Fabio Farinati

Summary

Affiliation: University of Padova
Country: Italy

Publications

  1. pmc Bax inhibitor-1 down-regulation in the progression of chronic liver diseases
    Andromachi Kotsafti
    Department of Surgical and Gastroenterological Sciences, University of Padua, Padua, Italy
    BMC Gastroenterol 10:35. 2010
  2. pmc Octreotide and hepatocellular carcinoma
    F Farinati
    Br J Cancer 96:1778-9. 2007
  3. doi request reprint Liver transplantation for hepatocellular carcinoma in clinical practice: the lesson from a 20-year multicentre experience in Italy
    Fabio Farinati
    Department of Surgical and Gastroenterological Sciences, Section of Gastroenterology, University of Padova, Padova, Italy
    Eur J Gastroenterol Hepatol 24:195-202. 2012
  4. pmc Nidogen 1 and 2 gene promoters are aberrantly methylated in human gastrointestinal cancer
    Linda Ulazzi
    Dipartimento di Medicina Sperimentale e Diagnostica e Centro Interdipartimentale per la Ricerca sul Cancro, Universita di Ferrara, Ferrara, Italy
    Mol Cancer 6:17. 2007
  5. pmc Tumor marker utility and prognostic relevance of cathepsin B, cathepsin L, urokinase-type plasminogen activator, plasminogen activator inhibitor type-1, CEA and CA 19-9 in colorectal cancer
    Laszlo Herszenyi
    2nd Department of Medicine, Semmelweis University, Budapest Hungarian Academy of Science, Clinical Gastroenterology Research Unit, Budapest, Hungary
    BMC Cancer 8:194. 2008
  6. ncbi request reprint Estrogens receptors and oxidative damage in the liver
    Fabio Farinati
    Dipartimento di Scienze Chirurgiche e Gastroenterologiche, Sezione di Gastroenterologia, Universita di Padova, Via Giustiniani 2, 35128 Padova, Italy
    Mol Cell Endocrinol 193:85-8. 2002
  7. ncbi request reprint Differential effects of Helicobacter pylori eradication on oxidative DNA damage at the gastroesophageal junction and at the gastric antrum
    Fabio Farinati
    Dipartimento di Scienze Chirurgiche e Gastroenterologiche, Sezione di Gastroenterologia, Policlinico Universitario, Via Giustiniani 2, 35128 Padova, Italy
    Cancer Epidemiol Biomarkers Prev 13:1722-8. 2004
  8. pmc Oxidative damage, pro-inflammatory cytokines, TGF-alpha and c-myc in chronic HCV-related hepatitis and cirrhosis
    Fabio Farinati
    Department of Surgical and Gastroenterological Sciences, University of Padua, Italy
    World J Gastroenterol 12:2065-9. 2006
  9. ncbi request reprint Hepatitis C virus: from oxygen free radicals to hepatocellular carcinoma
    F Farinati
    Dipartimento di Scienze Chirurgiche e Gastroenterologiche, Sezione di Gastroenterologia, Policlinico Universitario, Universita di Padova, Padova, Italy
    J Viral Hepat 14:821-9. 2007
  10. doi request reprint Oxidative DNA damage in gastric cancer: CagA status and OGG1 gene polymorphism
    Fabio Farinati
    Dipartimento di Scienze Chirurgiche e Gastroenterologiche, Universita di Padova, Padova, Italy
    Int J Cancer 123:51-5. 2008

Detail Information

Publications102 found, 100 shown here

  1. pmc Bax inhibitor-1 down-regulation in the progression of chronic liver diseases
    Andromachi Kotsafti
    Department of Surgical and Gastroenterological Sciences, University of Padua, Padua, Italy
    BMC Gastroenterol 10:35. 2010
    ....
  2. pmc Octreotide and hepatocellular carcinoma
    F Farinati
    Br J Cancer 96:1778-9. 2007
  3. doi request reprint Liver transplantation for hepatocellular carcinoma in clinical practice: the lesson from a 20-year multicentre experience in Italy
    Fabio Farinati
    Department of Surgical and Gastroenterological Sciences, Section of Gastroenterology, University of Padova, Padova, Italy
    Eur J Gastroenterol Hepatol 24:195-202. 2012
    ..Hepatocellular carcinoma (HCC) is an established indication for liver transplantation (LT), but the selection criteria and priority are still debated...
  4. pmc Nidogen 1 and 2 gene promoters are aberrantly methylated in human gastrointestinal cancer
    Linda Ulazzi
    Dipartimento di Medicina Sperimentale e Diagnostica e Centro Interdipartimentale per la Ricerca sul Cancro, Universita di Ferrara, Ferrara, Italy
    Mol Cancer 6:17. 2007
    ..Nidogens are highly conserved proteins of basement membranes. Two nidogen proteins, nidogen 1 and nidogen 2, are known in mammals...
  5. pmc Tumor marker utility and prognostic relevance of cathepsin B, cathepsin L, urokinase-type plasminogen activator, plasminogen activator inhibitor type-1, CEA and CA 19-9 in colorectal cancer
    Laszlo Herszenyi
    2nd Department of Medicine, Semmelweis University, Budapest Hungarian Academy of Science, Clinical Gastroenterology Research Unit, Budapest, Hungary
    BMC Cancer 8:194. 2008
    ..The tumor marker utility and prognostic relevance of these proteases have not been evaluated in the same experimental setting and compared with that of CEA and CA-19-9...
  6. ncbi request reprint Estrogens receptors and oxidative damage in the liver
    Fabio Farinati
    Dipartimento di Scienze Chirurgiche e Gastroenterologiche, Sezione di Gastroenterologia, Universita di Padova, Via Giustiniani 2, 35128 Padova, Italy
    Mol Cell Endocrinol 193:85-8. 2002
    ..Our own and other author's data are shedding new light on estrogen pathophysiology, liver damage and hepatic cancer...
