Giovanni Davi

Summary

Affiliation: University of Chieti
Country: Italy

Publications

  1. ncbi request reprint Lipid peroxidation in diabetes mellitus
    Giovanni Davi
    Center of Excellence on Aging, University of Chieti G D Annunzio School of Medicine, Chieti, Italy
    Antioxid Redox Signal 7:256-68. 2005
  2. ncbi request reprint Increased circulating resistin is associated with insulin resistance, oxidative stress and platelet activation in type 2 diabetes mellitus
    Francesca Santilli
    Prof Giovanni Davì, Internal Medicine and Center of Excellence on Aging, G d Annunzio University Foundation, Via Colle dell Ara, 66013 Chieti, Italy, E mail
    Thromb Haemost 116:1089-1099. 2016
  3. doi request reprint Oxidative stress and thromboxane-dependent platelet activation in inflammatory bowel disease: effects of anti-TNF-α treatment
    Antonio Di Sabatino
    Prof Giovanni Davì, Internal Medicine and Center of Excellence on Aging, G d Annunzio University Foundation, Via Colle dell Ara, 66013 Chieti, Italy, E mail
    Thromb Haemost 116:486-95. 2016
  4. doi request reprint Microparticles as new markers of cardiovascular risk in diabetes and beyond
    Francesca Santilli
    Prof Giovanni Davì, Center of Excellence on Aging, G d Annunzio University Foundation, Via Colle dell Ara, 66013 Chieti, Italy, Tel 39 0871 541312, Fax 39 0871 541261, E mail
    Thromb Haemost 116:220-34. 2016
  5. doi request reprint Thromboxane receptors antagonists and/or synthase inhibitors
    Giovanni Davi
    Internal Medicine, University of Chieti, Chieti, Italy
    Handb Exp Pharmacol . 2012
  6. doi request reprint Aspirin for primary prevention in diabetes mellitus: from the calculation of cardiovascular risk and risk/benefit profile to personalised treatment
    Francesca Santilli
    Giovanni Davì, Center of Excellence on Aging, G d Annunzio University Foundation, Via Luigi Polacchi 11, 66013 Chieti, Italy, Tel 39 0871 541312, Fax 39 0871 541261, E mail
    Thromb Haemost 114:876-82. 2015
  7. ncbi request reprint Oxidative stress drivers and modulators in obesity and cardiovascular disease: from biomarkers to therapeutic approach
    F Santilli
    Center of Excellence on Aging, G d Annunzio University Foundation, Via Colle dell Ara, 66013 Chieti, Italy
    Curr Med Chem 22:582-95. 2015
  8. pmc Increased expression of the homeostatic chemokines CCL19 and CCL21 in clinical and experimental Rickettsia conorii infection
    Elisabeth Astrup
    Institute of Clinical Medicine, Akershus University Hospital, Sykehusveien 25, Lørenskog 1478, Norway
    BMC Infect Dis 14:70. 2014
  9. doi request reprint Effects of high-amount-high-intensity exercise on in vivo platelet activation: modulation by lipid peroxidation and AGE/RAGE axis
    Francesca Santilli
    Giovanni Davì, Center of Excellence on Aging, G d Annunzio University Foundation, Via Colle dell Ara, 66013 Chieti, Italy, Tel 39 0871 541312, Fax 39 0871 541261, E mail
    Thromb Haemost 110:1232-40. 2013
  10. doi request reprint Biomarkers of platelet activation in acute coronary syndromes
    Patrizia Ferroni
    Department of Advanced Biotechnologies and Bioimaging, IRCCS San Raffaele Pisana, Rome, Italy
    Thromb Haemost 108:1109-23. 2012

Detail Information

Publications67

  1. ncbi request reprint Lipid peroxidation in diabetes mellitus
    Giovanni Davi
    Center of Excellence on Aging, University of Chieti G D Annunzio School of Medicine, Chieti, Italy
    Antioxid Redox Signal 7:256-68. 2005
    ..e., isoprostanes), and the association between isoprostane formation and platelet activation. Finally, possible targets of antioxidant therapy for diabetic vascular complications will be discussed...
