Affiliation: University of Rome La Sapienza
- Nutritional challenge in pseudo-obstruction: the bridge between motility and nutritionSalvatore Cucchiara
Department of Pediatrics, Gastroenterology Service, Sapienza University of Rome, Rome, Italy
J Pediatr Gastroenterol Nutr 48:S83-5. 2009..In the most severe cases, parenteral nutrition becomes mandatory in order to satisfy nutritional requirements and manage appropriately obstructive episodes...
- "New drugs: kids come first": children should be included in trials of new biological treatmentsSalvatore Cucchiara
Pediatric Gastroenterology Unit, University of Rome La Sapienza, University Hospital Umberto I, Rome, Italy
Inflamm Bowel Dis 13:1165-9; discussion 1176-7. 2007..This, however, requires multicenter randomized controlled trials to prove...
- The microbiota in inflammatory bowel disease in different age groupsSalvatore Cucchiara
Pediatric Gastroenterology and Liver Unit, Department of Pediatrics, Sapienza University of Rome, IT 00161 Rome, Italy
Dig Dis 27:252-8. 2009..On the other hand, existing differences in gut microbial community between distinct classes of age make sense of an increasing research in microbial shifts in IBD...
- Human Polyomavirus JC monitoring and noncoding control region analysis in dynamic cohorts of individuals affected by immune-mediated diseases under treatment with biologics: an observational studyAnna Bellizzi
Department of Public Health and Infectious Diseases, Sapienza University, P, le Aldo Moro, 5, 00185 Rome, Italy
Virol J 10:298. 2013..Therefore, the aims of this study were the JCPyV reactivation monitoring and the noncoding control region (NCCR) and viral protein 1 (VP1) analysis in patients affected by different immune-mediated diseases and treated with biologics...
- Efficacy and tolerability of α-galactosidase in treating gas-related symptoms in children: a randomized, double-blind, placebo controlled trialGiovanni Di Nardo
Pediatric Gastroenterology and Liver Unit, Sapienza University of Rome, Rome, Italy
BMC Gastroenterol 13:142. 2013..galactosidase has been shown to reduce gas production and related symptoms in adults. To evaluate the efficacy and tolerability of α-galactosidase in the treatment of gas-related symptoms in pediatric patients...
- Efficacy and tolerability of peg-only laxative on faecal impaction and chronic constipation in children. A controlled double blind randomized study vs a standard peg-electrolyte laxativeFrancesco Savino
Department of Pediatrics 1, Regina Margherita Children s Hospital, University of Turin, Azienda Ospedaliera Città della Salute e della Scienza della Città di Torino, Turin, Italy
BMC Pediatr 12:178. 2012....
- Interactions between intestinal microbiota and innate immune system in pediatric inflammatory bowel diseaseSalvatore Cucchiara
Department of Pediatrics, Pediatric Gastroenterology and Liver Unit, Sapienza University of Rome, Rome, Italy
J Clin Gastroenterol 46:S64-6. 2012..In this paper, we focus on the mechanisms that mediate host-microbe interactions and how the disruption of this balance leads to chronic intestinal inflammation in IBD...
- A distinctive 'microbial signature' in celiac pediatric patientsSerena Schippa
Department of Public Health Sciences, Sapienza University of Rome, Piazzale Aldo Moro 5, Rome, 00185, Italy
BMC Microbiol 10:175. 2010..Total DNA was extracted from duodenal biopsies and amplification products of 16S ribosomal DNA were compared by temporal temperature gradient gel electrophoresis (TTGE). TTGE profiles were analyzed by statistical multivariate analysis...
- Allergic proctocolitis refractory to maternal hypoallergenic diet in exclusively breast-fed infants: a clinical observationSandra Lucarelli
Pediatric Gastroenterology Endoscopy and Liver Unit, Sapienza University of Rome, Azienda Policlinico Umberto I, Viale Regina Elena 324, 00161 Rome, Italy
BMC Gastroenterol 11:82. 2011..Additionally, we assessed the efficacy of an amino acid-based formula (AAF) when multiple food allergy is suspected. amino acid-based formula..