  7. ncbi request reprint Differential effects of Helicobacter pylori eradication on oxidative DNA damage at the gastroesophageal junction and at the gastric antrum
    Fabio Farinati
    Dipartimento di Scienze Chirurgiche e Gastroenterologiche, Sezione di Gastroenterologia, Policlinico Universitario, Via Giustiniani 2, 35128 Padova, Italy
    Cancer Epidemiol Biomarkers Prev 13:1722-8. 2004
    ..This prospective study evaluates DNA oxidative damage in biopsy samples obtained from both the antrum and the gastroesophageal junction (GEJ) before and after H. pylori eradication...
  8. pmc Oxidative damage, pro-inflammatory cytokines, TGF-alpha and c-myc in chronic HCV-related hepatitis and cirrhosis
    Fabio Farinati
    Department of Surgical and Gastroenterological Sciences, University of Padua, Italy
    World J Gastroenterol 12:2065-9. 2006
    ..To assess whether a correlation exists between oxidative DNA damage occurring in chronic HCV-related hepatitis and expression levels of pro-inflammatory cytokines, TGF-alpha and c-myc...
  9. ncbi request reprint Hepatitis C virus: from oxygen free radicals to hepatocellular carcinoma
    F Farinati
    Dipartimento di Scienze Chirurgiche e Gastroenterologiche, Sezione di Gastroenterologia, Policlinico Universitario, Universita di Padova, Padova, Italy
    J Viral Hepat 14:821-9. 2007
    ....
  10. doi request reprint Oxidative DNA damage in gastric cancer: CagA status and OGG1 gene polymorphism
    Fabio Farinati
    Dipartimento di Scienze Chirurgiche e Gastroenterologiche, Universita di Padova, Padova, Italy
    Int J Cancer 123:51-5. 2008
    ..OGG1 1245C-->G polymorphism was common in both GC and IMA, but very rare in controls, and correlated more closely with 8-OHdG levels than do H. pylori infection or cagA status...
  11. doi request reprint Helicobacter pylori, inflammation, oxidative damage and gastric cancer: a morphological, biological and molecular pathway
    Fabio Farinati
    Departments of Surgical and Gastroenterological Sciences, Padua University, Padua, Italy
    Eur J Cancer Prev 17:195-200. 2008
    ..The growing body of evidence of the regression of precancerous changes and the high prevalence of superficial gastric carcinoma demonstrated in long-term follow-up studies on NiN make this approach mandatory...
  12. pmc Early and very early hepatocellular carcinoma: when and how much do staging and choice of treatment really matter? A multi-center study
    Fabio Farinati
    Dipartimento di Scienze Chirurgiche e Gastroenterologiche, Universita degli Studi di Padova, Padova, Italia
    BMC Cancer 9:33. 2009
    ..We investigated how many patients are diagnosed in "very early" and "early" stage, follow the AASLD guidelines for treatment and whether their survival depends on treatment...
  13. doi request reprint Is female sex a significant favorable prognostic factor in hepatocellular carcinoma?
    Fabio Farinati
    Dipartimento di Scienze Chirurgiche e Gastroenterologiche, Università di Genova iUnità di Gastroenterologia, Ospedale Belcolle, Viterbo, Italy
    Eur J Gastroenterol Hepatol 21:1212-8. 2009
    ..As sex favorably modulates the natural history of chronic liver diseases and the risk for neoplastic evolution, our study aimed to ascertain whether female hepatocellular carcinoma (HCC) patients are also characterized by better prognosis...
  14. doi request reprint Oxidative stress and inducible nitric oxide synthase induction in carcinogenesis
    Fabio Farinati
    Department of Surgical and Gastroenterological Sciences, Padua University, Padua, Italy
    Dig Dis 28:579-84. 2010
    ....
  15. ncbi request reprint Helicobacter pylori CagA status, mucosal oxidative damage and gastritis phenotype: a potential pathway to cancer?
    Fabio Farinati
    Dipartimento di Scienze Chirurgiche e Gastroenterologiche Sezione di Gastroenterologia, Universita degli Studi di Padova, Italy
    Helicobacter 8:227-34. 2003
    ..Oxidative DNA damage is associated with Helicobacter pylori infection, atrophy and intestinal metaplasia. H. pylori-cagA-positive strains are associated with the highest risk of gastric cancer...
  16. doi request reprint The survival benefit of liver transplantation in hepatocellular carcinoma patients
    Umberto Cillo
    Unità di Chirurgia Epatobiliare e Trapianto Epatico, Azienda Ospedaliera Universita di Padova, Via Giustiniani 2, 35128 Padova, Italy
    Dig Liver Dis 42:642-9. 2010
    ..There are no studies evaluating the survival benefit of liver transplantation over alternative therapies for patients with hepatocellular carcinoma...
  17. pmc Indefinite for non-invasive neoplasia lesions in gastric intestinal metaplasia: the immunophenotype
    Mauro Cassaro
    Department of Diagnostic Medicine and Special Therapies, University of Padova, II Pathology Unit, Padova, Italy
    J Clin Pathol 60:615-21. 2007
    ....
  18. pmc Molecular refinement of clinical staging in hepatocellular carcinoma patients evaluated for potentially curative therapies
    Alessandro Vitale
    Unità di Chirurgia Epatobiliare e Trapianto Epatico, Dipartimento di Chirurgia Generale e Trapianti d Organo, Universita di Padova, Padova, Italy
    PLoS ONE 6:e23093. 2011
    ..VEGF and AFP mRNA determinations in the blood are promising prognostic factors for patients with HCC. This study explores their potential prognostic synergy in a cohort of HCC patients evaluated for potentially curative therapies...
  19. ncbi request reprint Non-invasive diagnosis of Helicobacter pylori infection: simplified 13C-urea breath test, stool antigen testing, or DNA PCR in human feces in a clinical laboratory setting?
