Paola Brun

Summary

Affiliation: University of Padova
Country: Italy

Publications

  1. doi request reprint In vitro response of osteoarthritic chondrocytes and fibroblast-like synoviocytes to a 500-730 kDa hyaluronan amide derivative
    Paola Brun
    Department of Biomedical Sciences, University of Padova, Italy
    J Biomed Mater Res B Appl Biomater 100:2073-81. 2012
  2. pmc Disinfection of ocular cells and tissues by atmospheric-pressure cold plasma
    Paola Brun
    Histology Unit, Department of Biomedical Sciences, University of Padua, Padua, Italy
    PLoS ONE 7:e33245. 2012
  3. pmc Characteristics of repair tissue in second-look and third-look biopsies from patients treated with engineered cartilage: relationship to symptomatology and time after implantation
    Paola Brun
    Department of Histology, Microbiology and Medical Biotechnology, Histology Unit, Faculty of Medicine, University of Padova, Padova, Italy
    Arthritis Res Ther 10:R132. 2008
  4. doi request reprint Lactobacillus crispatus M247-derived H2O2 acts as a signal transducing molecule activating peroxisome proliferator activated receptor-gamma in the intestinal mucosa
    Sandra Voltan
    Department of Histology, Microbiology and Medical Biotechnologies, University of Padua, Italy
    Gastroenterology 135:1216-27. 2008
  5. pmc Aggregating phenotype in Lactobacillus crispatus determines intestinal colonization and TLR2 and TLR4 modulation in murine colonic mucosa
    Sandra Voltan
    University of Padua, Department of Histology, Microbiology, and Medical Biotechnologies, Via A Gabelli 63, Padua 35121, Italy
    Clin Vaccine Immunol 14:1138-48. 2007
  6. ncbi request reprint Improvement of Anselme's adhesion model for evaluating human osteoblast response to peptide-grafted titanium surfaces
    Andrea Bagno
    Department of Chemical Process Engineering, University of Padova, Via Marzolo 9, 35131, Padova, Italy
    Bone 41:704-12. 2007
  7. doi request reprint Toll-like receptor 2 regulates intestinal inflammation by controlling integrity of the enteric nervous system
    Paola Brun
    Department of Molecular Medicine, University of Padova, Padova, Italy
    Gastroenterology 145:1323-33. 2013
  8. pmc Synthesis and in vitro evaluation of 3h-pyrrolo[3,2-f]-quinolin-9-one derivatives that show potent and selective anti-leukemic activity
    Maria Grazia Ferlin
    Department of Pharmaceutical Sciences, University of Padova, Italy
    ChemMedChem 5:1373-85. 2010
  9. doi request reprint Relationship between virulence factor genes in bovine Staphylococcus aureus subclinical mastitis isolates and binding to anti-adhesin antibodies
    Melania Scarpa
    Department of Histology, Microbiology and Medical Biotechnologies, Padua, Italy
    J Dairy Res 77:159-67. 2010
  10. doi request reprint Self-assembling peptide-enriched electrospun polycaprolactone scaffolds promote the h-osteoblast adhesion and modulate differentiation-associated gene expression
    Roberta Danesin
    Department of Industrial Engineering, University of Padua, Via Marzolo 9, 35131, Padua, Italy
    Bone 51:851-9. 2012

Collaborators

Detail Information

Publications50

  1. doi request reprint In vitro response of osteoarthritic chondrocytes and fibroblast-like synoviocytes to a 500-730 kDa hyaluronan amide derivative
    Paola Brun
    Department of Biomedical Sciences, University of Padova, Italy
    J Biomed Mater Res B Appl Biomater 100:2073-81. 2012
    ..The longer residence time in the joint cavity, the increased viscoelasticity, and the anti-inflammatory potential of HYADD®4-G make it a better candidate than native HA for OA therapy...
  2. pmc Disinfection of ocular cells and tissues by atmospheric-pressure cold plasma
    Paola Brun
    Histology Unit, Department of Biomedical Sciences, University of Padua, Padua, Italy
    PLoS ONE 7:e33245. 2012
    ..This study explored whether atmospheric-pressure cold plasma (APCP) generated by a new portable device that ionizes a flow of helium gas can inactivate ocular pathogens without causing significant tissue damage...
