S Bonini

Summary

Affiliation: University of Rome Tor Vergata
Country: Italy

Publications

  1. ncbi Nerve growth factor: an important molecule in allergic inflammation and tissue remodelling
    S Bonini
    Institute of Experimental Medicine, CNR, University of Rome, Italy
    Int Arch Allergy Immunol 118:159-62. 1999
  2. ncbi The hygiene hypothesis: epidemiologic evidence
    Sergio Bonini
    Consiglio Nazionale Richerche, Rome, Italy
    J Pediatr Gastroenterol Nutr 40:S37-8. 2005
  3. ncbi Nerve growth factor: neurotrophin or cytokine?
    S Bonini
    Institute of Neurobiology and Molecular Medicine, Italian National Research Council INMM CNR, Rome, Italy
    Int Arch Allergy Immunol 131:80-4. 2003
  4. ncbi The heterogeneity of allergic phenotypes: genetic and environmental interactions
    S Bonini
    Institute of Neurobiology and Molecular Medicine, Italian National Research Council, Rome
    Ann Allergy Asthma Immunol 87:48-51. 2001
  5. ncbi Practical approach to diagnosis and treatment of ocular allergy: a 1-year systematic review
    Sergio Bonini
    Second University of Naples, Naples, Italy
    Curr Opin Allergy Clin Immunol 7:446-9. 2007
  6. doi Microarray evaluation of specific IgE to allergen components in elite athletes
    M Bonini
    Institute of Translational Pharmacology, Italian National Research Council, Rome, Italy
    Allergy 67:1557-64. 2012
  7. pmc Circulating nerve growth factor levels are increased in humans with allergic diseases and asthma
    S Bonini
    Department of Allergology and Clinical Immunology, Second University of Naples, Italy
    Proc Natl Acad Sci U S A 93:10955-60. 1996
  8. ncbi Nonspecific provocation of target organs in allergic diseases: EAACI-GA(2)LEN consensus report
    S Bonini
    Second University of Naples, Naples, Italy
    Allergy 62:683-94. 2007
  9. ncbi Methodology for development of the Allergic Rhinitis and its Impact on Asthma guideline 2008 update
    J L Brozek
    S C Epidemiologia, Italian National Cancer Institute Regina Elena, Rome, Italy
    Allergy 63:38-46. 2008
  10. ncbi Nerve growth factor and asthma
    S Bonini
    Allergology and Clinical Immunology, Department of Internal Medicine, Second University of Naples, Naples, Italy
    Allergy 57:13-5. 2002

