-94. 1998
  8. pmc Unexplained anaemia in older persons is characterised by low erythropoietin and low levels of pro-inflammatory markers
    Luigi Ferrucci
    Intramural Research Program, National Institute on Aging, Baltimore, MD 21225, USA
    Br J Haematol 136:849-55. 2007
  9. pmc Alzheimer risk variant CLU and brain function during aging
    Madhav Thambisetty
    Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    Biol Psychiatry 73:399-405. 2013
  10. pmc Higher serum concentrations of dietary antioxidants are associated with lower levels of inflammatory biomarkers during the year after hip fracture
    Christopher R D'Adamo
    Department of Epidemiology and Public Health, University of Maryland School of Medicine, 520 W Lombard Street, East Hall, Baltimore, MD 21201, USA
    Clin Nutr 31:659-65. 2012

Detail Information

Publications194 found, 100 shown here

  1. ncbi Biomarkers of frailty in older persons
    L Ferrucci
    Laboratory of Clinical Epidemiology, Geriatric Department, Italian National Institute of Research and Care on Aging Institute INRCA, Florence, Italy
    J Endocrinol Invest 25:10-5. 2002
    ..This is a research area undergoing a rapid, dynamic development that may profit from new ways of defining disability outcomes in epidemiological studies of the elderly...
  2. ncbi Does the Clock Drawing Test predict cognitive decline in older persons independent of the Mini-Mental State Examination? The FINE Study Group. Finland, Italy, The Netherlands Elderly
    L Ferrucci
    Geriatric Department, I Fraticini, National Research Institute INRCA, Florence, Italy
    J Am Geriatr Soc 44:1326-31. 1996
    ..To evaluate the value of the Clock Drawing Test (CDT) in predicting cognitive deterioration over a 4-year period, independent of baseline cognitive status evaluated by the Mini-Mental State Examination (MMSE)...
  3. ncbi The frailty syndrome: a critical issue in geriatric oncology
    Luigi Ferrucci
    Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA
    Crit Rev Oncol Hematol 46:127-37. 2003
    ..Improvements in the definition of the frailty syndrome may profit from the clinical experience of oncologists...
  4. ncbi Treatment of isolated systolic hypertension is most effective in older patients with high-risk profile
    L Ferrucci
    Laboratory of Clinical Epidemiology, INRCA Geriatric Department, Florence, Italy
    Circulation 104:1923-6. 2001
    ....
  5. ncbi Change in muscle strength explains accelerated decline of physical function in older women with high interleukin-6 serum levels
    Luigi Ferrucci
    Laboratory of Clinical Epidemiology, INRCA Geriatric Department, Florence, Italy
    J Am Geriatr Soc 50:1947-54. 2002
    ..To test whether accelerated sarcopenia in older persons with high interleukin (IL)-6 serum levels plays a role in the prospective association between inflammation and disability found in many studies...
  6. ncbi Preventive health care for older women: life-style recommendations and new directions
    L Ferrucci
    Dipartimento di Geriatria, INRCA
    Aging (Milano) 12:113-31. 2000
    ..This list of guidelines should be considered as a starting point for all those who are in charge of caring for middle-aged and older women...
  7. ncbi Constant hierarchic patterns of physical functioning across seven populations in five countries
    L Ferrucci
    INRCA Geriatric Department I Fraticini, Firenze, Italy
    Gerontologist 38:286-94. 1998
    ..In older persons the disabling process follows a general pattern of progression based on a typical sequence of impairments...
  8. pmc Unexplained anaemia in older persons is characterised by low erythropoietin and low levels of pro-inflammatory markers
    Luigi Ferrucci
    Intramural Research Program, National Institute on Aging, Baltimore, MD 21225, USA
    Br J Haematol 136:849-55. 2007
    ..Unexplained anaemia was characterised by unexpectedly low EPO and low lymphocyte count. Unexplained anaemia is associated with reduced kidney EPO response, low levels of pro-inflammatory markers and low lymphocyte counts...
  9. pmc Alzheimer risk variant CLU and brain function during aging
    Madhav Thambisetty
    Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    Biol Psychiatry 73:399-405. 2013
    ....
  10. pmc Higher serum concentrations of dietary antioxidants are associated with lower levels of inflammatory biomarkers during the year after hip fracture
    Christopher R D'Adamo
    Department of Epidemiology and Public Health, University of Maryland School of Medicine, 520 W Lombard Street, East Hall, Baltimore, MD 21201, USA
    Clin Nutr 31:659-65. 2012
    ....
  11. pmc Circulating selenium and carboxymethyl-lysine, an advanced glycation endproduct, are independent predictors of anemia in older community-dwelling adults
    Cindy N Roy
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Nutrition 28:762-6. 2012
    ..To assess whether selenium and carboxymethyl-lysine (CML), two biomarkers of oxidative stress, are independent predictors of anemia in older community-dwelling adults...