  3. pmc Characteristics of repair tissue in second-look and third-look biopsies from patients treated with engineered cartilage: relationship to symptomatology and time after implantation
    Paola Brun
    Department of Histology, Microbiology and Medical Biotechnology, Histology Unit, Faculty of Medicine, University of Padova, Padova, Italy
    Arthritis Res Ther 10:R132. 2008
    ..The present study established characteristics of tissue regrowth in patients suffering knee lesions treated with grafts of autologous chondrocytes grown on three-dimensional hyaluronic acid biomaterials...
  4. doi request reprint Lactobacillus crispatus M247-derived H2O2 acts as a signal transducing molecule activating peroxisome proliferator activated receptor-gamma in the intestinal mucosa
    Sandra Voltan
    Department of Histology, Microbiology and Medical Biotechnologies, University of Padua, Italy
    Gastroenterology 135:1216-27. 2008
    ....
  5. pmc Aggregating phenotype in Lactobacillus crispatus determines intestinal colonization and TLR2 and TLR4 modulation in murine colonic mucosa
    Sandra Voltan
    University of Padua, Department of Histology, Microbiology, and Medical Biotechnologies, Via A Gabelli 63, Padua 35121, Italy
    Clin Vaccine Immunol 14:1138-48. 2007
    ..We speculate that the aggregation phenotype in L. crispatus M247 is required to temper epithelial cell responsiveness to bacterial endotoxins, which thus affects the evolution of intestinal inflammatory processes...
  6. ncbi request reprint Improvement of Anselme's adhesion model for evaluating human osteoblast response to peptide-grafted titanium surfaces
    Andrea Bagno
    Department of Chemical Process Engineering, University of Padova, Via Marzolo 9, 35131, Padova, Italy
    Bone 41:704-12. 2007
    ..The results confirmed the capacity of the peptide to increase cell adhesion and adhesion strength; moreover, the role of the peptide was described by a mathematical equation characterizing cells behaviour...
  7. doi request reprint Toll-like receptor 2 regulates intestinal inflammation by controlling integrity of the enteric nervous system
    Paola Brun
    Department of Molecular Medicine, University of Padova, Padova, Italy
    Gastroenterology 145:1323-33. 2013
    ..We assessed the effects of TLR2 signaling on the enteric nervous system (ENS) in mice...
  8. pmc Synthesis and in vitro evaluation of 3h-pyrrolo[3,2-f]-quinolin-9-one derivatives that show potent and selective anti-leukemic activity
    Maria Grazia Ferlin
    Department of Pharmaceutical Sciences, University of Padova, Italy
    ChemMedChem 5:1373-85. 2010
    ..This effect was associated with apoptosis, mitochondrial depolarization, generation of reactive oxygen species, activation of caspase-3, and cleavage of the enzyme poly(ADP-ribose) polymerase...
  9. doi request reprint Relationship between virulence factor genes in bovine Staphylococcus aureus subclinical mastitis isolates and binding to anti-adhesin antibodies
    Melania Scarpa
    Department of Histology, Microbiology and Medical Biotechnologies, Padua, Italy
    J Dairy Res 77:159-67. 2010
    ..Thus, as opposed to other pathogens to obtain an effective vaccine we should characterize multiple strains and identify the prevalent virulence factors expressed...
  10. doi request reprint Self-assembling peptide-enriched electrospun polycaprolactone scaffolds promote the h-osteoblast adhesion and modulate differentiation-associated gene expression
    Roberta Danesin
    Department of Industrial Engineering, University of Padua, Via Marzolo 9, 35131, Padua, Italy
    Bone 51:851-9. 2012
    ..The possibility of linking biochemical messages to self-assembling peptides could lead the way to a 3D decoration of fibrous scaffolds...
  11. doi request reprint Pyrrolotetrazinones deazaanalogues of temozolomide induce apoptosis in Jurkat cell line: involvement of tubulin polymerization inhibition
    Giampietro Viola
    Dipartimento di Scienze Farmaceutiche, University of Padova, Padua, Italy
    Cancer Chemother Pharmacol 64:1235-51. 2009
    ....
  12. doi request reprint Triterpene glycosides with in vitro anti-inflammatory activity from Cyclamen repandum tubers
    Stefano Dall'acqua
    Department of Pharmaceutical Sciences, University of Padova, Italy
    Carbohydr Res 345:709-14. 2010
    ..We found that compounds 1 (repandoside), 2 (deglucocyclamin) and 4 (anagalloside B) at 100 microM inhibited the LPS-induced IL-8 and TNF-alpha expressions...
