Carlo Ferrarese

Summary

Affiliation: University of Milano-Bicocca
Country: Italy

Publications

  1. ncbi Biological markers in Alzheimer disease
    Carlo Ferrarese
    Department of Neuroscience and Biomedical Technologies, University of Milano Bicocca, Via Donizetti 106, 20052 Mi, Monza, Italy
    Neurobiol Aging 24:191-3. 2003
  2. ncbi Fibroblast glutamate transport in aging and in AD: correlations with disease severity
    Chiara P Zoia
    Department of Neuroscience and Biomedical Technology, University of Milano Bicocca, Italy
    Neurobiol Aging 26:825-32. 2005
  3. ncbi Impairment of glutamate transport and increased vulnerability to oxidative stress in neuroblastoma SH-SY5Y cells expressing a Cu,Zn superoxide dismutase typical of familial amyotrophic lateral sclerosis
    Gessica Sala
    Department of Neuroscience and Biomedical Technologies, University of Milano Bicocca, Via Cadore, 48 20052 Monza MI, Italy
    Neurochem Int 46:227-34. 2005
  4. doi Alpha-synuclein nitration and autophagy response are induced in peripheral blood cells from patients with Parkinson disease
    Alessandro Prigione
    Laboratory of Neurobiology, Department of Neuroscience and Biomedical Technologies, University of Milan Bicocca, Italy
    Neurosci Lett 477:6-10. 2010
  5. ncbi Partial mitochondrial complex I inhibition induces oxidative damage and perturbs glutamate transport in primary retinal cultures. Relevance to Leber Hereditary Optic Neuropathy (LHON)
    Simone Beretta
    Department of Neuroscience and Biomedical Technologies, University of Milano Bicocca, Via Cadore 48, 20052 Monza MI, Italy
    Neurobiol Dis 24:308-17. 2006
  6. doi Lymphomonocyte alpha-synuclein levels in aging and in Parkinson disease
    Laura Brighina
    Laboratory of Neurobiology, Department of Neuroscience and Biomedical Technologies, University of Milano Bicocca, San Gerardo Hospital, Monza, Italy
    Neurobiol Aging 31:884-5. 2010
  7. ncbi Increased susceptibility to plasma lipid peroxidation in Alzheimer disease patients
    Carmen Galbusera
    Department of Neuroscience and Biomedical Technologies, University of Milano, Bicocca, Milan, Italy
    Curr Alzheimer Res 1:103-9. 2004
  8. pmc Substrate-induced modulation of glutamate uptake in human platelets
    Barbara Begni
    Department of Neuroscience and Biomedical Technologies, University of Milano Bicocca, Via Cadore, Monza MI 48 20052, Italy
    Br J Pharmacol 145:792-9. 2005
  9. doi Lack of evidence for oxidative stress in sporadic amyotrophic lateral sclerosis fibroblasts
    Gessica Sala
    Department of Neuroscience and Biomedical Technologies, University of Milano Bicocca, Milano, Italy
    Neurodegener Dis 6:9-15. 2009
  10. pmc Rotenone upregulates alpha-synuclein and myocyte enhancer factor 2D independently from lysosomal degradation inhibition
    Gessica Sala
    Laboratory of Neurobiology, Department of Surgery and Interdisciplinary Medicine, University of Milano Bicocca, Via Cadore 48, 20900 Monza, Italy
    Biomed Res Int 2013:846725. 2013

Detail Information

Publications82

  1. ncbi Biological markers in Alzheimer disease
    Carlo Ferrarese
    Department of Neuroscience and Biomedical Technologies, University of Milano Bicocca, Via Donizetti 106, 20052 Mi, Monza, Italy
    Neurobiol Aging 24:191-3. 2003
  2. ncbi Fibroblast glutamate transport in aging and in AD: correlations with disease severity
    Chiara P Zoia
    Department of Neuroscience and Biomedical Technology, University of Milano Bicocca, Italy
    Neurobiol Aging 26:825-32. 2005
    ..05 MMSE-expression, p<0.005 MMSE-mRNA). We suggest fibroblast cultures as possible ex vivo peripheral model to study the glutamate involvement and possible molecular and therapeutic targets in AD...
  3. ncbi Impairment of glutamate transport and increased vulnerability to oxidative stress in neuroblastoma SH-SY5Y cells expressing a Cu,Zn superoxide dismutase typical of familial amyotrophic lateral sclerosis
    Gessica Sala
    Department of Neuroscience and Biomedical Technologies, University of Milano Bicocca, Via Cadore, 48 20052 Monza MI, Italy
    Neurochem Int 46:227-34. 2005
    ..These findings might lead to the identification of new therapeutic strategies aimed at preventing the damage associated with ALS...
