Antonio Curti

Summary

Affiliation: University of Bologna
Country: Italy

Publications

  1. doi Larger Size of Donor Alloreactive NK Cell Repertoire Correlates with Better Response to NK Cell Immunotherapy in Elderly Acute Myeloid Leukemia Patients
    Antonio Curti
    Department of Experimental, Diagnostic and Specialty Medicine, Institute of Hematology L and A Seràgnoli, University of Bologna, S Orsola Malpighi Hospital, Bologna, Italy
    Clin Cancer Res 22:1914-21. 2016
  2. doi Successful transfer of alloreactive haploidentical KIR ligand-mismatched natural killer cells after infusion in elderly high risk acute myeloid leukemia patients
    Antonio Curti
    Institute of Hematology, Department of Hematology and Oncological Sciences L and A Seràgnoli, University of Bologna, S Orsola Malpighi Hospital, Bologna, Italy
    Blood 118:3273-9. 2011
  3. ncbi Induction of regulatory T Cells by dendritic cells through indoleamine 2,3-dioxygenase: a potent mechanism of acquired peripheral tolerance
    S Trabanelli
    Department of Hematology and Oncological Sciences L and A Seràgnoli, Institute of Hematology and Medical Oncology L and A Seragnoli, Via Massarenti, Bologna, Italy
    Curr Med Chem 18:2234-9. 2011
  4. pmc Indoleamine 2,3-dioxygenase-expressing leukemic dendritic cells impair a leukemia-specific immune response by inducing potent T regulatory cells
    Antonio Curti
    Department of Hematology and Oncological Sciences L and A Seràgnoli, Via Massarenti, 9, 40138, Bologna, Italy
    Haematologica 95:2022-30. 2010
  5. doi The role of indoleamine 2,3-dioxygenase in the induction of immune tolerance: focus on hematology
    Antonio Curti
    Department of Hematology and Oncological Sciences L and A Seràgnoli, University of Bologna and Stem Cell Research Center, Azienda Ospedaliero Universitaria Policlinico S Orsola Malpighi, Bologna, Italy
    Blood 113:2394-401. 2009
  6. ncbi Generation of dendritic cells from positively selected CD14+ monocytes for anti-tumor immunotherapy
    Antonio Curti
    Institute of Hematology and Medical Oncology L and A Seragnoli, University of Bologna, Bologna, Italy
    Leuk Lymphoma 45:1419-28. 2004
  7. ncbi Positive selection and transplantation of autologous highly purified CD133(+) stem cells in resistant/relapsed chronic lymphocytic leukemia patients results in rapid hematopoietic reconstitution without an adequate leukemic cell purging
    Alessandro Isidori
    Institute of Hematology and Medical Oncology, L and A Seragnoli, University of Bologna, Bologna, Italy
    Biol Blood Marrow Transplant 13:1224-32. 2007
  8. pmc The SOCS3-independent expression of IDO2 supports the homeostatic generation of T regulatory cells by human dendritic cells
    Sara Trabanelli
    Department of Specialistic, Diagnostic, and Experimental Medicine, Institute of Hematology Seragnoli, University of Bologna, 40138 Bologna, Italy
    J Immunol 192:1231-40. 2014
  9. ncbi Interleukin-12 production by leukemia-derived dendritic cells counteracts the inhibitory effect of leukemic microenvironment on T cells
    Antonio Curti
    Institute of Hematology and Medical Oncology L and A Seragnoli, University of Bologna and Stem Cell Center, S Orsola Malpighi Hospital, Italy
    Exp Hematol 33:1521-30. 2005
  10. ncbi Phase II study of a single pegfilgrastim injection as an adjunct to chemotherapy to mobilize stem cells into the peripheral blood of pretreated lymphoma patients
    Alessandro Isidori
    Institute of Hematology and Medical Oncology L and A Seragnoli, University of Bologna, Italy
    Haematologica 90:225-31. 2005