    Carlo Federico Zambon
    Department of Medical and Surgical Sciences, University of Padova, Italy
    Clin Biochem 37:261-7. 2004
    ..2) To ascertain whether a simplified UBT (breath collection time = 10 min) is as reliable as the standard assay (30 min)...
  20. pmc Laparoscopic ablation of hepatocellular carcinoma in cirrhotic patients unsuitable for liver resection or percutaneous treatment: a cohort study
    Umberto Cillo
    Unità di Chirurgia Epatobiliare e Trapianto Epatico, Azienda Ospedaliera Universitaria di Padova, Padua, Italy
    PLoS ONE 8:e57249. 2013
    ..Laparoscopic ablation is a safe and effective therapeutic option for selected HCC patients ineligible for liver resection and/or percutaneous ablation...
  21. ncbi request reprint Partial hepatectomy as first-line treatment for patients with hepatocellular carcinoma
    Umberto Cillo
    Unità di chirurgia epatobiliare e trapianto di fegato, Dipartimento assistenziale di chirurgia generale e trapianti d organo, University of Padua, School of Medicine, Padova, Italy
    J Surg Oncol 95:213-20. 2007
    ..Partial hepatectomy (PH) and liver transplantation (LT) compete as first-line treatment for hepatocellular carcinoma (HCC). A prospectively collected database was retrospectively reviewed to establish when PH can compete with LT...
  22. pmc Let-7c down-regulation in Helicobacter pylori-related gastric carcinogenesis
    Matteo Fassan
    Department of Medicine DIMED, Surgical Pathology and Cytopathology Unit, University of Padua, Padua, Italy
    Oncotarget 7:4915-24. 2016
    ..In H. pylori infection, let-7c down-regulation regresses after the bacterium's eradication, while it progresses significantly with the increasing severity of the histological lesions...
  23. doi request reprint Barcelona Clinic Liver Cancer staging and transplant survival benefit for patients with hepatocellular carcinoma: a multicentre, cohort study
    Alessandro Vitale
    Unità di Chirurgia Epatobiliare e Trapianto Epatico, Azienda Ospedaliera, Universita di Padova, Padova, Italy
    Lancet Oncol 12:654-62. 2011
    ..We aimed to create a prediction model linking the BCLC stage of patients with hepatocellular carcinoma to their 5-year liver transplant benefit...
  24. pmc Oxidative DNA damage correlates with cell immortalization and mir-92 expression in hepatocellular carcinoma
    Romilda Cardin
    Department of Surgery, Oncology and Gastroenterology, Section of Gastroenterology, University of Padova, Via Giustiniani 2, Padova 35128, Italy
    BMC Cancer 12:177. 2012
    ....
  25. doi request reprint Rise and fall of HCV-related hepatocellular carcinoma in Italy: a long-term survey from the ITA.LI.CA centres
    Nora Cazzagon
    Dipartimento di Scienze Chirurgiche Oncologiche e Gastroenterologiche P G Cevese, Universita degli Studi di Padova, Padova, Italia
    Liver Int 33:1420-7. 2013
    ..The aim of this study was to evaluate epidemiology, clinical features and survival of HCV-related HCC (HCV-HCC) in a wide time range in Italy...
  26. ncbi request reprint Diagnostic and prognostic role of alpha-fetoprotein in hepatocellular carcinoma: both or neither?
    Fabio Farinati
    Dept of Surgical and Gastroenterological Sciences, Universitary Policlinic, Via Giustiniani 2, 35128 Padua, Italy
    Am J Gastroenterol 101:524-32. 2006
    ..The clinical usefulness of alpha-fetoprotein (AFP) in hepatocellular carcinoma (HCC) management is debatable...
  27. doi request reprint Transcatheter arterial chemoembolization (TACE) in hepatocellular carcinoma (HCC): the role of angiogenesis and invasiveness
    Adriana Sergio
    Istituto Oncologico Veneto, Padova, Italy
    Am J Gastroenterol 103:914-21. 2008
    ....
  28. pmc Autophagy and apoptosis-related genes in chronic liver disease and hepatocellular carcinoma
    Andromachi Kotsafti
    Department of Surgery, Oncology and Gastroenterology Division of Gastroenterology, University of Padova, Via Giustiniani 2, 35128 Padova, Italy
    BMC Gastroenterol 12:118. 2012
    ....
  29. pmc Operative link for gastritis assessment vs operative link on intestinal metaplasia assessment
    Massimo Rugge
    Surgical Pathology and Cytopathology Unit, Department of Diagnostic Medical Sciences and Special Therapies, University of Padova, 35100 Padova, Italy
    World J Gastroenterol 17:4596-601. 2011
    ..To compare the reliability of gastritis staging systems in ranking gastritis-associated cancer risk in a large series of consecutive patients...
  30. doi request reprint Immunotherapy for gastric premalignant lesions and cancer
    Valerio Zorzetto
    Department of Surgical, Oncological and Gastroenterological Sciences, Policlinico Universitario, Via Giustiniani 2, 35128 Padova, Italy
    Immunotherapy 4:587-99. 2012
    ..No study on immunotherapy of carcinoids is available but, in our experience, the administration of an antigastrin 17 vaccine induced carcinoid regression in two out of three patients treated...
  31. doi request reprint MINT31 methylation in gastric noninvasive neoplasia: potential role in the secondary prevention of gastric cancer
    Massimo Negrini
    Department of Experimental and Diagnostic Medicine, University of Ferrara, Ferrara, Italy
    Eur J Cancer Prev 21:442-8. 2012
    ..Hypermethylation of MINT31 predicted NIN persistence, as well as progression to higher grade or to GC, and might be used as a marker of GC risk...
  32. doi request reprint Lesions indefinite for intraepithelial neoplasia and OLGA staging for gastric atrophy
    Matteo Fassan
    Department of Medicine, Surgical Pathology and Cytopathology Unit, University of Padua, Italy
    Am J Clin Pathol 137:727-32. 2012
    ..OLGA staging can stratify indefinite for IEN lesions into different risk classes, potentially contributing to decisions for a patient-specific follow-up strategy...