  4. doi Alpha-synuclein nitration and autophagy response are induced in peripheral blood cells from patients with Parkinson disease
    Alessandro Prigione
    Laboratory of Neurobiology, Department of Neuroscience and Biomedical Technologies, University of Milan Bicocca, Italy
    Neurosci Lett 477:6-10. 2010
    ..We discuss the relevance of these findings with respect to PD pathogenesis and biomarker development...
  5. ncbi Partial mitochondrial complex I inhibition induces oxidative damage and perturbs glutamate transport in primary retinal cultures. Relevance to Leber Hereditary Optic Neuropathy (LHON)
    Simone Beretta
    Department of Neuroscience and Biomedical Technologies, University of Milano Bicocca, Via Cadore 48, 20052 Monza MI, Italy
    Neurobiol Dis 24:308-17. 2006
    ..Our findings suggest that complex I-derived free radicals and disruption of glutamate transport might represent key elements for explaining the selective retinal ganglion cell death in LHON...
  6. doi Lymphomonocyte alpha-synuclein levels in aging and in Parkinson disease
    Laura Brighina
    Laboratory of Neurobiology, Department of Neuroscience and Biomedical Technologies, University of Milano Bicocca, San Gerardo Hospital, Monza, Italy
    Neurobiol Aging 31:884-5. 2010
    ..Our findings suggest that alpha-synuclein levels in lymphomonocytes are affected by age, gender, and by the 20S proteasome activity in control subjects, but they are not useful as a diagnostic biomarker for PD...
  7. ncbi Increased susceptibility to plasma lipid peroxidation in Alzheimer disease patients
    Carmen Galbusera
    Department of Neuroscience and Biomedical Technologies, University of Milano, Bicocca, Milan, Italy
    Curr Alzheimer Res 1:103-9. 2004
    ..Thus, oxidative stress, expressed as ex vivo susceptibility to lipid peroxidation, appears to be an early phenomenon, probably related to AD pathogenetic mechanisms...
  8. pmc Substrate-induced modulation of glutamate uptake in human platelets
    Barbara Begni
    Department of Neuroscience and Biomedical Technologies, University of Milano Bicocca, Via Cadore, Monza MI 48 20052, Italy
    Br J Pharmacol 145:792-9. 2005
    ....
  9. doi Lack of evidence for oxidative stress in sporadic amyotrophic lateral sclerosis fibroblasts
    Gessica Sala
    Department of Neuroscience and Biomedical Technologies, University of Milano Bicocca, Milano, Italy
    Neurodegener Dis 6:9-15. 2009
    ..A special category of experimental models is represented by peripheral cells obtained directly from patients (ex vivo)...
  10. pmc Rotenone upregulates alpha-synuclein and myocyte enhancer factor 2D independently from lysosomal degradation inhibition
    Gessica Sala
    Laboratory of Neurobiology, Department of Surgery and Interdisciplinary Medicine, University of Milano Bicocca, Via Cadore 48, 20900 Monza, Italy
    Biomed Res Int 2013:846725. 2013
    ..These results highlight that rotenone affects alpha-synuclein and MEF2D protein levels through a mechanism independent from lysosomal degradation inhibition. ..
  11. doi Cholinesterase inhibitor use is associated with increased plasma levels of anti-Aβ 1-42 antibodies in Alzheimer's disease patients
    Elisa Conti
    Department of Neuroscience and Biomedical Technologies, University of Milano Bicocca, San Gerardo Hospital, Via Cadore 48, 20052 Monza MI, Italy
    Neurosci Lett 486:193-6. 2010
    ..We suggest that a strategy aimed at increasing the endogenous response against this peptide might represent an interesting therapeutic target to be further investigated...
  12. doi Antioxidants partially restore glutamate transport defect in leber hereditary optic neuropathy cybrids
    Gessica Sala
    Department of Neuroscience and Biomedical Technologies, University of Milano Bicocca, Monza, Italy
    J Neurosci Res 86:3331-7. 2008
    ..We suggest that selected antioxidants may be clinically tested in LHON patients and relatives to restore glutamate uptake defect caused by LHON-associated free radical overproduction...
  13. doi Diazepam binding inhibitor and dehydroepiandrosterone sulphate plasma levels in borderline personality disorder adolescents
    Elisa Conti
    Neurology, San Gerardo Hospital, University of Milano Bicocca, Monza, Italy
    Neuropsychobiology 69:19-24. 2014
    ..e. neuroactive steroids...
  14. pmc Analysis of vesicular monoamine transporter 2 polymorphisms in Parkinson's disease
    Laura Brighina
    Department of Neurology, San Gerardo Hospital, Monza, Italy
    Neurobiol Aging 34:1712.e9-13. 2013
    ..This study adds to the previous evidence suggesting that variability in VMAT2 promoter region may confer a reduced risk of developing PD, presumably via mechanisms of gene overexpression...