  2. ncbi request reprint Increased circulating resistin is associated with insulin resistance, oxidative stress and platelet activation in type 2 diabetes mellitus
    Francesca Santilli
    Prof Giovanni Davì, Internal Medicine and Center of Excellence on Aging, G d Annunzio University Foundation, Via Colle dell Ara, 66013 Chieti, Italy, E mail
    Thromb Haemost 116:1089-1099. 2016
    ..The adipokine-platelet interactions may be involved in platelet insulin resistance and their consequent pro-aggregatory phenotype in this setting...
  3. doi request reprint Oxidative stress and thromboxane-dependent platelet activation in inflammatory bowel disease: effects of anti-TNF-α treatment
    Antonio Di Sabatino
    Prof Giovanni Davì, Internal Medicine and Center of Excellence on Aging, G d Annunzio University Foundation, Via Colle dell Ara, 66013 Chieti, Italy, E mail
    Thromb Haemost 116:486-95. 2016
    ..Further studies are needed to clarify the implication of infliximab induced-proplatelet formation from IBD megakaryocytes. ..
  4. doi request reprint Microparticles as new markers of cardiovascular risk in diabetes and beyond
    Francesca Santilli
    Prof Giovanni Davì, Center of Excellence on Aging, G d Annunzio University Foundation, Via Colle dell Ara, 66013 Chieti, Italy, Tel 39 0871 541312, Fax 39 0871 541261, E mail
    Thromb Haemost 116:220-34. 2016
    ....
  5. doi request reprint Thromboxane receptors antagonists and/or synthase inhibitors
    Giovanni Davi
    Internal Medicine, University of Chieti, Chieti, Italy
    Handb Exp Pharmacol . 2012
    ..Drugs with dual action, such as dual TXS inhibitors/TP antagonist and dual COXIB/TP antagonists are currently in clinical development. The theoretical rationale for their benefit and the ongoing clinical studies are herein discussed...
  6. doi request reprint Aspirin for primary prevention in diabetes mellitus: from the calculation of cardiovascular risk and risk/benefit profile to personalised treatment
    Francesca Santilli
    Giovanni Davì, Center of Excellence on Aging, G d Annunzio University Foundation, Via Luigi Polacchi 11, 66013 Chieti, Italy, Tel 39 0871 541312, Fax 39 0871 541261, E mail
    Thromb Haemost 114:876-82. 2015
    ....
  7. ncbi request reprint Oxidative stress drivers and modulators in obesity and cardiovascular disease: from biomarkers to therapeutic approach
    F Santilli
    Center of Excellence on Aging, G d Annunzio University Foundation, Via Colle dell Ara, 66013 Chieti, Italy
    Curr Med Chem 22:582-95. 2015
    ..Further understanding of ROS-generating mechanisms, their biological role as well as potential therapeutic implications would translate into consistent benefits for effective CV prevention. ..
  8. pmc Increased expression of the homeostatic chemokines CCL19 and CCL21 in clinical and experimental Rickettsia conorii infection
    Elisabeth Astrup
    Institute of Clinical Medicine, Akershus University Hospital, Sykehusveien 25, Lørenskog 1478, Norway
    BMC Infect Dis 14:70. 2014
    ..Based on their essential role in concerting immunological and inflammatory responses we hypothesized that the homeostatic chemokines CCL19 and CCL21 may play a pathogenic role in rickettsiae infection...
  9. doi request reprint Effects of high-amount-high-intensity exercise on in vivo platelet activation: modulation by lipid peroxidation and AGE/RAGE axis
    Francesca Santilli
    Giovanni Davì, Center of Excellence on Aging, G d Annunzio University Foundation, Via Colle dell Ara, 66013 Chieti, Italy, Tel 39 0871 541312, Fax 39 0871 541261, E mail
    Thromb Haemost 110:1232-40. 2013
    ..Our findings may help explaining why a similar amount of exercise exerts significant benefits in preventing cardiovascular events...