  33. ncbi request reprint Micronuclei and broken eggs in human liver carcinogenesis
    Maria Guido
    Department of Diagnostic Medical Sciences and Special Therapies, Pathology Unit, Universita degli Studi di Padova, Italy
    Anticancer Res 28:2507-11. 2008
    ..MNi/BE formation may result in activation of the p53-mediated cell cycle checkpoint...
  34. doi request reprint Differential timing of oxidative DNA damage and telomere shortening in hepatitis C and B virus-related liver carcinogenesis
    Marika Piciocchi
    Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy Electronic address
    Transl Res 168:122-33. 2016
    ..Finally, TERT localizes in mitochondria in HCC, where it lacks a canonical function. ..
  35. doi request reprint Diagnostic and prognostic role of SCCA-IgM serum levels in hepatocellular carcinoma (HCC)
    Caterina Pozzan
    Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy
    J Gastroenterol Hepatol 29:1637-44. 2014
    ..We aimed to further evaluate SCCA-IgM diagnostic accuracy and to determine its prognostic role...
  36. doi request reprint The HER2-miR125a5p/miR125b loop in gastric and esophageal carcinogenesis
    Matteo Fassan
    Department of Medicine, Surgical Pathology and Cytopathology Unit, University of Padua, 35100 Padua, Italy
    Hum Pathol 44:1804-10. 2013
    ..In both oncogenetic cascades, miR-125 expression correlates inversely with HER2 status. MiR-125a-5p/125b can be considered among the therapeutic targets in HER2-positive esophageal and gastric adenocarcinoma. ..
  37. doi request reprint BCLC stage B hepatocellular carcinoma and transcatheter arterial chemoembolization: a 20-year survey by the Italian Liver Cancer group
    Fabio Farinati
    Department of Surgery, Oncology and Gastroenterology, Section of Gastroenterology, University of Padua, Padua, Italy
    Liver Int 35:223-31. 2015
    ..We aimed to ascertain adherence to current guidelines, survival and prognostic factors in BCLC stage B patients...
  38. pmc Laparoscopic microwave ablation in patients with hepatocellular carcinoma: a prospective cohort study
    Umberto Cillo
    Hepatobiliary Surgery and Liver Transplant Unit, University of Padua Hospital Trust, Padua, Italy
    HPB (Oxford) 16:979-86. 2014
    ..There are no prospective studies of laparoscopic microwave (MW) ablation in patients with hepatocellular carcinoma (HCC). The aim of this study was to demonstrate the safety and efficacy of laparoscopic MW ablation...
  39. pmc Oxidative damage in the progression of chronic liver disease to hepatocellular carcinoma: an intricate pathway
    Romilda Cardin
    Romilda Cardin, Marika Piciocchi, Marina Bortolami, Andromachi Kotsafti, Kryssia Isabel Rodriguez Castro, Fabio Farinati, Department of Surgery, Oncology and Gastroenterology, University of Padova, 35128 Padova, Italy
    World J Gastroenterol 20:3078-86. 2014
    ....
  40. doi request reprint Oxidative DNA damage in Barrett mucosa: correlation with telomeric dysfunction and p53 mutation
    Romilda Cardin
    Section of Gastroenterology, Department of Surgery, Oncology and Gastroenterology, Padua University, Padua, Italy
    Ann Surg Oncol 20:S583-9. 2013
    ..This study aimed to evaluate the link among 8-hydroxydeoxyguanosine, OGG1 polymorphism, telomerase activity, telomere length, and p53 mutation in Barrett progression...
  41. ncbi request reprint Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms
    Carlo Federico Zambon
    Departments of Medical and Surgical Sciences, Laboratory Medicine, Oncological and Surgical Sciences, Gastroenterology, and Pathology, University of Padova, Padova, Italy
    Gastroenterology 126:382-4. 2004
  42. ncbi request reprint Gastric mucosa-associated lymphoid tissue lymphoma and Helicobacter pylori: scratch and win
    Monica Franco
    Department of Surgical and Gastroenterological Sciences, University of Padua, Italy
    Scand J Gastroenterol 40:115-9. 2005
    ..Additionally, treatment with CD20 monoclonal antibody (rituximab) is suggested as an alternative to surgery or treatment with chemotherapy or radiotherapy in patients with truly H. pylori-negative gastric MALT lymphoma...
  43. ncbi request reprint Prospective validation of the Barcelona Clinic Liver Cancer staging system
    Umberto Cillo
    Clinica Chirurgica I, Dipartimento di Scienze Chirurgiche e Gastroenterologiche, School of Medicine, University of Padua, Via Giustiniani 2, Policlinico III Piano, 35128 Padova, Italy
    J Hepatol 44:723-31. 2006
    ..The aim of this study was to evaluate the BCLC system prospectively in a subsequent separate group of HCC patients enrolled at the same surgically oriented liver unit...
  44. doi request reprint Operative Link for Gastritis Assessment gastritis staging incorporates intestinal metaplasia subtyping
    Massimo Rugge
    Surgical Pathology and Cytopathology Unit, Department of Diagnostic Medical Sciences and Special Therapies, University of Padova, Italy
    Hum Pathol 42:1539-44. 2011
    ..001) and H pylori status (Fisher exact, P < .001). Operative Link for Gastritis Assessment staging incorporates the prognostic message obtainable from histochemical gastric mucin subtyping...
  45. ncbi request reprint Zinc treatment prevents lipid peroxidation and increases glutathione availability in Wilson's disease
    Fabio Farinati
    Department of Surgical and Gastroenterological Sciences, University of Padua, Padua, Italy
    J Lab Clin Med 141:372-7. 2003
    ....
