Annamaria Cimini

Summary

Affiliation: University of L'Aquila
Country: Italy

Publications

  1. pmc PPARs in Human Neuroepithelial Tumors: PPAR Ligands as Anticancer Therapies for the Most Common Human Neuroepithelial Tumors
    Elisabetta Benedetti
    Department of Basic and Applied Biology, University of L Aquila, 67100 L Aquila, Italy
    PPAR Res 2010:427401. 2010
  2. pmc Innovative Therapies against Human Glioblastoma Multiforme
    Annamaria Cimini
    Department of Basic and Applied Biology, University of L Aquila, Via Vetoio No 10, 67010 L Aquila, Italy
    ISRN Oncol 2011:787490. 2011
  3. pmc PPARs Expression in Adult Mouse Neural Stem Cells: Modulation of PPARs during Astroglial Differentiaton of NSC
    A Cimini
    Department of Basic and Applied Biology, University of L Aquila, 67100 L Aquila, Italy
    PPAR Res 2007:48242. 2007
  4. pmc Age-dependent roles of peroxisomes in the hippocampus of a transgenic mouse model of Alzheimer's disease
    Francesca Fanelli
    Department of Biology LIME, University Roma Tre, Viale Marconi 446, Rome 00146, Italy
    Mol Neurodegener 8:8. 2013
  5. ncbi request reprint Neuronal response of peroxisomal and peroxisome-related proteins to chronic and acute Abeta injury
    A Cimini
    Dept of Basic and Applied Biology, University of L Aquila, via Vetoio n 10 67100 L Aquila, Italy
    Curr Alzheimer Res 6:238-51. 2009
  6. doi request reprint Emerging roles of peroxisome proliferator-activated receptors (PPARs) in the regulation of neural stem cells proliferation and differentiation
    Annamaria Cimini
    Department of Basic and Applied Biology, University of L Aquila, L Aquila, Italy
    Stem Cell Rev 4:293-303. 2008
  7. ncbi request reprint TNFalpha downregulates PPARdelta expression in oligodendrocyte progenitor cells: implications for demyelinating diseases
    Annamaria Cimini
    Department of Basic and Applied Biology, Universita di L Aquila, Italy
    Glia 41:3-14. 2003
  8. ncbi request reprint PPARgamma-dependent effects of conjugated linoleic acid on the human glioblastoma cell line (ADF)
    Annamaria Cimini
    Department of Basic and Applied Biology, University of L Aquila, L Aquila, Italy
    Int J Cancer 117:923-33. 2005
  9. ncbi request reprint Expression of peroxisome proliferator-activated receptors (PPARs) and retinoic acid receptors (RXRs) in rat cortical neurons
    A Cimini
    Department of Basic and Applied Biology, University of L Aquila, via Vetoio n 10, 67010 Coppito AQ, Italy
    Neuroscience 130:325-37. 2005
  10. ncbi request reprint Peroxisomes and PPARs in cultured neural cells
    Annamaria Cimini
    Department of Basic and Applied Biology, University of L Aquila, via Vetoio n 10, 67010 Coppito AQ, Italy
    Adv Exp Med Biol 544:271-80. 2003

