Manuela Contin

Summary

Affiliation: University of Bologna
Country: Italy

Publications

  1. ncbi Evidence of polymorphic CYP2C19 involvement in the human metabolism of N-desmethylclobazam
    Manuela Contin
    Neurology Clinic, Department of Neurological Sciences, University of Bologna, Italy
    Ther Drug Monit 24:737-41. 2002
  2. doi Levetiracetam clinical pharmacokinetics in elderly and very elderly patients with epilepsy
    M Contin
    UOC Clinica Neurologica, IRCCS Istituto delle Scienze Neurologiche, corrected Department of Neurological Sciences, University of Bologna, Via Foscolo 7, 40123 Bologna, Italy
    Epilepsy Res 98:130-4. 2012
  3. doi Simultaneous HPLC-UV analysis of rufinamide, zonisamide, lamotrigine, oxcarbazepine monohydroxy derivative and felbamate in deproteinized plasma of patients with epilepsy
    Manuela Contin
    Laboratory of Clinical Neuropharmacology, Neurology Clinic, Department of Neurological Sciences, University of Bologna, Via Foscolo 7, 40123 Bologna, Italy
    J Chromatogr B Analyt Technol Biomed Life Sci 878:461-5. 2010
  4. ncbi Simultaneous liquid chromatographic determination of lamotrigine, oxcarbazepine monohydroxy derivative and felbamate in plasma of patients with epilepsy
    Manuela Contin
    Laboratory of Clinical Neuropharmacology, Neurology Clinic, Department of Neurological Sciences, University of Bologna, Via Foscolo 7, 40123 Bologna, Italy
    J Chromatogr B Analyt Technol Biomed Life Sci 828:113-7. 2005
  5. ncbi Genetic polymorphism of catechol-O-methyltransferase and levodopa pharmacokinetic-pharmacodynamic pattern in patients with Parkinson's disease
    Manuela Contin
    Neurology Clinic, Department of Neurological Sciences, University of Bologna, Via Foscolo 7, 40123 Bologna, Italy
    Mov Disord 20:734-9. 2005
  6. doi Simple and validated HPLC-UV analysis of levetiracetam in deproteinized plasma of patients with epilepsy
    Manuela Contin
    Laboratory of Clinical Neuropharmacology, Neurology Clinic, Department of Neurological Sciences, University of Bologna, Bologna, Italy
    J Chromatogr B Analyt Technol Biomed Life Sci 873:129-32. 2008
  7. ncbi Variation in lamotrigine plasma concentrations with hormonal contraceptive monthly cycles in patients with epilepsy
    Manuela Contin
    Neurology Clinic, Department of Neurological Sciences, University of Bologna, Bologna, Italy
    Epilepsia 47:1573-5. 2006
  8. doi The effect of entacapone on levodopa rate of absorption and latency to motor response in patients with Parkinson disease
    Manuela Contin
    Neurology Clinic, Department of Neurological Sciences, University of Bologna, Bologna, Italy
    Clin Neuropharmacol 31:267-71. 2008
  9. doi Pharmacokinetics of levodopa
    Manuela Contin
    Department of Neurological Sciences, Neurology Clinic, University of Bologna, Bologna, Italy
    J Neurol 257:S253-61. 2010
  10. ncbi Dopamine transporter gene polymorphism, spect imaging, and levodopa response in patients with Parkinson disease
    Manuela Contin
    Neurology Clinic, Department of Neurological Sciences, University of Bologna, Italy
    Clin Neuropharmacol 27:111-5. 2004