  12. pmc Carboxymethyl-lysine, an advanced glycation end product, and decline of renal function in older community-dwelling adults
    Richard D Semba
    Johns Hopkins University School of Medicine, 550N Broadway, Suite 700, Baltimore, MD 21205, USA
    Eur J Nutr 48:38-44. 2009
    ..AGEs have been associated with impaired renal function in diabetes and in uremia. The relationship between AGEs and renal function in community-dwelling adults has not been well characterized...
  13. pmc Trail Making Test predicts physical impairment and mortality in older persons
    Rosamaria Vazzana
    Department of Medicine and Sciences of Aging, Laboratory of Clinical Epidemiology, University G D Annunzio, Chieti, Italy
    J Am Geriatr Soc 58:719-23. 2010
    ..To examine whether performance in the Trail Making Test (TMT) predicts mobility impairment and mortality in older persons...
  14. pmc Low total plasma carotenoids are independent predictors of mortality among older persons: the InCHIANTI study
    Fulvio Lauretani
    Tuscany Regional Agency, Florence, Italy
    Eur J Nutr 47:335-40. 2008
    ..Plasma carotenoids are considered a valid biological marker for fruit and vegetable dietary intake. Recent studies show that low carotenoid levels are associated with a high risk of inflammation, cancer, and cardiovascular disease...
  15. ncbi Proinflammatory state and circulating erythropoietin in persons with and without anemia
    Luigi Ferrucci
    Clinical Research Branch, National Institute on Aging, Longitudinal Studies Section Clinical Research Branch, ASTRA Unit, Harbor Hospital Baltimore, MD 21225, USA
    Am J Med 118:1288. 2005
    ..High circulating levels of proinflammatory cytokines cause anemia, perhaps by interacting with erythropoietin production or biological activity. We characterize the relationships of systemic inflammation, erythropoietin, and hemoglobin...
  16. pmc Oxidative protein damage is associated with poor grip strength among older women living in the community
    Caitlin Howard
    Johns Hopkins Medical Institutions, Baltimore, MD, USA
    J Appl Physiol (1985) 103:17-20. 2007
    ..043). These results suggest oxidative protein damage is independently associated with low grip strength among older women living in the community. Increased oxidative stress may be contributing to loss of muscle strength in older adults...
  17. pmc Use of the Frank-Starling mechanism during exercise is linked to exercise-induced changes in arterial load
    Paul D Chantler
    Intramural Research Program, National Institute on Aging, Baltimore, Maryland 21225, USA
    Am J Physiol Heart Circ Physiol 302:H349-58. 2012
    ..These findings provide interesting insights into the dynamic cardiovascular alterations during exercise...
  18. pmc Single nucleotide polymorphisms and the likelihood of prostate cancer at a given prostate specific antigen level
    Stacy Loeb
    James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Urol 182:101-4; discussion 105. 2009
    ..Prostate specific antigen is used for prostate cancer screening but its specificity is limited. Specificity might be increased by considering genotype associated prostate specific antigen levels...
  19. pmc Advanced glycation end products and their circulating receptors and level of kidney function in older community-dwelling women
    Richard D Semba
    Johns Hopkins Medical Institutions, 550 N Broadway, Baltimore, MD 21205, USA
    Am J Kidney Dis 53:51-8. 2009
    ..Advanced glycation end products (AGEs) and the receptor for AGE (RAGE) are implicated in the pathogenesis of kidney disease; however, their relation with level of kidney function has not been well characterized...
  20. pmc Low testosterone levels and the risk of anemia in older men and women
    Luigi Ferrucci
    Clinical Research Branch, Longitudinal Studies Section, National Institute on Aging, Baltimore, MD 21225, USA
    Arch Intern Med 166:1380-8. 2006
    ..Anemia is a frequent feature of male hypogonadism and anti-androgenic treatment. We hypothesized that the presence of low testosterone levels in older persons is a risk factor for anemia...
  21. pmc A randomized, controlled trial of disability prevention in frail older patients screened in primary care: the FRASI study. Design and baseline evaluation
    Stefania Bandinelli
    Geriatric Rehabilitation Unit, ASF, Tuscany Regional Health Agency, and Laboratory of Clinical Epidemiology, Italian National Institute of Research and Care of Aging, Firenze, Italy
    Aging Clin Exp Res 18:359-66. 2006
    ..We describe the enrollment and intervention phases of FRASI (FRAilty, Screening and Intervention), a randomized controlled trial aimed at preventing ADL disability in frail older persons screened in primary care...
  22. pmc Caffeine and alcohol intakes and overall nutrient adequacy are associated with longitudinal cognitive performance among U.S. adults
    May A Beydoun
    Intramural Research Program NIA NIH IRP, National Institute on Aging, Baltimore, MD
    J Nutr 144:890-901. 2014
    ..Further longitudinal studies conducted on larger samples of adults are needed to determine whether dietary factors individually or in combination are modifiers of cognitive trajectories among adults. ..
