Affiliation: University of Rome Tor Vergata
- Nerve growth factor: an important molecule in allergic inflammation and tissue remodellingS Bonini
Institute of Experimental Medicine, CNR, University of Rome, Italy
Int Arch Allergy Immunol 118:159-62. 1999..Several studies provide evidence that nerve growth factor (NGF) has an expanding role in neuroimmune interactions...
- The hygiene hypothesis: epidemiologic evidenceSergio Bonini
Consiglio Nazionale Richerche, Rome, Italy
J Pediatr Gastroenterol Nutr 40:S37-8. 2005
- Nerve growth factor: neurotrophin or cytokine?S Bonini
Institute of Neurobiology and Molecular Medicine, Italian National Research Council INMM CNR, Rome, Italy
Int Arch Allergy Immunol 131:80-4. 2003..Data reviewed suggest, therefore, that NGF might also be viewed as a (Th2?) cytokine with a modulatory role in allergic inflammation and tissue remodeling...
- The heterogeneity of allergic phenotypes: genetic and environmental interactionsS Bonini
Institute of Neurobiology and Molecular Medicine, Italian National Research Council, Rome
Ann Allergy Asthma Immunol 87:48-51. 2001..This article reinforces the reader's knowledge of the multifactorial nature of allergic diseases and of the heterogeneity of allergic phenotypes...
- Practical approach to diagnosis and treatment of ocular allergy: a 1-year systematic reviewSergio Bonini
Second University of Naples, Naples, Italy
Curr Opin Allergy Clin Immunol 7:446-9. 2007..A 1-year systematic review in the field of ocular allergy was carried out to select new information which may be useful for a practical approach to allergic conjunctivitis...
- Microarray evaluation of specific IgE to allergen components in elite athletesM Bonini
Institute of Translational Pharmacology, Italian National Research Council, Rome, Italy
Allergy 67:1557-64. 2012..Allergic sensitization and diseases have been reported to have a very high and increasing prevalence in elite athletes. Over 80% of allergic athletes are poly-sensitized...
- Circulating nerve growth factor levels are increased in humans with allergic diseases and asthmaS Bonini
Department of Allergology and Clinical Immunology, Second University of Naples, Italy
Proc Natl Acad Sci U S A 93:10955-60. 1996..This study represents the first observation (that we know of) that NGF is increased in human allergic inflammatory diseases and asthma...
- Nonspecific provocation of target organs in allergic diseases: EAACI-GA(2)LEN consensus reportS Bonini
Second University of Naples, Naples, Italy
Allergy 62:683-94. 2007..This consensus document aims at reviewing procedures currently used for nonspecific provocation of the bronchi, nose and eye and for measuring their responsiveness to nonspecific stimuli...
- Methodology for development of the Allergic Rhinitis and its Impact on Asthma guideline 2008 updateJ L Brozek
S C Epidemiologia, Italian National Cancer Institute Regina Elena, Rome, Italy
Allergy 63:38-46. 2008..The most prominent change is the application of the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach to compiling evidence, assessing the quality of evidence and grading of recommendations...
- Nerve growth factor and asthmaS Bonini
Allergology and Clinical Immunology, Department of Internal Medicine, Second University of Naples, Naples, Italy
Allergy 57:13-5. 2002..4) NGF increases airway hyperreactivity to histamine in an animal model of asthma, while anti-NGF treatment reduces airway hyperreactivity induced by ovalbumin topical challenge in the sensitized mouse...
- Clinical application of nerve growth factor on human corneal ulcerA Lambiase
Interdisciplinary Center for Biomedical Research CIR, Laboratory of Ophthalmology, University of Rome Campus Bio Medico, G B Bietti Eye Foundation, Rome, Italy
Arch Ital Biol 141:141-8. 2003..These findings indicate that failure of cutaneous tissues to produce sufficient amounts of NGF might represent a prominent mechanism implicated in the clinical manifestation of ocular ulcers...
- Neurotrophic keratitisS Bonini
Laboratory of Ophthalmology, Interdisciplinary Center for Biomedical Research, University of Rome, Rome, Italy
Eye (Lond) 17:989-95. 2003..Future developments in the medical treatment including the administration of neuropeptide and growth factors are presented...
- Atopic keratoconjunctivitisS Bonini
Institute of Neurobiology and Molecular Medicine, Italian National Research Council and San Raffaele H, Rome, Italy
Allergy 59:71-3. 2004..AKC and VKC may thus represent a model of atopy quite distinct from the classical type-1 hypersensitivity mechanism...