  15. doi MELAS mitochondrial DNA mutation A3243G reduces glutamate transport in cybrids cell lines
    Jacopo C DiFrancesco
    Department of Neuroscience and Biomedical Technologies, University of Milano Bicocca, Monza, Italy
    Exp Neurol 212:152-6. 2008
    ..These data suggest that a defect of glutamate transport in MELAS neurons may be due to decreased energy production and might be involved in mediating the pathogenic effects of the A3243G mtDNA mutation...
  16. doi Vesicular monoamine transporter 2 mRNA levels are reduced in platelets from patients with Parkinson's disease
    Gessica Sala
    Department of Neuroscience and Biomedical Technologies, University of Milano Bicocca, Via Cadore, 48, 20052 Monza MI, Italy
    J Neural Transm (Vienna) 117:1093-8. 2010
    ....
  17. pmc Expression and distribution of 'high affinity' glutamate transporters GLT1, GLAST, EAAC1 and of GCPII in the rat peripheral nervous system
    Valentina Alda Carozzi
    Department of Neurosciences and Biomedical Technologies, University of Milano Bicocca, Monza MI, Italy
    J Anat 213:539-46. 2008
    ..Therefore, they are important both for understanding glutamatergic signalling in the PNS and for establishing new strategies to treat peripheral neuropathies...
  18. ncbi Enhanced GM1 ganglioside catabolism in cultured fibroblasts from Alzheimer patients
    Marina Pitto
    Department of Experimental, Environmental Medicine and Medical Biotechnology, University of Milano Bicocca, Via Cadore 48, 20052 Monza MI, Italy
    Neurobiol Aging 26:833-8. 2005
    ..The increased hydrolysis rate of sphingolipids could be taken as peripheral hallmark of Alzheimer's disease patients...
  19. doi Increased tissue factor pathway inhibitor and homocysteine in Alzheimer's disease
    Fabrizio Piazza
    Department of Neuroscience and Biomedical Technologies, University of Milano Bicocca, Monza MI, Italy
    Neurobiol Aging 33:226-33. 2012
    ..Therefore, TFPI may represent a candidate marker of endothelial damage in AD and might be used for the identification and monitoring of patients that would benefit from folate supplementation treatment...
  20. ncbi Increased plasma glutamate in stroke patients might be linked to altered platelet release and uptake
    Angelo Aliprandi
    Department of Neuroscience and Biomedical Technologies, University of Milano Bicocca, Monza MI, Italy
    J Cereb Blood Flow Metab 25:513-9. 2005
    ..Our data show a prolonged increase of glutamate in plasma after stroke, which might presumably be linked to altered platelet functions, such as excessive release of the amino acid or impaired uptake...
  21. pmc Association analysis of PARP1 polymorphisms with Parkinson's disease
    Laura Brighina
    Department of Neurology, San Gerardo Hospital, Monza, Italy
    Parkinsonism Relat Disord 17:701-4. 2011
    ..We conclude that, despite previous evidence, PARP1 is not a susceptibility gene for PD in our population...
  22. doi Nonfibrillar Abeta 1-42 inhibits glutamate uptake and phosphorylates p38 in human fibroblasts
    Chiara Paola Zoia
    Department of Neuroscience and Biomedical Technologies, University of Milano Bicocca, Via Cadore, Monza, Italy
    Alzheimer Dis Assoc Disord 25:164-72. 2011
    ..Thus, modulating complex kinase signaling pathway might represent a future therapeutic target in AD...
  23. doi BDNF Serum Levels with Respect to Multidimensional Assessment in Amyotrophic Lateral Sclerosis
    Lucio Tremolizzo
    Neurology Unit, San Gerardo Hospital, Monza, Italy
    Neurodegener Dis 16:192-8. 2016
    ..The clinical presentation of amyotrophic lateral sclerosis (ALS) is characterized by high heterogeneity, the greatest part of which still remains unexplained...
  24. doi MEF2D and MEF2C pathways disruption in sporadic and familial ALS patients
    Alessandro Arosio
    School of Medicine and Surgery and Milan Center for Neuroscience NeuroMI, University of Milano Bicocca, 20900 Monza, MB, Italy PhD Program in Neuroscience, University of Milano Bicocca, Italy Electronic address
    Mol Cell Neurosci 74:10-7. 2016
    ....
  25. doi Rotenone down-regulates HSPA8/hsc70 chaperone protein in vitro: A new possible toxic mechanism contributing to Parkinson's disease
    Gessica Sala
    Lab of Neurobiology, School of Medicine and Surgery, University of Milano Bicocca, Milano, Italy NeuroMI Milan Center for Neuroscience, University of Milano Bicocca, Milano, Italy Electronic address
    Neurotoxicology 54:161-9. 2016
    ....
