Salvatore Chirumbolo

Summary

Affiliation: University of Verona
Country: Italy

Publications

  1. pmc PERM Hypothesis: The Fundamental Machinery Able to Elucidate the Role of Xenobiotics and Hormesis in Cell Survival and Homeostasis
    Salvatore Chirumbolo
    Department of Neurological and Movement Sciences, University of Verona, Verona 37134, Italy
    Int J Mol Sci 18:. 2017
  2. ncbi request reprint The sesquiterpene α-bisabolol in the adipocyte-cancer desmoplastic crosstalk: does it have an action on epithelial-mesenchymal transition mechanisms?
    Salvatore Chirumbolo
    Department of Neurological and Movement Sciences, University of Verona, Strada Le Grazie 9, Verona, Italy
    Int J Clin Oncol . 2016
  3. pmc On Gelsemium and Complementary and Alternative Medicine (CAM) in Anxiety and Experimental Neurology
    Salvatore Chirumbolo
    Department of Medicine, Univerity of Verona, LURM Est Policlinico GB Rossi, Piazzale AL Scuro 10, 37134, Verona, Italy
    Neurol Ther 4:1-10. 2015
  4. doi request reprint Can Wnt5a and Wnt non-canonical pathways really mediate adipocyte de-differentiation in a tumour microenvironment?
    Salvatore Chirumbolo
    Department of Medicine, University of Verona, Italy Electronic address
    Eur J Cancer 64:96-100. 2016
  5. ncbi request reprint The role of vitamin D towards immune tolerance in white adipose tissue (WAT)
    Salvatore Chirumbolo
    Department of Medicine University of Verona, Italy LURM Est Policlinico GB Rossi, Piazzale AL Scuro 10, 37134 Verona, Italy
    Endocr Metab Immune Disord Drug Targets 15:277-87. 2015
  6. doi request reprint Iron primes 3T3-L1 adipocytes to a TLR4-mediated inflammatory response
    Salvatore Chirumbolo
    Department of Medicine University of Verona, Verona, Italy Electronic address
    Nutrition 31:1266-74. 2015
  7. doi request reprint LPS response pattern of inflammatory adipokines in an in vitro 3T3-L1 murine adipocyte model
    Salvatore Chirumbolo
    Unit of Geriatry, Department of Medicine, University of Verona, Verona, Italy
    Inflamm Res 63:495-507. 2014
  8. pmc In vitro Biphasic Effect of Honey Bee Venom on Basophils from Screened Healthy Blood Donors
    Salvatore Chirumbolo
    Department of Pathology and Diagnostics, University of Verona, Verona, Italy
    Allergy Asthma Immunol Res 3:58-61. 2011
  9. ncbi request reprint Dietary assumption of plant polyphenols and prevention of allergy
    Salvatore Chirumbolo
    Department of Medicine University of Verona, LURM Est Policlinico GB Rossi, Piazzale AL Scuro 10, 37134 Verona, Italy
    Curr Pharm Des 20:811-39. 2014
  10. ncbi request reprint Basophil activation test to optimize the diagnosis of adverse effects following immunization to vaccines
    Salvatore Chirumbolo
    Laboratory of Physiopathology of Obesity, Department of Medicine, University of Verona, Italy
    Iran J Allergy Asthma Immunol 12:196-202. 2013