  10. doi request reprint Biomarkers of platelet activation in acute coronary syndromes
    Patrizia Ferroni
    Department of Advanced Biotechnologies and Bioimaging, IRCCS San Raffaele Pisana, Rome, Italy
    Thromb Haemost 108:1109-23. 2012
    ....
  11. doi request reprint Variability in the response to antiplatelet treatment in diabetes mellitus
    Giovanni Davi
    Internal Medicine and Center of Excellence on Aging, G D Annunzio University of Chieti, Italy
    Prostaglandins Other Lipid Mediat 98:48-55. 2012
    ....
  12. doi request reprint Oxidative stress and platelet activation in subjects with moderate hyperhomocysteinaemia due to MTHFR 677 C→T polymorphism
    Alfredo Dragani
    Department of Haematology, Civil Hospital Pescara, Italy
    Thromb Haemost 108:533-42. 2012
    ..An integrated biomarker approach may help identifying appropriate candidates for effective folate supplementation...
  13. ncbi request reprint Increased thromboxane metabolites excretion in liver cirrhosis
    G Davi
    Department of Medicine, University of Chieti, Italy
    Thromb Haemost 79:747-51. 1998
    ..We, also, find a significant correlation between urinary excretion of 2,3-dinor-TXB2 and plasma F1+2, suggesting that clotting activation could partly account for in vivo platelet activation...
  14. ncbi request reprint Determinants of increased cardiovascular disease in obesity and metabolic syndrome
    N Vazzana
    Center of Excellence on Aging, G d Annunzio University Foundation, Via Colle dell Ara, 66013 Chieti, Italy
    Curr Med Chem 18:5267-80. 2011
    ..Evaluation of the impact of these therapeutic strategies on the pathobiology of atherothrombosis, as discussed in this review, will translate into an optimized approach for cardiovascular prevention...
  15. ncbi request reprint CD40 ligand and MCP-1 as predictors of cardiovascular events in diabetic patients with stroke
    Giovanni Davi
    Department of Medicine and Aging, G d Annunzio University School of Medicine, Chieti, Italy
    J Atheroscler Thromb 16:707-13. 2009
    ..We asked whether (i) the two molecules are similarly upregulated among non-lacunar and lacunar diabetic strokes and (ii) sCD40L and/or MCP-1 predict the risk of cardiovascular events in this setting...
  16. ncbi request reprint Unveiling the inflammatory face of antiplatelet drugs
    G Davi
    Center of Excellence on Aging, G d Annunzio University Foundation, Chieti, Italy
    J Thromb Haemost 4:2137-9. 2006
  17. ncbi request reprint Oxidant stress, inflammation and atherogenesis
    G Davi
    Center of Excellence on Aging, G d Annunzio Foundation, University of Chieti, G d Annunzio School of Medicine, Chieti, Italy
    Lupus 14:760-4. 2005
    ..The use of F2-isoprostane as a biochemical end-point for dose-finding studies may allow reassessing the adequacy of vitamin supplementation in different clinical settings...
  18. ncbi request reprint Increased levels of soluble P-selectin in hypercholesterolemic patients
    G Davi
    Department of Medicine, University of Chieti G D Annunzio School of Medicine, Italy
    Circulation 97:953-7. 1998
    ..P-selectin may play an important role in the pathogenesis of multicellular events, including atherosclerosis. We studied the impact of hypercholesterolemia and oxidative stress on plasma levels of P-selectin...
  19. ncbi request reprint Oxidative stress and platelet activation in homozygous homocystinuria
    G Davi
    Center of Excellence on Aging, Department of Biomedical Sciences, University of Chieti G D Annunzio, Chieti, Italy
    Circulation 104:1124-8. 2001
    ....