- Infliximab for pediatric ulcerative colitis: a retrospective Italian multicenter studyS Cucchiara
Division Pediatric Gastroenterology and Hepatology, Department of Pediatrics, University of Rome La Sapienza, Rome, Italy
Dig Liver Dis 40:S260-4. 2008..Infliximab (IFX), the chimeric anti TNFalpha antibody, an established treatment for Crohn's disease in adults and in children, is used less frequently in ulcerative colitis (UC)...
- New therapeutic approach in the management of intestinal disease: probiotics in intestinal disease in paediatric ageS Cucchiara
Pediatric Gastroenterology and Gastrointestinal Endoscopy Unit, Department of Paediatrics, Rome, Italy
Dig Liver Dis 34:S44-7. 2002..Much work needs to be done in this area by clearly defining indications, delivery system, costs, safety long-term effects...
- Infliximab heals intestinal inflammatory lesions and restores growth in children with Crohn's diseaseO Borrelli
Division of Paediatric Gastroenterology, Department of Paediatrics, University of Rome La Sapienza, Viale Regina Elena, Rome 324 00161, Italy
Dig Liver Dis 36:342-7. 2004..There are only few studies on the use of infliximab in children with Crohn's disease: most of them are retrospective and deal only with the clinical response to the drug...
- Role of drug therapy in the treatment of gastro-oesophageal reflux disorder in childrenS Cucchiara
Department of Paediatrics, University of Naples Federico II, Italy
Paediatr Drugs 2:263-72. 2000..It is still unclear whether patients with frequent relapses are candidates for long term administration of antisecretory drugs or for surgical fundoplication...
- Gut-associated bacterial microbiota in paediatric patients with inflammatory bowel diseaseM P Conte
Paediatric Gastroenterology Unit, University of Rome La Sapienza, Viale Regina Elena 324, Rome 00161, Italy
Gut 55:1760-7. 2006..No paediatric reports are available on intestinal endogenous microflora in IBD...
- Short- and long-term therapeutic efficacy of nutritional therapy and corticosteroids in paediatric Crohn's diseaseR Berni Canani
Department of Paediatrics, University of Naples Federico II, Naples, Italy
Dig Liver Dis 38:381-7. 2006....
- Inflammation is the main determinant of low bone mineral density in pediatric inflammatory bowel diseaseMassimiliano Paganelli
Pediatric Gastroenterology and Liver Unit, University of Rome La Sapienza, Rome Italy
Inflamm Bowel Dis 13:416-23. 2007..To assess bone mineral density (BMD) in children with Crohn's disease (CD) and ulcerative colitis (UC) and to investigate the role of inflammation and steroids on BMD...
- Autonomic imbalance in celiac childrenM Barbato
Department of Pediatrics, La Sapienza University, Rome, Italy
Minerva Pediatr 62:333-8. 2010..The aim of the study was to evaluate autonomic function in children with celiac disease...
- Contrast enhanced magnetic resonance imaging of the terminal ileum in children with Crohn's diseaseA Laghi
Department of Radiology, University of Rome La Sapienza, Rome, Italy
Gut 52:393-7. 2003..MRI was performed using a polyethylene glycol (PEG) solution as oral contrast agent to distend the small bowel (CE-PEG-MRI)...
- Mechanisms of gastro-oesophageal reflux in cystic fibrosisS Cucchiara
Department of Paediatrics, 2nd School of Medicine, University of Naples, Italy
Arch Dis Child 66:617-22. 1991..The predominant reflux mechanism in these patients is a transient inappropriate lower oesophageal sphincter relaxation rather than a low steady state basal lower oesophageal sphincter pressure...
- Chronic intestinal inflammation and seronegative spondyloarthropathy in childrenF Conti
Department of Rheumatology, University of Rome La Sapienza, Rome, Italy
Dig Liver Dis 37:761-7. 2005..Spondyloarthropathy in adults has been shown to be associated with either clinical or subclinical intestinal inflammation, however this association has rarely been described in children...
- Size and dynamics of mucosal and peripheral IL-17A+ T-cell pools in pediatric age, and their disturbance in celiac diseaseR La Scaleia
Department of Experimental Medicine, Sapienza University, Rome, Italy
Mucosal Immunol 5:513-23. 2012....