Collaborators

Detail Information

Publications28

  1. doi Larger Size of Donor Alloreactive NK Cell Repertoire Correlates with Better Response to NK Cell Immunotherapy in Elderly Acute Myeloid Leukemia Patients
    Antonio Curti
    Department of Experimental, Diagnostic and Specialty Medicine, Institute of Hematology L and A Seràgnoli, University of Bologna, S Orsola Malpighi Hospital, Bologna, Italy
    Clin Cancer Res 22:1914-21. 2016
    ..We aimed at determining whether the composition of NK graft in terms of frequency of alloreactive NK cells influence the clinical response in a group of elderly AML patients undergoing NK immunotherapy...
  2. doi Successful transfer of alloreactive haploidentical KIR ligand-mismatched natural killer cells after infusion in elderly high risk acute myeloid leukemia patients
    Antonio Curti
    Institute of Hematology, Department of Hematology and Oncological Sciences L and A Seràgnoli, University of Bologna, S Orsola Malpighi Hospital, Bologna, Italy
    Blood 118:3273-9. 2011
    ..In conclusion, infusion of purified NK cells is feasible in elderly patients with high-risk acute myeloid leukemia. This trial was registered at www.clinicaltrial.gov as NCT00799799...
  3. ncbi Induction of regulatory T Cells by dendritic cells through indoleamine 2,3-dioxygenase: a potent mechanism of acquired peripheral tolerance
    S Trabanelli
    Department of Hematology and Oncological Sciences L and A Seràgnoli, Institute of Hematology and Medical Oncology L and A Seragnoli, Via Massarenti, Bologna, Italy
    Curr Med Chem 18:2234-9. 2011
    ..The aim of the present paper is to highlight the most recent data about IDO expression in dendritic cells and its role as a potent inducer of T regulatory cells...
  4. pmc Indoleamine 2,3-dioxygenase-expressing leukemic dendritic cells impair a leukemia-specific immune response by inducing potent T regulatory cells
    Antonio Curti
    Department of Hematology and Oncological Sciences L and A Seràgnoli, Via Massarenti, 9, 40138, Bologna, Italy
    Haematologica 95:2022-30. 2010
    ..Acute myeloid leukemia cells can be differentiated into dendritic cells, which have increased immunogenicity and have been proposed as vaccines against leukemia...
  5. doi The role of indoleamine 2,3-dioxygenase in the induction of immune tolerance: focus on hematology
    Antonio Curti
    Department of Hematology and Oncological Sciences L and A Seràgnoli, University of Bologna and Stem Cell Research Center, Azienda Ospedaliero Universitaria Policlinico S Orsola Malpighi, Bologna, Italy
    Blood 113:2394-401. 2009
    ..In this review, the role of IDO in the induction of immunologic tolerance is addressed with a specific focus on its recently discovered effect on hematologic malignancies...
  6. ncbi Generation of dendritic cells from positively selected CD14+ monocytes for anti-tumor immunotherapy
    Antonio Curti
    Institute of Hematology and Medical Oncology L and A Seragnoli, University of Bologna, Bologna, Italy
    Leuk Lymphoma 45:1419-28. 2004
    ..Based on these results, a DCs-based phase II trial of anti-Id vaccination with VDJ-derived HLA class I-restricted peptides and KLH is underway for lymphoma patients...
  7. ncbi Positive selection and transplantation of autologous highly purified CD133(+) stem cells in resistant/relapsed chronic lymphocytic leukemia patients results in rapid hematopoietic reconstitution without an adequate leukemic cell purging
    Alessandro Isidori
    Institute of Hematology and Medical Oncology, L and A Seragnoli, University of Bologna, Bologna, Italy
    Biol Blood Marrow Transplant 13:1224-32. 2007
    ..However, the purging potential of positive selection of CD133(+) cells is not adequate to achieve tumor-free autografts...
  8. pmc The SOCS3-independent expression of IDO2 supports the homeostatic generation of T regulatory cells by human dendritic cells
    Sara Trabanelli
    Department of Specialistic, Diagnostic, and Experimental Medicine, Institute of Hematology Seragnoli, University of Bologna, 40138 Bologna, Italy
    J Immunol 192:1231-40. 2014
    ....
  9. ncbi Interleukin-12 production by leukemia-derived dendritic cells counteracts the inhibitory effect of leukemic microenvironment on T cells
    Antonio Curti
    Institute of Hematology and Medical Oncology L and A Seragnoli, University of Bologna and Stem Cell Center, S Orsola Malpighi Hospital, Italy
    Exp Hematol 33:1521-30. 2005
    ..AML-derived dendritic cells (AML-DCs) have better antigen-presentation capacity than undifferentiated leukemic blasts, but may not be fully competent to stimulate T cells previously inhibited by leukemic cells...