Collaborators

  • Antonio Giordano
  • Fernanda Amicarelli
  • Francesco Angelucci
  • Giovambattista Desideri
  • Claudio Ferri
  • C Festuccia
  • Paolo Giovanni Artini
  • Ernesto Di Cesare
  • Claudio Borghi
  • Davide Grassi
  • Mara Massimi
  • Francesca Fanelli
  • Sandra Moreno
  • Marcello D'Amelio
  • Adriano Angelucci
  • Francesco Cecconi
  • D Lombardi
  • Elisabetta Benedetti
  • Rodolfo Ippoliti
  • Benedetta Cinque
  • Andrea Antonosante
  • Loredana Cristiano
  • Alessia Fidoamore
  • Maria Grazia Cifone
  • Renato Galzio
  • Michele d'angelo
  • Matteo Ardini
  • Francesco Giansanti
  • Carlo Astarita
  • Anne Chloè Dhez
  • Erica Di Giacomo
  • Tiziana Marilena Florio
  • Stefano Falone
  • Silvia Di Loreto
  • E Benedetti
  • Maurizio Vitti
  • Luca Ottaviano
  • Giuseppina Pitari
  • Marcello Alecci
  • Roberta Falcone
  • Sandro Santucci
  • Luana Di Leandro
  • Laura Brandolini
  • L Cristiano
  • Barbara D'Angelo
  • B Cinque
  • M G Cifone
  • S Di Loreto
  • Paola Palumbo
  • Cristina La Torre
  • Francesca Lombardi
  • Zoran Evtoski
  • Silvano Jr Santini
  • Meganne Christian
  • Michela Di Carlo
  • Chiara Laezza
  • Giovanna Di Emidio
  • Gaspare Carta
  • Emanuele Treossi
  • Paolo Passaretti
  • Gloria Panella
  • Francesco Perrozzi
  • Raffaella Golini
  • Rosa Amoroso
  • Vittorio Morandi
  • Alessandra Ammazzalorso
  • Giordana Golia
  • Luca Ortolani
  • Carla Tatone
  • Vincenzo Palermo
  • Giovanni Luca Gravina
  • Marcello Allegretti
  • Domenica Sabatini
  • Damien Destouches
  • Floriana Rosati
  • Jose Courty
  • Maria Rosaria Pennacchio
  • Stefano Scotti
  • Angelo Galante
  • Maria De Pizzol
  • Pier Adelchi Ruffini
  • Giuseppina Confalone
  • Maurizio Donarelli
  • Paola Menghini
  • Sohelia Raysi Dehcordi
  • Maria Paola Ceru
  • M A D'Amico
  • R Galzio
  • B D'Angelo
  • G Laurenti