Collaborators

Detail Information

Publications41

  1. ncbi Nerve growth factor: an important molecule in allergic inflammation and tissue remodelling
    S Bonini
    Institute of Experimental Medicine, CNR, University of Rome, Italy
    Int Arch Allergy Immunol 118:159-62. 1999
    ..Several studies provide evidence that nerve growth factor (NGF) has an expanding role in neuroimmune interactions...
  2. ncbi The hygiene hypothesis: epidemiologic evidence
    Sergio Bonini
    Consiglio Nazionale Richerche, Rome, Italy
    J Pediatr Gastroenterol Nutr 40:S37-8. 2005
  3. ncbi Nerve growth factor: neurotrophin or cytokine?
    S Bonini
    Institute of Neurobiology and Molecular Medicine, Italian National Research Council INMM CNR, Rome, Italy
    Int Arch Allergy Immunol 131:80-4. 2003
    ..Data reviewed suggest, therefore, that NGF might also be viewed as a (Th2?) cytokine with a modulatory role in allergic inflammation and tissue remodeling...
  4. ncbi The heterogeneity of allergic phenotypes: genetic and environmental interactions
    S Bonini
    Institute of Neurobiology and Molecular Medicine, Italian National Research Council, Rome
    Ann Allergy Asthma Immunol 87:48-51. 2001
    ..This article reinforces the reader's knowledge of the multifactorial nature of allergic diseases and of the heterogeneity of allergic phenotypes...
  5. ncbi Practical approach to diagnosis and treatment of ocular allergy: a 1-year systematic review
    Sergio Bonini
    Second University of Naples, Naples, Italy
    Curr Opin Allergy Clin Immunol 7:446-9. 2007
    ..A 1-year systematic review in the field of ocular allergy was carried out to select new information which may be useful for a practical approach to allergic conjunctivitis...
  6. doi Microarray evaluation of specific IgE to allergen components in elite athletes
    M Bonini
    Institute of Translational Pharmacology, Italian National Research Council, Rome, Italy
    Allergy 67:1557-64. 2012
    ..Allergic sensitization and diseases have been reported to have a very high and increasing prevalence in elite athletes. Over 80% of allergic athletes are poly-sensitized...
  7. pmc Circulating nerve growth factor levels are increased in humans with allergic diseases and asthma
    S Bonini
    Department of Allergology and Clinical Immunology, Second University of Naples, Italy
    Proc Natl Acad Sci U S A 93:10955-60. 1996
    ..This study represents the first observation (that we know of) that NGF is increased in human allergic inflammatory diseases and asthma...
  8. ncbi Nonspecific provocation of target organs in allergic diseases: EAACI-GA(2)LEN consensus report
    S Bonini
    Second University of Naples, Naples, Italy
    Allergy 62:683-94. 2007
    ..This consensus document aims at reviewing procedures currently used for nonspecific provocation of the bronchi, nose and eye and for measuring their responsiveness to nonspecific stimuli...
  9. ncbi Methodology for development of the Allergic Rhinitis and its Impact on Asthma guideline 2008 update
    J L Brozek
    S C Epidemiologia, Italian National Cancer Institute Regina Elena, Rome, Italy
    Allergy 63:38-46. 2008
    ..The most prominent change is the application of the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach to compiling evidence, assessing the quality of evidence and grading of recommendations...
  10. ncbi Nerve growth factor and asthma
    S Bonini
    Allergology and Clinical Immunology, Department of Internal Medicine, Second University of Naples, Naples, Italy
    Allergy 57:13-5. 2002
    ..4) NGF increases airway hyperreactivity to histamine in an animal model of asthma, while anti-NGF treatment reduces airway hyperreactivity induced by ovalbumin topical challenge in the sensitized mouse...
  11. ncbi Clinical application of nerve growth factor on human corneal ulcer
    A Lambiase
    Interdisciplinary Center for Biomedical Research CIR, Laboratory of Ophthalmology, University of Rome Campus Bio Medico, G B Bietti Eye Foundation, Rome, Italy
    Arch Ital Biol 141:141-8. 2003
    ..These findings indicate that failure of cutaneous tissues to produce sufficient amounts of NGF might represent a prominent mechanism implicated in the clinical manifestation of ocular ulcers...
  12. ncbi Neurotrophic keratitis
    S Bonini
    Laboratory of Ophthalmology, Interdisciplinary Center for Biomedical Research, University of Rome, Rome, Italy
    Eye (Lond) 17:989-95. 2003
    ..Future developments in the medical treatment including the administration of neuropeptide and growth factors are presented...
  13. ncbi Atopic keratoconjunctivitis
    S Bonini
    Institute of Neurobiology and Molecular Medicine, Italian National Research Council and San Raffaele H, Rome, Italy
    Allergy 59:71-3. 2004
    ..AKC and VKC may thus represent a model of atopy quite distinct from the classical type-1 hypersensitivity mechanism...
  14. ncbi Vernal keratoconjunctivitis
    S Bonini
    Interdisciplinary Center for Biomedical Research CIR, Laboratory of Ophthalmology, University of Rome, Campus Bio Medico, Rome, Italy
    Eye (Lond) 18:345-51. 2004
    ..A 2% solution of cyclosporine in olive oil or in castor oil should be considered as an alternative. The long-term prognosis of patients is generally good; however 6% of patients develop corneal damage, cataract, or glaucoma...
  15. ncbi Epidemiology of allergic occupational diseases induced by Tetranychus urticae in greenhouse and open-field farmers living in a temperate climate area
    C Astarita
    Section of Allergology and Clinical Immunology, Division of Internal Medicine, Flaviano Magrassi Department of Clinical and Experimental Medicine, Second University of Naples Medical School, Via Vittorio Veneto, 80067 Sorrento, Naples, Italy
    Allergy 56:1157-63. 2001
