Alessandra Cucina

Summary

Affiliation: University of Rome La Sapienza
Country: Italy

Publications

  1. doi request reprint Nicotine stimulates proliferation and inhibits apoptosis in colon cancer cell lines through activation of survival pathways
    Alessandra Cucina
    Department of Surgery Pietro Valdoni, Sapienza University of Rome, Rome, Italy
    J Surg Res 178:233-41. 2012
  2. doi request reprint Nicotine inhibits apoptosis and stimulates proliferation in aortic smooth muscle cells through a functional nicotinic acetylcholine receptor
    Alessandra Cucina
    Department of Surgery Pietro Valdoni, La Sapienza University of Rome, Rome, Italy
    J Surg Res 150:227-35. 2008
  3. doi request reprint The effect of locally administered anti-growth factor antibodies on neointimal hyperplasia formation in expanded polytetrafluoroethylene grafts
    Paolo Sapienza
    Department of Surgery Pietro Valdoni, University of Rome La Sapienza, Policlinico Umberto I, Rome, Italy
    Ann Vasc Surg 23:398-409. 2009
  4. pmc TCam-2 seminoma cells exposed to egg-derived microenvironment modify their shape, adhesive pattern and migratory behaviour: a molecular and morphometric analysis
    Francesca Ferranti
    Department of Anatomy, Histology, Forensic Medicine and Orthopedics Section of Histology and Medical Embryology, Sapienza University of Rome, Rome, Italy
    PLoS ONE 8:e76192. 2013
  5. doi request reprint Nicotine increases survival in human colon cancer cells treated with chemotherapeutic drugs
    Simona Dinicola
    Department of Clinical and Molecular Medicine, Sapienza University of Rome, Piazza Sassari 3, 00161 Rome, Italy Department of Surgery Pietro Valdoni, Sapienza University of Rome, Via Antonio Scarpa 14, 00161 Rome, Italy
    Toxicol In Vitro 27:2256-63. 2013
  6. pmc Phenotypic switch induced by simulated microgravity on MDA-MB-231 breast cancer cells
    Maria Grazia Masiello
    Department of Clinical and Molecular Medicine, Sapienza University of Rome, Piazza Sassari 3, 00161 Rome, Italy Department of Surgery PietroValdoni, Sapienza University of Rome, Via A Scarpa 14, 00161 Rome, Italy
    Biomed Res Int 2014:652434. 2014
  7. doi request reprint Melatonin down-regulates MDM2 gene expression and enhances p53 acetylation in MCF-7 cells
    Sara Proietti
    Department of Surgery P Valdoni, Sapienza University of Rome, Rome, Italy
    J Pineal Res 57:120-9. 2014
  8. ncbi request reprint High density lipoproteins downregulate basic fibroblast growth factor production and release in minimally oxidated-LDL treated smooth muscle cells
    Alessandra Cucina
    Department of Surgery Pietro Valdoni, University of Rome La Sapienza, Via A Scarpa, 14, 00161 Rome, Italy
    Atherosclerosis 189:303-9. 2006
  9. doi request reprint Inositol induces mesenchymal-epithelial reversion in breast cancer cells through cytoskeleton rearrangement
    Simona Dinicola
    Department of Clinical and Molecular Medicine, Sapienza University of Rome, Viale Regina Elena 336, 00161 Rome, Italy Department of Surgery Pietro Valdoni, Sapienza University of Rome, Via A Scarpa 14, 00161 Rome, Italy
    Exp Cell Res 345:37-50. 2016
  10. doi request reprint Paradoxical E-cadherin increase in 5FU-resistant colon cancer is unaffected during mesenchymal-epithelial reversion induced by γ-secretase inhibition
    Simona Dinicola
    Department of Clinical and Molecular Medicine, Sapienza University of Rome, Viale Regina Elena 336, 00161 Rome, Italy Department of Surgery Pietro Valdoni, Sapienza University of Rome, Via A Scarpa 14, 00161 Rome, Italy
    Life Sci 145:174-83. 2016