- Vernal keratoconjunctivitisS Bonini
Interdisciplinary Center for Biomedical Research CIR, Laboratory of Ophthalmology, University of Rome, Campus Bio Medico, Rome, Italy
Eye (Lond) 18:345-51. 2004..A 2% solution of cyclosporine in olive oil or in castor oil should be considered as an alternative. The long-term prognosis of patients is generally good; however 6% of patients develop corneal damage, cataract, or glaucoma...
- Epidemiology of allergic occupational diseases induced by Tetranychus urticae in greenhouse and open-field farmers living in a temperate climate areaC Astarita
Section of Allergology and Clinical Immunology, Division of Internal Medicine, Flaviano Magrassi Department of Clinical and Experimental Medicine, Second University of Naples Medical School, Via Vittorio Veneto, 80067 Sorrento, Naples, Italy
Allergy 56:1157-63. 2001..Since occupational seasonal symptoms could be directly related to the presence of TU sensitization, allergy to this mite should be routinely investigated in farmers...
- Ocular prostheses in the last century: a retrospective analysis of 8018 patientsA Modugno
Ocularistica Italiana of Rome, Rome, Italy
Eye (Lond) 27:865-70. 2013..To analyze the clinical characteristics of patients with ocular prosthesis to assess the causes of eye loss in the different genders and age groups, and their incidence over the years...
- The future of microarray technology: networking the genome searchC D'Ambrosio
IRCCS San Raffaele, Research Center, Rome, Italy
Allergy 60:1219-26. 2005..Networks of excellence like GA(2)LEN may represent the best approach for teaching, cost reduction, data repositories, and functional studies implementation...
- Rhinitis and asthma in athletes: an ARIA document in collaboration with GA2LENS Bonini
IRCCS San Raffale, Rome, Italy
Allergy 61:681-92. 2006....
- Allergy and Clinical Immunology Services in EuropeS Bonini
Second University of Naples and INMM CNR, Rome, Italy
Allergy 61:1191-6. 2006
- Nerve growth factor and tissue repair remodeling: trkA(NGFR) and p75(NTR), two receptors one fateAlessandra Micera
Department of Pharmacology, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Israel
Cytokine Growth Factor Rev 18:245-56. 2007..In summary, these novel findings on the potential pro-healing capacity of NGF might open new possibilities for this growth factor in modulating the healing processes in several pathological conditions...
- Nerve growth factor and the immune system: old and new concepts in the cross-talk between immune and resident cells during pathophysiological conditionsAlessandro Lambiase
CIR Ophthalmology Laboratory, Campus Bio Medico and G B Bietti Eye Foundation, and San Raffaele H Research, Rome, Italy
Curr Opin Allergy Clin Immunol 4:425-30. 2004..Furthermore, recent data are provided revealing new important insights into the mechanisms of action of nerve growth factor in allergic reaction...
- Allergic eye disordersLeonard Bielory
UMDNJ New Jersey Medical School, Newark, New Jersey, USA
Clin Allergy Immunol 16:311-23. 2002
- Nerve growth factor has a modulatory role on human primary fibroblast cultures derived from vernal keratoconjunctivitis-affected conjunctivaAlessandra Micera
CIR Laboratory of Ophthalmology, University Campus Bio Medico, Rome, Italy
Mol Vis 13:981-7. 2007..NGF, a pleiotrophic factor with documented profibrogenic activities, is produced by inflammatory and structural cells populating the VKC conjunctiva and is increased in the serum and tears of VKC patients...
- Allergic chronic inflammation of the ocular surface in vernal keratoconjunctivitisStefano Bonini
Interdisciplinary Center for Biomedical Research CIR Laboratory of Ophthalmology, University of Rome Campus Bio Medico, and G B Bietti Eye Foundation, Italy
Curr Opin Allergy Clin Immunol 3:381-7. 2003....
- Development and testing of the quality of life in children with vernal keratoconjunctivitis questionnaireMarta Sacchetti
Department of Ophthalmology, University of Rome Campus Bio Medico, Rome, Italy
Am J Ophthalmol 144:557-63. 2007..To develop and validate a questionnaire that measures health-related quality of life (HRQoL) in children with vernal keratoconjunctivitis (VKC)...
- Cytokines in ocular allergyStefano Bonini
Institute of Neurobiology and Molecular Medicine, National Research Council, Rome, Italy
Int Ophthalmol Clin 43:27-32. 2003
- The elite athlete: yes, with allergy we canSergio Bonini
J Allergy Clin Immunol 122:249-50. 2008
- Low- versus high-baseline epinephrine output shapes opposite innate cytokine profiles: presence of Lewis- and Fischer-like neurohormonal immune phenotypes in humans?Ilia J Elenkov
Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 181:1737-45. 2008....