  23. pmc What physical attributes underlie self-reported vs. observed ability to walk 400 m in later life? An analysis from the InCHIANTI Study
    Marla K Beauchamp
    From the Department of Physical Medicine and Rehabilitation, Harvard Medical School, Spaulding Rehabilitation Hospital, Boston, Massachusetts MKB, JFB College of Nursing Health Sciences, University of Massachusetts Boston, Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Harvard Medical School SGL Department of Anesthesiology and Pain Medicine, University of Washington, Seattle KVP Institute for Aging Research, Hebrew SeniorLife, Harvard Medical School, Boston, Massachusetts DKK Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Bethesda, Maryland CLP Geriatric Rehabilitation Unit, Azienda Sanitaria Firenze, Florence, Italy SB National Institute on Aging, Baltimore, Maryland LF and Department of Epidemiology and Public Health, Division of Gerontology, University of Maryland School of Medicine, Baltimore JG
    Am J Phys Med Rehabil 93:396-404. 2014
    ..The aims of this study were to evaluate and contrast the physical attributes that are associated with self-reported vs. observed ability to walk 400 m among older adults...
  24. pmc Effect of complement CR1 on brain amyloid burden during aging and its modification by APOE genotype
    Madhav Thambisetty
    Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA
    Biol Psychiatry 73:422-8. 2013
    ..We examined the association between rs3818361 and brain amyloid deposition in nondemented older individuals...
  25. pmc Apolipoprotein E ε4 allele interacts with sex and cognitive status to influence all-cause and cause-specific mortality in U.S. older adults
    May A Beydoun
    National Institute on Aging, National Institutes of Health, Intramural Research Program, Baltimore, MD 21224, USA
    J Am Geriatr Soc 61:525-34. 2013
    ..To confirm associations of apolipoprotein E (ApoE) ε4 carrier status, sex, and time-dependent cognitive status with mortality risk and to investigate these joint effects of these associations in a cohort of community-dwelling U.S. adults...
  26. pmc Relationship of low plasma klotho with poor grip strength in older community-dwelling adults: the InCHIANTI study
    Richard D Semba
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Smith Building, M015, 400 N Broadway, Baltimore, MD 21287, USA
    Eur J Appl Physiol 112:1215-20. 2012
    ..20, standard error = 0.35, P = 0.0009) in adults with plasma klotho <681 pg/mL. These results suggest that older adults with lower plasma klotho have poor skeletal muscle strength...
  27. pmc Low serum carotenoids and development of severe walking disability among older women living in the community: the women's health and aging study I
    Richard D Semba
    The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Age Ageing 36:62-7. 2007
    ..to determine whether low serum carotenoid levels, an indicator of low intake of fruits and vegetables, are associated with the progression of disability in older women...
  28. pmc Risk factors for disability in older persons over 3-year follow-up
    Daniela Balzi
    Azienda Sanitaria Firenze, Florence, Italy
    Age Ageing 39:92-8. 2010
    ..the identification of modifiable risk factors for preventing disability in older individuals is essential for planning preventive strategies...
  29. pmc Plasma klotho and mortality risk in older community-dwelling adults
    Richard D Semba
    Baltimore, MD 21287, USA
    J Gerontol A Biol Sci Med Sci 66:794-800. 2011
    ..It is not known whether there is a relationship between plasma levels of secreted klotho protein and longevity in humans...
  30. pmc Markers of inflammation, vitamin E and peripheral nervous system function: the InCHIANTI study
    Angelo Di Iorio
    Laboratory of Clinical Epidemiology, Department of Medicine and Sciences of Aging, University G D Annunzio, Via dei Vestini 5, 66013 Chieti Scalo, Italy
    Neurobiol Aging 27:1280-8. 2006
    ..The aim of this study was to characterize the decline in nerve conduction velocity in the peripheral nervous system over the aging process and to identify factors that, independent of age, affect nerve conduction velocity...
  31. pmc Serum carboxymethyl-lysine, a dominant advanced glycation end product, is associated with chronic kidney disease: the Baltimore longitudinal study of aging
    Richard D Semba
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Ren Nutr 20:74-81. 2010
    ..Our objective was to characterize the relationship between AGEs and renal function in community-dwelling adults...
  32. pmc Advanced glycation end products and their circulating receptors predict cardiovascular disease mortality in older community-dwelling women
    Richard D Semba
    Johns Hopkins University School of Medicine, 550 N Broadway, Suite 700, Baltimore, MD 21205, USA
    Aging Clin Exp Res 21:182-90. 2009
    ..To characterize the relationship between advanced glycation end products (AGEs) and circulating receptors for AGEs (RAGE) with cardiovascular disease mortality...
  33. pmc Haemoglobin concentration and the risk of death in older adults: differences by race/ethnicity in the NHANES III follow-up
    Kushang V Patel
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, NIH, Bethesda, MD 20892 9205, USA
    Br J Haematol 145:514-23. 2009
    ..In conclusion, the haemoglobin threshold below which mortality rises significantly is a full g/dl lower in non-Hispanic blacks than in non-Hispanic whites and Mexican Americans...