Collaborators

Detail Information

Publications28

  1. doi request reprint Nicotine stimulates proliferation and inhibits apoptosis in colon cancer cell lines through activation of survival pathways
    Alessandra Cucina
    Department of Surgery Pietro Valdoni, Sapienza University of Rome, Rome, Italy
    J Surg Res 178:233-41. 2012
    ..However, although nicotine appears to have a role in stimulating cell proliferation of colon cancer cells, there is no information on its role in inhibiting apoptosis in these cells...
  2. doi request reprint Nicotine inhibits apoptosis and stimulates proliferation in aortic smooth muscle cells through a functional nicotinic acetylcholine receptor
    Alessandra Cucina
    Department of Surgery Pietro Valdoni, La Sapienza University of Rome, Rome, Italy
    J Surg Res 150:227-35. 2008
    ..We also showed that nicotine signaling occurs as a result of activation of the classical nicotine receptor pathways...
  3. doi request reprint The effect of locally administered anti-growth factor antibodies on neointimal hyperplasia formation in expanded polytetrafluoroethylene grafts
    Paolo Sapienza
    Department of Surgery Pietro Valdoni, University of Rome La Sapienza, Policlinico Umberto I, Rome, Italy
    Ann Vasc Surg 23:398-409. 2009
    ..001). The combined use of locally administered anti-PDGF-BB, bFGF, and TGF-beta1 monoclonal antibodies reduces neointimal hyperplasia formation...
  4. pmc TCam-2 seminoma cells exposed to egg-derived microenvironment modify their shape, adhesive pattern and migratory behaviour: a molecular and morphometric analysis
    Francesca Ferranti
    Department of Anatomy, Histology, Forensic Medicine and Orthopedics Section of Histology and Medical Embryology, Sapienza University of Rome, Rome, Italy
    PLoS ONE 8:e76192. 2013
    ..Prompted by these observations we hypothesize that EW treatment could rescue, at least in part, the neoplastic-metastatic behaviour of seminoma cells. ..
  5. doi request reprint Nicotine increases survival in human colon cancer cells treated with chemotherapeutic drugs
    Simona Dinicola
    Department of Clinical and Molecular Medicine, Sapienza University of Rome, Piazza Sassari 3, 00161 Rome, Italy Department of Surgery Pietro Valdoni, Sapienza University of Rome, Via Antonio Scarpa 14, 00161 Rome, Italy
    Toxicol In Vitro 27:2256-63. 2013
    ..Nicotine interfered with colorectal cancer pharmacological treatment in vitro by inhibiting apoptosis induced by chemotherapeutic drugs. Nicotine anti-apoptotic effects were exerted through ERK and AKT pathway activation. ..
  6. pmc Phenotypic switch induced by simulated microgravity on MDA-MB-231 breast cancer cells
    Maria Grazia Masiello
    Department of Clinical and Molecular Medicine, Sapienza University of Rome, Piazza Sassari 3, 00161 Rome, Italy Department of Surgery PietroValdoni, Sapienza University of Rome, Via A Scarpa 14, 00161 Rome, Italy
    Biomed Res Int 2014:652434. 2014
    ..Overall these data outline the fundamental role gravity plays in shaping form and function in living systems. ..
  7. doi request reprint Melatonin down-regulates MDM2 gene expression and enhances p53 acetylation in MCF-7 cells
    Sara Proietti
    Department of Surgery P Valdoni, Sapienza University of Rome, Rome, Italy
    J Pineal Res 57:120-9. 2014
    ..Our results provide evidence that melatonin enhances p53 acetylation by modulating the MDM2/MDMX/p300 pathway, disclosing new insights for understanding its anticancer effect. ..
  8. ncbi request reprint High density lipoproteins downregulate basic fibroblast growth factor production and release in minimally oxidated-LDL treated smooth muscle cells
    Alessandra Cucina
    Department of Surgery Pietro Valdoni, University of Rome La Sapienza, Via A Scarpa, 14, 00161 Rome, Italy
    Atherosclerosis 189:303-9. 2006
    ..0) produced the inhibition of MM-LDL effects. Our data suggest that the protective role of HDL could also be exerted through the inhibition of the pro-atherosclerotic effects of MM-LDL on SMCs...
  9. doi request reprint Inositol induces mesenchymal-epithelial reversion in breast cancer cells through cytoskeleton rearrangement
    Simona Dinicola
    Department of Clinical and Molecular Medicine, Sapienza University of Rome, Viale Regina Elena 336, 00161 Rome, Italy Department of Surgery Pietro Valdoni, Sapienza University of Rome, Via A Scarpa 14, 00161 Rome, Italy