Collaborators

Detail Information

Publications28

  1. ncbi Evidence of polymorphic CYP2C19 involvement in the human metabolism of N-desmethylclobazam
    Manuela Contin
    Neurology Clinic, Department of Neurological Sciences, University of Bologna, Italy
    Ther Drug Monit 24:737-41. 2002
    ..According to genotyping, subjects carrying one or two copies of the defective CYP2C19*2 allele might develop markedly elevated steady-state plasma concentrations of N-CLB and be at higher risk of adverse effects...
  2. doi Levetiracetam clinical pharmacokinetics in elderly and very elderly patients with epilepsy
    M Contin
    UOC Clinica Neurologica, IRCCS Istituto delle Scienze Neurologiche, corrected Department of Neurological Sciences, University of Bologna, Via Foscolo 7, 40123 Bologna, Italy
    Epilepsy Res 98:130-4. 2012
    ..001). LEV CL/F significantly declines with aging, elderly and very elderly patients requiring an about 30% and 50% lower dose, respectively, compared to nonelderly adults to achieve a given LEV plasma concentration...
  3. doi Simultaneous HPLC-UV analysis of rufinamide, zonisamide, lamotrigine, oxcarbazepine monohydroxy derivative and felbamate in deproteinized plasma of patients with epilepsy
    Manuela Contin
    Laboratory of Clinical Neuropharmacology, Neurology Clinic, Department of Neurological Sciences, University of Bologna, Via Foscolo 7, 40123 Bologna, Italy
    J Chromatogr B Analyt Technol Biomed Life Sci 878:461-5. 2010
    ..By grouping different new AEDs in the same assay the method can be advantageous for therapeutic drug monitoring (TDM)...
  4. ncbi Simultaneous liquid chromatographic determination of lamotrigine, oxcarbazepine monohydroxy derivative and felbamate in plasma of patients with epilepsy
    Manuela Contin
    Laboratory of Clinical Neuropharmacology, Neurology Clinic, Department of Neurological Sciences, University of Bologna, Via Foscolo 7, 40123 Bologna, Italy
    J Chromatogr B Analyt Technol Biomed Life Sci 828:113-7. 2005
    ..The simple sample pre-treatment, combined with the fast chromatographic run permit rapid processing of a large series of patient samples...
  5. ncbi Genetic polymorphism of catechol-O-methyltransferase and levodopa pharmacokinetic-pharmacodynamic pattern in patients with Parkinson's disease
    Manuela Contin
    Neurology Clinic, Department of Neurological Sciences, University of Bologna, Via Foscolo 7, 40123 Bologna, Italy
    Mov Disord 20:734-9. 2005
    ..We failed to identify clinically relevant levodopa pharmacokinetic-pharmacodynamic response patterns associated with the COMT polymorphism in PD patients...
  6. doi Simple and validated HPLC-UV analysis of levetiracetam in deproteinized plasma of patients with epilepsy
    Manuela Contin
    Laboratory of Clinical Neuropharmacology, Neurology Clinic, Department of Neurological Sciences, University of Bologna, Bologna, Italy
    J Chromatogr B Analyt Technol Biomed Life Sci 873:129-32. 2008
    ..Applied to a large population of patients with epilepsy this assay proved very practical in our therapeutic drug monitoring setting (TDM)...
  7. ncbi Variation in lamotrigine plasma concentrations with hormonal contraceptive monthly cycles in patients with epilepsy
    Manuela Contin
    Neurology Clinic, Department of Neurological Sciences, University of Bologna, Bologna, Italy
    Epilepsia 47:1573-5. 2006
    ..We describe the variation in LTG plasma concentrations with hormonal contraceptive (HC) monthly intake cycles in a series of eight patients with epilepsy...
  8. doi The effect of entacapone on levodopa rate of absorption and latency to motor response in patients with Parkinson disease
    Manuela Contin
    Neurology Clinic, Department of Neurological Sciences, University of Bologna, Bologna, Italy
    Clin Neuropharmacol 31:267-71. 2008
    ....
  9. doi Pharmacokinetics of levodopa
    Manuela Contin
    Department of Neurological Sciences, Neurology Clinic, University of Bologna, Bologna, Italy
    J Neurol 257:S253-61. 2010