  20. ncbi request reprint Microparticles in type 2 diabetes mellitus
    G Davi
    Center of Excellence on Aging, G d Annunzio University Foundation, Chieti, Italy
    J Thromb Haemost 3:1166-7. 2005
  21. ncbi request reprint Enhanced lipid peroxidation and platelet activation in the early phase of type 1 diabetes mellitus: role of interleukin-6 and disease duration
    Giovanni Davi
    Center of Excellence on Aging and Department of Medicine, University of Chieti G d Annunzio Schools of Medicine and Pharmacy, Chieti, Italy
    Circulation 107:3199-203. 2003
    ..We also investigated the relationship between inflammatory markers and F2-isoprostane formation in this setting...
  22. ncbi request reprint Platelet activation in obese women: role of inflammation and oxidant stress
    Giovanni Davi
    Center of Excellence on Aging, G D Annunzio University Schools of Medicine and Pharmacy, Chieti, Italy
    JAMA 288:2008-14. 2002
    ..Obesity, in particular abdominal adiposity, is associated with increased cardiovascular morbidity and mortality through mechanisms possibly linking the metabolic disorder to platelet and vascular abnormalities...
  23. ncbi request reprint Thromboxane-dependent CD40 ligand release in type 2 diabetes mellitus
    Francesca Santilli
    Center of Excellence on Aging and Department of Medicine, University of Chieti G d Annunzio Schools of Medicine and Pharmacy, Chieti, Italy
    J Am Coll Cardiol 47:391-7. 2006
    ....
  24. doi request reprint Endogenous secretory RAGE in obese women: association with platelet activation and oxidative stress
    Natale Vazzana
    Internal Medicine and Center of Excellence on Aging, Gabriele d Annunzio University of Chieti, 66013 Chieti, Italy
    J Clin Endocrinol Metab 97:E1726-30. 2012
    ..The receptor for advanced glycation end-products (RAGE) has been implicated in obesity-related metabolic disease and accelerated atherothrombosis...
  25. ncbi request reprint Association of inflammation markers with impaired insulin sensitivity and coagulative activation in obese healthy women
    Mario Romano
    Department of Medicine and Aging, University of Chieti G D Annunzio, School of Medicine, 66013 Chieti, Italy
    J Clin Endocrinol Metab 88:5321-6. 2003
    ..The elevated TGF-beta 1 levels detected in the obese population may provide a biochemical link between insulin resistance and an increased risk for cardiovascular disease...
  26. ncbi request reprint Association between enhanced soluble CD40L and prothrombotic state in hypercholesterolemia: effects of statin therapy
    Francesco Cipollone
    Center of Excellence on Aging, University of Chieti G D Annunzio School of Medicine, Chieti, Italy
    Circulation 106:399-402. 2002
    ..The aim of this study was to characterize the in vivo expression of soluble CD40L (sCD40L) in hypercholesterolemia, to correlate it with the extent of the prothrombotic state, and to investigate whether it may be modified by statins...
  27. doi request reprint Inflammation, oxidative stress and platelet activation in aspirin-treated critical limb ischaemia: beneficial effects of iloprost
    Gianfranco Lessiani
    Center of Excellence on Aging, G d Annunzio University Foundation, Chieti, Italy
    Thromb Haemost 105:321-8. 2011
    ....
  28. ncbi request reprint Determinants of platelet activation in hypertensives with microalbuminuria
    Maria Teresa Guagnano
    Center of Excellence on Aging, G d Annunzio University Foundation, University of Chieti G d Annunzio Schools of Medicine and Pharmacy, Chieti, Italy
    Free Radic Biol Med 46:922-7. 2009
    ..We conclude that lipid peroxidation is a major determinant of persistent platelet activation in hypertensive patients with microalbuminuria...
  29. doi request reprint Circulating endothelial progenitor cells and residual in vivo thromboxane biosynthesis in low-dose aspirin-treated polycythemia vera patients
    Francesca Santilli
    Center of Excellence on Aging, G d Annunzio University Foundation, Chieti, Italy
    Blood 112:1085-90. 2008
    ..Thus, additional antithrombotic strategies may be beneficial in PV...