  46. doi request reprint Gastric type I carcinoid: a pilot study with human G17DT immunogen vaccination
    Chiara Tieppo
    Department of Surgical and Gastroenterological Sciences, Policlinico Universitario, Via Giustiniani 2, Padua, Italy
    Cancer Immunol Immunother 60:1057-60. 2011
    ..The approach to treatment, either endoscopic, medical or surgical, is not well defined, particularly in multifocal tumours or carcinoids with rapid growth/frequent recurrence...
  47. ncbi request reprint Does the choice of treatment influence survival of patients with small hepatocellular carcinoma in compensated cirrhosis?
    F Farinati
    Cattedra di Gastroenterologia Sezione di Gastroenterologia, Dipartimento di Scienze Chirurgiche e Gastroenterologiche, Policlinico Universitario, Padova, Italy
    Eur J Gastroenterol Hepatol 13:1217-24. 2001
    ..Untreated patients with small, single hepatocellular carcinoma (HCC) in compensated cirrhosis are characterized by a relatively good prognosis...
  48. pmc Development and Validation of a New Prognostic System for Patients with Hepatocellular Carcinoma
    Fabio Farinati
    Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy
    PLoS Med 13:e1002006. 2016
    ..Using the Italian Liver Cancer (ITA.LI.CA) database as a training set, we sought to develop and validate a new prognostic system for patients with HCC...
  49. doi request reprint Utility-based criteria for selecting patients with hepatocellular carcinoma for liver transplantation: A multicenter cohort study using the alpha-fetoprotein model as a survival predictor
    Alessandro Vitale
    Dipartimento di Chirurgia Generale e Trapianto d Organo, Unità di Chirurgia Epatobiliare e Trapianti Epatici, Universita di Padova, Padova, Italy
    Liver Transpl 21:1250-8. 2015
    ..LT proved always cost-effective for HCC patients with AFP model values ≤ 3, whereas the cost-ineffectiveness threshold ranged between 3 and 7 using nontumor variables...
  50. doi request reprint Barrett's esophagus and adenocarcinoma risk: the experience of the North-Eastern Italian Registry (EBRA)
    Massimo Rugge
    Department of Pathology, University of Padova, Padua, Italy
    Ann Surg 256:788-94; discussion 794-5. 2012
    ..To establish the incidence and risk factors for progression to high-grade intraepithelial neoplasia (HG-IEN) or Barrett's esophageal adenocarcinoma (BAc) in a prospective cohort of patients with esophageal intestinal metaplasia [(BE)]...
  51. ncbi request reprint Occurrence of post-transplant lymphoproliferative disorders among over thousand adult recipients: any role for hepatitis C infection?
    Patrizia Burra
    Department of Surgical and Gastroenterological Sciences, University of Padua, Padua Italy
    Eur J Gastroenterol Hepatol 18:1065-70. 2006
    ..Hepatitis C virus may induce clonal expansion of B-lymphocytes and has been associated with extrahepatic lymphoproliferative disorders...
  52. doi request reprint Survival benefit of liver resection for patients with hepatocellular carcinoma across different Barcelona Clinic Liver Cancer stages: a multicentre study
    Alessandro Vitale
    Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy
    J Hepatol 62:617-24. 2015
    ..We aimed at measuring the survival benefit of resection vs. non-surgical-therapies in each BCLC stage...
  53. doi request reprint Molecular targeted therapy in hepatocellular carcinoma: present achievements and future challenges
    Anna Giacomin
    Section of Gastroenterology, Department of Surgical, Oncological and Gastroenterological Sciences, Padua University, Italy
    Dig Dis 30:284-8. 2012
    ..In this paper we try to review the most important molecular agents in development, with a specific focus on sorafenib's role and safety profile, especially in the treatment of patients with suboptimal liver function...
  54. ncbi request reprint Lymphadenectomy in patients with gastric cancer. A critical review
    Donato Nitti
    Department of Oncological and Surgical Sciences, Clinica Chirurgica II, University of Padua, Italy
    Suppl Tumori 2:S35-8. 2003
    ..The aim of the present study was therefore to evaluate the outcome following extended lymphadenectomy, and the prognostic significance of lymph node status, in a group of patients who underwent radical resection for gastric cancer...
  55. doi request reprint Use of sorafenib in patients with hepatocellular carcinoma before liver transplantation: a cost-benefit analysis while awaiting data on sorafenib safety
    Alessandro Vitale
    Unità di Chirurgia Oncologica, Istituto Oncologico Veneto, IRCCS, Padova, Italy
    Hepatology 51:165-73. 2010
    ....
  56. doi request reprint Pegylated liposomal doxorubicin and gemcitabine in patients with advanced hepatocellular carcinoma: results of a phase 2 study
    Giuseppe Lombardi
    Department of Medical Oncology 1 Unit, Veneto Institute of Oncology IOV IRCCS, Padua, Italy
    Cancer 117:125-33. 2011
    ..The authors report the results of a phase 2 study of the combination of gemcitabine plus pegylated liposomal doxorubicin...
  57. doi request reprint Hepatitis B virus-related hepatocellular carcinoma: primary, secondary, and tertiary prevention
    Anna Giacomin
    Department of Surgical and Gastroenterological Sciences, Section of Gastroenterology, University of Padova Padova, Italy
    Eur J Cancer Prev 20:381-8. 2011
    ....
  58. ncbi request reprint DNA oxidative damage in leukocytes correlates with the severity of HCV-related liver disease: validation in an open population study
    R Cardin
    Dipartimento Scienze Chirurgiche e Gastroenterologie, Sezione di Gastroenterologia, Policlinico Universitario, Padova, Italy
    J Hepatol 34:587-92. 2001
    ..This genomic damage may contribute to liver carcinogenesis by causing persistent DNA changes...
  59. pmc Autoimmune gastritis: Pathologist's viewpoint
    Irene Coati
    Irene Coati, Matteo Fassan, Massimo Rugge, Department of Medicine DIMED, Surgical Pathology Unit, University of Padua, 35121 Padua, Italy
    World J Gastroenterol 21:12179-89. 2015
    ....