    ..Unfortunately, these attempts have proved so far only partly successful, due to the complex alterations in cerebral levodopa kinetics which accompany the progressive degeneration of the nigrostriatal dopaminergic system in PD patients...
  10. ncbi Dopamine transporter gene polymorphism, spect imaging, and levodopa response in patients with Parkinson disease
    Manuela Contin
    Neurology Clinic, Department of Neurological Sciences, University of Bologna, Italy
    Clin Neuropharmacol 27:111-5. 2004
    ....
  11. ncbi Topiramate therapeutic monitoring in patients with epilepsy: effect of concomitant antiepileptic drugs
    Manuela Contin
    Laboratory of Clinical Neuropharmacology, Department of Neurological Sciences, University of Bologna, Via Foscolo 7, 40123 Bologna, Italy
    Ther Drug Monit 24:332-7. 2002
    ....
  12. ncbi Levetiracetam therapeutic monitoring in patients with epilepsy: effect of concomitant antiepileptic drugs
    Manuela Contin
    Laboratory of Neuropharmacology, Neurology Clinic, Department of Neurological Sciences, University of Bologna, Bologna, Italy
    Ther Drug Monit 26:375-9. 2004
    ..Concomitant AED inducers can contribute to variability in levetiracetam disposition in patients with epilepsy. The observed differences were moderate and possibly of minor clinical significance...
  13. doi The effect of a clinically practical exercise on levodopa bioavailability and motor response in patients with Parkinson disease
    Giovanna Lopane
    Department of Neurological Sciences University of Bologna, Bologna, Italy
    Clin Neuropharmacol 33:254-6. 2010
    ....
  14. doi Lacosamide therapeutic monitoring in patients with epilepsy: effect of concomitant antiepileptic drugs
    Manuela Contin
    Laboratory of Clinical Neuropharmacology, Department of Biomedical and Neuromotor Sciences, University of Bologna and Institute of Research and Treatment IRCCS, Institute of Neurological Sciences of Bologna, Bologna, Italy
    Ther Drug Monit 35:849-52. 2013
    ..The purpose of this study was to assess the effect of concomitant AED therapy on steady state plasma concentrations of LCM in a population of patients with epilepsy...
  15. ncbi Polysomnographic and pharmacokinetic findings in levodopa-induced augmentation of restless legs syndrome
    Roberto Vetrugno
    Department of Neurological Sciences, University of Bologna, Bologna, Italy
    Mov Disord 21:254-8. 2006
    ..This case is the first report in which RLS augmentation is shown to be characterized by motor hyperkinesias paralleling levodopa plasma pharmacokinetic profile...
  16. ncbi Assessing dopaminergic function in Parkinson's disease: levodopa kinetic-dynamic modeling and SPECT
    Manuela Contin
    Neurology Clinic, Department of Neurological Sciences, University of Bologna, Italy
    J Neurol 250:1475-81. 2003
    ..Levodopa PK-PD modeling can be a practical clinical tool indirectly assessing the functional integrity of the nigrostriatal dopaminergic system in PD patients...
  17. ncbi Excessive daytime sleepiness and levodopa in Parkinson's disease: polygraphic, placebo-controlled monitoring
    Manuela Contin
    Neurology Clinic, Department of Neurological Sciences, University of Bologna, Italy
    Clin Neuropharmacol 26:115-8. 2003
    ..The subacute levodopa challenge was accompanied by physiologic sleep episodes, worsened reaction times, and a reduction in mean blood pressure and heart rate over baseline values, linked temporally to the sleep episodes...
  18. doi Pharmacodynamics of a low subacute levodopa dose helps distinguish between multiple system atrophy with predominant Parkinsonism and Parkinson's disease
    Giovanna Calandra-Buonaura
    IRCCS, Institute of Neurological Sciences of Bologna, c o Padiglione G, Ospedale Bellaria, Via Altura 3, 40139, Bologna, Italy
    J Neurol 263:250-6. 2016
    ..A combined estimation of these pharmacodynamic variables after a subacute low levodopa dose may be a simple and practical clinical tool to aid the differential diagnosis between MSA-P and PD. ..
  19. doi Multiple system atrophy with prolonged survival: is late onset of dysautonomia the clue?
    Giovanna Calandra-Buonaura