    Exp Cell Res 345:37-50. 2016
    ..These data suggest that inositol may induce an EMT reversion in breast cancer cells, suppressing motility and invasiveness through cytoskeleton modifications. ..
  10. doi request reprint Paradoxical E-cadherin increase in 5FU-resistant colon cancer is unaffected during mesenchymal-epithelial reversion induced by γ-secretase inhibition
    Simona Dinicola
    Department of Clinical and Molecular Medicine, Sapienza University of Rome, Viale Regina Elena 336, 00161 Rome, Italy Department of Surgery Pietro Valdoni, Sapienza University of Rome, Via A Scarpa 14, 00161 Rome, Italy
    Life Sci 145:174-83. 2016
    ..However, we hypothesize that EMT and chemoresistance should be deemed separate processes in HCT-8 colon cancer cells...
  11. pmc Microenvironment promotes tumor cell reprogramming in human breast cancer cell lines
    Fabrizio D'Anselmi
    Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy Department of Surgery Pietro Valdoni, Sapienza University of Rome, Rome, Italy
    PLoS ONE 8:e83770. 2013
    ..Given that egg-conditioned medium behaves as a 3D-medium, it is likely that cancer phenotype reversion could be ascribed to the changed interactions between cells and their microenvironment. ..
  12. ncbi request reprint Vascular endothelial growth factor increases the migration and proliferation of smooth muscle cells through the mediation of growth factors released by endothelial cells
    Alessandra Cucina
    Department of Surgery Pietro Valdoni University of Rome La Sapienza, Via A Scarpa 14, 00161, Rome, Italy
    J Surg Res 109:16-23. 2003
    ..The purpose of our study was to assess if VEGF might indirectly stimulate SMC migration and proliferation in a EC-SMC coculture system, through the mediation of growth factors released by EC...
  13. doi request reprint Role of growth factors on human parathyroid adenoma cell proliferation
    Giuseppe Cavallaro
    Department of Surgery P Valdoni, Policlinico Umberto I, Sapienza University, Viale del Policlinico, Rome, Italy
    World J Surg 34:48-54. 2010
    ....
  14. doi request reprint Multiwalled carbon nanotube buckypaper induces cell cycle arrest and apoptosis in human leukemia cell lines through modulation of AKT and MAPK signaling pathways
    Simona Dinicola
    Department of Surgery Pietro Valdoni, Sapienza University of Rome, Via A Scarpa 14, 00161 Rome, Italy Department of Clinical and Molecular Medicine, Sapienza University of Rome, Viale Regina Elena 336, 00161 Rome, Italy
    Toxicol In Vitro 29:1298-308. 2015
    ..These results raised the issue of biocompatibility of MWCNT BP for the creation of carbon nanotubes based scaffolds to utilize as prostheses in tissue engineering. ..
  15. doi request reprint Evidence for a biphasic apoptotic pathway induced by melatonin in MCF-7 breast cancer cells
    Alessandra Cucina
    Surgery Department Pietro Valdoni, Rome, Italy
    J Pineal Res 46:172-80. 2009
    ....
  16. doi request reprint Molecular mechanisms of the pro-apoptotic actions of melatonin in cancer: a review
    Mariano Bizzarri
    University La Sapienza, Department of Experimental Medicine, Systems Biology Group, Rome, Italy
    Expert Opin Ther Targets 17:1483-96. 2013
    ..Melatonin behaves as a 'smart killer', i.e., modulating anti-apoptotic processes in normal cells, and triggering pro-apoptotic signals in cancer cells...
  17. doi request reprint Grape seed extract suppresses MDA-MB231 breast cancer cell migration and invasion
    Simona Dinicola
    Department of Clinical and Molecular Medicine, La Sapienza University, Piazza Sassari 3, 00161, Rome, Italy
    Eur J Nutr 53:421-31. 2014
    ..e., cell migration and invasion...
  18. doi request reprint Molecular mechanisms of melatonin's inhibitory actions on breast cancers
    Sara Proietti
    Department of Clinical and Molecular Medicine, University La Sapienza, Rome, Italy
    Cell Mol Life Sci 70:2139-57. 2013
    ..Melatonin acts at different physiological levels and its antitumoral properties are supported by a set of complex, different mechanisms of action, involving apoptosis activation, inhibition of proliferation, and cell differentiation...
  19. ncbi request reprint TIMP-2 modulates neointimal formation in experimental ePTFE arterial grafts
    Giuseppe Cavallaro