  34. pmc Elevated serum advanced glycation end products and their circulating receptors are associated with anaemia in older community-dwelling women
    Richard D Semba
    Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Age Ageing 38:283-9. 2009
    ..to determine whether serum carboxymethyl-lysine, a dominant advanced glycation end product (AGE), and circulating total receptor for AGEs (sRAGE) and endogenous secretory receptor for AGEs (esRAGE) are associated with anaemia...
  35. pmc White blood cell count and mortality in the Baltimore Longitudinal Study of Aging
    Carmelinda Ruggiero
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21225, USA
    J Am Coll Cardiol 49:1841-50. 2007
    ..We investigated the secular trend in white blood cell (WBC) count and the relationship between WBC count and mortality between 1958 and 2002...
  36. pmc The relationship between plasma carotenoids and depressive symptoms in older persons
    Yuri Milaneschi
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Baltimore, MD 21225, USA
    World J Biol Psychiatry 13:588-98. 2012
    ..We examined the cross-sectional and longitudinal relationship between plasma carotenoids and depressive symptoms over a 6-year follow-up in older persons...
  37. pmc Relation of angiotensin-converting enzyme inhibitor treatment to insulin-like growth factor-1 serum levels in subjects >65 years of age (the InCHIANTI study)
    Marcello Maggio
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, Maryland, USA
    Am J Cardiol 97:1525-9. 2006
    ..This may be 1 of the mechanisms by which ACE inhibitors might slow the decreases in muscle strength and physical function that are often observed in older subjects...
  38. pmc Oxidative stress is associated with greater mortality in older women living in the community
    Richard D Semba
    Department of Ophthalmology, National Institute on Aging, Baltimore, Maryland, USA
    J Am Geriatr Soc 55:1421-5. 2007
    ..To determine whether oxidative stress, as implied by oxidative damage to proteins, is associated with greater mortality in older women living in the community...
  39. pmc Arterial stiffness and bone demineralization: the Baltimore longitudinal study of aging
    Francesco Giallauria
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Baltimore, Maryland, USA
    Am J Hypertens 24:970-5. 2011
    ..The aims of this study were to evaluate whether the association between arterial stiffness and bone demineralization is independent of age, and to explore putative mechanisms that may mediate their relationship...
  40. pmc Trait antagonism and the progression of arterial thickening: women with antagonistic traits have similar carotid arterial thickness as men
    Angelina R Sutin
    National Institute on Aging, National Institutes of Health, Department of Health and HumanServices, Baltimore, MD 21224
    Hypertension 56:617-22. 2010
    ..Antagonistic individuals, especially those who are manipulative and aggressive, have greater increases in arterial thickening, independent of traditional cardiovascular risk factors...
  41. pmc Is longitudinal pulse pressure a better predictor of 24-hour urinary albumin excretion than other indices of blood pressure?
    S Morteza Farasat
    MedStar Research Institute, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA
    Hypertension 55:415-21. 2010
    ..The pulsatile component of BP confers the highest risk for BP-induced renal microvascular injury. Future studies should examine whether PP reduction provides additional renoprotection beyond that attained by conventional BP goals alone...
  42. pmc Proinflammatory state, hepcidin, and anemia in older persons
    Luigi Ferrucci
    Intramural Research Program, National Institute on Aging, Baltimore, MD 21225, USA
    Blood 115:3810-6. 2010
    ..Future studies should test whether hepcidin production becomes up-regulated only in situations of overt inflammation...
  43. pmc Usefulness of uric acid to predict changes in C-reactive protein and interleukin-6 in 3-year period in Italians aged 21 to 98 years
    Carmelinda Ruggiero
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
    Am J Cardiol 100:115-21. 2007
    ..In conclusion, our study suggests that in a population-based cohort, baseline UA and changes in circulating UA during 3 years of follow-up predict changes in circulating CRP independent of relevant confounders, including baseline IL-6...
  44. pmc Impaired glucose tolerance in midlife and longitudinal changes in brain function during aging
    Madhav Thambisetty
    Clinical and Translational Neuroscience Unit, Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Neurobiol Aging 34:2271-6. 2013
    ..Our findings suggest that IGT in midlife is associated with subsequent longitudinal changes in brain function during aging even in cognitively normal older individuals. ..
  45. pmc Types of anemia and mortality among older disabled women living in the community: the Women's Health and Aging Study I
    Richard D Semba
    The Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Aging Clin Exp Res 19:259-64. 2007
    ..To classify the different types of anemia among moderately to severely disabled women living in the community and examine the relationship between types of anemia and mortality...
  46. pmc Personality and resilience to Alzheimer's disease neuropathology: a prospective autopsy study
    Antonio Terracciano
    National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Neurobiol Aging 34:1045-50. 2013
    ..In sum, a resilient personality profile is associated with lower risk or delay of clinical dementia even in persons with AD neuropathology...
  47. pmc Midlife obesity and trajectories of brain volume changes in older adults
    Ira Driscoll
    Laboratory of Personality and Cognition, National Institute on Aging, Baltimore, MD 21224, USA
    Hum Brain Mapp 33:2204-10. 2012
    ..Moreover, the discrepancies in findings between studies may be in part due to participant sampling and methodological differences...
