Romana Fato

Summary

Affiliation: University of Bologna
Country: Italy

Publications

  1. pmc Pro-apoptotic activity of α-bisabolol in preclinical models of primary human acute leukemia cells
    Elisabetta Cavalieri
    Department of Medicine, Section of Hematology, University of Verona, Italy
    J Transl Med 9:45. 2011
  2. ncbi Mitochondrial production of reactive oxygen species: role of complex I and quinone analogues
    Romana Fato
    Dipartimento di Biochimica G Moruzzi, University of Bologna, 40126 Bologna, Italy
    Biofactors 32:31-9. 2008
  3. doi Toward a rational design of multitarget-directed antioxidants: merging memoquin and lipoic acid molecular frameworks
    Maria Laura Bolognesi
    Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy
    J Med Chem 52:7883-6. 2009
  4. doi Polyamine conjugation of curcumin analogues toward the discovery of mitochondria-directed neuroprotective agents
    Elena Simoni
    Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy
    J Med Chem 53:7264-8. 2010
  5. ncbi Potential antitumor agents. 37. Synthesis and antitumor activity of guanylhydrazones from imidazo[2,1-b]thiazoles and from the new heterocyclic system thiazolo[2',3':2,3]imidazo[4,5-c]quinoline
    Aldo Andreani
    Dipartimento di Scienze Farmaceutiche, Universita di Bologna, Via Belmeloro 6, 40126 Bologna, Italy
    J Med Chem 48:3085-9. 2005
  6. pmc Differential effects of mitochondrial Complex I inhibitors on production of reactive oxygen species
    Romana Fato
    Dipartimento di Biochimica G Moruzzi, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
    Biochim Biophys Acta 1787:384-92. 2009
  7. doi Mitochondrial respiratory chain super-complex I-III in physiology and pathology
    Giorgio Lenaz
    Dipartimento di Biochimica, Universita di Bologna, Via Irnerio 48, 40126 Bologna, Italy
    Biochim Biophys Acta 1797:633-40. 2010
  8. pmc A water soluble CoQ10 formulation improves intracellular distribution and promotes mitochondrial respiration in cultured cells
    Christian Bergamini
    Department of Biochemistry G Moruzzi, University of Bologna, Bologna, Italy
    PLoS ONE 7:e33712. 2012
  9. ncbi Structural and functional organization of Complex I in the mitochondrial respiratory chain
    Cristina Bianchi
    Universtiy of Bologna, Bologna, Italy
    Biofactors 18:3-9. 2003
  10. ncbi The role of Coenzyme Q in mitochondrial electron transport
    Giorgio Lenaz
    Dipartimento di Biochimica, Universita di Bologna, Via Irnerio 48, 40126 Bologna, Italy
    Mitochondrion 7:S8-33. 2007