  26. doi Reduced fasting plasma levels of diazepam-binding inhibitor in adolescents with anorexia nervosa
    Elisa Conti
    Neurology and Laboratory of Neurobiology, University of Milano Bicocca, San Gerardo Hospital, Monza, Italy
    Int J Eat Disord 46:626-9. 2013
    ..Diazepam-binding inhibitor (DBI) is an interesting peptide for understanding this crosstalk. The aim of this work was to assess fasting plasma levels of DBI and leptin in patients with AN...
  27. doi Platelets might mediate the increase of plasma glutamate in acute ischemic stroke: relevance for early neurological deterioration
    Lucio Tremolizzo
    Department of Neurology, San Gerardo Hospital, Monza, Italy
    Med Hypotheses 73:553-4. 2009
    ....
  28. ncbi Oxidative stress in peripheral blood mononuclear cells from patients with Parkinson's disease: negative correlation with levodopa dosage
    Alessandro Prigione
    Laboratory of Neurobiology, Department of Neuroscience and Biomedical Technologies, University of Milan Bicocca, Italy
    Neurobiol Dis 23:36-43. 2006
    ..Our data support the view of systemic oxidative stress involvement in PD and give further rationale for using PBMCs as an easily accessible ex-vivo dopaminergic model for exploring the biological effects of LD therapy...
  29. ncbi Peripheral markers of glutamatergic dysfunction in neurological diseases: focus on ex vivo tools
    Lucio Tremolizzo
    Department of Neurology, S Gerardo Hospital and University of Milano Bicocca, Monza, Italy
    Crit Rev Neurobiol 16:141-6. 2004
    ....
  30. doi Valproate induces epigenetic modifications in lymphomonocytes from epileptic patients
    Lucio Tremolizzo
    Dept of Neurology, S Gerardo Hospital, University of Milano Bicocca, Monza, Italy
    Prog Neuropsychopharmacol Biol Psychiatry 39:47-51. 2012
    ..We suggest that the epigenetic properties of VPA expressed on PBMC at these concentrations might be operative in different tissues, with possible implications for the field of neuropsychiatric disorders...
  31. doi Donepezil modulates the endogenous immune response: implications for Alzheimer's disease
    Elisa Conti
    Laboratory of Neurobiology, School of Medicine and Milan Center for Neuroscience, University of Milano Bicocca, Monza, Italy
    Hum Psychopharmacol 31:296-303. 2016
    ..We hypothesized the involvement of the cholinergic receptors [α7-nicotnic acetylcholine receptor (α7nAChR)] expressed on peripheral blood mononuclear cells (PBMC)...
  32. doi Beta-amyloid plasma levels in adolescents with anorexia nervosa of the restrictive type
    Elisa Conti
    Neurology Unit, Milan Center for Neuroscience Neuro MI, University of Milano Bicocca, Monza, Italy
    Neuropsychobiology 71:154-7. 2015
    ..AN subjects display several neuropsychiatric manifestations, which may entail Aβ-mediated altered synaptic functions. The aim of this study consisted in assessing Aβ plasma levels in AN patients...
  33. doi Paradoxical increase of plasma vitamin B12 and folates with disease severity in anorexia nervosa
    Fabiola Corbetta
    Department of Child and Adolescent Mental Health, San Gerardo Hospital and Department of Surgery and Translational Medicine, University of Milano Bicocca, Monza, Italy
    Int J Eat Disord 48:317-22. 2015
    ..The primary aim of this study consisted in assessing plasma levels of vitamin B12 and folates with respect to liver function enzymes considering the liver-storage properties of this vitamin...
  34. doi Positive signs of functional weakness
    Lucio Tremolizzo
    Section of Neurology, DCMT, University of Milano Bicocca, Milan, Italy San Gerardo Hospital, Monza, Italy Electronic address
    J Neurol Sci 340:13-8. 2014
    ....
  35. ncbi Leber hereditary optic neuropathy mtDNA mutations disrupt glutamate transport in cybrid cell lines
    Simone Beretta
    Department of Neuroscience and Biomedical Technologies, University of Milano Bicocca, San Gerardo Hospital, Monza, MI, Italy
    Brain 127:2183-92. 2004
    ..This observation is particularly relevant since EAAT1 is the major means of glutamate removal in the inner retina and this prevents retinal ganglion cells being damaged as a result of excitotoxicity...
  36. pmc Optimized system for cerebral perfusion monitoring in the rat stroke model of intraluminal middle cerebral artery occlusion
    Simone Beretta
    Department of Neuroscience and Biomedical Technologies, University of Milano Bicocca
    J Vis Exp . 2013
    ..A continuous and prolonged monitoring of cerebral perfusion could easily be obtained over the intact skull...