Detail Information

Publications36

  1. pmc PPARs in Human Neuroepithelial Tumors: PPAR Ligands as Anticancer Therapies for the Most Common Human Neuroepithelial Tumors
    Elisabetta Benedetti
    Department of Basic and Applied Biology, University of L Aquila, 67100 L Aquila, Italy
    PPAR Res 2010:427401. 2010
    ..This review will focus on the major studies dealing with PPAR expression in gliomas and neuroblastoma and the therapeutic implications of using PPAR agonists for the treatment of these neoplasms...
  2. pmc Innovative Therapies against Human Glioblastoma Multiforme
    Annamaria Cimini
    Department of Basic and Applied Biology, University of L Aquila, Via Vetoio No 10, 67010 L Aquila, Italy
    ISRN Oncol 2011:787490. 2011
    ..e., ATRA, PPARγ agonists). All these aspects will be discussed in the view of progress clinical trials and of possible new approaches for directed drug formulations...
  3. pmc PPARs Expression in Adult Mouse Neural Stem Cells: Modulation of PPARs during Astroglial Differentiaton of NSC
    A Cimini
    Department of Basic and Applied Biology, University of L Aquila, 67100 L Aquila, Italy
    PPAR Res 2007:48242. 2007
    ..PPARs may be involved in cell proliferation and differentiation processes of neural stem cells (NSC). To this aim, in this work the expression of the three PPAR isotypes and RXRs in NSC has been investigated...
  4. pmc Age-dependent roles of peroxisomes in the hippocampus of a transgenic mouse model of Alzheimer's disease
    Francesca Fanelli
    Department of Biology LIME, University Roma Tre, Viale Marconi 446, Rome 00146, Italy
    Mol Neurodegener 8:8. 2013
    ..Several peroxisome-related markers in transgenic and wild-type hippocampal formation were comparatively studied, by a combined molecular/immunohistochemical/ultrastructural approach...
  5. ncbi request reprint Neuronal response of peroxisomal and peroxisome-related proteins to chronic and acute Abeta injury
    A Cimini
    Dept of Basic and Applied Biology, University of L Aquila, via Vetoio n 10 67100 L Aquila, Italy
    Curr Alzheimer Res 6:238-51. 2009
    ..Our results support the notion that substances able to activate PPARalpha and/or to induce peroxisomal proliferation may constitute a novel preventive and/or therapeutic tool against neurodegenerative diseases...
  6. doi request reprint Emerging roles of peroxisome proliferator-activated receptors (PPARs) in the regulation of neural stem cells proliferation and differentiation
    Annamaria Cimini
    Department of Basic and Applied Biology, University of L Aquila, L Aquila, Italy
    Stem Cell Rev 4:293-303. 2008
    ..e. Wnt signalling pathway, STAT3 and NFkB pathways. In this review the findings related to PPARs and NSC are reported as well as their possible linkage to other signal transduction pathways involved in NSC specification...
  7. ncbi request reprint TNFalpha downregulates PPARdelta expression in oligodendrocyte progenitor cells: implications for demyelinating diseases
    Annamaria Cimini
    Department of Basic and Applied Biology, Universita di L Aquila, Italy
    Glia 41:3-14. 2003
    ..We propose a hypothetical model possibly explaining the perturbation effects of proinflammatory cytokines on myelin synthesis, maturation, and turnover...
  8. ncbi request reprint PPARgamma-dependent effects of conjugated linoleic acid on the human glioblastoma cell line (ADF)
    Annamaria Cimini
    Department of Basic and Applied Biology, University of L Aquila, L Aquila, Italy
    Int J Cancer 117:923-33. 2005
    ..Moreover, the gamma-agonist, once experimented and validated on man, may represent a useful coadjuvant in glioblastoma therapy and in the prevention of recurrences...
  9. ncbi request reprint Expression of peroxisome proliferator-activated receptors (PPARs) and retinoic acid receptors (RXRs) in rat cortical neurons
    A Cimini
    Department of Basic and Applied Biology, University of L Aquila, via Vetoio n 10, 67010 Coppito AQ, Italy
    Neuroscience 130:325-37. 2005
    ..In particular, we point toward the PPARbeta/delta isotype as a key factor in neuronal differentiation...
  10. ncbi request reprint Peroxisomes and PPARs in cultured neural cells
    Annamaria Cimini
    Department of Basic and Applied Biology, University of L Aquila, via Vetoio n 10, 67010 Coppito AQ, Italy
    Adv Exp Med Biol 544:271-80. 2003
  11. ncbi request reprint Transient maintenance in bioreactor improves health of neuronal cells
    Silvia Di Loreto
    Institute of Organ Transplants and Immunocytology, Consiglio Nazionale delle Ricerche, L Aquila, Italy
    In Vitro Cell Dev Biol Anim 42:134-42. 2006
    ..This experimental environment does not induce detrimental effects but may have an activator role, leading cells to development and maturation in a tridimensional state...
  12. pmc Glioblastoma Stem Cells Microenvironment: The Paracrine Roles of the Niche in Drug and Radioresistance
    Alessia Fidoamore
    Department of Life, Health and Environmental Sciences, University of L Aquila, 67100 L Aquila, Italy
    Stem Cells Int 2016:6809105. 2016