Collaborators

Detail Information

Publications30

  1. pmc Pro-apoptotic activity of α-bisabolol in preclinical models of primary human acute leukemia cells
    Elisabetta Cavalieri
    Department of Medicine, Section of Hematology, University of Verona, Italy
    J Transl Med 9:45. 2011
    ..Here we studied the activity of α-bisabolol in acute leukemia cells...
  2. ncbi Mitochondrial production of reactive oxygen species: role of complex I and quinone analogues
    Romana Fato
    Dipartimento di Biochimica G Moruzzi, University of Bologna, 40126 Bologna, Italy
    Biofactors 32:31-9. 2008
    ....
  3. doi Toward a rational design of multitarget-directed antioxidants: merging memoquin and lipoic acid molecular frameworks
    Maria Laura Bolognesi
    Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy
    J Med Chem 52:7883-6. 2009
    ..They also displayed a balanced inhibitory profile against amyloid-beta aggregation and acetylcholinesterase, emerging as promising molecules for neuroprotectant lead discovery...
  4. doi Polyamine conjugation of curcumin analogues toward the discovery of mitochondria-directed neuroprotective agents
    Elena Simoni
    Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy
    J Med Chem 53:7264-8. 2010
    ..It also resulted in a significant decrease in the cytotoxicity effects. 2-5 are therefore promising molecules for neuroprotectant lead discovery...
  5. ncbi Potential antitumor agents. 37. Synthesis and antitumor activity of guanylhydrazones from imidazo[2,1-b]thiazoles and from the new heterocyclic system thiazolo[2',3':2,3]imidazo[4,5-c]quinoline
    Aldo Andreani
    Dipartimento di Scienze Farmaceutiche, Universita di Bologna, Via Belmeloro 6, 40126 Bologna, Italy
    J Med Chem 48:3085-9. 2005
    ....
  6. pmc Differential effects of mitochondrial Complex I inhibitors on production of reactive oxygen species
    Romana Fato
    Dipartimento di Biochimica G Moruzzi, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
    Biochim Biophys Acta 1787:384-92. 2009
    ..The results suggest that electron transfer from the iron-sulphur clusters (N2) to Coenzyme Q occurs in two steps gated by two different conformations, the former being sensitive to Rotenone and the latter to Stigmatellin...
  7. doi Mitochondrial respiratory chain super-complex I-III in physiology and pathology
    Giorgio Lenaz
    Dipartimento di Biochimica, Universita di Bologna, Via Irnerio 48, 40126 Bologna, Italy
    Biochim Biophys Acta 1797:633-40. 2010
    ..There is increasing evidence that disruption of the super-complex organization leads to functional derangements responsible for pathological changes, as we have found in K-ras-transformed fibroblasts...
  8. pmc A water soluble CoQ10 formulation improves intracellular distribution and promotes mitochondrial respiration in cultured cells
    Christian Bergamini
    Department of Biochemistry G Moruzzi, University of Bologna, Bologna, Italy
    PLoS ONE 7:e33712. 2012
    ..Controversial clinical and in vitro results are mainly due to the high hydrophobicity of this compound, which reduces its bioavailability...
  9. ncbi Structural and functional organization of Complex I in the mitochondrial respiratory chain
    Cristina Bianchi
    Universtiy of Bologna, Bologna, Italy
    Biofactors 18:3-9. 2003
    ....
  10. ncbi The role of Coenzyme Q in mitochondrial electron transport
    Giorgio Lenaz
    Dipartimento di Biochimica, Universita di Bologna, Via Irnerio 48, 40126 Bologna, Italy
    Mitochondrion 7:S8-33. 2007
    ..metabolic channeling, respectively, both in physiological and in some pathological conditions. As an example of intra-complex electron transfer, we discuss in particular Complex I, a topic that is still under active investigation...
  11. ncbi Effects of new ubiquinone-imidazo[2,1-b]thiazoles on mitochondrial complex I (NADH-ubiquinone reductase) and on mitochondrial permeability transition pore
    Aldo Andreani
    Dipartimento di Scienze Farmaceutiche, Universita di Bologna, Via Belmeloro 6, 40126 Bologna, Italy
    Bioorg Med Chem 12:5525-32. 2004
    ..Unlike CoQ(0), which is considered a mitochondrial membrane permeability transition inhibitor, the new compounds were inducers...
  12. ncbi Mitochondrial Complex I: structural and functional aspects
    Giorgio Lenaz
    Department of Biochemistry, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
    Biochim Biophys Acta 1757:1406-20. 2006
    ..The implications in human pathology of better knowledge on these aspects of Complex I structure and function are briefly discussed...
  13. ncbi New insights into structure and function of mitochondria and their role in aging and disease
    Giorgio Lenaz
    Dipartimento di Biochimica, Universita di Bologna, Bologna, Italy
    Antioxid Redox Signal 8:417-37. 2006
    ..Evidence is presented favoring the mitochondrial theory, with primary mitochondrial alterations, although the problem is made more complex by changes in the cross-talk between nuclear and mitochondrial DNA...
  14. ncbi Mitochondrial Complex I: structure, function, and implications in neurodegeneration
    Giorgio Lenaz
    Dipartimento di Biochimica G Moruzzi, Universita di Bologna, Italy
    Ital J Biochem 55:232-53. 2006
    ....
  15. doi Generation of reactive oxygen species by mitochondrial complex I: implications in neurodegeneration
    Romana Fato
    Dipartimento di Biochimica G Moruzzi, Universita di Bologna, Via Irnerio 48, 40126, Bologna, Italy
    Neurochem Res 33:2487-501. 2008
    ....
  16. doi 2-Phenoxy-1,4-naphthoquinones: From a Multitarget Antitrypanosomal to a Potential Antitumor Profile
    Federica Prati
    Department of Pharmacy and Biotechnology, Alma Mater Studiorum University of Bologna, Via Belmeloro 6 Via Irnerio 48, 40126 Bologna, Italy
    J Med Chem 58:6422-34. 2015
    ..Overall, the development of further derivatives, able to finely modulate multiple pathways of cancer or parasite cell metabolism, might lead to more effective treatments against these devastating diseases. ..