- Nerve growth factor (NGF): an important molecule for trophism and healing of the ocular surfaceStefano Bonini
Department of Ophthalmology, University of Rome Tor Vergata and the G B Bietti Eye Foundation, CNR, Rome, Italy
Adv Exp Med Biol 506:531-7. 2002
- Conjunctival expression of thymosin-beta4 in vernal keratoconjunctivitisAlessandra Micera
Istituto di Ricovero e Cura a Carattere Scientifico Gian Battista Bietti Eye Foundation and CIR, Laboratory of Ophthalmology, University Campus Bio Medico, Rome, Italy
Mol Vis 12:1594-600. 2006....
- Allergic bronchial airway inflammation in nerve growth factor (NGF)-deprived rats: evidence suggesting a neuroimmunomodulatory role of NGFBarbara Stampachiacchiere
Institute of Neurobiology and Molecular Medicine, Section of Neurobiology, National Research Council CNR, Rome, Italy
Exp Lung Res 32:305-20. 2006..The present findings suggest that at least NGF does not act as a proper proinflammatory factor but most probably as a neuroimmune modulator molecule of the allergic state...
- Montelukast, a leukotriene receptor antagonist, in vernal keratoconjunctivitis associated with asthmaAlessandro Lambiase
Interdisciplinary Research Center, University Campus Bio Medico, Laboratory of Ophthalmology, Rome, Italy
Arch Ophthalmol 121:615-20. 2003..To evaluate the effects on signs and symptoms of a coexisting vernal keratoconjunctivitis in patients treated with oral montelukast sodium for asthma...
- Practice evidence to put evidence into practiceBarbara Caracciolo
Allergy 59:1165-7. 2004
- Nerve growth factor involvement in the visual system: implications in allergic and neurodegenerative diseasesAlessandra Micera
CIR Laboratorio di Oftalmologia, Campus Bio Medico and Fondazione GB Bietti, Rome, Italy
Cytokine Growth Factor Rev 15:411-7. 2004..The present review of experimental and clinical studies will highlight old and recent strategies for treating ocular surface and tear disorders with NGF...
- The hygiene hypothesis: does it function worldwide?Megon Bresciani
IRCCS San Raffaele Pisana, Research Center, Rome, Italy
Curr Opin Allergy Clin Immunol 5:147-51. 2005....
- CD34-positive cells in human umbilical cord blood express nerve growth factor and its specific receptor TrkALuisa Bracci-Laudiero
Institute of Neurobiology and Molecular Medicine, CNR, Viale Marx 15 43, 00137 Rome, Italy
J Neuroimmunol 136:130-9. 2003..Our findings suggest that NGF may play a role in the differentiation of hematopoietic progenitors and indicate a different requirement for NGF by immune cells, depending on their state of maturity...
- Expression of Toll-like receptors in healthy and allergic conjunctivaStefano Bonini
CIR Laboratory of Ophthalmology, Campus Bio Medico and G B Bietti Eye Foundation, Rome, Italy
Ophthalmology 112:1528; discussion 1548-9. 2005..To investigate the expression of toll-like receptors (TLRs) in healthy and active vernal keratoconjunctivitis (VKC) conjunctiva...
- Allergic conjunctivitis: the forgotten diseaseSergio Bonini
Chair Allergology and Clinical Immunology, Second University of Naples and IRCCS San Raffaele, Rome, Italy
Chem Immunol Allergy 91:110-20. 2006..In particular, the classification of the various forms of a 'red eye' of allergic origin appears inadequate to answer the progress achieved in their multifactorial pathogenesis...
- Nerve growth factor effect on human primary fibroblastic-keratocytes: possible mechanism during corneal healingAlessandra Micera
CIR Laboratory of Ophthalmology, University Campus Bio Medico and G B Bietti, Foundation, Via Emilio Longoni 83, 00155 Rome, Italy
Exp Eye Res 83:747-57. 2006..To sum up, the findings of this study indicate that NGF can modulate some functional activities of fibroblastic-keratocytes, thus substantiating the healing effects of NGF on corneal wound-healing...
- Hyperosmolar conjunctival provocation for the evaluation of nonspecific hyperreactivity in healthy patients and patients with allergyMarta Sacchetti
Department of Ophthalmology, University of Rome, Campus Bio Medico, Italy
J Allergy Clin Immunol 118:872-7. 2006..Tissue hyperreactivity of target organs to nonspecific stimuli is known to be an important factor in influencing the clinical picture of allergic disease...
- Natural killer cells in vernal keratoconjunctivitisAlessandro Lambiase
Interdisciplinary Center for Biomedical Research CIR, Laboratory of Ophthalmology, University Campus Bio Medico of Rome, Italy
Mol Vis 13:1562-7. 2007..The aim of this study was to evaluate NK in the blood and the conjunctiva of patients with vernal keratoconjunctivitis (VKC)...