    IRCCS, Istituto delle Scienze Neurologiche e Dipartimento di Scienze Biomediche e Neuromotorie DIBINEM, Universita di Bologna, c o Ospedale Bellaria, Via Altura n 3, 40139, Bologna, Italy
    Neurol Sci 34:1875-8. 2013
    ..In conclusion, our study showed that late onset of both cardiovascular autonomic failure and urinary voiding disorders may be positive prognostic factors in MSA irrespective of the MSA subtype...
  20. doi A longitudinal study of a family with adult-onset autosomal dominant leukodystrophy: Clinical, autonomic and neuropsychological findings
    Rossana Terlizzi
    IRCCS Institute of Neurological Sciences of Bologna, Bologna, Italy Department of Biomedical and NeuroMotor Sciences DIBINEM, University of Bologna, Bologna, Italy
    Auton Neurosci 195:20-6. 2016
    ..Our aim was to investigate longitudinally the pattern of the autonomic dysfunction and the degree of neuropsychological involvement...
  21. ncbi Daytime sympathetic hyperactivity in OSAS is related to excessive daytime sleepiness
    Vincenzo Donadio
    Department of Neurological Sciences, University of Bologna, Bologna, Italy
    J Sleep Res 16:327-32. 2007
    ..The results obtained in this pilot study need, however, to be confirmed in a larger study involving more patients...
  22. doi A patient with PMP22-related hereditary neuropathy and DBH-gene-related dysautonomia
    Anna Bartoletti-Stella
    Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum University of Bologna, Via Ugo Foscolo 7, 40123, Bologna, Italy
    J Neurol 262:2373-81. 2015
    ..Finding the right, complete diagnosis is crucial to obtain adequate medical care and appropriate genetic counseling...
  23. doi Dyskinesia detection and monitoring by a single sensor in patients with Parkinson's disease
    Giovanna Lopane
    IRCCS Institute of Neurological Sciences of Bologna, Bologna, Italy
    Mov Disord 30:1267-71. 2015
    ..We aimed to assess the feasibility, clinical validity, and usability of a waist-worn inertial sensor for discriminating between LIDs and physiological sway in both supervised and unsupervised settings...
  24. doi Isolated noradrenergic failure in adult-onset autosomal dominant leukodystrophy
    Pietro Guaraldi
    Neurological Sciences Department, University of Bologna, Bologna, Italy
    Auton Neurosci 159:123-6. 2011
    ..This peculiar autonomic dysfunction may represent a hallmark for ADLD...
  25. ncbi Drug rash with eosinophilia and systemic symptoms secondary to phenobarbitone
    Agostino Baruzzi
    Department of Neurological Sciences, Neurology Clinic, University of Bologna, Via Foscolo 7, 40123 Bologna, Italy
    Clin Neuropharmacol 26:177-8. 2003
    ..They highlight the main characteristics of this syndrome and the diagnostic difficulties...
  26. doi Validated UHPLC-MS/MS method for the simultaneous determination of pramipexole and ropinirole in plasma of patients with Parkinson's disease
    Susan Mohamed
    IRCCS ISNB Institute of Neurological Sciences of Bologna, Bologna, Italy
    J Chromatogr B Analyt Technol Biomed Life Sci 1017:114-9. 2016
    ..By grouping the two dopaminergic agents in the same assay, the method allows a large series of patient samples to be processed in a single analytical session. ..
  27. doi HPLC-UV analysis of thymidine and deoxyuridine in plasma of patients with thymidine phosphorylase deficiency
    Susan Mohamed
    IRCCS ISNB Institute of Neurological Sciences of Bologna, Bologna, Italy
    J Chromatogr B Analyt Technol Biomed Life Sci 949:58-62. 2014
    ..This assay simplifies both plasma pretreatment and chromatographic conditions of previously reported procedures and describes the first validated method for the determination of the two nucleotides in human plasma. ..
  28. doi Mucuna pruriens in Parkinson Disease: A Kinetic-Dynamic Comparison With Levodopa Standard Formulations
    Manuela Contin
    IRCCS ISNB Institute of Neurological Sciences of Bologna Department of Biomedical and Neuromotor Sciences, University of Bologna Department of Pharmacy and Biotechnology, University of Bologna Neurology Unit, St Orsola Malpighi Hospital, University of Bologna, Bologna, Italy
    Clin Neuropharmacol 38:201-3. 2015
    ....