  48. pmc Hearing loss and cognition in the Baltimore Longitudinal Study of Aging
    Frank R Lin
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Neuropsychology 25:763-70. 2011
    ..We hypothesized a priori that greater hearing loss is associated with lower cognitive test scores on tests of memory and executive function...
  49. pmc The interplay between uric acid and antioxidants in relation to physical function in older persons
    Carmelinda Ruggiero
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21225, USA
    J Am Geriatr Soc 55:1206-15. 2007
    ..To investigate the relationship between circulating uric acid (UA) levels and plasma antioxidants and whether antioxidant levels modulate the association between UA and physical function...
  50. ncbi Relationship of plasma polyunsaturated fatty acids to circulating inflammatory markers
    Luigi Ferrucci
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Harbor Hospital, 5th Floor, 3001 Hanover Street, Baltimore, MD 21225, USA
    J Clin Endocrinol Metab 91:439-46. 2006
    ..The protective effect of PUFAs is mediated by multiple mechanisms, including their antiinflammatory properties. The association of physiological PUFA levels with pro- and antiinflammatory markers has not been established...
  51. pmc Predictors of vitamin B6 and folate concentrations in older persons: the InCHIANTI study
    Anna Maria Gori
    Department of Medical and Surgical Critical Care, Multidisciplinary Centre of Research on Food Sciences G R A, University of Florence, Florence, Italy
    Clin Chem 52:1318-24. 2006
    ....
  52. ncbi Lower plasma vitamin E levels are associated with the frailty syndrome: the InCHIANTI study
    Alessandro Ble
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21225, USA
    J Gerontol A Biol Sci Med Sci 61:278-83. 2006
    ....
  53. pmc Circulating oxidized low-density lipoproteins are associated with overweight, obesity, and low serum carotenoids in older community-dwelling women
    Justine Beck
    Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Nutrition 24:964-8. 2008
    ....
  54. ncbi Relation of plasma leptin to C-reactive protein in older adults (from the Invecchiare nel Chianti study)
    Alessandro Ble
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA
    Am J Cardiol 96:991-5. 2005
    ..In conclusion, these findings suggest that leptin may directly stimulate the production of CRP independent of fat-cell produced cytokines in older adults...
  55. pmc Does prostate growth confound prostate specific antigen velocity? Data from the Baltimore longitudinal study of aging
    Stacy Loeb
    The James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions and National Institute on Aging, National Institutes of Health Clinical Research Branch, Baltimore, Maryland, USA
    J Urol 180:1314-7; discussion 1317. 2008
    ..Thus, we investigated the relationship between changes in prostate size and prostate specific antigen changes in a large cohort of men without prostate cancer...
  56. pmc Glucose and insulin measurements from the oral glucose tolerance test and mortality prediction
    E Jeffrey Metter
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21225, USA
    Diabetes Care 31:1026-30. 2008
    ..To verify what information from oral glucose tolerance tests (OGTTs) independently predicts mortality...
  57. pmc Inflammation and race and gender differences in computerized tomography-measured adipose depots
    Lydia E Beasley
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland, USA
    Obesity (Silver Spring) 17:1062-9. 2009
    ..Despite the previously established differences in abdominal fat distribution across gender and race, visceral fat remained a significant predictor of inflammatory marker concentration across all four subgroups examined...
  58. pmc Adipocytokines and the metabolic syndrome among older persons with and without obesity: the InCHIANTI study
    Sari Stenholm
    Clinical Research Branch, National Institute on Aging, 3001 S Hanover Street, Baltimore, MD 21225, USA
    Clin Endocrinol (Oxf) 73:55-65. 2010
    ..The purpose of this study was to: (1) examine the role of adipocytokines in the association between obesity and the MetS and (2) to determine whether the association is different in obese and non-obese persons...
  59. pmc The central arterial burden of the metabolic syndrome is similar in men and women: the SardiNIA Study
    Angelo Scuteri
    Laboratory of Cardiovascular Sciences, National Institute on Aging, NIH, Baltimore, USA
    Eur Heart J 31:602-13. 2010
    ..We evaluated whether specific clusters of metabolic syndrome (MetS) components differentially impact on arterial structure and function, and whether the impact is similar in men and in women...
  60. ncbi Age-associated changes in skeletal muscles and their effect on mobility: an operational diagnosis of sarcopenia
    Fulvio Lauretani
    Geriatric Department, Italian National Insitute of Research and Care on Aging, Florence, Italy
    J Appl Physiol 95:1851-60. 2003
    ..The findings of the study lay the basis for a cost-effective, clinical marker of sarcopenia based on a measure of isometric handgrip strength. Our findings should be verified in a longitudinal study...
  61. pmc Hearing loss and incident dementia
    Frank R Lin
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins School of Medicine, JHOC 6120, 601 N Caroline St, Baltimore, MD 21287, USA
    Arch Neurol 68:214-20. 2011
    ..To determine whether hearing loss is associated with incident all-cause dementia and Alzheimer disease (AD)...