  37. doi TREX1 C-terminal frameshift mutations in the systemic variant of retinal vasculopathy with cerebral leukodystrophy
    Jacopo C DiFrancesco
    Department of Neurology, San Gerardo Hospital, Via Pergolesi 33, 20900, Monza, Italy
    Neurol Sci 36:323-30. 2015
    ..Here we confirm the causative role played by TREX1 autosomal dominant fs mutations disrupting the C-terminal of the protein, providing a model for the study of stroke in young adults. ..
  38. doi Behavioural But Not Cognitive Impairment Is a Determinant of Caregiver Burden in Amyotrophic Lateral Sclerosis
    Lucio Tremolizzo
    ALS Center, Neurology Unit, San Gerardo Hospital, Monza, Italy
    Eur Neurol 75:191-4. 2016
    ..Caregivers of patients affected by amyotrophic lateral sclerosis (ALS) are involved with great determination in the treatment process since the earliest stages of the disease with an increasing burden to be of help to the ailing persons...
  39. doi Muscle ultrasonography for detecting fasciculations in frontotemporal dementia
    Lucio Tremolizzo
    Neurology Unit, San Gerardo Hospital Monza and DCMT, University of Milano Bicocca, Italy
    Amyotroph Lateral Scler Frontotemporal Degener 15:546-50. 2014
    ..LMN dysfunction is a frequent condition in FTD and might identify a subset of patients with a different clinical course...
  40. doi Anti-amyloid β autoantibodies in cerebral amyloid angiopathy-related inflammation: implications for amyloid-modifying therapies
    Fabrizio Piazza
    Department of Neuroscience and Biomedical Technologies, University of Milano Bicocca, Monza, Italy
    Ann Neurol 73:449-58. 2013
    ..Herein, we investigated the role of anti-amyloid β (Aβ) autoantibodies in the acute and remission phases of CAA-ri...
  41. doi Post-methionine load test: A more sensitive tool to reveal hyperhomocysteinemia in Alzheimer patients?
    Gloria Galimberti
    Department of Neuroscience and Biomedical Technology, University of Milano Bicocca, Via Cadore 48, 20052 Monza MI, Italy
    Clin Biochem 41:914-6. 2008
    ..To identify the real number of hyperhomocysteinemic Alzheimer's patients who may benefit from homocysteine-lowering therapy...
  42. ncbi Oxidative stress impairs glutamate uptake in fibroblasts from patients with Alzheimer's disease
    Barbara Begni
    Department of Neuroscience and Biomedical Technologies, University of Milano Bicocca, 20052 Monza, Italy
    Free Radic Biol Med 37:892-901. 2004
    ..Therefore, we suggest fibroblast cultures as a tool for exploring pathogenetic mechanisms and possible therapeutic strategies in patients with AD...
  43. doi Increased soluble APPalpha, Abeta 1-42, and anti-Abeta 1-42 antibodies in plasma from down syndrome patients
    Elisa Conti
    Department of Neuroscience and Biomedical Technologies, San Gerardo Hospital, University of Milano Bicocca, Monza, Italy
    Alzheimer Dis Assoc Disord 24:96-100. 2010
    ..Our results suggested sAPPalpha as a possible peripheral marker for the alteration in APP metabolism in DS and highlighted an alteration in anti-abeta antibodies, for the first time evaluated in plasma from DS subjects...
  44. doi Giuseppe Ferrario and the epidemiology of apoplexy during the 19th century
    Michele Augusto Riva
    Section of History of Medicine, Department of Neuroscience and Biomedical Technologies, University of Milano Bicocca, Monza, Italy
    Neurology 79:1056-9. 2012
    ..To our knowledge, his work might have been the first to systematically investigate the epidemiology of cerebrovascular accidents, with the aim of shedding light on the underlying causes...
  45. doi Neuroligand binding endophenotypes in blood cells distinguish two subsets of borderline personality disorder patients
    Barbara Begni
    Department of Neuroscience and Biomedical Technologies, University of Milano Bicocca, Monza, Italy
    Neurosci Lett 462:144-6. 2009
    ..Further confirmation of the presence of different molecular endophenotypes underlying the dissimilar clinical presentations in BPD may advance our possibility of successfully treating these patients...
  46. ncbi Glutamate transporters in platelets: EAAT1 decrease in aging and in Alzheimer's disease
    Chiara Zoia
    Department of Neuroscience and Biomedical Technology, University of Milano Bicocca, 20052 Mi, Monza, Italy
    Neurobiol Aging 25:149-57. 2004
    ..Platelet glutamate transporters may be used as peripheral markers to investigate the role of glutamate in patients with neuropsychiatric disorders...