  10. ncbi Phase II study of a single pegfilgrastim injection as an adjunct to chemotherapy to mobilize stem cells into the peripheral blood of pretreated lymphoma patients
    Alessandro Isidori
    Institute of Hematology and Medical Oncology L and A Seragnoli, University of Bologna, Italy
    Haematologica 90:225-31. 2005
    ..The aim of this study was to evaluate the efficacy of pegfilgrastim, in combination with salvage chemotherapy, in mobilizing CD34(+) stem cells into the peripheral blood of pretreated lymphoma patients...
  11. ncbi Phase I/II clinical trial of sequential subcutaneous and intravenous delivery of dendritic cell vaccination for refractory multiple myeloma using patient-specific tumour idiotype protein or idiotype (VDJ)-derived class I-restricted peptides
    Antonio Curti
    Institute of Haematology and Medical Oncology L and A Seragnoli, University of Bologna, Bologna, Italy
    Br J Haematol 139:415-24. 2007
    ..In conclusion, sc injections of cryopreserved Id-pulsed DCs were safe and, in contrast with intravenous administrations, induced anti-MM T-cell responses...
  12. ncbi Generation of dendritic cells from CD14+ monocytes positively selected by immunomagnetic adsorption for multiple myeloma patients enrolled in a clinical trial of anti-idiotype vaccination
    Maria R Motta
    Institute of Haematology and Medical Oncology, L and A Seragnoli, University of Bologna, Bologna, Italy
    Br J Haematol 121:240-50. 2003
    ..The recovery of thawed, viable DC was 78 +/- 10%. Finally, interferon-alpha-2b was at least as efficient as IL-4 in inducing the differentiation of mature, functional DC from monocytes...
  13. doi Decreased expression of indoleamine 2,3-dioxygenase 1 in dendritic cells contributes to impaired regulatory T cell development in immune thrombocytopenia
    Lucia Catani
    Institute of Hematology, Department of Hematology and Oncological Sciences L e A Seràgnoli, University of Bologna, Bologna, Italy
    Ann Hematol 92:67-78. 2013
    ..In conclusion, these data point out the role of IDO1 in the impaired regulatory T cell development of ITP patients and suggest that the cross-talk between Tregs and DCs is hampered and plays a pathogenetic role...
  14. ncbi Nucleofection is an efficient nonviral transfection technique for human bone marrow-derived mesenchymal stem cells
    Michela Aluigi
    Institute of Hematology and Medical Oncology L e A Seràgnoli, Via Massarenti, 9, 40137 Bologna, Italy
    Stem Cells 24:454-61. 2006
    ..In conclusion, nucleofection is an efficient nonviral transfection technique for hMSCs, which then may be used as cellular vehicles for the delivery of biological agents...
  15. ncbi Modulation of tryptophan catabolism by human leukemic cells results in the conversion of CD25- into CD25+ T regulatory cells
    Antonio Curti
    Institute of Hematology and Medical Oncology L and A Seragnoli, University of Bologna and Stem Cell Center, S Orsola Malpighi Hospital, Bologna, Italy
    Blood 109:2871-7. 2007
    ..These data indicate that AML cells induce T-cell tolerance by directly converting CD4+CD25- T cells into CD4+CD25+ T(reg) cells through an IDO-dependent mechanism...
  16. ncbi The therapeutic role of dendritic cells in cancer immunotherapy
    Roberto M Lemoli
    Institute of Hematology and Medical Oncology Lorenzo and Ariosto Seràgnoli, University of Bologna, Italy
    Haematologica 87:62-6. 2002
  17. pmc PGE2-induced IDO1 inhibits the capacity of fully mature DCs to elicit an in vitro antileukemic immune response
    Sara Trabanelli
    Department of Specialistic, Diagnostic and Experimental Medicine, Institute of Hematology L and A Seràgnoli, University of Bologna, 40138 Bologna, Italy Ludwig Center for Cancer Research of the University of Lausanne, 1011 Lausanne, Switzerland
    J Immunol Res 2015:253191. 2015
    ..Moreover, the inhibition of IDO1 enhances the antileukemic response. Overall, these results point toward the use of IDO1 inhibitors to enhance the vaccination capacity of DCs, matured with PGE2. ..
  18. pmc The tissue inhibitor of metalloproteinases-1 (TIMP-1) promotes survival and migration of acute myeloid leukemia cells through CD63/PI3K/Akt/p21 signaling
    Dorian Forte
    Department of Experimental, Diagnostic and Specialty Medicine DIMES, Institute of Hematology L and A Seràgnoli, University of Bologna, Bologna, Italy
    Oncotarget 8:2261-2274. 2017
    ..As a "bad actor" in a "bad soil", we propose TIMP-1 as a potential novel therapeutic target in leukemic BM microenvironment...