  62. pmc Longitudinal patterns of β-amyloid deposition in nondemented older adults
    Jitka Sojkova
    Laboratory of Behavioral Neuroscience, National Institutes of Health Biomedical Research Center, National Institute on Aging, Intramural Research Program, 251 Bayview Blvd, Baltimore, MD 21224, USA
    Arch Neurol 68:644-9. 2011
    ..High levels of β-amyloid (Aβ) characterize Alzheimer disease...
  63. pmc Relationship of low-circulating "anti-aging" klotho hormone with disability in activities of daily living among older community-dwelling adults
    Candace L Crasto
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Rejuvenation Res 15:295-301. 2012
    ..Low plasma klotho concentrations were independently associated with ADL disability among older community-dwelling men and women...
  64. pmc Carotid atherosclerosis and prospective risk of dementia
    Carrington R Wendell
    Intramural Research Program, National Institute on Aging, NIH, 251 Bayview Blvd, Baltimore, MD 21224, USA
    Stroke 43:3319-24. 2012
    ..Although vascular risk factors have been implicated in the development of all-cause dementia and Alzheimer disease (AD), few studies have examined the association between subclinical atherosclerosis and prospective risk of dementia...
  65. pmc Relationship of serum fibroblast growth factor 21 with abnormal glucose metabolism and insulin resistance: the Baltimore Longitudinal Study of Aging
    Richard D Semba
    Department of Opthalmology, Johns Hopkins School of Medicine, Smith Building, 400 North Broadway, M015, Baltimore, Maryland 21287, USA
    J Clin Endocrinol Metab 97:1375-82. 2012
    ..The relationship of fibroblast growth factor 21 (FGF21) with glucose metabolism and insulin resistance has not been well characterized in community-dwelling adults...
  66. pmc Selective contribution of regional adiposity, skeletal muscle, and adipokines to glucose disposal in older adults
    Ramona Ramachandran
    Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21225, USA
    J Am Geriatr Soc 60:707-12. 2012
    ..To study the relationships between muscle mass, regional adiposity, and adipokines and glucose disposal in an older population...
  67. pmc Serum 25-hydroxyvitamin D, transitions between frailty states, and mortality in older adults: the Invecchiare in Chianti Study
    Michelle Shardell
    Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA
    J Am Geriatr Soc 60:256-64. 2012
    ..To assess whether serum 25-hydroxyvitamin D (25(OH)D) concentrations relate to transitions between the states of robustness, prefrailty, and frailty and to mortality in older adults...
  68. pmc Serum vitamin E concentrations and recovery of physical function during the year after hip fracture
    Christopher R D'Adamo
    Baltimore, MD 21201, USA
    J Gerontol A Biol Sci Med Sci 66:784-93. 2011
    ..Low serum concentrations of vitamin E have been associated with decline in physical function among older adults, but the role of vitamin E in physical recovery from hip fracture has never been explored...
  69. pmc Association between hormones and metabolic syndrome in older Italian men
    Marcello Maggio
    Clinical Research Branch, National Institute on Aging, Baltimore, Maryland 21225, USA
    J Am Geriatr Soc 54:1832-8. 2006
    ....
  70. pmc Low-serum carotenoid concentrations and carotenoid interactions predict mortality in US adults: the Third National Health and Nutrition Examination Survey
    Michelle D Shardell
    Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Nutr Res 31:178-89. 2011
    ..Interventions of balanced carotenoid combinations are needed for confirmation...
  71. pmc Gender differences in the accuracy of time-dependent blood pressure indices for predicting coronary heart disease: A random-effects modeling approach
    Larry J Brant
    Research Resources Branch, National Institute on Aging, Baltimore, Maryland, USA
    Gend Med 7:616-27. 2010
    ....
  72. pmc Association of low plasma selenium concentrations with poor muscle strength in older community-dwelling adults: the InCHIANTI Study
    Fulvio Lauretani
    Tuscany Regional Agency, Florence, Italy
    Am J Clin Nutr 86:347-52. 2007
    ..Although selenium plays an important role in muscle function, the relation between circulating selenium and muscle strength in elderly adults has not been characterized...
  73. ncbi Renal function, erythropoietin, and anemia of older persons: the InCHIANTI study
    Alessandro Ble
    Longitudinal Studies Section, National Institute on Aging, National Institutes of Health, Baltimore, MD 21225, USA
    Arch Intern Med 165:2222-7. 2005
    ..We tested the hypothesis that the age-related decline in kidney function is associated with an increased prevalence of anemia and that such an increase is accompanied by a concomitant decrement in erythropoietin levels...
  74. ncbi Correlation between testosterone and the inflammatory marker soluble interleukin-6 receptor in older men
    Marcello Maggio
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21225, USA
    J Clin Endocrinol Metab 91:345-7. 2006
    ..An age-associated decline in testosterone (T) levels and an increase in proinflammatory cytokines contribute to chronic diseases in older men. Whether and how these changes are related is unclear...