- Randomised clinical trial: the effectiveness of Lactobacillus reuteri ATCC 55730 rectal enema in children with active distal ulcerative colitisS Oliva
Pediatric Gastroenterology and Liver Unit, Sapienza University of Rome, Italy
Aliment Pharmacol Ther 35:327-34. 2012..Intestinal microbiota manipulation, one of the pathogenetic components of inflammatory bowel disease (IBD), has become an attractive therapy for ulcerative colitis (UC)...
- Non-acid gastro-oesophageal reflux in children with suspected pulmonary aspirationO Borrelli
Department of Paediatric Gastroenterology and Hepatology, Sapienza University of Rome, Italy
Dig Liver Dis 42:115-21. 2010....
- Methotrexate in paediatric ulcerative colitis: a retrospective survey at a single tertiary referral centreM Aloi
Department of Pediatrics, Sapienza University of Rome, Italy
Aliment Pharmacol Ther 32:1017-22. 2010..If unresponsive or intolerant to these agents, patients are treated with methotrexate, an antimetabolite never assessed in paediatric ulcerative colitis...
- Vertebral fractures and increased sensitivity to corticosteroids in a child with ulcerative colitis: successful use of pamidronateSandra Lucarelli
Pediatric Gastroenterology Division, La Sapienza University of Rome, Italy
J Pediatr Gastroenterol Nutr 43:533-5. 2006
- Coeliac disease and ganglioneuroblastoma: an unusual associationMaria Barbato
Pediatric Gastroenterology Unit, Istitute of Pediatrics, University of Rome La Sapienza, Italy
Med Pediatr Oncol 39:215-6. 2002
- MR of the small bowel with a biphasic oral contrast agent (polyethylene glycol): technical aspects and findings in patients affected by Crohn's diseaseAndrea Laghi
Dipartimento di Scienze Radiologiche, Universita degli Studi di Roma La Sapienza, Rome, Italy
Radiol Med 106:18-27. 2003..To report our experience using MR of the small bowel with polyethylene glycol (PEG) solution as an oral contrast agent in a population of adults and children with known Crohn's disease...
- Headache and recurrent abdominal pain: a controlled study by the means of the Child Behaviour Checklist (CBCL)F Galli
Faculty of Psychology 1, Univesity of Rome La Sapienza, Rome, Italy
Cephalalgia 27:211-9. 2007..In conclusion, headache and RAP show a very similar psychological profile that should be considered not only for diagnostic and therapeutic purposes, but also from the aetiological aspect...
- Effect of intragastric volume and osmolality on mechanisms of gastroesophageal reflux in children with gastroesophageal reflux diseaseG Salvia
Department of Pediatrics, University of Naples, Federico II, Italy
Am J Gastroenterol 96:1725-32. 2001..This finding correlates with a high postfeeding antral distension...
- Mucosal NOD2 expression and NF-kappaB activation in pediatric Crohn's diseaseLaura Stronati
Section of Toxicology and Biomedical Sciences, ENEA, Rome, Italy
Inflamm Bowel Dis 14:295-302. 2008..The present study was aimed at investigating the expression and activity of NOD2, NF-kappaB, and of 2 proinflammatory cytokines, TNFalpha and IL-1beta, in mucosal biopsies of CD affected children compared to healthy controls...
- Dominant genotypes in mucosa-associated Escherichia coli strains from pediatric patients with inflammatory bowel diseaseSerena Schippa
Department of Public Health Sciences, University of Rome La Sapienza, Rome, Italy
Inflamm Bowel Dis 15:661-72. 2009..The aim of this study was to characterize E. coli strains from the intestinal mucosa of pediatric IBD patients to investigate whether a particular subset of strains could be associated with the disease...
- Neuroimmune interactions at different intestinal sites are related to abdominal pain symptoms in children with IBSG Di Nardo
Department of Pediatrics, Pediatric Gastroenterology Unit, Sapienza University of Rome, Rome, Italy
Neurogastroenterol Motil 26:196-204. 2014..In children with IBS and healthy controls, we measured ileocolonic mast cell infiltration and fecal calprotectin and evaluated the relationships between these parameters and abdominal pain symptoms and stooling pattern...