  13. pmc Adenosine-mediated enteric neuromuscular function is affected during herpes simplex virus type 1 infection of rat enteric nervous system
    Chiara Zoppellaro
    Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy
    PLoS ONE 8:e72648. 2013
    ..As such, this may represent a valid therapeutic target for modulating gut contractility associated to a primary neurodysfunction. ..
  14. ncbi request reprint Increased intestinal permeability in obese mice: new evidence in the pathogenesis of nonalcoholic steatohepatitis
    Paola Brun
    Department of Histology, Univ of Padua, Via Gabelli 63, Padova, Italy
    Am J Physiol Gastrointest Liver Physiol 292:G518-25. 2007
    ..We suggest that in metabolic syndrome, patients may likewise have a greater intestinal mucosa permeability and increased lipopolysaccharide levels in portal blood that can contribute to the liver inflammatory damage...
  15. doi request reprint Clostridium difficile TxAC314 and SLP-36kDa enhance the immune response toward a co-administered antigen
    Paola Brun
    Department of Histology, Microbiology and Medical Biotechnologies, University of Padua, Padua, Italy
    J Med Microbiol 57:725-31. 2008
    ..These studies provide insight into the ability of different C. difficile-derived peptides to differentially affect and polarize the activity of the immune system and on their potential use as adjuvants in newly developed vaccines...
  16. ncbi request reprint Urokinase plasminogen activator, uPa receptor, and its inhibitor in vernal keratoconjunctivitis
    Andrea Leonardi
    Department of Neuroscience, Ophthalmology Unit, University of Padua, Padua, Italy
    Invest Ophthalmol Vis Sci 46:1364-70. 2005
    ..The serine protease urokinase (uPA) is a potent chemoattractant for leukocytes that may be involved in the pathogenesis of severe forms of allergic conjunctivitis such as vernal keratoconjunctivitis (VKC)...
  17. doi request reprint Innate immune environment in ileal pouch mucosa: α5 defensin up-regulation as predictor of chronic/relapsing pouchitis
    Marco Scarpa
    Oncological Surgery Unit, Veneto Institute of Oncology IOV IRCCS, Via Gattamelata 64, 35128, Padua, Italy
    J Gastrointest Surg 16:188-201; discussion 201-2. 2012
    ..In patients with chronic/relapsing pouchitis, HD-5 and TLR-4 over-expression is likely to create a hostile environment against Enterobacteriaceae, thus favouring Clostridiaceae spp by decreasing competing bacteria families...
  18. doi request reprint TAK1 is a key modulator of the profibrogenic phenotype of human ileal myofibroblasts in Crohn's disease
    Alessia Rosaria Grillo
    Department of Molecular Medicine, University of Padova, Padova, Italy Department of Surgery Oncology and Gastroenterology, University of Padova, Padova, Italy and
    Am J Physiol Gastrointest Liver Physiol 309:G443-54. 2015
    ..Thus the TAK1 signaling pathway may represent a suitable target to design new, antifibrotic therapies. ..
  19. doi request reprint Quinazoline-based multi-tyrosine kinase inhibitors: synthesis, modeling, antitumor and antiangiogenic properties
    Maria Teresa Conconi
    Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5, 35131 Padova, Italy
    Eur J Med Chem 67:373-83. 2013
    ..Finally, the biphenylamino derivatives, at noncytotoxic concentrations, acted as antiangiogenic agents both in in vitro and in vivo assays. ..
  20. doi request reprint T cells in the myenteric plexus of achalasia patients show a skewed TCR repertoire and react to HSV-1 antigens
    Monica Facco
    Department of Clinical and Experimental Medicine, Hematology and Clinical Immunology Branch, Padua University School of Medicine, Padova, Italy
    Am J Gastroenterol 103:1598-609. 2008
    ....
  21. doi request reprint Snail1 transcription factor is a critical mediator of hepatic stellate cell activation following hepatic injury
    Melania Scarpa
    University of Padova, School of Pharmacy, Dept of Histology, Microbiology and Medical Biotechnologies, Via A Gabelli 63, 35121 Padova, Italy
    Am J Physiol Gastrointest Liver Physiol 300:G316-26. 2011
    ..Our data support a role for Snail1 transcription factor in the hepatic wound-healing response and its involvement in the HSC transdifferentiation process...