  75. pmc Carotenoids as protection against disability in older persons
    Fulvio Lauretani
    Tuscany Regional Agency, Florence, Italy
    Rejuvenation Res 11:557-63. 2008
    ..054, SE = 0.03, p = 0.04). High plasma carotenoids concentrations may be protective against the decline in walking speed and the development of severe walking disability in older adults...
  76. pmc Sex-specific correlates of walking speed in a wide age-ranged population
    Magdalena I Tolea
    Clinical Research Branch, National Institute on Aging, Harbor Hospital, 3001 South Hanover Street, Baltimore, MD 21225, USA
    J Gerontol B Psychol Sci Soc Sci 65:174-84. 2010
    ..If these patterns are confirmed in longitudinal studies, personality may be an important target for prevention...
  77. pmc Oxidative protein damage is associated with elevated serum interleukin-6 levels among older moderately to severely disabled women living in the community
    Margaret Dayhoff-Brannigan
    John Hopkins Medical Institutes, Baltimore, MD, USA
    J Gerontol A Biol Sci Med Sci 63:179-83. 2008
    ..Elevated interleukin (IL)-6 is associated with adverse outcomes. Our objective was to determine whether serum protein carbonyls, an indicator of oxidative protein damage and oxidative stress, were associated with IL-6...
  78. pmc Serum 25-hydroxyvitamin D and depressive symptoms in older women and men
    Yuri Milaneschi
    Longitudinal Studies Section, National Institute on Aging, Clinical Research Branch, Harbor Hospital Center, Room NM540, 3001 South Hanover Street, Baltimore, MD 21225, USA
    J Clin Endocrinol Metab 95:3225-33. 2010
    ..Hypovitaminosis D and depressive symptoms are common conditions in older adults...
  79. pmc Relationship between low levels of anabolic hormones and 6-year mortality in older men: the aging in the Chianti Area (InCHIANTI) study
    Marcello Maggio
    National Institute on Aging, National Institutes of Health, NIA Clinical Research Branch at Harbor Hospital, 3001 S Hanover Street, Baltimore, MD 21225, USA
    Arch Intern Med 167:2249-54. 2007
    ..We hypothesized that in older men a parallel age-associated decline in bioavailable testosterone, IGF-1, and DHEA-S secretion is associated with higher mortality independent of potential confounders...
  80. pmc Personality and metabolic syndrome
    Angelina R Sutin
    Laboratory of Personality and Cognition, National Institute on Aging, NIH, DHHS, 251 Bayview Blvd, Baltimore, MD 21224, USA
    Age (Dordr) 32:513-9. 2010
    ..The present research indicates that those with fewer psychological resources are more vulnerable to metabolic syndrome and suggests a psychological component to other established risk factors...
  81. pmc Low serum selenium concentrations are associated with poor grip strength among older women living in the community
    Justine Beck
    Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Biofactors 29:37-44. 2007
    ..04). This study supports the idea that selenium is important to muscle strength in older women...
  82. ncbi Designing randomized, controlled trials aimed at preventing or delaying functional decline and disability in frail, older persons: a consensus report
    Luigi Ferrucci
    Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
    J Am Geriatr Soc 52:625-34. 2004
    ....
  83. ncbi Insulin-like growth factor I and interleukin-6 contribute synergistically to disability and mortality in older women
    Anne R Cappola
    Department of Medicine, University of Maryland, Baltimore, Maryland 21201, USA
    J Clin Endocrinol Metab 88:2019-25. 2003
    ..The joint effects of IGF-I and IL-6 may be important targets for treatments to prevent or minimize disability associated with aging...
  84. pmc Characteristics of 400-meter walk test performance and subsequent mortality in older adults
    Sonja Vestergaard
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892 9205, USA
    Rejuvenation Res 12:177-84. 2009
    ..We conclude that multiple aspects of performance in the 400-meter walk test provide complementary information on mortality prognosis in older persons...
  85. ncbi Incidence of loss of ability to walk 400 meters in a functionally limited older population
    Milan Chang
    Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Am Geriatr Soc 52:2094-8. 2004
    ..To assess the incidence of and factors related to nondisabled but functionally limited older adults aged 75 to 85 years losing the ability to walk 400 m...
  86. ncbi Handgrip strength and cause-specific and total mortality in older disabled women: exploring the mechanism
    Taina Rantanen
    Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA
    J Am Geriatr Soc 51:636-41. 2003
    ....
  87. ncbi Black/white differences in the relationship between MMSE scores and disability: the Women's Health and Aging Study
    S G Leveille
    Epidemiology, Demography, and Biometry Program, National Institute on Aging, Bethesda, Maryland, USA
    J Gerontol B Psychol Sci Soc Sci 53:P201-8. 1998
    ..Since no explanation for these racial differences could be identified, these findings suggest that the MMSE may not be a valid predictor of functional difficulty in Black women who score > or = 18 on the instrument...
  88. pmc Low serum carotenoids are associated with a decline in walking speed in older women
    N Alipanah
    Johns Hopkins Medical Institutions, Baltimore, MD, USA
    J Nutr Health Aging 13:170-5. 2009
    ..The aim was to determine whether total serum carotenoid concentrations, a marker for fruit and vegetable intake, and serum selenium are related to changes in walking speed in older women...