  60. doi request reprint Sorafenib use in the transplant setting
    Giulia Castelli
    Department of Surgery, Oncology, and Gastroenterology, Padua University School of Medicine, Padua, Italy
    Liver Transpl 20:1021-8. 2014
    ..Overall, the data do not support the use of SFN in the pre- or post-LT setting as adjuvant therapy, and additional studies are needed to reach sound conclusions on the topic...
  61. doi request reprint Effects of coffee consumption in chronic hepatitis C: a randomized controlled trial
    Romilda Cardin
    Department of Surgical, Oncological and Gastroenterological Sciences, Section of Gastroenterology, Padua University, Padua, Italy
    Dig Liver Dis 45:499-504. 2013
    ..Coffee is associated with a reduced risk of hepatocellular carcinoma in patients with chronic C hepatitis. This prospective trial was aimed at assessing the mechanisms underlying coffee-related protective effects...
  62. ncbi request reprint Non-invasive neoplasia of the stomach
    Massimo Rugge
    Department of Oncological and Surgical Sciences Pathology Unit, Universita degli Studi di Padova, Italy
    Eur J Gastroenterol Hepatol 17:1191-6. 2005
    ..The molecular profile of NiN is summarized and the spectrum of the options in the clinical management of gastric NiN are reported...
  63. doi request reprint Hepatic spleen nodules (HSN)
    Claudia Mescoli
    Department of Pathology, University of Padova, Padova, Italy
    Scand J Gastroenterol 45:628-32. 2010
    ..Although they are rare, hepatic spleen nodules should always be included in the diagnostic spectrum of nodular liver lesions because of their impact on treatment decisions...
  64. pmc Liver transplantation for the treatment of moderately or well-differentiated hepatocellular carcinoma
    Umberto Cillo
    Clinica Chirurgica I, Dipartimento di Scienze Chirurgiche e Gastroenterlogiche, Italy
    Ann Surg 239:150-9. 2004
    ..To determine the long-term results of liver transplantation for well- or moderately differentiated hepatocellular carcinoma (HCC)...
  65. ncbi request reprint Hepatic and extrahepatic malignancies in primary biliary cirrhosis
    A Floreani
    Department of Surgical and Gastroenterological Sciences, University of Padova, Padova, Italy
    Hepatology 29:1425-8. 1999
    ..HCC has a relatively high prevalence in PBC and HCV superinfection may play an important part in favoring HCC. The incidence of breast cancer is not significantly higher in PBC than in the general population of the same area...
  66. ncbi request reprint Oxidative DNA damage in circulating leukocytes occurs as an early event in chronic HCV infection
    F Farinati
    Cattedra Malattie Apparato Digerente, Istituto di Medicina Interna, Universita di Padova, Italy
    Free Radic Biol Med 27:1284-91. 1999
    ..Serum levels of thiobarbituric acid reactive substances (TBARS) were also assessed as an index of lipid peroxidation...
  67. ncbi request reprint How should patients with hepatocellular carcinoma be staged? Validation of a new prognostic system
    F Farinati
    Cattedra Malattie Apparato Digerente, Dipartimento di Scienze Chirurgiche e Gastroenterologiche Università di Padova, Italy
    Cancer 89:2266-73. 2000
    ....
  68. ncbi request reprint Imbalance between cytoproliferation and apoptosis in hepatitis C virus related chronic liver disease
    F Farinati
    Sezione di Gastroenterologia, Dipartimento di Scienze Chirurgiche e Gastroenterologiche, Universita di Bologna, Italy
    J Viral Hepat 8:34-40. 2001
    ..APO and MIB1 are directly related to the extent of liver damage and, from a biochemical point of view, to tissue iron levels...
  69. pmc The phenotype of gastric mucosa coexisting with Barrett's oesophagus
    M Rugge
    Department of Oncological and Surgical Sciences, Cattedra di Istochimica e Immunoistochimica Patologica, ULSS 15 del Veneto, Italia
    J Clin Pathol 54:456-60. 2001
    ..No systematic study has investigated the phenotype of the gastric mucosa coexisting with Barrett's oesophagus. This study was designed to identify the phenotype of gastric mucosa associated with Barrett's oesophagus...
  70. ncbi request reprint HBV and HCV infections in heart transplant recipients
    S Fagiuoli
    Department of Surgical and Gastroenterological Sciences, University of Padova, Padova, Italy
    J Heart Lung Transplant 20:718-24. 2001
    ..The aim of the present study was to define the prevalence, clinical features, and natural history of HBV and HCV infections in a cohort of HTx recipients...
  71. ncbi request reprint Cytokine, infiltrating macrophage and T cell-mediated response to development of primary and secondary human liver cancer
    M Bortolami
    Department of Surgical and Gastroenterological Sciences, University of Padua, Italy
    Dig Liver Dis 34:794-801. 2002
    ....
  72. pmc The long term outcome of gastric non-invasive neoplasia
    M Rugge
    Department of Oncological and Surgical Sciences, III Cattedra di Anatomia Patologica, Università degli Studi di Padova Azienda Ospedale Padova, Italia
    Gut 52:1111-6. 2003
    ..This prospective long term follow up study investigates the clinicopathological behaviour of non-invasive gastric neoplasia (and related lesions), focusing on the cancer risk associated with each different histological phenotype...
  73. ncbi request reprint Tumour staging, morphology and p53 overexpression concur in predicting survival in hepatocellular carcinoma
    S Gianni
    Gastroenterology Unit, Department of Surgical and Gastroenterological Sciences, Padua University School of Medicine, 35128 Padova, Italy
    J Intern Med 257:367-73. 2005
    ..The prognosis of hepatocellular carcinoma (HCC) on cirrhosis is hard to predict as it depends on tumour stage, underlying liver disease, type of treatment and, possibly, biological factors of the tumour itself...