Detail Information

Publications29

  1. pmc PERM Hypothesis: The Fundamental Machinery Able to Elucidate the Role of Xenobiotics and Hormesis in Cell Survival and Homeostasis
    Salvatore Chirumbolo
    Department of Neurological and Movement Sciences, University of Verona, Verona 37134, Italy
    Int J Mol Sci 18:. 2017
    ..Mild stress is probably the main stimulus in this sense. Hormesis is therefore re-interpreted in the light of this hypothetical model and that experimental evidence arising from flavonoid and hormesis reasearch...
  2. ncbi request reprint The sesquiterpene α-bisabolol in the adipocyte-cancer desmoplastic crosstalk: does it have an action on epithelial-mesenchymal transition mechanisms?
    Salvatore Chirumbolo
    Department of Neurological and Movement Sciences, University of Verona, Strada Le Grazie 9, Verona, Italy
    Int J Clin Oncol . 2016
    ..This review addresses the issue on the basis of the most recent reported literature in the field...
  3. pmc On Gelsemium and Complementary and Alternative Medicine (CAM) in Anxiety and Experimental Neurology
    Salvatore Chirumbolo
    Department of Medicine, Univerity of Verona, LURM Est Policlinico GB Rossi, Piazzale AL Scuro 10, 37134, Verona, Italy
    Neurol Ther 4:1-10. 2015
    ..Comments about the ability of negligible doses of Gelsemium hydroalcoholic extracts to affect gene expression were recently reported. ..
  4. doi request reprint Can Wnt5a and Wnt non-canonical pathways really mediate adipocyte de-differentiation in a tumour microenvironment?
    Salvatore Chirumbolo
    Department of Medicine, University of Verona, Italy Electronic address
    Eur J Cancer 64:96-100. 2016
    ....
  5. ncbi request reprint The role of vitamin D towards immune tolerance in white adipose tissue (WAT)
    Salvatore Chirumbolo
    Department of Medicine University of Verona, Italy LURM Est Policlinico GB Rossi, Piazzale AL Scuro 10, 37134 Verona, Italy
    Endocr Metab Immune Disord Drug Targets 15:277-87. 2015
    ..The role of active vitamin D3 therefore is fundamental in the immune homeostasis of the WAT immune microenvironment and to support the role of WAT as an endocrine, tolerogenic organ. ..
  6. doi request reprint Iron primes 3T3-L1 adipocytes to a TLR4-mediated inflammatory response
    Salvatore Chirumbolo
    Department of Medicine University of Verona, Verona, Italy Electronic address
    Nutrition 31:1266-74. 2015
    ..The aim of this study was to investigate the role of iron in an in vitro-inflamed adipocyte model...
  7. doi request reprint LPS response pattern of inflammatory adipokines in an in vitro 3T3-L1 murine adipocyte model
    Salvatore Chirumbolo
    Unit of Geriatry, Department of Medicine, University of Verona, Verona, Italy
    Inflamm Res 63:495-507. 2014
    ..In this study we have evaluated the differential expression of adipokines in response to increasing doses of LPS and various incubation times...
  8. pmc In vitro Biphasic Effect of Honey Bee Venom on Basophils from Screened Healthy Blood Donors
    Salvatore Chirumbolo
    Department of Pathology and Diagnostics, University of Verona, Verona, Italy
    Allergy Asthma Immunol Res 3:58-61. 2011
    ..Autocrine interleukin-3 may play a role in the observed biphasic behavior...
  9. ncbi request reprint Dietary assumption of plant polyphenols and prevention of allergy
    Salvatore Chirumbolo
    Department of Medicine University of Verona, LURM Est Policlinico GB Rossi, Piazzale AL Scuro 10, 37134 Verona, Italy
    Curr Pharm Des 20:811-39. 2014
    ..In this review, special emphasis is placed on the effects of dietary polyphenols on allergy prevention, the possible mechanism of action of polyphenols-containing food and future perspectives for pharmacology design. ..
  10. ncbi request reprint Basophil activation test to optimize the diagnosis of adverse effects following immunization to vaccines
    Salvatore Chirumbolo
    Laboratory of Physiopathology of Obesity, Department of Medicine, University of Verona, Italy
    Iran J Allergy Asthma Immunol 12:196-202. 2013
    ..This may extend BAT use in many other forms of chronic allergy and immunity disorders related to AEFI with vaccines...
  11. doi request reprint Quercetin in cancer prevention and therapy
    Salvatore Chirumbolo
    Department of Medicine, University of Verona, LURM Policlinico GB Rossi, Piazzale LA Scuro 10 37134 Verona, Italy
    Integr Cancer Ther 12:97-102. 2013
    ..The challenge is to highlight an eligible target in order to address possible natural compounds, either in food extracts or as pharmaceuticals, as real drugs against cancer...
  12. doi request reprint Role of quercetin in vascular physiology
    Salvatore Chirumbolo
    Department of Medicine, Laboratorio Universitario di Ricerca, Medica LURM Policlinico G B Rossi, University of Verona, Piazzale, Verona, Italy
    Can J Physiol Pharmacol 90:1652-7. 2012
    ..The majority of these mechanisms have been identified with models using animals treated with quercetin, and relatively few have been corroborated in human studies, which indicates the need for further investigation...
  13. doi request reprint Plant-derived extracts in the neuroscience of anxiety on animal models: biases and comments
    Salvatore Chirumbolo
    Department of Medicine, University of Verona, Verona, Italy
    Int J Neurosci 122:177-88. 2012
    ..Biases about several aspects related with experimental setting, animal selection, environments, operators and investigators, selection and performance of behavioral tests, controls, results managing, and statistics are here discussed...
  14. doi request reprint Possible role of NF-κB in hormesis during ageing
    S Chirumbolo
    Department of Medicine Unit of Geriatry, University of Verona, LURM Policlinico GB Rossi Piazzale AL Scuro, 10, 37134 Verona, Italy
    Biogerontology 13:637-46. 2012