  17. pmc Naphthoquinone derivatives exert their antitrypanosomal activity via a multi-target mechanism
    Simone Pieretti
    Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy
    PLoS Negl Trop Dis 7:e2012. 2013
    ..To disclose such a multitarget profile of B6, we exploited a chemical proteomics approach...
  18. ncbi Enhanced activity of the plasma membrane oxidoreductase in circulating lymphocytes from insulin-dependent diabetes mellitus patients
    Giorgio Lenaz
    Dipartimento di Biochimica, Universita di Bologna, Via Irnerio 48, Bologna 40126, Italy
    Biochem Biophys Res Commun 290:1589-92. 2002
    ..The increase of PMOR in diabetes is likely due to overexpression of the enzyme, in view of the very low K(m) for NADH indicating that, in intact cells, the enzyme is practically saturated with the reductant substrate...
  19. pmc Polyamine Conjugation as a Promising Strategy To Target Amyloid Aggregation in the Framework of Alzheimer's Disease
    Elena Simoni
    Department of Pharmacy and Biotechnology, Alma Mater Studiorum University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy
    ACS Med Chem Lett 7:1145-1150. 2016
    ..Hence, we propose polyamine conjugation as a promising strategy for the development of neuroprotectant leads that may contribute to decipher the complex picture of Aβ toxicity...
  20. ncbi Novel class of quinone-bearing polyamines as multi-target-directed ligands to combat Alzheimer's disease
    Maria Laura Bolognesi
    Department of Pharmaceutical Sciences, Alma Mater Studiorum, University of Bologna, Via Belmeloro 6, Italy
    J Med Chem 50:4882-97. 2007
    ....
  21. doi Role of mitochondrial complex I and protective effect of CoQ10 supplementation in propofol induced cytotoxicity
    Christian Bergamini
    Department of Pharmacy and Biotechnology, University of Bologna, Via Irnerio 48, Bologna, Italy
    J Bioenerg Biomembr 48:413-23. 2016
    ..The site of propofol inhibition on Complex I is the Q module. CoQ10 supplementation protects cells against the loss of energy suggesting its possible therapeutic role to minimizing the detrimental effects of general anaesthesia. ..
  22. doi Versatility of the Curcumin Scaffold: Discovery of Potent and Balanced Dual BACE-1 and GSK-3β Inhibitors
    Rita Maria Concetta Di Martino
    Department of Pharmacy and Biotechnology, Alma Mater Studiorum University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy
    J Med Chem 59:531-44. 2016
    ..Notably, for some new compounds the symmetrical diketo and the β-keto-enol tautomeric forms were purposely isolated and tested in vitro, allowing us to gain insight into the key requirements for BACE-1 and GSK-3β inhibition...
  23. ncbi Role of mitochondria in oxidative stress and aging
    Giorgio Lenaz
    Dipartimento di Biochimica G Moruzzi, Universita di Bologna, Via Irnerio 48, 40126 Bologna, Italy
    Ann N Y Acad Sci 959:199-213. 2002
    ..The plasma membrane oxidoreductase and DT-diaphorase are two such systems: likewise, they are overexpressed under oxidative stress conditions...
  24. doi Synthesis of new lipoic acid conjugates and evaluation of their free radical scavenging and neuroprotective activities
    Maria Laura Bolognesi
    Department of Pharmacy and Biotechnology, University of Bologna, Via Belmeloro 6 and Via Irnerio 4, 40126, Bologna, Italy
    Chem Biol Drug Des 83:688-96. 2014
    ..However, these promising in vitro results were not mirrored by the antioxidant activity in T67 cell line. This suggests that multiple factors are at stake and warrant further investigations. ..
  25. pmc Hydrophobic alpha-helices 1 and 2 of herpes simplex virus gH interact with lipids, and their mimetic peptides enhance virus infection and fusion
    Tatiana Gianni
    Department of Experimental Pathology, Section on Microbiology and Virology, University of Bologna, Via San Giacomo, 12 40126 Bologna, Italy
    J Virol 80:8190-8. 2006
    ..However, alpha-H2 differs from alpha-H1 in that it is of lower hydrophobicity and cannot be replaced with heterologous fusion peptides...
  26. doi Synthesis, cytotoxicity and anti-cancer activity of new alkynyl-gold(I) complexes
    Assunta De Nisi
    Department of Chemistry G Ciamician, Alma Mater Studiorum University of Bologna, Via Selmi 2, 40126 Bologna, Italy
    Dalton Trans 45:1546-53. 2016
    ..In particular the lead compound 3ab was identified as the most active compound in all cell lines (IC50: 1.7-7.9 μM). ..
  27. pmc Antiinflammatory effect of phytosterols in experimental murine colitis model: prevention, induction, remission study
    Rita Aldini
    Department of Pharmacy and Biotecnology, University of Bologna, Bologna, Italy
    PLoS ONE 9:e108112. 2014
    ..Phytosterols seem a potential nutraceutical tool for gastrointestinal inflammatory diseases, combining metabolic systematic and local anti-inflammatory effects. ..
  28. ncbi Yessotoxin, a shellfish biotoxin, is a potent inducer of the permeability transition in isolated mitochondria and intact cells
    Cristina Bianchi
    Department of Biochemistry G Moruzzi, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
    Biochim Biophys Acta 1656:139-47. 2004
    ....
  29. pmc Infection of human monocytes by Chlamydia pneumoniae and Chlamydia trachomatis: an in vitro comparative study
    Antonella Marangoni
    Microbiology, DIMES, University of Bologna, S, Orsola Hospital, Via Massarenti 9, 40138 Bologna, Italy
    BMC Res Notes 7:230. 2014
    ..The aim of this study was to comparatively evaluate Chlamydia pneumoniae (CP) and Chlamydia trachomatis (CT) interactions with in vitro infected human blood monocytes...
  30. doi Noise-induced hearing loss (NIHL) as a target of oxidative stress-mediated damage: cochlear and cortical responses after an increase in antioxidant defense
    Anna Rita Fetoni
    Institute of Otolaryngology, Catholic University School of Medicine, I 00168 Rome, Italy
    J Neurosci 33:4011-23. 2013
    ....