  30. doi request reprint Platelet cyclooxygenase inhibition by low-dose aspirin is not reflected consistently by platelet function assays: implications for aspirin "resistance"
    Francesca Santilli
    Center of Excellence on Aging, G d Annunzio University Foundation, Chieti, Italy
    J Am Coll Cardiol 53:667-77. 2009
    ..This study was conducted to assess the thromboxane (TX) dependence of biochemical and functional indexes used to monitor the effect of low-dose aspirin...
  31. ncbi request reprint Decreased in vivo oxidative stress and decreased platelet activation following metformin treatment in newly diagnosed type 2 diabetic subjects
    Gloria Formoso
    Department of Medicine and Aging Sciences, University G D Annunzio, Chieti, Italy
    Diabetes Metab Res Rev 24:231-7. 2008
    ..Since oxidative stress and the consequent enhanced platelet activation contribute to accelerated atherosclerosis in diabetes, we hypothesized that metformin could reduce oxidative stress in this condition...
  32. ncbi request reprint Cyclooxygenase-1 haplotype C50T/A-842G does not affect platelet response to aspirin
    Caterina Pettinella
    Center of Excellence on Aging, G d Annunzio University Foundation, Chieti, Italy
    Thromb Haemost 101:687-90. 2009
    ..Platelet cyclooxygenase activity, as reflected by serum TXB(2), was uniformly and persistently suppressed by low-dose aspirin in both carriers and non carriers of these polymorphisms...
  33. ncbi request reprint Determinants of platelet activation in Alzheimer's disease
    Giovanni Ciabattoni
    Center of Excellence on Aging, G d Annunzio University Foundation, Italy
    Neurobiol Aging 28:336-42. 2007
    ..To investigate the rate of platelet thromboxane (TX) biosynthesis and its determinants in Alzheimer's disease...
  34. doi request reprint Determinants of thromboxane biosynthesis in rheumatoid arthritis: Role of RAGE and oxidant stress
    Elisabetta Ferrante
    Center of Excellence on Aging, G d Annunzio University Foundation, Chieti, Italy
    Free Radic Biol Med 49:857-64. 2010
    ..We suggest that RAGE hyperactivity may escape TNF blockade, thus contributing to persistent TX biosynthesis in this setting...
  35. pmc Enhanced lipid peroxidation and platelet activation as potential contributors to increased cardiovascular risk in the low-HDL phenotype
    Natale Vazzana
    Department of Internal Medicine and Center of Excellence on Aging, G D Annunzio University of Chieti, Chieti, Italy
    J Am Heart Assoc 2:e000063. 2013
    ..In animal models HDLs protect LDL from oxidation and blunt platelet activation. Our study aimed to examine whether HDL levels are related to in vivo oxidative stress and platelet activation, as determinants of atherothrombosis...
  36. ncbi request reprint Helicobacter pylori infection causes persistent platelet activation in vivo through enhanced lipid peroxidation
    Giovanni Davi
    Center of Excellence on Aging, Fondazione Universita G D Annunzio, Chieti, Italy
    Arterioscler Thromb Vasc Biol 25:246-51. 2005
    ....
  37. doi request reprint Pentraxin 3 and Platelet Activation in Obese Patients After Gastric Banding
    Francesca Santilli
    Internal Medicine and Center of Excellence on Aging, G D Annunzio University of Chieti
    Circ J 80:502-11. 2016
    ..Circulating pentraxin 3 (PTX3), the main regulator of the inflammatory response, rapidly increases following cardiovascular events, and low PTX3 is associated with high body mass index...
  38. pmc Circulating dickkopf-1 in diabetes mellitus: association with platelet activation and effects of improved metabolic control and low-dose aspirin
    Stefano Lattanzio
    Center of Excellence on Aging, G D Annunzio University of Chieti, Italy S L, F S, R L, N V, P D F, G F, A C, G D
    J Am Heart Assoc 3:. 2014
    ....
  39. ncbi request reprint Decreased plasma soluble RAGE in patients with hypercholesterolemia: effects of statins
    Francesca Santilli
    Center of Excellence on Aging, Department of Medicine, and Department of Drug Sciences, University of Chieti G d Annunzio Schools of Medicine and Pharmacy, 66013 Chieti, Italy
    Free Radic Biol Med 43:1255-62. 2007
    ..sRAGE might serve as an endogenous protecting factor for accelerated atherosclerosis mediated by oxidative stress and endothelial dysfunction in hypercholesterolemia...