    ..Due to its tight relationship with main signaling system NF-κB plays a fundamental role in stress response, apoptosis and autophagy and appears to be a possible target for hormesis in ageing...
  15. doi request reprint Basophil activation test in allergy: time for an update?
    Salvatore Chirumbolo
    Department of Pathology and Diagnostics, Unit of General Pathology, University of Verona, Verona, Italy
    Int Arch Allergy Immunol 158:99-114. 2012
    ..BAT is certainly a useful technique, also for isolated cases of hypersensitivity to various other compounds and drugs, and an update of its application is certainly an interesting topic to expand the debate on allergy diagnosis...
  16. doi request reprint Plant phytochemicals as new potential drugs for immune disorders and cancer therapy: really a promising path?
    Salvatore Chirumbolo
    Department of Medicine Section Geriatry, University of Verona, Policlinico GB Rossi piazzale AL Scuro 10, 37134 Verona, Italy
    J Sci Food Agric 92:1573-7. 2012
    ....
  17. pmc Differential response of human basophil activation markers: a multi-parameter flow cytometry approach
    Salvatore Chirumbolo
    Department of Morphological and Biomedical Science University of Verona, Italy
    Clin Mol Allergy 6:12. 2008
    ..In this context, polychromatic flow cytometry (PFC) is a proper tool to investigate basophil function, as it allows to distinguish the expression of several membrane markers upon activation in multiple experimental conditions...
  18. doi request reprint Use of basophil activation test in the investigation of adverse effects to vaccines
    Salvatore Chirumbolo
    Department of Pathology and Diagnostics, Unit of General Pathology, University of Verona, Verona, Italy
    Hum Vaccin 7:878-80. 2011
    ....
  19. ncbi request reprint Quercetin as a potential anti-allergic drug: which perspectives?
    Salvatore Chirumbolo
    Iran J Allergy Asthma Immunol 10:139-40. 2011
    ....
  20. doi request reprint Stimulus-specific regulation of CD63 and CD203c membrane expression in human basophils by the flavonoid quercetin
    S Chirumbolo
    Department of Morphological and Biomedical Sciences Sect Clinical Chemistry, University of Verona University Hospital GB Rossi piazzale AL Scuro 10 37134 Verona, Italy
    Int Immunopharmacol 10:183-92. 2010
    ..Flavonoids, such as quercetin, were reported to inhibit histamine release and cytokine production by basophils, but there is no evidence describing their action on membrane markers and intracellular biochemical pathways...
  21. ncbi request reprint The role of quercetin, flavonols and flavones in modulating inflammatory cell function
    Salvatore Chirumbolo
    Department of Pathology and Diagnostics, University of Verona, Strada Le Grazie 8 37135 Verona, Italy
    Inflamm Allergy Drug Targets 9:263-85. 2010
    ....
  22. pmc Bimodal action of the flavonoid quercetin on basophil function: an investigation of the putative biochemical targets
    Salvatore Chirumbolo
    Department of Pathology and Diagnostics, Sect, General Pathology, Strada Le Grazie 8, 37134 Verona, Italy
    Clin Mol Allergy 8:13. 2010
    ..As this mechanism needs to be elucidated, in this study we focused the possible signal transduction pathways which may be affected by this compound...
  23. doi request reprint Phenotypic shift of adipocytes by cholecalciferol and 1α,25 dihydroxycholecalciferol in relation to inflammatory status and calcium content
    Elena Zoico
    Department of Medicine, Division of Geriatrics, University of Verona, 37126 Verona, Italy
    Endocrinology 155:4178-88. 2014
    ....
  24. pmc A comparative method for processing immunological parameters: developing an "Immunogram"
    Riccardo Ortolani
    Sezione di Immunologia Clinica, Dipartimento di Patologia Generale, Azienda Ospedaliero Universitaria di Verona, Verona, Italy
    Blood Transfus 8:118-25. 2010
    ..Therefore, in order to study the immune system correctly, it must be considered in all its complexity by analysing its components with multiparametric tools that take its dynamic characteristic into account...
  25. pmc Inhibition of CD203c membrane up-regulation in human basophils by high dilutions of histamine: a controlled replication study
    Salvatore Chirumbolo
    Department of Morphological and Biomedical Science, University of Verona, Piazza L A Scuro, Verona, Italy
    Inflamm Res 58:755-64. 2009
    ..However, uncertainties about the nature of the phenomenon and its reproducibility mean that further, rigorously controlled studies are necessary...
  26. ncbi request reprint Advances in homeopathy and immunology: a review of clinical research
    Paolo Bellavite
    Department of Pathology and Diagnostics, University of Verona, Verona, Italy
    Front Biosci (Schol Ed) 3:1363-89. 2011
    ....
  27. doi request reprint Colostrum-derived B and T cells as an extra-lymphoid compartment of effector cell populations in humans
    Diego G Peroni
    Department of Mothers and Children Biology and Genetics, Section of Pediatrics, Azienda Ospedaliera Universitaria Integrata, Verona, Italy
    J Matern Fetal Neonatal Med 26:137-42. 2013
    ..Colostrum T and B lymphocytes appear to be enriched with subsets possessing effector functions or belonging to the innate immune system, what could transfer a prompt line of defence to offspring...
  28. doi request reprint Adipose tissue, diet and aging
    Mauro Zamboni
    Department of Medicine, Geriatric Medicine, University of Verona, Italy Electronic address
    Mech Ageing Dev 136:129-37. 2014
    ....
  29. doi request reprint Hormesis and its relationship with homeopathy
    Paolo Bellavite
    Department of Pathology, University of Verona, Verona, Italy
    Hum Exp Toxicol 29:573-9. 2010
    ..Thus, the well-established and consolidated field of hormesis can help cast light, through its ideas and research methods, on the possible mechanisms of action of remedies in ultra-low doses...