Giovanna De Benedictis

Summary

Affiliation: University of Calabria
Country: Italy

Publications

  1. ncbi Age-related changes of the 3'APOB-VNTR genotype pool in ageing cohorts
    G De Benedictis
    Cell Biology Dept, University of Calabria, Italy
    Ann Hum Genet 62:115-22. 1998
  2. ncbi Gene/longevity association studies at four autosomal loci (REN, THO, PARP, SOD2)
    G De Benedictis
    Cell Biology Department, University of Calabria, Italy
    Eur J Hum Genet 6:534-41. 1998
  3. ncbi Mitochondrial DNA inherited variants are associated with successful aging and longevity in humans
    G De Benedictis
    Department of Cell Biology, University of Calabria Rende, Italy Italian National Research Center on Aging, Ancona, Italy
    FASEB J 13:1532-6. 1999
  4. ncbi Does a retrograde response in human aging and longevity exist?
    G De Benedictis
    Cell Biology Department, University of Calabria, Rende, Italy
    Exp Gerontol 35:795-801. 2000
  5. ncbi Recent advances in human gene-longevity association studies
    G De Benedictis
    Cell Biology Department, University of Calabria, 87030, Rende, Italy
    Mech Ageing Dev 122:909-20. 2001
  6. ncbi The unusual genetics of human longevity
    Giovanna De Benedictis
    Department of Cell Biology, University of Calabria, Calabria, Italy
    Sci Aging Knowledge Environ 2006:pe20. 2006
  7. ncbi The G/C915 polymorphism of transforming growth factor beta1 is associated with human longevity: a study in Italian centenarians
    Giuseppina Carrieri
    I N R C A, Italian National Research Center on Aging, Ancona, Italy
    Aging Cell 3:443-8. 2004
  8. ncbi Genes involved in immune response/inflammation, IGF1/insulin pathway and response to oxidative stress play a major role in the genetics of human longevity: the lesson of centenarians
    Claudio Franceschi
    Italian National Research Center on Aging, Ancona, Italy
    Mech Ageing Dev 126:351-61. 2005
  9. ncbi A novel sampling design to explore gene-longevity associations: the ECHA study
    Francesco De Rango
    Department of Cell Biology, University of Calabria, Rende, Italy
    Eur J Hum Genet 16:236-42. 2008
  10. ncbi Sex and age specificity of susceptibility genes modulating survival at old age
    Giuseppe Passarino
    Department of Cell Biology, University of Calabria, Rende, Italy
    Hum Hered 62:213-20. 2006