  47. doi Fahr's disease linked to a novel SLC20A2 gene mutation manifesting with dynamic aphasia
    Laura Brighina
    Department of Neurology, San Gerardo Hospital, Milan Center for Neuroscience, Monza, Italy
    Neurodegener Dis 14:133-8. 2014
    ....
  48. doi The Neurologist in Dante's Inferno
    Michele Augusto Riva
    Section of History of Medicine, Research Centre on Public Health, University of Milano Bicocca, Monza, Italy
    Eur Neurol 73:278-82. 2015
    ..The analysis of Dante's works confirms that poetry - as well as literature in general - may be an important source of information for historians of neurology...
  49. doi Primitive reflexes in amyotrophic lateral sclerosis: prevalence and correlates
    Lucio Tremolizzo
    Neurology Unit, ALS center and Memory Clinic, San Gerardo Hospital, Via Pergolesi 33, Monza, 20900, Italy
    J Neurol 261:1196-202. 2014
    ....
  50. doi A panel of macroautophagy markers in lymphomonocytes of patients with amyotrophic lateral sclerosis
    Gessica Sala
    Department of Neuroscience and Biomedical Technologies, University of Milano Bicocca Via Cadore 48, Monza MB, Italy
    Amyotroph Lateral Scler 13:119-24. 2012
    ....
  51. doi Diagnostic validity of optic disc and retinal nerve fiber layer evaluations in detecting structural changes after optic neuritis
    Francesca Bertuzzi
    Department of Ophthalmology, Ospedale Policlinico di Monza, University of Milano Bicocca, Monza, Italy
    Ophthalmology 117:1256-1264.e1. 2010
    ..To assess the diagnostic validity of morphometric examination of the optic disc and retinal nerve fiber layer (RNFL) thickness to detect permanent structural changes after retrobulbar optic neuritis (ON)...
  52. doi Rapidly cycling encephalopathy from an almost forgotten entity
    Lucio Tremolizzo
    Department of Neurology, S Gerardo Hospital, Monza, Italy
    Neurol Sci 29:125-6. 2008
  53. doi Treatment of transiently symptomatic acute internal carotid artery occlusion: learning from the interventional field
    Simone Beretta
    Acute Stroke Unit, Department of Neurology, San Gerardo Hospital, University of Milano Bicocca, Monza, Italy
    J Stroke Cerebrovasc Dis 18:458-9. 2009
    ..Transcranial ultrasound showed normal flow in the right middle and anterior cerebral arteries. How should he be treated?..
  54. doi Short term memory for single surface features and bindings in ageing: A replication study
    Valeria Isella
    DSTM, Milan Centre for Neurosciences, University of Milano Bicocca, Italy Neurology Unit, San Gerardo Hospital, Monza, Italy Electronic address
    Brain Cogn 96:38-42. 2015
    ..The absence of a specific deficit of short term memory for conjunctions of surface features seems to distinguish cognitive ageing from Alzheimer's Disease. ..
  55. doi The neuropsychiatric profile of posterior cortical atrophy
    Valeria Isella
    Department of Surgery and Translational Medicine, Milan Center for Neurosciences, University of Milan Bicocca, Milan, Italy Neurology Unit, S Gerardo Hospital, Monza, Italy
    J Geriatr Psychiatry Neurol 28:136-44. 2015
    ..In agreement with anecdotal reports, anxiety seems particularly relevant in PCA. ..
  56. doi Myasthenia gravis mimicking stroke: a case series with sudden onset dysarthria
    Lucio Tremolizzo
    Neurology Unit San Gerardo Hospital, DCMT and Neuro MI, University of Milano Bicocca, Via Cadore 48, 20900, Monza, Italy
    Neurol Sci 36:895-8. 2015
    ..In fact, even if myasthenia is a rare condition, lacunar stroke only with this clinical presentation is also unusual, and significant risks may arise (e.g., unexpected myasthenic crisis). ..
  57. doi Novel neurofibromatosis type 2 mutation presenting with status epilepticus
    Jacopo C DiFrancesco
    Department of Neurology, San Gerardo Hospital and Laboratory of Neurobiology, Department of Surgery and Interdisciplinary Medicine, University of Milano Bicocca, Monza
    Epileptic Disord 16:132-7. 2014
    ..Bioinformatic analyses revealed an important structural perturbation of the FERM domain, with a predicted impairment of the anti-tumour activity. ..
  58. ncbi A case of spinal epidural haematoma during breath-hold diving
    Lucio Tremolizzo
    Department of Neurology, University of Milano Bicocca, Monza, Italy
    Diving Hyperb Med 42:98-100. 2012
    ..Protracted minor trauma (neck flexion) and repeated Valsalva manoeuvres might have played a role in the genesis of this event. The role of decompression sickness is discussed as well...