  74. pmc Microsatellite instability and gastric non-invasive neoplasia in a high risk population in Cesena, Italy
    M Rugge
    Department of Oncology and Surgical Sciences, University of Padova, I 35121 Padova, Italy
    J Clin Pathol 58:805-10. 2005
    ..In this retrospective cross sectional study, microsatellite instability (MSI) was analysed in a consecutive series of NiN and NiN related histological alterations from a northern Italian region at high risk for gastric cancer...
  75. ncbi request reprint Extended lymphadenectomy (D2) in patients with early gastric cancer
    D Nitti
    Department of Oncological and Surgical Sciences, University of Padova, Padova, Italy
    Eur J Surg Oncol 31:875-81. 2005
    ..To investigate the survival benefit of extended lymphadenectomy (D2) in EGC patients in one European Institution...
  76. ncbi request reprint The Veneto Region's Barrett's Oesophagus Registry: aims, methods, preliminary results
    G Zaninotto
    Department of General Surgery and Organ Transplantation, University of Padova, Padova, Italy
    Dig Liver Dis 39:18-25. 2007
    ..A Barrett's Oeosphagus Registry has been therefore established in the Veneto Region and neighbouring provinces...
  77. ncbi request reprint Experimental hepatology applied to stem cells
    P Burra
    Department of Surgical and Gastroenterological Sciences, University of Padua, Italy
    Dig Liver Dis 40:54-61. 2008
    ..The fact that numerous specialties were represented helped the audience to understand the stem cell research area from different standpoints, and what research has achieved so far...
  78. doi request reprint Fas / FasL system, IL-1beta expression and apoptosis in chronic HBV and HCV liver disease
    M Bortolami
    Department of Surgical and Gastroenterological Sciences, University of Padua, Padua, Italy
    J Viral Hepat 15:515-22. 2008
    ....
  79. doi request reprint HCV histological recurrence and survival following liver transplantation in patients with and without hepatocellular carcinoma
    E De Martin
    Department of Surgical and Gastroenterological Sciences, Gastroenterology, Padova University, Padova, Italy
    Transplant Proc 40:1974-5. 2008
    ..HCV recurrence after LT is universal. This study evaluated HCV recurrence and survival in patients transplanted for HCV and HCC...
  80. doi request reprint From Barrett metaplasia to esophageal adenocarcinoma: the molecular background
    Deborah Saraggi
    Department of Medicine DIMED, Surgical Pathology and Cytopathology Unit, University of Padua, Padua, Italy
    Histol Histopathol 31:25-32. 2016
    ..This will allow the introduction of innovative strategies for secondary prevention of esophageal adenocarcinoma based on biological rationales, and the implementation of potential novel therapeutic targets. ..
  81. doi request reprint Changes in microRNA expression during disease progression in patients with chronic viral hepatitis
    Alessandro Sinigaglia
    Department of Molecular Medicine, University of Padova, Padova, Italy IOV Istituto Oncologico Veneto, Padova, Italy
    Liver Int 35:1324-33. 2015
    ..Aim of this study was to identify miRNA signatures associated with stages of disease progression in patients with chronic viral hepatitis...
  82. ncbi request reprint Megestrol and embryonic extracts in the treatment of advanced hepatocellular carcinoma: A prospective randomized trial in the pre-sorafenib era
    Anna Giacomin
    Department of Surgical and Gastroenterological Sciences, Padua University, Via Giustiniani, Padua, Italy
    Hepatol Res 40:153-60. 2010
    ..Conclusion: Megestrol treatment shows good results in advanced HCC and could become part of best supportive care in patients not suitable for other treatments, that, despite sorafenib, remain an important share...
  83. ncbi request reprint Gemcitabine and liposomal doxorubicin in biliary and hepatic carcinoma (HCC) chemotherapy: preliminary results and review of the literature
    D Pastorelli
    O U C Medical Oncology, Busonera Hospital 1 floor, National Oncology Institute of Veneto, IOV IRCCS, Padua, Italy
    Ann Oncol 17:v153-7. 2006
    ..Systemic chemotherapy in hepatocellular carcinoma represents a palliative treatment. Gemcitabine in combination with Liposomal Doxorubicin (LD) may represent an active treatment option...
  84. doi request reprint Gastrin: from pathophysiology to cancer prevention and treatment
    Gemma Maddalo
    aDepartment of Surgery, Oncology and Gastroenterology, Padua University Hospital bDepartment of Medicine, Padua University, Padova, Italy
    Eur J Cancer Prev 23:258-63. 2014
    ..Antigastrin vaccination in the treatment of gastrointestinal cancer obviously needs validation, but this immunotherapy may well represent a simple, inexpensive, and active 'adjuvant' treatment. ..
  85. ncbi request reprint Hepatocyte proliferation and apoptosis in relation to oxidative damage in alcohol-related liver disease
    Romilda Cardin
    Dipartimento di Scienze Chirurgiche e Gastroenterologiche, Sezione di Gastroenterologia, Universita di Padova, Via Giustiniani 2, 35128 Padua, Italy
    Alcohol Alcohol 37:43-8. 2002
    ..This last finding may explain the different types of liver cirrhosis deriving from alcoholic liver damage and the lower cancer risk...
  86. ncbi request reprint Systemic efficacy of combined suicide/cytokine gene therapy in a murine model of hepatocellular carcinoma
    Anna Lisa Stefani
    Department of Histology, Microbiology and Medical Biotechnologies, University of Padova, Padova, Italy
    J Hepatol 42:728-35. 2005
    ..The aim of the study was to evaluate the in vitro and in vivo efficacy of combined gene therapy of HCC with two different MoMLV-derived retroviral vectors, an MFG- and a LXSN-derived vector, both containing HSV-TK and hIL-2...
  87. ncbi request reprint Percutaneous radiofrequency thermal ablation for hepatocellular carcinoma
    A Baldan
    Dipartimento di Scienze Chirurgiche e Gastroenterologiche, Universita di Padova, Padova, Italy
    Aliment Pharmacol Ther 24:1495-501. 2006
    ..Radiofrequency thermal ablation is the first therapeutic option in percutaneous treatment of hepatocellular carcinoma but data on its long-term efficacy and safety are not conclusive...