  40. doi request reprint Arterial stiffness and sedentary lifestyle: Role of oxidative stress
    Gianfranco Lessiani
    Internal Medicine and Center of Excellence on Aging, G D Annunzio University of Chieti, Italy
    Vascul Pharmacol 79:1-5. 2016
    ..PWV levels were also related to urinary 8-iso-PGF2α in our previously sedentary subjects. We conclude that regular physical exercise may be a natural antioxidant strategy, lowering oxidant stress and thereby the AS degree. ..
  41. doi request reprint Plasma levels of soluble CD36, platelet activation, inflammation, and oxidative stress are increased in type 2 diabetic patients
    Rossella Liani
    Center of Excellence on Aging, University of Chieti G D Annunzio, Via Colle dell Ara, 66013, Chieti, Italy
    Free Radic Biol Med 52:1318-24. 2012
    ....
  42. ncbi request reprint Soluble RAGE in type 2 diabetes: association with oxidative stress
    Eleonora Devangelio
    Center of Excellence on Aging and Departments of Medicine and Drug Sciences, University of Chieti G d Annunzio Schools of Medicine and Pharmacy, 66013 Chieti, Italy
    Free Radic Biol Med 43:511-8. 2007
    ..0001). Thus, poor glycemic control reduces sRAGE levels, in association with enhanced oxidative stress and endothelial dysfunction in diabetes. These abnormalities are susceptible to modulation by improvement in metabolic control...
  43. doi request reprint Cystic fibrosis transmembrane conductance regulator (CFTR) expression in human platelets: impact on mediators and mechanisms of the inflammatory response
    Domenico Mattoscio
    Department of Biomedical Sciences, Aging Research Center, CeSI, Gabriele D Annunzio University Foundation, Via Colle dell Ara, 66013 Chieti, Italy
    FASEB J 24:3970-80. 2010
    ..650±0.09 vs. 1.04±0.24 U; P=0.03). Taken together, these findings indicate that PLTs from CF patients are affected by the molecular defect of CFTR. Moreover, this CF PLT abnormality may explain the failure of resolution in CF...
  44. ncbi request reprint Platelet activation and atherothrombosis
    Giovanni Davi
    Center of Excellence on Aging, G d Annunzio University Foundation, Chieti, Italy
    N Engl J Med 357:2482-94. 2007
  45. doi request reprint Diabetes mellitus and thrombosis
    Natale Vazzana
    Internal Medicine and Center of Excellence on Aging, G d Annunzio University Foundation, Chieti, Italy
    Thromb Res 129:371-7. 2012
    ..This review will provide an overview of the current status of knowledge on mechanisms of accelerated atherothrombosis in patients with diabetes mellitus...
  46. doi request reprint Soluble forms of RAGE in internal medicine
    Natale Vazzana
    Center of Excellence on Aging, G d Annunzio University Foundation, Via Colle dell Ara, 66013 Chieti, Italy
    Intern Emerg Med 4:389-401. 2009
    ....
  47. doi request reprint Oxidative-induced membrane damage in diabetes lymphocytes: effects on intracellular Ca(2 +) homeostasis
    Silvia Belia
    Center of Excellence on Aging, G d Annunzio University Foundation, Chieti, Italy
    Free Radic Res 43:138-48. 2009
    ..The data support a correlation between oxidative damage and alterations in intracellular Ca(2 +) homeostasis, possibly due to modification of the ionic control in lymphocytes of type-2 diabetes patients...
  48. doi request reprint Homocysteine, methylenetetrahydrofolate reductase, folate status and atherothrombosis: A mechanistic and clinical perspective
    Francesca Santilli
    Center of Excellence on Aging, G d Annunzio University Foundation and Department of Medicine and Aging, University of Chieti G D Annunzio School of Medicine, Italy Electronic address
    Vascul Pharmacol 78:1-9. 2016
    ....