  59. ncbi Association between serum values of C-reactive protein and cytokine production in whole blood of patients with type 2 diabetes
    Giovanna Castoldi
    Clinica Nefrologica, Az Ospedaliera San Gerardo, Monza, Italy
    Clin Sci (Lond) 113:103-8. 2007
    ....
  60. ncbi An unusual transthyretin gene missense mutation (TTR Phe33Val) linked to familial amyloidotic polyneuropathy
    Roberta Frigerio
    Department of Neuroscience and Biomedical Technologies, University of Milano Bicocca, Monza, Italy
    Amyloid 11:121-4. 2004
    ..This mutation has been previously reported only twice, without complete clinical descriptions...
  61. doi Mood disorder with psychotic symptoms and overlooked skin lesions: the strange case of Mrs. O
    Lucio Tremolizzo
    Department of Neurology, San Gerardo Hospital, Monza, Italy
    Riv Psichiatr 47:447-50. 2012
    ..This case stresses the importance for not discarding a priori neurological diagnoses when facing with psychiatric patients, especially when atypical details are present...
  62. pmc A case of classic neuromyelitis optica (Devic's syndrome) triggered by pegylated-interferon α
    Davide Mangioni
    Division of Infectious Diseases, Department of Internal Medicine, San Gerardo Hospital, University of Milano Bicocca, 20900 Monza, Italy
    BMC Pharmacol Toxicol 15:56. 2014
    ..Despite recent development of direct acting antivirals for treatment of hepatitis C, the current standard of care may still include pegylated-interferon, which is associated with frequent and, at times, serious adverse events...
  63. ncbi Anatomical identification of active contacts in subthalamic deep brain stimulation
    Francesco Vergani
    Department of Neurosciences and Medical Biotechnologies, University of Milano Bicocca, 20052 Monza, Italy
    Surg Neurol 67:140-6; discussion 146-7. 2007
    ..Identifying the location of active contacts for StnDBS can yield interesting insights on the mechanisms of action of DBS and the different role played by the anatomical structures of the subthalamic region...
  64. doi Sleepwalking in Italian operas: a window on popular and scientific knowledge on sleep disorders in the 19th century
    Michele Augusto Riva
    Research Centre on the History of Biomedical Thought, Department of Clinical and Preventive Medicine, University of Milano Bicocca, and Department of Cardiology, S Luca Hospital, IRCCS, Istituto Auxologico Italiano, Monza, Italy
    Eur Neurol 63:116-21. 2010
    ..At the same time, this analysis throws some light on the history of psychological illnesses...
  65. ncbi On scrapie interference and artificial prions
    Lucio Tremolizzo
    Laboratory of Neurobiology, D N T B, University of Milano Bicocca, S Gerardo Hospital, Villa Serena 4 p Sud, Via Donizetti 106, 20052 Monza MI, Italy
    Med Hypotheses 63:838-40. 2004
    ..In this paper the two aforementioned strategies are outlined, briefly discussing the consequent implications for TSE therapy...
  66. ncbi Peripheral cytokine release in Alzheimer patients: correlation with disease severity
    Gessica Sala
    Department of Neurology, University of Milano Bicocca, San Gerardo Hospital, Via Donizetti, 106, Monza 20052 MI, Italy
    Neurobiol Aging 24:909-14. 2003
    ..IL-1beta, IL-6 and TNF-alpha secretion was negatively correlated with the severity of dementia, quantified by the MMSE. Our data suggest that alterations of the immune profile are associated with AD progression...
  67. ncbi Altered glutamate uptake in peripheral tissues from Down syndrome patients
    Barbara Begni
    Department of Neuroscience and Biomedical Technologies, University of Milano Bicocca, Milan, Italy
    Neurosci Lett 343:73-6. 2003
    ..Systemic impairment of glutamate uptake in DS is suggested, probably related to APP overexpression and mitochondrial dysfunction. Such mechanisms may contribute to neurodegeneration and dementia development in these patients...
  68. doi Enhanced folate binding of cultured fibroblasts from Alzheimer's disease patients
    Emanuela Cazzaniga
    Department of Experimental Medicine, University of Milano Bicocca Via Cadore 48, 20052 Monza, MI, Italy
    Neurosci Lett 436:317-20. 2008
    ..01; n=8) higher (2-4-fold) with respect to controls. RT-PCR experiments suggest that the higher folate binding could be due to an enhanced expression in AD fibroblasts of folate receptor alpha...
  69. ncbi Mitochondrial dysfunction due to mutant copper/zinc superoxide dismutase associated with amyotrophic lateral sclerosis is reversed by N-acetylcysteine
    Simone Beretta
    Department of Neuroscience and Biomedical Technologies, University of Milano Bicocca, San Gerardo Hospital, Via Donizetti, 106, 20052, Monza MI, Italy
    Neurobiol Dis 13:213-21. 2003
    ..Our findings indicate that mitochondrial homeostasis is affected by mutant SOD1-generated ROS independently from the formation of aggregates and that this alteration is reversed by antioxidants...
