Alessio Cortelazzo

Summary

Affiliation: University of Siena
Country: Italy

Publications

  1. pmc Effects of snake venom proteases on human fibrinogen chains
    Alessio Cortelazzo
    Department of Internal Medicine, Endocrine Metabolic Sciences and Biochemistry, University of Siena, Italy
    Blood Transfus 8:s120-5. 2010
  2. doi request reprint In vitro effects of Echis carinatus venom on the human plasma proteome
    Roberto Guerranti
    Department of Internal Medicine, Endocrine Metabolic Sciences and Biochemistry, University of Siena, Siena, Italy
    Proteomics 10:3712-22. 2010
  3. pmc Subclinical inflammatory status in Rett syndrome
    Alessio Cortelazzo
    Child Neuropsychiatry Unit, University Hospital Azienda Ospedaliera Universitaria Senese AOUS, Viale M Bracci 16, 53100 Siena, Italy Department of Medical Biotechnologies, University of Siena, Via A Moro 2, 53100 Siena, Italy
    Mediators Inflamm 2014:480980. 2014
  4. pmc MECP2 Duplication Syndrome: Evidence of Enhanced Oxidative Stress. A Comparison with Rett Syndrome
    Cinzia Signorini
    Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy
    PLoS ONE 11:e0150101. 2016
  5. pmc Beta-actin deficiency with oxidative posttranslational modifications in Rett syndrome erythrocytes: insights into an altered cytoskeletal organization
    Alessio Cortelazzo
    Department of Medical Biotechnologies, University of Siena, Siena, Italy Child Neuropsychiatry Unit, University Hospital, Azienda Ospedaliera Universitaria Senese AOUS, Siena, Italy
    PLoS ONE 9:e93181. 2014
  6. doi request reprint Alteration of serum lipid profile, SRB1 loss, and impaired Nrf2 activation in CDKL5 disorder
    Alessandra Pecorelli
    Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy Child Neuropsychiatry Unit, Azienda Ospedaliera Universitaria Senese, Santa Maria alle Scotte General Hospital, Siena, Italy
    Free Radic Biol Med 86:156-65. 2015
  7. pmc Cytokine Dysregulation in MECP2- and CDKL5-Related Rett Syndrome: Relationships with Aberrant Redox Homeostasis, Inflammation, and ω-3 PUFAs
    Silvia Leoncini
    Child Neuropsychiatry Unit, University Hospital, Azienda Ospedaliera Universitaria Senese AOUS, Policlinico S M alle Scotte, 53100 Siena, Italy Department of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy
    Oxid Med Cell Longev 2015:421624. 2015
  8. pmc A plasma proteomic approach in Rett syndrome: classical versus preserved speech variant
    Alessio Cortelazzo
    Department of Medical Biotechnologies, University of Siena, Via A Moro 2, 53100 Siena, Italy Child Neuropsychiatry Unit, University Hospital Azienda Ospedaliera Universitaria Senese AOUS, Viale M Bracci 16, 53100 Siena, Italy
    Mediators Inflamm 2013:438653. 2013
  9. doi request reprint Effects of Mucuna pruriens protease inhibitors on Echis carinatus venom
    Nnadozie Stanley Hope-Onyekwere
    Department of Internal Medicine, Endocrine Metabolic Science and Biochemistry, University of Siena, Via A Moro 2, 53100 Siena, Italy
    Phytother Res 26:1913-9. 2012
  10. doi request reprint Proteomic profiling and post-translational modifications in human keratinocytes treated with Mucuna pruriens leaf extract
    Alessio Cortelazzo
    Department of Medical Biotechnologies, University of Siena, Siena, Italy Child Neuropsychiatry Unit, University Hospital AOUS, Siena, Italy
    J Ethnopharmacol 151:873-81. 2014

Collaborators

  • Roberto Guerranti
  • Helena Cerutti
  • Concetta Gardi
  • NNADOZIE HOPE-ONYEKWERE
  • Cinzia Signorini
  • Silvia Leoncini
  • Lucia Ciccoli
  • Joussef Hayek
  • Claudio De Felice
  • Gloria Zollo
  • Thierry Durand
  • Alessandra Pecorelli
  • Marcello Rossi
  • Giuseppe Belmonte
  • Giuseppe Valacchi
  • Theodora Hadjistilianou
  • Sabrina Buoni
  • Kirstine Ravn
  • Rikke S Møller
  • Maurizio D'Esposito
  • Ilaria Meloni
  • Alessandra Renieri
  • Claudia Sticozzi
  • Jean Marie Galano
  • Henry Jay Forman
  • Franco Cervellati
  • Mariangela Gentile
  • Eugenio Paccagnini
  • Sonia De Francesco
  • Roberto Leoncini
  • Elena Brogi
  • Lavinia Micheli
  • Felice Menicacci
  • Gabriele Cevenini
  • Daniela Vannoni
  • Stefania Giglioni