- Regulation of the T helper cell type 1 transcription factor T-bet in coeliac disease mucosaI Monteleone
Dipartimento di Medicina Interna e Centro di Eccellenza per lo studio delle malattie complesse e multifattoriali, Universita Tor Vergata, Rome, Italy
Gut 53:1090-5. 2004..In coeliac disease (CD) mucosa, the histological lesion is associated with marked infiltration of T helper cell type 1 (Th1) cells. However, the molecular mechanisms which regulate Th1 cell differentiation in CD mucosa are unknown...
- Crohn's-like ileo-colitis in patients affected by glycogen storage disease Ib: two years' follow-up of patients with a wide spectrum of gastrointestinal signsD Melis
Department of Paediatrics, Federico II University, Naples, Italy
Acta Paediatr 92:1415-21. 2003..To investigate the presence of inflammatory bowel disease (IBD) and to evaluate the progression of bowel involvement after two years' follow-up in seven patients affected by glycogen storage disease type Ib (GSDIb)...
- Domperidone is more effective than cisapride in children with diabetic gastroparesisA Franzese
Department of Paediatrics, University of Naples Federico II, Naples, Italy
Aliment Pharmacol Ther 16:951-7. 2002..Disorders of gastrointestinal motility are commonly detected in patients with insulin-dependent diabetes mellitus and are associated with significant morbidity. They contribute to poor metabolic control of diabetes...
- A child with aphthae and diarrhoeaGianluca Terrin
Pediatric Gastroenterology Unit, University of Rome La Sapienza, 00161 Rome, Italy
Lancet 359:316. 2002
- Effects of disease activity on anti-Saccharomyces cerevisiae antibodies: implications for diagnosis and follow-up of children with Crohn's diseaseRoberto Berni Canani
Department of Pediatrics, University Federico II, Naples, Italy
Inflamm Bowel Dis 10:234-9. 2004....
- Polymeric diet alone versus corticosteroids in the treatment of active pediatric Crohn's disease: a randomized controlled open-label trialOsvaldo Borrelli
Division of Pediatric Gastroenterology, Department of Pediatrics, University of Rome La Sapienza, Rome, Italy
Clin Gastroenterol Hepatol 4:744-53. 2006..In a randomized controlled trial in children with active CD we compared the efficacy of nutritional therapy alone or corticosteroids on clinical variables and intestinal mucosal healing...
- Extradigestive manifestations of IBD in pediatricsM Aloi
Pediatric Gastroenterology and Hepatology Unit, Department of Pediatrics, University La Sapienza, Rome, Italy
Eur Rev Med Pharmacol Sci 13:23-32. 2009....
- Idiopathic dilated cardiomyopathy associated with coeliac disease: the effect of a gluten-free diet on cardiac performanceM Curione
Policlinico Umberto I, Rome, Italy
Dig Liver Dis 34:866-9. 2002..These preliminary data appear to suggest that the gluten-free diet may have a beneficial effect on cardiac performance in patients with idiopathic dilated cardiomyopathy...
- Efficacy of adalimumab in moderate-to-severe pediatric Crohn's diseaseFranca Viola
Department of Pediatrics, Pediatric Gastroenterology and Liver Unit, University Hospital Umberto I, Sapienza University of Rome, Rome 324 00161, Italy
Am J Gastroenterol 104:2566-71. 2009..However, the use of ADA is rarely reported in pediatric CD. We performed an open prospective evaluation of short- and long-term efficacy and safety of ADA in children with moderate-to-severe CD...
- Activation of NOD2-mediated intestinal pathway in a pediatric population with Crohn's diseaseAnna Negroni
Section of Toxicology and Biomedical Sciences, University of Rome, Sapienza University Hospital Umberto I, Rome, Italy
Inflamm Bowel Dis 15:1145-54. 2009....
- Pediatric inflammatory bowel diseases and the risk of lymphoma: should we revise our treatment strategies?Salvatore Cucchiara
Pediatric Gastroenterology Unit, University of Rome La Sapienza, University Hospital Umberto I, Rome, Italy
J Pediatr Gastroenterol Nutr 48:257-67. 2009..There is a major need for comparative studies before evidence-based guidelines can be established for safest and best treatment strategies of pediatric patients with IBD...