    ..It is, therefore, crucial to investigate the components/factors of the niche in order to formulate new adjuvant therapies rendering more efficiently the gold standard therapies for this neoplasm. ..
  13. pmc Cocoa powder triggers neuroprotective and preventive effects in a human Alzheimer's disease model by modulating BDNF signaling pathway
    Annamaria Cimini
    Department of Life, Health and Environmental Sciences, University of L Aquila, L Aquila, Italy
    J Cell Biochem 114:2209-20. 2013
    ..On the light of the results obtained the use of cocoa powder as preventive agent for neurodegeneration is further supported...
  14. doi request reprint Early biochemical and morphological modifications in the brain of a transgenic mouse model of Alzheimer's disease: a role for peroxisomes
    Annamaria Cimini
    Department of Basic and Applied Biology, University of L Aquila, 67010 L Aquila, Italy
    J Alzheimers Dis 18:935-52. 2009
    ..This different behavior could be related to metabolic differences in the two brain areas, also involving peroxisome abundance and/or enzymatic content...
  15. doi request reprint Hypoxia modulation of peroxisome proliferator-activated receptors (PPARs) in human glioblastoma stem cells. Implications for therapy
    Renato Galzio
    Department of Health Sciences, University of L Aquila, L Aquila, Italy
    J Cell Biochem 113:3342-52. 2012
    ..The results obtained suggest a differential regulation of the three PPARs by hypoxia, thus indicating a possible therapeutic strategy to counteract GB recurrencies...
  16. doi request reprint Neuroprotective effects of PrxI over-expression in an in vitro human Alzheimer's disease model
    Annamaria Cimini
    Department of Life, Health and Environmental Sciences, University of L Aquila, L Aquila, Italy
    J Cell Biochem 114:708-15. 2013
    ..The results obtained indicated a protective role for PrxI in counteracting Aβ injury by increasing cell viability, preserving neurites, and decreasing cell death...
  17. pmc Nucleolin antagonist triggers autophagic cell death in human glioblastoma primary cells and decreased in vivo tumor growth in orthotopic brain tumor model
    Elisabetta Benedetti
    Department of Life, Health and Environmental Sciences, University of L Aquila, L Aquila, Italy
    Oncotarget 6:42091-104. 2015
    ..The results obtained indicated an anti-proliferative and pro-autophagic effect of N6L and point towards its possible use as adjuvant agent to the standard therapeutic protocols presently utilized for glioblastoma. ..
  18. doi request reprint The PPARβ/δ Agonist GW0742 Induces Early Neuronal Maturation of Cortical Post-Mitotic Neurons: Role of PPARβ/δ in Neuronal Maturation
    Elisabetta Benedetti
    Department of Life Health and Environmental Sciences, University of L Aquila, Italy
    J Cell Physiol 231:597-606. 2016
    ..These effects appear to be mediated by the activation of BDNF pathway...
  19. ncbi request reprint Scavenging system efficiency is crucial for cell resistance to ROS-mediated methylglyoxal injury
    Fernanda Amicarelli
    Department of Basic and Applied Biology, Faculty of Science, L Aquila University, L Aquila, Italy
    Free Radic Biol Med 35:856-71. 2003
    ..These data emphasize the pivotal role of antioxidant and detoxifying systems in determining the grade of sensitivity of cells to methylglyoxal...
  20. doi request reprint Uric Acid Amplifies Aβ Amyloid Effects Involved in the Cognitive Dysfunction/Dementia: Evidences From an Experimental Model In Vitro
    Giovambattista Desideri
    Department of Life, Health and Environmental Sciences, University of L Aquila, L Aquila, Italy
    J Cell Physiol . 2016
    ..J. Cell. Physiol. 9999: 1-10, 2016. © 2016 Wiley Periodicals, Inc...
  21. doi request reprint Supramolecular self-assembly of graphene oxide and metal nanoparticles into stacked multilayers by means of a multitasking protein ring
    Matteo Ardini
    Dept of Life, Health and Environmental Sciences, University of L Aquila, Italy
    Nanoscale 8:6739-53. 2016
    ..This feature is exploited to both capture presynthesized gold nanoparticles and grow in situ palladium nanoparticles paving the way to straightforward and "green" routes to 3D reduced GO-metal composite materials. ..
  22. pmc Targeting CXCR1 on breast cancer stem cells: signaling pathways and clinical application modelling
    Laura Brandolini
    Dompé Farmaceutici SpA, via Campo di Pile, L Aquila, Italy
    Oncotarget 6:43375-94. 2015
    ....
  23. doi request reprint Gastroprotective effects of L-lysine salification of ketoprofen in ethanol-injured gastric mucosa
    Annamaria Cimini
    Department of Life, Health and Environmental Sciences, University of L Aquila, Via Vetoio, L Aquila, Italy Sbarro Institute for Cancer Research and Molecular Medicine, Temple University, Philadelphia, Pennsylvania
    J Cell Physiol 230:813-20. 2015
    ..The data obtained indicate a gastroprotective effect of L-lysine on gastric mucosa integrity...
  24. doi request reprint Flavopiridol: An Old Drug With New Perspectives? Implication for Development of New Drugs
    Annamaria Cimini