Detail Information

Publications12

  1. pmc Effects of snake venom proteases on human fibrinogen chains
    Alessio Cortelazzo
    Department of Internal Medicine, Endocrine Metabolic Sciences and Biochemistry, University of Siena, Italy
    Blood Transfus 8:s120-5. 2010
    ..This study will help us to understand the mechanism of envenomation and to find alternative treatments other than the common treatment with the administration of IgG...
  2. doi request reprint In vitro effects of Echis carinatus venom on the human plasma proteome
    Roberto Guerranti
    Department of Internal Medicine, Endocrine Metabolic Sciences and Biochemistry, University of Siena, Siena, Italy
    Proteomics 10:3712-22. 2010
    ..In particular, the cleavage of protease inhibitors appears to be the mechanism through which the venom neutralizes the body's defenses...
  3. pmc Subclinical inflammatory status in Rett syndrome
    Alessio Cortelazzo
    Child Neuropsychiatry Unit, University Hospital Azienda Ospedaliera Universitaria Senese AOUS, Viale M Bracci 16, 53100 Siena, Italy Department of Medical Biotechnologies, University of Siena, Via A Moro 2, 53100 Siena, Italy
    Mediators Inflamm 2014:480980. 2014
    ..Our findings reveal for the first time the presence of a subclinical chronic inflammatory status related to the "pseudo-autistic" phase of RTT, which is related to the severity carried by the MECP2 gene mutation. ..
  4. pmc MECP2 Duplication Syndrome: Evidence of Enhanced Oxidative Stress. A Comparison with Rett Syndrome
    Cinzia Signorini
    Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy
    PLoS ONE 11:e0150101. 2016
    ..A finely tuned balance of MECP2 expression appears to be critical to oxidative stress homeostasis, thus shedding light on the relevance of the redox balance in the central nervous system integrity. ..
  5. pmc Beta-actin deficiency with oxidative posttranslational modifications in Rett syndrome erythrocytes: insights into an altered cytoskeletal organization
    Alessio Cortelazzo
    Department of Medical Biotechnologies, University of Siena, Siena, Italy Child Neuropsychiatry Unit, University Hospital, Azienda Ospedaliera Universitaria Senese AOUS, Siena, Italy
    PLoS ONE 9:e93181. 2014
    ..Our findings demonstrate, for the first time, a beta-actin down-regulation and oxidative PTMs for RBCs of RTT patients, thus indicating an altered cytoskeletal organization. ..
  6. doi request reprint Alteration of serum lipid profile, SRB1 loss, and impaired Nrf2 activation in CDKL5 disorder
    Alessandra Pecorelli
    Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy Child Neuropsychiatry Unit, Azienda Ospedaliera Universitaria Senese, Santa Maria alle Scotte General Hospital, Siena, Italy
    Free Radic Biol Med 86:156-65. 2015
    ..This study highlights a possible common denominator between two different RTT variants (MECP2 and CDKL5) and a possible common future therapeutic target. ..
  7. pmc Cytokine Dysregulation in MECP2- and CDKL5-Related Rett Syndrome: Relationships with Aberrant Redox Homeostasis, Inflammation, and ω-3 PUFAs
    Silvia Leoncini
    Child Neuropsychiatry Unit, University Hospital, Azienda Ospedaliera Universitaria Senese AOUS, Policlinico S M alle Scotte, 53100 Siena, Italy Department of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy
    Oxid Med Cell Longev 2015:421624. 2015
    ..RTT is associated with a subclinical immune dysregulation as the likely consequence of a defective inflammation regulatory signaling system. ..
  8. pmc A plasma proteomic approach in Rett syndrome: classical versus preserved speech variant
    Alessio Cortelazzo
    Department of Medical Biotechnologies, University of Siena, Via A Moro 2, 53100 Siena, Italy Child Neuropsychiatry Unit, University Hospital Azienda Ospedaliera Universitaria Senese AOUS, Viale M Bracci 16, 53100 Siena, Italy
    Mediators Inflamm 2013:438653. 2013
    ..Therefore, the examined RTT siblings pairs proved to be an important benchmark model to test the molecular basis of phenotypical expression variability and to identify potential therapeutic targets of the disease. ..
  9. doi request reprint Effects of Mucuna pruriens protease inhibitors on Echis carinatus venom
    Nnadozie Stanley Hope-Onyekwere
    Department of Internal Medicine, Endocrine Metabolic Science and Biochemistry, University of Siena, Via A Moro 2, 53100 Siena, Italy
    Phytother Res 26:1913-9. 2012
    ..The whole protein extract of M. pruriens seeds inhibited prothrombin activation by ecarin and whole E. carinatus venom, and also thrombin-like activity using chromogenic assay...
  10. doi request reprint Proteomic profiling and post-translational modifications in human keratinocytes treated with Mucuna pruriens leaf extract
    Alessio Cortelazzo
    Department of Medical Biotechnologies, University of Siena, Siena, Italy Child Neuropsychiatry Unit, University Hospital AOUS, Siena, Italy
    J Ethnopharmacol 151:873-81. 2014
    ..The aim was to investigate the effects of Mp leaf methanolic extract (MPME) on human keratinocytes protein expression and its role in preventing proteins oxidation after oxidative stress (OS) exposure...
  11. pmc Erythrocyte shape abnormalities, membrane oxidative damage, and β-actin alterations: an unrecognized triad in classical autism
    Lucia Ciccoli
    Department of Molecular and Developmental Medicine, University of Siena, Via A Moro 2, 53100 Siena, Italy
    Mediators Inflamm 2013:432616. 2013
    ....
  12. doi request reprint Analysis of aqueous humour proteins in patients with retinoblastoma
    Theodora Hadjistilianou
    Retinoblastoma Referral Center, Ophthalmology Unit, University of Siena, Siena, Italy
    Clin Experiment Ophthalmol 40:e8-e15. 2012
    ..To investigate aqueous humour protein composition from retinoblastoma patients...