  49. doi request reprint Determinants of thromboxane biosynthesis in patients with moderate to severe chronic kidney disease
    Natale Vazzana
    Internal Medicine and Center of Excellence on Aging, G d Annunzio University Foundation, Chieti, Italy
    Eur J Intern Med 33:74-80. 2016
    ....
  50. ncbi request reprint Determinants of F2-isoprostane biosynthesis and inhibition in man
    Giovanni Davi
    Center of Excellence on Aging, School of Medicine, University of Chieti G D Annunzio, Via Colle dell Ara, 66013 Chieti, Italy
    Chem Phys Lipids 128:149-63. 2004
    ..This information could be extremely valuable in the selection of the appropriate patient subgroups that may benefit from antioxidant interventions...
  51. doi request reprint TP receptor activation and inhibition in atherothrombosis: the paradigm of diabetes mellitus
    Francesca Santilli
    Center of Excellence on Aging, G d Annunzio University Foundation, Via Colle dell Ara, 66013, Chieti, Italy
    Intern Emerg Med 6:203-12. 2011
    ....
  52. ncbi request reprint Soluble forms of RAGE in human diseases: clinical and therapeutical implications
    Francesca Santilli
    Center of Excellence on Aging, G d Annunzio University Foundation, Chieti, Italy
    Curr Med Chem 16:940-52. 2009
    ....
  53. doi request reprint Nutraceuticals in diabetes and metabolic syndrome
    Giovanni Davi
    Center of Excellence on Aging, G d Annunzio University Foundation, Chieti, Italy
    Cardiovasc Ther 28:216-26. 2010
    ....
  54. doi request reprint Ankle-Brachial Index and cardiovascular events in atrial fibrillation. The ARAPACIS Study
    Francesco Violi
    Prof Francesco Violi, I Clinica Medica, Sapienza University of Rome, Viale del Policlinico 155, Rome, 00161, Italy, Tel 39 06 4461933, Fax 39 06 49970103, E mail
    Thromb Haemost 115:856-63. 2016
    ..91). In conclusion, low ABI is useful to predict MI and vascular death in NVAF patients and may independently facilitate cardiovascular risk assessment in NVAF patients...
  55. pmc Circulating myeloid-related protein-8/14 is related to thromboxane-dependent platelet activation in patients with acute coronary syndrome, with and without ongoing low-dose aspirin treatment
    Francesca Santilli
    Department of Medicine and Aging, University of Chieti G D Annunzio School of Medicine, Chieti, Italy F S, R L, S L, S L B, S P, G D
    J Am Heart Assoc 3:. 2014
    ..Among platelet transcripts, MRP-14 has emerged as a powerful predictor of ACS...
  56. ncbi request reprint Homocysteine modulates the CD40/CD40L system
    Cesaria Prontera
    Department of Medicine, Gabriele D Annunzio University Foundation, Chieti Pescara, Italy
    J Am Coll Cardiol 49:2182-90. 2007
    ..This study evaluated the impact of hyperhomocysteinemia (HHcy) on the CD40/CD40 ligand (CD40L) dyad in vivo and in vitro...
  57. ncbi request reprint Urinary excretion of lipoxin A(4) and related compounds: development of new extraction techniques for lipoxins
    Mario Romano
    Center of Excellence of Aging, Department of Biomedical Sciences, University G D Annunzio, Chieti, Italy
    Lab Invest 82:1253-4. 2002
    ....
  58. ncbi request reprint Isoprostane formation and inhibition in atherothrombosis
    Carlo Patrono
    Department of Pharmacology, Universita di Roma La Sapienza, Ospedale Sant Andrea, Via di Grottarossa 1035, 00189 Rome, Italy
    Curr Opin Pharmacol 5:198-203. 2005
    ..Clinical studies support the hypothesis that enhanced lipid peroxidation may contribute, at least in part, to persistent platelet activation...