  88. ncbi request reprint Sex hormone profile and endometrial cancer risk in primary biliary cirrhosis: a case-control study
    Annarosa Floreani
    Division of Gastroenterologia, Department of Surgical Sciences, University of Padova, Via Giustiniani 2, 35128, Padova, Italy
    Eur J Obstet Gynecol Reprod Biol 103:154-7. 2002
    ..To investigate the sex hormone profile and endometrial histology in primary biliary cirrhosis (PBC)...
  89. ncbi request reprint An oncolytic adenovirus controlled by a modified telomerase promoter is attenuated in telomerase-negative cells, but shows reduced activity in cancer cells
    S Bortolanza
    Padua University Surgical and Gastroenterological Sciences, Padua, 35128, Italy
    J Mol Med (Berl) 83:736-47. 2005
    ..Further modifications in the telomerase-based promoters should be introduced in order to combine maximal attenuation of oncolytic adenoviruses in normal tissues and enhanced activity in tumors...
  90. ncbi request reprint Semiannual and annual surveillance of cirrhotic patients for hepatocellular carcinoma: effects on cancer stage and patient survival (Italian experience)
    Franco Trevisani
    Dipartimento di Medicina Interna, Cardioangiologia, Epatologia, Semeiotica Medica, Universita di Bologna, Italy
    Am J Gastroenterol 97:734-44. 2002
    ..However, it has not been proved that this procedure can improve patient survival...
  91. ncbi request reprint Surveillance for hepatocellular carcinoma in elderly Italian patients with cirrhosis: effects on cancer staging and patient survival
    Franco Trevisani
    Dipartimento di Medicina Interna, Cardioangiologia, Epatologia and Dipartimento di Medicina Interna e Gastroenterologia University of Bologna, Italy
    Am J Gastroenterol 99:1470-6. 2004
    ..However, several age-related factors may jeopardize the results of surveillance in these patients. Aim of the study was to evaluate the benefit of surveillance for HCC in elderly individuals...
  92. ncbi request reprint Effect of the etiology of viral cirrhosis on the survival of patients with hepatocellular carcinoma
    Maria Chiara Cantarini
    Dipartimento di Medicina Interna, Cardioangiologia, Epatologia, Alma Mater Studiorum University of Bologna, Bologna, Italy
    Am J Gastroenterol 101:91-8. 2006
    ..The aim of this study was to assess whether hepatocellular carcinoma occurring in the setting of hepatitis B or C virus infection has different prognosis...
  93. ncbi request reprint Prevalence and prognostic significance of the presence of esophageal varices in patients with hepatocellular carcinoma
    Edoardo Giovanni Giannini
    Cattedra di Gastroenterologia, Dipartimento di Medicina Interna, Universita di Genova, Genova, Italia
    Clin Gastroenterol Hepatol 4:1378-84. 2006
    ..In this study our aim was to evaluate the prevalence and prognostic relevance of the presence of esophageal varices in a large series of patients with HCC...
  94. ncbi request reprint Impact of etiology of cirrhosis on the survival of patients diagnosed with hepatocellular carcinoma during surveillance
    Franco Trevisani
    Dipartimento di Medicina Interna, Cardioangiologia, Epatologia, Alma Mater Studiorum Universita di Bologna, Bologna, Italy
    Am J Gastroenterol 102:1022-31. 2007
    ..We analyzed the impact of etiology on the characteristics and outcome of HCC detected during surveillance...
  95. ncbi request reprint Surveillance for early diagnosis of hepatocellular carcinoma: is it effective in intermediate/advanced cirrhosis?
    Franco Trevisani
    Dipartimento di Medicina Interna, Cardioangiologia, Epatologia, Alma Mater Studiorum Universita di Bologna, Bologna, Italy
    Am J Gastroenterol 102:2448-57; quiz 2458. 2007
    ..Its effectiveness depends on liver function, which affects the feasibility of treatments and cirrhosis-related mortality. We assessed whether patients with intermediate/advanced cirrhosis benefit from surveillance...
  96. doi request reprint TGF-beta and hepatocellular carcinoma
    Marina Bortolami
    Hepatology 47:1095; author reply 1095-6. 2008
  97. ncbi request reprint The mechanisms underlying hepatitis C virus genotype 3-mediated liver damage
    Fabio Farinati
    J Hepatol 39:292-4. 2003
  98. ncbi request reprint Hepatitis B virus maintains its pro-oncogenic properties in the case of occult HBV infection
    Teresa Pollicino
    Department of Internal Medicine, University of Messina, Messina, Italy
    Gastroenterology 126:102-10. 2004
    ..In particular, the impact of occult HBV infection in cases of hepatocellular carcinoma (HCC) is uncertain. We investigated the prevalence and molecular status of occult HBV in patients with HCC...
  99. ncbi request reprint Re: CDX2 homeotic gene expression in gastric noninvasive neoplasia
    Massimo Rugge
    Am J Surg Pathol 28:834-5; author reply 835. 2004
  100. ncbi request reprint Up and down regulation of apoptosis in hepatitis C virus-related liver damage
    Fabio Farinati
    J Hepatol 41:883-5; author reply 885-6. 2004
  101. ncbi request reprint Characteristics at presentation and outcome of hepatocellular carcinoma (HCC) in the elderly. A study of the Cancer of the Liver Italian Program (CLIP)
    Sandro Pignata
    Oncologia Medica B, Istituto Nazionale per lo Studio e la Cura dei Tumori, Napoli, Italy
    Crit Rev Oncol Hematol 59:243-9. 2006
    ..To describe the characteristics at presentation and the outcome of elderly patients (> or =70 years old) with HCC, a retrospective analysis using a CLIP database was performed...