    Department of Life, Health and Environmental Sciences, University of L Aquila, L Aquila, Italy
    J Cell Physiol 232:312-322. 2017
    ..J. Cell. Physiol. 232: 312-322, 2017. © 2016 Wiley Periodicals, Inc...
  25. doi request reprint PPARα Antagonist AA452 Triggers Metabolic Reprogramming and Increases Sensitivity to Radiation Therapy in Human Glioblastoma Primary Cells
    Elisabetta Benedetti
    Depatment of Life, Health and Environmental Sciences, University of L Aquila, L Aquila, Italy
    J Cell Physiol . 2016
    ..J. Cell. Physiol. 9999: 1-9, 2016. © 2016 Wiley Periodicals, Inc...
  26. doi request reprint PDZ Domain in the Engineering and Production of a Saporin Chimeric Toxin as a Tool for targeting Cancer Cells
    Francesco Giansanti
    Department of Health, Life and Environmental Sciences, University of L Aquila, I 67100 L Aquila, Italy
    J Cell Biochem 116:1256-66. 2015
    ..These constructs proved to be toxic, with increasing activity as a function of the number of PDZ domains, and induce cell death by apoptotic mechanisms in a dose-dependent and/or time dependent manner...
  27. doi request reprint Antibody-conjugated PEGylated cerium oxide nanoparticles for specific targeting of Aβ aggregates modulate neuronal survival pathways
    Annamaria Cimini
    Department of Basic and Applied Biology, University of L Aquila, L Aquila, Italy
    Acta Biomater 8:2056-67. 2012
    ..This proof of concept work may allow in the future, once validated in vivo, for the selective delivery of CNPs only to affected brain areas...
  28. doi request reprint Neuroendocrine transdifferentiation induced by VPA is mediated by PPARgamma activation and confers resistance to antiblastic therapy in prostate carcinoma
    Adriano Angelucci
    Department of Basic and Applied Biology, University of L Aquila, L Aquila, Italy
    Prostate 68:588-98. 2008
    ..However molecular mechanisms underlying VPA action in PCa cells are largely unknown and further experimental validation to prove its potential application in clinic practice is needed...
  29. ncbi request reprint Peroxisome proliferator-activated receptors (PPARs) and related transcription factors in differentiating astrocyte cultures
    L Cristiano
    Department of Basic and Applied Biology, University of L Aquila, Via Vetoio 10, Coppito, L Aquila, 67010 Italy
    Neuroscience 131:577-87. 2005
    ....
  30. doi request reprint VSL#3 Probiotic Differently Influence IEC-6 Intestinal Epithelial Cell Status and Function
    Benedetta Cinque
    Division of Public Health, Department of Life, Health and Environmental Sciences, University of L Aquila, Coppito, L Aquila, Italy
    J Cell Physiol . 2017
    ..This article is protected by copyright. All rights reserved...
  31. doi request reprint PPARβ/δ and γ in a rat model of Parkinson's disease: possible involvement in PD symptoms
    Roberta Falcone
    Department of Life, Health and Environmental Sciences, University of L Aquila, Italy
    J Cell Biochem 116:844-55. 2015
    ..The results obtained indicate the possible use of a dual PPARβ/δ antagonist/PPARγ agonist to counteract primary and secondary signs of PD neurodegeneration...
  32. doi request reprint Metal-induced self-assembly of peroxiredoxin as a tool for sorting ultrasmall gold nanoparticles into one-dimensional clusters
    Matteo Ardini
    Dept of Life, Health and Environmental Sciences, University of L Aquila, Piazzale Salvatore Tommasi 1, 67100 L Aquila, Italy
    Nanoscale 6:8052-61. 2014
    ..These results open up possibilities in developing Prx-based methods to synthesize new advanced functional materials. ..
  33. pmc Peroxisome Proliferator-Activated Receptors in Female Reproduction and Fertility
    Maurizio Vitti
    Department of Life, Health and Environmental Sciences, University of L Aquila, 67100 L Aquila, Italy
    PPAR Res 2016:4612306. 2016
    ..Finally, the therapeutic potential of their manipulation through several drugs is also discussed. ..
  34. ncbi request reprint PPARbeta agonists trigger neuronal differentiation in the human neuroblastoma cell line SH-SY5Y
    S Di Loreto
    ITOI, CNR, L Aquila, Italy
    J Cell Physiol 211:837-47. 2007
    ....
  35. doi request reprint Biomolecular characterization of human glioblastoma cells in primary cultures: differentiating and antiangiogenic effects of natural and synthetic PPARgamma agonists
    E Benedetti
    Department of Basic and Applied Biology, University of L Aquila, L Aquila, Italy
    J Cell Physiol 217:93-102. 2008
    ..We provide evidence that PPARgamma agonists may interfere with glioblastoma growth and malignancy and might be taken in account as novel antitumoral drugs...
  36. ncbi request reprint Fifty hertz extremely low-frequency electromagnetic field causes changes in redox and differentiative status in neuroblastoma cells
    Stefano Falone
    Department of Biomedical Sciences, Excellent Center on Aging Studies, Faculty of Medicine G d Annunzio, Via dei Vestini, 66013 Chieti, Italy
    Int J Biochem Cell Biol 39:2093-106. 2007
    ..Results clearly showed that 50 Hz extremely low-frequency electromagnetic fields exposure reduces cell tolerance towards oxidative attacks...