  19. doi CD103 marks a subset of human CD34+-derived langerin+ dendritic cells that induce T-regulatory cells via indoleamine 2,3-dioxygenase-1
    Darina Ocadlikova
    Department of Specialistic, Diagnostic and Experimental Medicine, Institute of Hematology Seragnoli, University of Bologna, Bologna, Italy
    Exp Hematol 43:268-76.e5. 2015
    ..These data point toward IDO1 expression as part of a tolerogenic signature during DC development...
  20. ncbi Dendritic cells of immune thrombocytopenic purpura (ITP) show increased capacity to present apoptotic platelets to T lymphocytes
    Lucia Catani
    Istituto di Ematologia e Oncologia Medica L e A Seragnoli, Universita di Bologna, Bologna, Italy
    Exp Hematol 34:879-87. 2006
    ..Therefore, in the present study we investigated whether platelet apoptosis and/or dendritic cells (DCs) may play a role in the stimulation of the immuno-mediated anti-platelet response in chronic immune thrombocytopenic purpura (ITP)...
  21. doi Extracellular ATP exerts opposite effects on activated and regulatory CD4+ T cells via purinergic P2 receptor activation
    Sara Trabanelli
    Department of Hematology and Oncological Sciences L and A Seràgnoli, University of Bologna, 9 40138 Bologna, Italy
    J Immunol 189:1303-10. 2012
    ....
  22. pmc The Human Mesenchymal Stromal Cell-Derived Osteocyte Capacity to Modulate Dendritic Cell Functions Is Strictly Dependent on the Culture System
    Sara Trabanelli
    Department of Experimental, Diagnostic and Specialty Medicine, Institute of Hematology L and A Seràgnoli, University of Bologna, 40138 Bologna, Italy Ludwig Center for Cancer Research, The University of Lausanne, 1011 Lausanne, Switzerland
    J Immunol Res 2015:526195. 2015
    ..This finding may have relevant implications for the design of cell-based tissue-engineering strategies. ..
  23. ncbi Functional and kinetic characterization of granulocyte colony-stimulating factor-primed CD34- human stem cells
    Roberto M Lemoli
    Istituto di Ematologia e Oncologia Medica L and A Seragnoli, University of Bologna, Bologna, Italy
    Br J Haematol 123:720-9. 2003
    ..Thus, our study indicated that CD34 expression on human PB stem cells was associated with haematopoietic activity, cell-cycle recruitment and downregulation of p27Kip1 in vitro and higher engraftment capacity in vivo...
  24. ncbi Autologous transplantation of granulocyte colony-stimulating factor-primed bone marrow is effective in supporting myeloablative chemotherapy in patients with hematologic malignancies and poor peripheral blood stem cell mobilization
    Roberto M Lemoli
    Institute of Hematology and Medical Oncology Seràgnoli Via Massarenti, 9, 40100 Bologna, Italy
    Blood 102:1595-600. 2003
    ..TRM was 4.6%, whereas 15 patients died of disease. G-CSF-primed BM induces effective multilineage hematopoietic recovery after high-dose chemotherapy and can be safely used in patients with poor stem cell mobilization...
  25. pmc Extracellular ATP induces apoptosis through P2X7R activation in acute myeloid leukemia cells but not in normal hematopoietic stem cells
    Valentina Salvestrini
    Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy
    Oncotarget . 2016
    ..These results provide evidence that ATP would be promising for developing innovative therapy for AML...
  26. ncbi Interleukin-11 induces proliferation of human T-cells and its activity is associated with downregulation of p27(kip1)
    Antonio Curti
    Institute of Hematology and Medical Oncology Lorenzo and Ariosto Seràgnoli, University of Bologna, Bologna, Italy
    Haematologica 87:373-80. 2002
    ..In this study, we investigated the effects of IL-11 on the kinetic activation and apoptosis of T-cell subsets stimulated with anti-CD3/CD28 antibodies, anti-CD3 and IL-2 or dendritic cells...
  27. doi The tissue inhibitor of metalloproteinases 1 increases the clonogenic efficiency of human hematopoietic progenitor cells through CD63/PI3K/Akt signaling
    Lara Rossi
    Department of Experimental, Diagnostic and Specialty Medicine, Institute of Hematology L and A Seràgnoli, University of Bologna, Bologna, Italy
    Exp Hematol 43:974-985.e1. 2015
    ....
  28. ncbi Dendritic cells are functionally defective in multiple myeloma: the role of interleukin-6
    Marina Ratta
    Institute of Hematology and Medical Oncology, Lorenzo e Ariosto Seràgnoli, University of Bologna, Italy
    Blood 100:230-7. 2002
    ..This brings into question the advisability of using PBDCs as antigen carriers for immunotherapy trials in MM. The results also suggest a novel mechanism whereby myeloma cells escape immune recognition...