  22. pmc CD80 down-regulation is associated to aberrant DNA methylation in non-inflammatory colon carcinogenesis
    Marco Scarpa
    Esophageal and Digestive Tract Surgery Unit, Veneto Institute of Oncology IOV IRCCS, Padova, Italy
    BMC Cancer 16:388. 2016
    ..The aim of this study was to examine the expression of the costimulatory molecule CD80 in relationship with genomic methylation in non-inflammatory colon carcinogenesis...
  23. doi request reprint Peroxisome proliferator-activated receptor-γ mediates the anti-inflammatory effect of 3-hydroxy-4-pyridinecarboxylic acid derivatives: synthesis and biological evaluation
    Paola Brun
    Department of Molecular Medicine, University of Padova, Padova, Italy
    Eur J Med Chem 62:486-97. 2013
    ..Finally, daily treatment with HP 24 ameliorated the outcome of DSS-induced colitis in mice, significantly reducing colonic MPO activity and IL-1β tissue levels...
  24. doi request reprint Mechanisms underlying the attachment and spreading of human osteoblasts: from transient interactions to focal adhesions on vitronectin-grafted bioactive surfaces
    Paola Brun
    Department of Molecular Medicine, University of Padova, 35121 Padova, Italy
    Acta Biomater 9:6105-15. 2013
    ..Thus an interfacial layer of an endosseous device grafted with specifically immobilized HVP peptide not only selects the attachment and supports differentiation of osteoblasts but also promotes cellular migration...
  25. ncbi request reprint Exposure to bacterial cell wall products triggers an inflammatory phenotype in hepatic stellate cells
    Paola Brun
    Department of Histology, University of Padua, Padua, Italy
    Am J Physiol Gastrointest Liver Physiol 289:G571-8. 2005
    ..We speculate that high levels of bacterial endotoxins in the portal vein may directly induce a proinflammatory phenotype in HSCs that contributes to liver damage...
  26. doi request reprint Intranasal delivery of DNA encoding antigens of Mycobacterium tuberculosis by non-pathogenic invasive Escherichia coli
    Paola Brun
    Department of Histology, Microbiology and Medical Biotechnologies, University of Padua, Via Gabelli 63, 35121 Padua, Italy
    Vaccine 26:1934-41. 2008
    ..Both DNA vaccines were able to induce an antigen-specific T-cell response. Moreover, mice immunized with the recombinant bacteria carrying the DNA vaccine encoding HtpX, were significatively protected from challenge with M. tuberculosis...
  27. pmc MG-2477, a new tubulin inhibitor, induces autophagy through inhibition of the Akt/mTOR pathway and delayed apoptosis in A549 cells
    Giampietro Viola
    Department of Pediatrics, Laboratory of Oncohematology, University of Padova, Italy
    Biochem Pharmacol 83:16-26. 2012
    ..Taken together, these results indicated that the autophagy induced by MG-2477 delayed apoptosis by exerting an adaptive response following microtubule damage...
  28. pmc MiR-155 modulates the inflammatory phenotype of intestinal myofibroblasts by targeting SOCS1 in ulcerative colitis
    Surajit Pathak
    1 Department of Surgery Oncology and Gastroenterology DISCOG, University of Padova, Padova, Italy 2 Department of Molecular Medicine, University of Padova, Padova, Italy
    Exp Mol Med 47:e164. 2015
    ..In all, our data suggest that inflammatory mediators induce miR-155 expression in IMF of patients with UC. By downregulating the expression of SOCS1, miR-155 wires IMF inflammatory phenotype. ..
  29. pmc Atmospheric-Pressure Cold Plasma Induces Transcriptional Changes in Ex Vivo Human Corneas
    Umberto Rosani
    Department of Biology, University of Padova, Padova, Italy
    PLoS ONE 10:e0133173. 2015
    ....
  30. pmc Induction of erythroid differentiation and increased globin mRNA production with furocoumarins and their photoproducts
    Alessia Salvador
    Department of Drug Sciences, University of Padova, Italy
    J Photochem Photobiol B 121:57-66. 2013
    ..5,5'-Dimethylpsoralen photoproducts induced an important increase in γ-globin gene transcription in K562 cells...