    Department of Surgery P Valdoni, University La Sapienza, Rome, Italy
    J Surg Res 137:122-9. 2007
    ..The aims of our study was to investigate the effects of selective MMP-2 inhibitor (TIMP-2) in endothelialization rate, SMC proliferation, and myointimal hyperplasia in experimental ePTFE arterial grafts...
  20. doi request reprint Does myo-inositol effect on PCOS follicles involve cytoskeleton regulation?
    Mariano Bizzarri
    Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy Systems Biology Group Lab, Sapienza University of Rome, Rome, Italy Electronic address
    Med Hypotheses 91:1-5. 2016
    ..A more compelling understanding of the mechanisms of action of inositol (and its derivatives) would greatly improve its therapeutic utilization, by conferring to current treatments a well-grounded scientific rationale. ..
  21. pmc A Randomized Pilot Study of Inositol in Association with Betaine and Boswellia in the Management of Mastalgia and Benign Breast Lump in Premenopausal Women
    Vittorio Pasta
    Department of Surgical Sciences, Sapienza University of Rome, Rome, Italy Azienda Policlinico Umberto I, Rome, Italy
    Breast Cancer (Auckl) 10:37-43. 2016
    ....
  22. pmc Cytoskeleton modifications and autophagy induction in TCam-2 seminoma cells exposed to simulated microgravity
    Francesca Ferranti
    Italian Space Agency ASI, Via del Politecnico snc, 00133 Rome, Italy Department of Anatomy, Histology, Forensic Medicine and Orthopedics, Sapienza University of Rome, Viale Regina Elena 336, 00161 Rome, Italy
    Biomed Res Int 2014:904396. 2014
    ..This observation is of relevant interest because it shows, for the first time, TCam-2 cell autophagy as a biological response induced by a mechanical stimulus instead of a biochemical one. ..
  23. doi request reprint Pharmacodynamics and pharmacokinetics of inositol(s) in health and disease
    Mariano Bizzarri
    a Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy
    Expert Opin Drug Metab Toxicol 12:1181-96. 2016
    ....
  24. pmc Broad Spectrum Anticancer Activity of Myo-Inositol and Inositol Hexakisphosphate
    Mariano Bizzarri
    Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy Systems Biology Group Lab, Sapienza University of Rome, Rome, Italy
    Int J Endocrinol 2016:5616807. 2016
    ..This effect is reinforced by the inositol-induced inhibition on metalloproteinases and ROCK1/2 release. Overall, these effects enable inositols to remodel the cytoskeleton architecture...
  25. doi request reprint SMT and TOFT: Why and How They are Opposite and Incompatible Paradigms
    Mariano Bizzarri
    Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161, Rome, Italy
    Acta Biotheor 64:221-39. 2016
    ..The main issue is actually to submit SMT to rigorous testing. This concern includes the imperatives to seek evidence for disproving one's hypothesis, and to consider the whole, and not just selective evidence. ..
  26. pmc Tumor and the microenvironment: a chance to reframe the paradigm of carcinogenesis?
    Mariano Bizzarri
    Department of Experimental Medicine, Sapienza University of Rome, Systems Biology Group, Viale Regina Elena 324, Via A Scarpa 14, 00161 Rome, Italy
    Biomed Res Int 2014:934038. 2014
    ..e., the systems to which we are looking for), and the principles of biological organization that would help in integrating and understanding experimental data. ..
  27. doi request reprint Theoretical aspects of Systems Biology
    Mariano Bizzarri
    Department of Experimental Medicine, Systems Biology Group Lab, Sapienza University of Rome, Via Scarpa 14 16, 00161 Rome, Italy
    Prog Biophys Mol Biol 112:33-43. 2013
    ..Indeed, both evolution and physiology work on these levels. Thus, by no means Systems Biology could be considered a 'simple' 'gradual' extension of Molecular Biology...
  28. ncbi request reprint Autocrine production of basic fibroblast growth factor translated from novel synthesized mRNA mediates thrombin-induced mitogenesis in smooth muscle cells
    Alessandra Cucina
    First Department of Surgery, University of Rome La Sapienza, Rome, Italy
    Cell Biochem Funct 20:39-46. 2002
    ..In conclusion, thrombin-induced mitogenesis was partially mediated by the autocrine production of bFGF, mainly due to protein synthesis by novel mRNA with a transcription peak at 24 h and a later translation peak...