  89. pmc Care available to severely disabled older persons living at home in Florence, Italy
    Mauro Di Bari
    Unit of Gerontology and Geriatrics, Department of Critical Care Medicine and Surgery, University of Florence and Azienda Ospedaliero Universitaria Careggi, Florence, Italy
    Aging Clin Exp Res 20:31-9. 2008
    ..To characterize the epidemiology of disability in, and the level of care available to, older community-dwellers in an Italian urban sample...
  90. ncbi Changes in anthropometric measures in men and women across the life-span: findings from the InCHIANTI study
    Benedetta Bartali
    Laboratory of Clinical Epidemiology, INRCA Geriatric Department, Florence
    Soz Praventivmed 47:336-48. 2002
    ..To describe the age distribution of anthropometric parameters in a population-based sample of older persons...
  91. pmc Changes in weight at the end of life: characterizing weight loss by time to death in a cohort study of older men
    Dawn E Alley
    Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Am J Epidemiol 172:558-65. 2010
    ..Results suggest that weight loss in older persons may begin earlier than previously believed. The duration of weight loss for noncancer deaths suggests that even distal changes in energy balance may be linked to risk of death...
  92. pmc Subclinical hypothyroidism and functional mobility in older adults
    Eleanor M Simonsick
    Clinical Research Branch, National Institute on Aging, Harbor Hospital, 3001 S Hanover St, Fifth Floor, Baltimore, MD 21225, USA
    Arch Intern Med 169:2011-7. 2009
    ..4 to <4.5 mIU/L), mild subclinical hypothyroid (>or=4.5 to <7.0 mIU/L), or moderate subclinical hypothyroid (>or=7.0 to <or=20.0 mIU/L with a normal free thyroxine level) cross-sectionally and over 2 years...
  93. ncbi Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care
    Linda P Fried
    Department of Medicine, The Johns Hopkins University School of Medicine and Bloomberg School of Public Health, Baltimore, MD 21205, USA
    J Gerontol A Biol Sci Med Sci 59:255-63. 2004
    ....
  94. pmc Characteristic gait patterns in older adults with obesity--results from the Baltimore Longitudinal Study of Aging
    Seung uk Ko
    Clinical Research Branch, NIA, Harbor Hospital, 3001 S Hanover Street, Baltimore, MD 21225, USA
    J Biomech 43:1104-10. 2010
    ..Since forward progression forces are mainly implicated in normal walking, this pattern found in obese participants is suggestive of lower energetic efficiency...
  95. pmc Mapping the road to resilience: novel math for the study of frailty
    Luigi Ferrucci
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21225, United States
    Mech Ageing Dev 129:677-9. 2008
    ....
  96. ncbi Summarizing amount of difficulty in ADLs: a refined characterization of disability. Results from the women's health and aging study
    G V Ostir
    Epidemiology, Demography and Biometry Program, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
    Aging (Milano) 13:465-72. 2001
    ..Additionally, it gives us a way to identify earlier functional changes, and a way to track the natural history of functional problems as well as a response to interventions...
  97. pmc [The role of professional activity in arterial hypertension]
    N Barbini
    Centro Epidemiologico, INRCA, Ancona, Italy
    G Ital Med Lav Ergon 29:174-81. 2007
    ..It seems in fact that "blue collar" workers are more at risk that "white collar" ones...
  98. pmc Plasma BDNF concentration, Val66Met genetic variant and depression-related personality traits
    A Terracciano
    Laboratory of Personality and Cognition, National Institute on Aging, Baltimore, MD 21224, USA
    Genes Brain Behav 9:512-8. 2010
    ..These findings challenge the prevailing hypothesis that lower peripheral levels of BDNF are a marker of depression...
  99. ncbi The hormonal pathway to frailty in older men
    M Maggio
    Clinical Research Branch, Longitudinal Studies Section, National Institute on Aging, National Institutes of Health, USA
    J Endocrinol Invest 28:15-9. 2005
    ..Observational and interventional studies will be needed to better define the role of "hormonal dysregulation", alone and in combination with other pathways, in the development of frailty in older men...
  100. pmc Longitudinal cognitive decline is associated with fibrillar amyloid-beta measured by [11C]PiB
    S M Resnick
    Laboratory of Personality and Cognition, National Institute on Aging, 251 Bayview Blvd BRC Room 4B335, Baltimore, MD 21224 6825, USA
    Neurology 74:807-15. 2010
    ..To investigate whether longitudinal declines in cognition are associated with higher fibrillar amyloid-beta (Abeta) deposition in vivo in individuals without dementia...
  101. ncbi Measuring higher level physical function in well-functioning older adults: expanding familiar approaches in the Health ABC study
    E M Simonsick
    Epidemiology, Demography, and Biometry Program, National Institute on Aging, Bethesda, Maryland, USA
    J Gerontol A Biol Sci Med Sci 56:M644-9. 2001
    ..This study evaluated the utility and concurrent validity of these expanded measures...