  31. ncbi request reprint In vitro reconstruction of an endothelialized skin substitute provided with a microcapillary network using biopolymer scaffolds
    Carolin Tonello
    Department of Histology, Microbiology, and Medical Biotechnologies, University of Padova, Padova, Italy
    FASEB J 19:1546-8. 2005
    ..Furthermore, the biodegradable fabric produced from hyaluronic acid and used as the scaffolding support for this in vitro constructed skin graft greatly facilitated handling in the perioperative period...
  32. pmc Aberrant gene methylation in non-neoplastic mucosa as a predictive marker of ulcerative colitis-associated CRC
    Marco Scarpa
    Surgical Oncology Unit, Veneto Institute of Oncology IOV IRCCS, Padova, Italy
    Oncotarget 7:10322-31. 2016
    ....
  33. doi request reprint The Importance of Descriptor-Based Clusterization in QSAR Models Development: Tyrosine Kinases Inhibitors as a Key Study
    Giovanni Marzaro
    Department of Pharmaceutical Sciences, University of Padova, Via Marzolo 5, 35131 Padova, Italy
    Mol Inform 30:721-32. 2011
    ..e. from the scaffold type). The herein proposed methodology can lead to QSAR models useful for virtual screening processes. ..
  34. pmc Electrospun Scaffolds for Osteoblast Cells: Peptide-Induced Concentration-Dependent Improvements of Polycaprolactone
    Monica Dettin
    Department of Industrial Engineering, University of Padova, Padova, Italy
    PLoS ONE 10:e0137505. 2015
    ....
  35. pmc Helium generated cold plasma finely regulates activation of human fibroblast-like primary cells
    Paola Brun
    Department of Molecular Medicine, Unit of Microbiology, University of Padova, Padova, Italy
    PLoS ONE 9:e104397. 2014
    ....
  36. pmc Hyaluronic acid induces activation of the κ-opioid receptor
    Barbara Zavan
    Department of Biomedical Sciences, University of Padova, Padova, Italy
    PLoS ONE 8:e55510. 2013
    ..Intra-articular administration of exogenous hyaluronic acid (HA) in patients with osteoarthritis (OA) appears to be particularly effective in reducing pain and improving patient function...
  37. ncbi request reprint Beneficial effect of auto-aggregating Lactobacillus crispatus on experimentally induced colitis in mice
    Ignazio Castagliuolo
    School of Pharmacy, Department of Histology, University of Padua, Via A Gabelli 63, Padua 35121 Padua, Italy
    FEMS Immunol Med Microbiol 43:197-204. 2005
    ..crispatus M247. These results indicate that a surface-mediated property such as aggregation may play a pivotal role in the protective effects obtained by dietary supplementation with L. crispatus M247 during colitis...
  38. doi request reprint Electrospun scaffolds of self-assembling peptides with poly(ethylene oxide) for bone tissue engineering
    Paola Brun
    Department of Histology, Microbiology and Medical Biotechnologies, University of Padova, Via Gabelli 63, 35121 Padova, Italy
    Acta Biomater 7:2526-32. 2011
    ..The results of in vitro osteoblast adhesion and proliferation assays on the electrospun scaffolds obtained using different self-assembling peptide sequences are discussed...
  39. doi request reprint Rectal administration of Lactobacillus casei DG modifies flora composition and Toll-like receptor expression in colonic mucosa of patients with mild ulcerative colitis
    Renata D'Incà
    Department of Surgical and Gastroenterological Sciences, University of Padova, Padova, Italy
    Dig Dis Sci 56:1178-87. 2011
    ..Although it has been suggested that probiotic supplementation is an effective approach to colitis, its effects on intestinal flora and on mucosal cytokine balance have never been explored...
  40. doi request reprint Herpes simplex virus type 1 infection of the rat enteric nervous system evokes small-bowel neuromuscular abnormalities
    Paola Brun
    Department of Histology, Microbiology and Medical Biotechnologies, University of Padua, Padua, Italy
    Gastroenterology 138:1790-801. 2010
    ..Our purpose was to assess whether herpes simplex virus type-1 (HSV-1) establishes an enteric-neuronal infection and induces gut dysmotility...
  41. pmc Boswellia serrata Preserves Intestinal Epithelial Barrier from Oxidative and Inflammatory Damage
    Daniela Catanzaro
    Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Largo E Meneghetti 2, 35131, Padova, Italy
    PLoS ONE 10:e0125375. 2015
    ..This study elucidates the pharmacological mechanisms mediated by BSE, in protecting intestinal epithelial barrier from inflammatory damage and supports its use as safe adjuvant in patients affected by IBD...