- Evolution of gastric electrical features and gastric emptying in children with Duchenne and Becker muscular dystrophyOsvaldo Borrelli
Department of Pediatrics, Pediatric Gastroenterology Unit, University of Rome, Rome, Italy
Am J Gastroenterol 100:695-702. 2005..We recorded gastric electrical activity and gastric emptying time (GET) in children with MD at initial presentation and at 3-yr follow-up in order to detect gastric motor abnormalities and study their evolution along the clinical course...
- Enteric neuropathology of congenital intestinal obstruction: A case reportGiovanni Di Nardo
Department of Pediatrics, Pediatric Gastroenterology Unit, University of Rome La Sapienza, Rome, Italy
World J Gastroenterol 12:5229-33. 2006..Such ENS changes mimic neuronal abnormalities observed in intestinal pseudo-obstruction...
- Cardiac involvement in children with IBD during infliximab therapyMaria Barbato
Inflamm Bowel Dis 12:828-9. 2006
- Comment on: Gadolinium-enhance magnetic resonance imaging: a useful radiologic tool in diagnosing pediatric IBDPasquale Paolantonio
Inflamm Bowel Dis 11:79-80. 2005
- Polymorphisms of tumor necrosis factor-alpha but not MDR1 influence response to medical therapy in pediatric-onset inflammatory bowel diseaseSalvatore Cucchiara
Clinica Pediatrica Universita La Sapienza, Roma, Italy
J Pediatr Gastroenterol Nutr 44:171-9. 2007....
- Nitric oxide production in rectal dialysate is a marker of disease activity and location in children with inflammatory bowel diseaseRoberto Berni Canani
Am J Gastroenterol 97:1574-6. 2002
- Motility disorders in childhood: Working Group Report of the First World Congress of Pediatric Gastroenterology, Hepatology, and NutritionPeter Milla
European Society for Paediatric Gastroenterology, Hepatology, and Nutrition
J Pediatr Gastroenterol Nutr 35:S187-95. 2002
- The infant gastroesophageal reflux questionnaire revised: development and validation as an evaluative instrumentLeah Kleinman
Center for Health Outcomes Research, United BioSource Corporation, Seattle, Washington 98121, USA
Clin Gastroenterol Hepatol 4:588-96. 2006..We revised the Infant Gastroesophageal Reflux Questionnaire (I-GERQ) on the basis of information from parents of infants with GERD and physicians and subjected it to a psychometric evaluation...
- Introduction: First International Symposium on: pediatric inflammatory bowel disease: September 16-18, 2003; Irvington, Virginia, U.S.AClaudio Fiocchi
Case Western Reserve University, Cleveland, Ohio, USA
J Pediatr Gastroenterol Nutr 40:S1. 2005
- Tacrolimus and food allergyLucia Pacifico
Transplantation 76:1778. 2003
- Analysis of candidate genes on chromosomes 5q and 19p in celiac diseaseAnna Latiano
U O Gastroenterologia e Lab di Ricerca I R C C S Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
J Pediatr Gastroenterol Nutr 45:180-6. 2007..Additionally, any possible correlation with the HLA-DQ status was investigated. Finally, our data were pooled with the results of other studies by a meta-analysis...
- Pediatric onset Crohn's colitis is characterized by genotype-dependent age-related susceptibilityArie Levine
Pediatric Gastroenterology Unit, Wolfson Medical Center and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Inflamm Bowel Dis 13:1509-15. 2007..Differences in disease site by age may suggest a different genotype, or different host responses such as decreased ileal susceptibility or increased susceptibility of the colon...
- Dual vs. triple therapy for childhood Helicobacter pylori gastritis: a double-blind randomized multicentre trialGiuseppina Oderda
Pediatric Department of the University of Novara, Italy
Helicobacter 9:293-301. 2004..Data on the efficacy of eradication treatment for Helicobacter pylori gastritis in children are scarce...
- Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel diseaseSubra Kugathasan
Department of Pediatrics, Children s Research Institute and Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Nat Genet 40:1211-5. 2008..30 x 10(-8) and 6.95 x 10(-8), respectively; odds ratio (OR) = 0.74 for both) and 21q22 (rs2836878[A]; P = 6.01 x 10(-8); OR = 0.73), located close to the TNFRSF6B and PSMG1 genes, respectively...