Collaborators

Detail Information

Publications19

  1. ncbi Age-related changes of the 3'APOB-VNTR genotype pool in ageing cohorts
    G De Benedictis
    Cell Biology Dept, University of Calabria, Italy
    Ann Hum Genet 62:115-22. 1998
    ..58 +/- 0.90%). The observed trajectory is in agreement with that expected by assuming crossing of mortality curves relevant to subgroups of individuals having different genotypes...
  2. ncbi Gene/longevity association studies at four autosomal loci (REN, THO, PARP, SOD2)
    G De Benedictis
    Cell Biology Department, University of Calabria, Italy
    Eur J Hum Genet 6:534-41. 1998
    ..However, the data is consistent with an association between the THO locus and longevity...
  3. ncbi Mitochondrial DNA inherited variants are associated with successful aging and longevity in humans
    G De Benedictis
    Department of Cell Biology, University of Calabria Rende, Italy Italian National Research Center on Aging, Ancona, Italy
    FASEB J 13:1532-6. 1999
    ..0052 by Fisher exact test). Since haplogroups are defined on the basis of inherited variants, these data show that mtDNA inherited variability could play a role in successful aging and longevity...
  4. ncbi Does a retrograde response in human aging and longevity exist?
    G De Benedictis
    Cell Biology Department, University of Calabria, Rende, Italy
    Exp Gerontol 35:795-801. 2000
    ....
  5. ncbi Recent advances in human gene-longevity association studies
    G De Benedictis
    Cell Biology Department, University of Calabria, 87030, Rende, Italy
    Mech Ageing Dev 122:909-20. 2001
    ..We discuss this issue and suggest new methodological approaches...
  6. ncbi The unusual genetics of human longevity
    Giovanna De Benedictis
    Department of Cell Biology, University of Calabria, Calabria, Italy
    Sci Aging Knowledge Environ 2006:pe20. 2006
    ....
  7. ncbi The G/C915 polymorphism of transforming growth factor beta1 is associated with human longevity: a study in Italian centenarians
    Giuseppina Carrieri
    I N R C A, Italian National Research Center on Aging, Ancona, Italy
    Aging Cell 3:443-8. 2004
    ..These results suggest that, at least in this population, the variability of the TGF-beta1 gene influences longevity and that the age-related increase in plasma levels of active TGF-beta1 seems not to be genetically regulated...
  8. ncbi Genes involved in immune response/inflammation, IGF1/insulin pathway and response to oxidative stress play a major role in the genetics of human longevity: the lesson of centenarians
    Claudio Franceschi
    Italian National Research Center on Aging, Ancona, Italy
    Mech Ageing Dev 126:351-61. 2005
    ..We extensively screened Alu-rich genomic sites and found a new genomic region associated with longevity...
  9. ncbi A novel sampling design to explore gene-longevity associations: the ECHA study
    Francesco De Rango
    Department of Cell Biology, University of Calabria, Rende, Italy
    Eur J Hum Genet 16:236-42. 2008
    ..This will allow to dimension future sampling campaigns to study-genetic basis of human longevity...
  10. ncbi Sex and age specificity of susceptibility genes modulating survival at old age
    Giuseppe Passarino
    Department of Cell Biology, University of Calabria, Rende, Italy
    Hum Hered 62:213-20. 2006
    ..We aimed to investigate the influence of the genetic variability of candidate genes on survival at old age in good health...
  11. ncbi A genetic-demographic approach reveals male-specific association between survival and tumor necrosis factor (A/G)-308 polymorphism
    Maurizio Cardelli
    Department of Gerontological Research, Italian National Research Center on Aging, Ancona, Italy
    J Gerontol A Biol Sci Med Sci 63:454-60. 2008
    ..A haplotype analysis carried out in men by screening the TNFa, TNFc, and TNFe microsatellite polymorphisms (spanning about 20 kb) confirmed the association of the TNF region with life expectancy...
  12. ncbi Gene expression of cytokines and cytokine receptors is modulated by the common variability of the mitochondrial DNA in cybrid cell lines
    Dina Bellizzi
    Department of Cell Biology, 87030 Rende, University of Calabria, Italy
    Genes Cells 11:883-91. 2006
    ..These findings provide a first experimental evidence of a relationship between mtDNA common variability and expression pattern of stress responder nuclear genes in human cells...
  13. pmc The mitochondrial DNA control region shows genetically correlated levels of heteroplasmy in leukocytes of centenarians and their offspring
    Giuseppina Rose
    Department of Cell Biology, University of Calabria, 87036 Rende, Italy
    BMC Genomics 8:293. 2007
    ....
  14. ncbi Association of the mitochondrial DNA haplogroup J with longevity is population specific
    Serena Dato
    Department of Cell Biology, University of Calabria, Rende, Italy
    Eur J Hum Genet 12:1080-2. 2004
    ..This finding shows that, as for other genetic factors, the association of mtDNA inherited variability with longevity is population specific...
  15. ncbi A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages
    Dina Bellizzi
    Department of Cell Biology, University of Calabria, 87036 Rende, Italy
    Genomics 85:258-63. 2005
    ..Thus the underexpression of a human sirtuin gene seems to be detrimental for longevity as it occurs in model organisms...
  16. ncbi The role of IL-1 gene cluster in longevity: a study in Italian population
    Luca Cavallone
    Direzione Scientifica, Italian National Research Center on Aging, Villa Gusso, Via S Margherita, n 5 60121, Ancona, Italy
    Mech Ageing Dev 124:533-8. 2003
    ....
  17. doi Identification of GATA2 and AP-1 Activator elements within the enhancer VNTR occurring in intron 5 of the human SIRT3 gene
    Dina Bellizzi
    Department of Cell Biology, University of Calabria, 87036, Rende, Italy
    Mol Cells 28:87-92. 2009
    ..Therefore, GATA2 and AP-1 are functional sites and the T S> C transition of the second VNTR repeat affects their activity...
  18. pmc A study of the average effect of the 3'APOB-VNTR polymorphism on lipidemic parameters could explain why the short alleles (<35 repeats) are rare in centenarians
    Sabrina Garasto
    Department of Cell Biology, University of Calabria, 87030 Rende, Italy
    BMC Med Genet 5:3. 2004
    ..This apparent paradox could be due to possible effects exerted by the above polymorphism on lipidemic parameters. Aim of the work was to get insights into these puzzling findings..
  19. pmc Experimental testing of a mathematical model relevant to the extrinsic pathway of apoptosis
    Vincenza Pace
    Department of Cell Biology, University of Calabria, Rende, Italy
    Cell Stress Chaperones 15:13-23. 2010
    ....