  42. pmc Clostridium difficile toxin A carboxyl-terminus peptide lacking ADP-ribosyltransferase activity acts as a mucosal adjuvant
    Ignazio Castagliuolo
    Department of Histology, Microbiology and Medical Biotechnologies, University of Padua, Padua, Italy
    Infect Immun 72:2827-36. 2004
    ....
  43. ncbi request reprint Synthesis and biological activity of 7-phenyl-6,9-dihydro-3H-pyrrolo[3,2-f]quinolin-9-ones: a new class of antimitotic agents devoid of aromatase activity
    Venusia Gasparotto
    Department of Pharmaceutical Sciences, University of Padova, 35131 Padova, Italy
    J Med Chem 49:1910-5. 2006
    ....
  44. ncbi request reprint Human osteoblast-like cell adhesion on titanium substrates covalently functionalized with synthetic peptides
    Andrea Bagno
    Department of Chemical Process Engineering, University of Padova, Via Marzolo 9, 35131, Padova, Italy
    Bone 40:693-9. 2007
    ..The amount of human osteoblasts adhered onto peptide-enriched or not enriched titanium oxidized surfaces and the strength of cell binding were estimated, thus comparing the capacity of the bioactive substrates in promoting cell adhesion...
  45. doi request reprint UVB photolysis of hydrocortisone 21-acetate
    Sergio Caffieri
    Department of Pharmaceutical Sciences, University of Padova, Via F Marzolo 5, I 35131 Padova, Italy
    J Pharm Biomed Anal 47:771-7. 2008
    ..The radical mechanism involved in HCA photolysis seems also responsible for the in vitro photohemolytic effect and lipid peroxidation induced by HCA in combination with UVB light...
  46. doi request reprint Using the TOPS-MODE approach to fit multi-target QSAR models for tyrosine kinases inhibitors
    Giovanni Marzaro
    Department of Pharmaceutical Sciences, University of Padova, Via Marzolo 5, 35131 Padua, Italy
    Eur J Med Chem 46:2185-92. 2011
    ..Herein we present the development of several multi-target classification QSAR (mtc-QSAR) models useful to assess the activity profile of the tyrosine kinases inhibitors...
  47. doi request reprint Hyaluronic acid three-dimensional scaffold for surgical revision of retracting scars: a human experimental study
    Angela Faga
    Plastic and Reconstructive Surgery Unit, Salvatore Maugeri Research and Care Institute, University of Pavia, Pavia, Italy
    Int Wound J 10:329-35. 2013
    ..Although the histological features would suggest regeneration of a skin-like tissue, with a good dermis and no signs of scarring, the clinical problem of secondary contracture is still unsolved...
  48. ncbi request reprint Lymphocytes endowed with colon-selective homing and engineered to produce TGF-beta1 prevent the development of dinitrobenzene sulphonic acid colitis
    Ignazio Castagliuolo
    Department of Histology, Microbiology and Medical Biotechnologies, University of Padua, Padua, Italy
    Eur J Gastroenterol Hepatol 15:1257-65. 2003
    ..Gene therapy is an attractive approach to the treatment of inflammatory diseases. However, the lack of tissue targeting of available vectors jeopardizes their clinical use...
  49. ncbi request reprint Esophageal achalasia: is the herpes simplex virus really innocent?
    Ignazio Castagliuolo
    Department of Histology, Medical and Surgical Sciences Clinica Chirurgica 4, University of Padova School of Medicine, Padova, Italy
    J Gastrointest Surg 8:24-30; discussion 30. 2004
    ..We hypothesize that the HSV-1-reactive lymphocytes in lower esophageal sphincter muscles of achalasia patients may contribute to damage of the neurons in the myenteric plexus and lead to the motor dysfunction...
  50. ncbi request reprint Tear levels and activity of matrix metalloproteinase (MMP)-1 and MMP-9 in vernal keratoconjunctivitis
    Andrea Leonardi
    Department of Neuroscience, Ophthalmology and Ocular Inflammation Unit, University of Padua, Padua, Italy
    Invest Ophthalmol Vis Sci 44:3052-8. 2003
    ..To study levels and activity of matrix metalloproteinase (MMP)-1 and -9 and their tissue inhibitor (TIMP-1) in tears of patients with vernal keratoconjunctivitis (VKC), with and without severe corneal damage...