  59. doi request reprint Platelets and diabetes mellitus
    Francesca Santilli
    Internal Medicine and Center of Excellence on Aging, G D Annunzio University of Chieti, Italy
    Prostaglandins Other Lipid Mediat 120:28-39. 2015
    ..Taken together, these pathophysiological aspects may contribute to the development of promising mechanism-based therapeutic strategies to reduce the progression of atherothrombosis in diabetic subjects. ..
  60. ncbi request reprint Oxidative Stress Modulation Through Habitual Physical Activity
    Andrea Boccatonda
    Center of Excellence on Aging, and 34 G D and 39 Annunzio and 34 University Foundation, Via Colle dell and 39 Ara, 66013 Chieti, Italy
    Curr Pharm Des 22:3648-80. 2016
    ..Indeed, ROS, generated during physical activity, are likely main mediators of antioxidant molecules upregulation, as reflected by increased glutathione reductase levels after exercise training...
  61. doi request reprint The Coxib case: Are EP receptors really guilty?
    Francesca Santilli
    Department of Internal Medicine, G D Annunzio University, Chieti, Italy
    Atherosclerosis 249:164-73. 2016
    ..These changes may powerfully synergize with NSAID-induced prostaglandin (PG) modifications, thus regulating vascular side effects. ..
  62. ncbi request reprint Association between serum leptin levels and 24-hour blood pressure in obese women
    Maria T Guagnano
    Department of Internal Medicine and Aging, University of Chieti, Italy
    Obes Res 11:549-55. 2003
    ..To assess the relationship between serum leptin and 24-hour blood pressure (BP) in obese women, according to body fat distribution...
  63. doi request reprint Correlation between Migraine Severity and Cholesterol Levels
    Claudio Tana
    Department of Medicine and Science of Aging, G D Annunzio University, Chieti, Italy
    Pain Pract 15:662-70. 2015
    ..However, no studies have investigated the possible relationship between headache severity parameters and lipid serum levels...
  64. pmc MicroRNA-181b regulates ALX/FPR2 receptor expression and proresolution signaling in human macrophages
    Anna Maria Pierdomenico
    From the Department of Medicine and Aging Sciences and Center of Excellence on Aging G D Annunzio University Foundation, 66013 Chieti, Italy
    J Biol Chem 290:3592-600. 2015
    ..These results unravel novel regulatory mechanisms of ALX/FPR2 expression and ligand-evoked macrophages proresolution responses mediated by miR-181b, thus uncovering novel components of the endogenous inflammation resolution circuits. ..
  65. doi request reprint Oxidative stress in chronic vascular disease: From prediction to prevention
    Francesca Santilli
    Center of Excellence on Aging, G d Annunzio University Foundation, Italy Department of Medicine and Aging, University of Chieti G D Annunzio School of Medicine, Italy Electronic address
    Vascul Pharmacol 74:23-37. 2015
    ....
  66. doi request reprint Oxidative stress-related mechanisms affecting response to aspirin in diabetes mellitus
    Francesca Santilli
    Center of Excellence on Aging, G d Annunzio University Foundation, and Department of Medicine and Aging, University of Chieti G D Annunzio School of Medicine, 66013 Chieti, Italy Electronic address
    Free Radic Biol Med 80:101-10. 2015
    ....
  67. pmc Estimated glomerular filtration rate is an easy predictor of venous thromboembolism in cancer patients undergoing platinum-based chemotherapy
    Patrizia Ferroni
    Biomarker Discovery and Advanced Technologies BioDAT Laboratory, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS San Raffaele Pisana Research Center, Rome, Italy Department of System Medicine, Medical Oncology, Tor Vergata Clinical Center, University of Rome Tor Vergata, Rome, Italy Section of Medical Oncology, Department of Surgical and Oncology Sciences, University of Palermo, Palermo, Italy Internal Medicine and Center of Excellence on Aging, G d Annunzio University Foundation, Chieti, Italy
    Oncologist 19:562-7. 2014
    ..Determining eGFR before chemotherapy could represent a simple predictor of VTE, at no additional cost to health care systems. ..