  70. ncbi Pathogenesis of retinal ganglion cell death in Leber hereditary optic neuropathy (LHON): possible involvement of mitochondria, light and glutamate
    Simone Beretta
    Mitochondrion 6:102-3. 2006
  71. ncbi Assessing early to late stage dementia: the TSI and BANS-S scales in the nursing-home
    Ildebrando Appollonio
    Mons L Biraghi Nursing home, Cernusco S N MI, Italy
    Int J Geriatr Psychiatry 20:1138-45. 2005
    ..Specific observational and performance-based instruments were recently developed...
  72. ncbi Peripheral markers of oxidative stress and excitotoxicity in neurodegenerative disorders: tools for diagnosis and therapy?
    Maurizio Facheris
    Department of Neurosciences and Biomedical Technologies University of Milano Bicocca, Italy
    J Alzheimers Dis 6:177-84. 2004
    ....
  73. ncbi The sinister side of Italian soccer
    Simone Beretta
    Department of Neuroscience, University of Milano Bicocca, Milan, Italy
    Lancet Neurol 2:656-7. 2003
  74. ncbi Is M129V of PRNP gene associated with Alzheimer's disease? A case-control study and a meta-analysis
    Roberto Del Bo
    Dino Ferrari Centre, Department of Neurological Sciences, University of Milan and Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Padiglione Ponti, Milano, Italy
    Neurobiol Aging 27:770.e1-770.e5. 2006
    ..We also observed that MM genotype and M allele represent a risk factor for AD, independently from the ethnic background, providing a significant but modest association between this polymorphism and AD...
  75. ncbi Is the inverse association between Alzheimer's disease and cancer the result of a different propensity to methylate DNA?
    Lucio Tremolizzo
    Med Hypotheses 66:1251-2. 2006
  76. ncbi Glutamate may be the soluble cerebrospinal fluid factor that induces calcium dysregulation in cultured astrocytes in HIV dementia
    Lucio Tremolizzo
    AIDS 16:1691-2; author reply 1692-3. 2002
  77. doi Lack of evidence for Borrelia burgdorferi seropositivity in Alzheimer disease
    Alessio Galbussera
    Alzheimer Dis Assoc Disord 22:308. 2008
  78. ncbi Mitochondrial DNA haplogroup K is associated with a lower risk of Parkinson's disease in Italians
    Daniele Ghezzi
    Unit of Molecular Neurogenetics, National Neurological Institute, Carlo Besta, Milan, Italy
    Eur J Hum Genet 13:748-52. 2005
    ..Our study suggests that haplogroup K might confer a lower risk for PD in Italians, corroborating the idea that the mitochondrial oxidative phosphorylation pathway is involved in the susceptibility to idiopathic PD...
  79. ncbi Vascular endothelial growth factor gene variability is associated with increased risk for AD
    Roberto Del Bo
    Department of Neurological Sciences, Dino Ferrari Centre and Centre of Excellence on Neurodegenerative Diseases, University of Milan, I R C C S Ospedale Maggiore Policlinico, Via F Sforza 35, 20122 Milan, Italy
    Ann Neurol 57:373-80. 2005
    ..These findings suggest that polymorphisms within the promoter region of the VEGF gene confer greater risk for AD, probably by reducing its neuroprotective effect, and confirm the biological role of VEGF in neurodegenerative processes...
  80. ncbi Clinical, neuropsychological, and morphometric correlates of apathy in Parkinson's disease
    Valeria Isella
    Neurological Department, University of Milan Bicocca, S Gerardo Hospital, Monza MI, Italy
    Mov Disord 17:366-71. 2002
    ..Thus, apathy seems to be a frequent and important companion of PD, in many cases probably due to a primary motivational impairment, possibly related to a frontosubcortical dysfunction...
  81. ncbi Pharmacological manipulation of glutamate transport
    Simone Beretta
    Department of Neuroscience and Biomedical Technologies, University of Milano Bicocca, San Gerardo Hospital, Monza, Italy
    Drug News Perspect 16:435-45. 2003
    ..New insight into molecular pathways involved in EAAT regulation will allow pharmacological manipulation of excitatory CNS activity, possibly avoiding adverse effects of glutamate receptor blockade...
  82. ncbi Young-onset CJD: age and disease phenotype in variant and sporadic forms
    Manuel Corato
    Laboratory of Experimental Neurobiology, IRCCS C Mondino Institute of Neurology Foundation, Pavia, Italy
    Funct Neurol 21:211-5. 2006
    ..5 years. Our series displays a long disease duration and other vCJD-like features, suggesting that CJD in young people is different from classic CJD and that the vCJD phenotype may be partly related to young age...