    ..Since occupational seasonal symptoms could be directly related to the presence of TU sensitization, allergy to this mite should be routinely investigated in farmers...
  16. pmc Ocular prostheses in the last century: a retrospective analysis of 8018 patients
    A Modugno
    Ocularistica Italiana of Rome, Rome, Italy
    Eye (Lond) 27:865-70. 2013
    ..To analyze the clinical characteristics of patients with ocular prosthesis to assess the causes of eye loss in the different genders and age groups, and their incidence over the years...
  17. ncbi The future of microarray technology: networking the genome search
    C D'Ambrosio
    IRCCS San Raffaele, Research Center, Rome, Italy
    Allergy 60:1219-26. 2005
    ..Networks of excellence like GA(2)LEN may represent the best approach for teaching, cost reduction, data repositories, and functional studies implementation...
  18. ncbi Rhinitis and asthma in athletes: an ARIA document in collaboration with GA2LEN
    S Bonini
    IRCCS San Raffale, Rome, Italy
    Allergy 61:681-92. 2006
    ....
  19. ncbi Allergy and Clinical Immunology Services in Europe
    S Bonini
    Second University of Naples and INMM CNR, Rome, Italy
    Allergy 61:1191-6. 2006
  20. ncbi Nerve growth factor and tissue repair remodeling: trkA(NGFR) and p75(NTR), two receptors one fate
    Alessandra Micera
    Department of Pharmacology, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Israel
    Cytokine Growth Factor Rev 18:245-56. 2007
    ..In summary, these novel findings on the potential pro-healing capacity of NGF might open new possibilities for this growth factor in modulating the healing processes in several pathological conditions...
  21. ncbi Nerve growth factor and the immune system: old and new concepts in the cross-talk between immune and resident cells during pathophysiological conditions
    Alessandro Lambiase
    CIR Ophthalmology Laboratory, Campus Bio Medico and G B Bietti Eye Foundation, and San Raffaele H Research, Rome, Italy
    Curr Opin Allergy Clin Immunol 4:425-30. 2004
    ..Furthermore, recent data are provided revealing new important insights into the mechanisms of action of nerve growth factor in allergic reaction...
  22. ncbi Allergic eye disorders
    Leonard Bielory
    UMDNJ New Jersey Medical School, Newark, New Jersey, USA
    Clin Allergy Immunol 16:311-23. 2002
  23. pmc Nerve growth factor has a modulatory role on human primary fibroblast cultures derived from vernal keratoconjunctivitis-affected conjunctiva
    Alessandra Micera
    CIR Laboratory of Ophthalmology, University Campus Bio Medico, Rome, Italy
    Mol Vis 13:981-7. 2007
    ..NGF, a pleiotrophic factor with documented profibrogenic activities, is produced by inflammatory and structural cells populating the VKC conjunctiva and is increased in the serum and tears of VKC patients...
  24. ncbi Allergic chronic inflammation of the ocular surface in vernal keratoconjunctivitis
    Stefano Bonini
    Interdisciplinary Center for Biomedical Research CIR Laboratory of Ophthalmology, University of Rome Campus Bio Medico, and G B Bietti Eye Foundation, Italy
    Curr Opin Allergy Clin Immunol 3:381-7. 2003
    ....
  25. ncbi Development and testing of the quality of life in children with vernal keratoconjunctivitis questionnaire
    Marta Sacchetti
    Department of Ophthalmology, University of Rome Campus Bio Medico, Rome, Italy
    Am J Ophthalmol 144:557-63. 2007
    ..To develop and validate a questionnaire that measures health-related quality of life (HRQoL) in children with vernal keratoconjunctivitis (VKC)...
  26. ncbi Cytokines in ocular allergy
    Stefano Bonini
    Institute of Neurobiology and Molecular Medicine, National Research Council, Rome, Italy
    Int Ophthalmol Clin 43:27-32. 2003
  27. doi The elite athlete: yes, with allergy we can
    Sergio Bonini
    J Allergy Clin Immunol 122:249-50. 2008
  28. ncbi Low- versus high-baseline epinephrine output shapes opposite innate cytokine profiles: presence of Lewis- and Fischer-like neurohormonal immune phenotypes in humans?
    Ilia J Elenkov
    Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 181:1737-45. 2008
    ....
  29. ncbi Nerve growth factor (NGF): an important molecule for trophism and healing of the ocular surface
    Stefano Bonini
    Department of Ophthalmology, University of Rome Tor Vergata and the G B Bietti Eye Foundation, CNR, Rome, Italy
    Adv Exp Med Biol 506:531-7. 2002
  30. ncbi Conjunctival expression of thymosin-beta4 in vernal keratoconjunctivitis
    Alessandra Micera
    Istituto di Ricovero e Cura a Carattere Scientifico Gian Battista Bietti Eye Foundation and CIR, Laboratory of Ophthalmology, University Campus Bio Medico, Rome, Italy
    Mol Vis 12:1594-600. 2006
    ....
  31. ncbi Allergic bronchial airway inflammation in nerve growth factor (NGF)-deprived rats: evidence suggesting a neuroimmunomodulatory role of NGF
    Barbara Stampachiacchiere
    Institute of Neurobiology and Molecular Medicine, Section of Neurobiology, National Research Council CNR, Rome, Italy
    Exp Lung Res 32:305-20. 2006
    ..The present findings suggest that at least NGF does not act as a proper proinflammatory factor but most probably as a neuroimmune modulator molecule of the allergic state...
  32. ncbi Montelukast, a leukotriene receptor antagonist, in vernal keratoconjunctivitis associated with asthma
    Alessandro Lambiase
    Interdisciplinary Research Center, University Campus Bio Medico, Laboratory of Ophthalmology, Rome, Italy
    Arch Ophthalmol 121:615-20. 2003
    ..To evaluate the effects on signs and symptoms of a coexisting vernal keratoconjunctivitis in patients treated with oral montelukast sodium for asthma...
  33. ncbi Practice evidence to put evidence into practice
    Barbara Caracciolo
    Allergy 59:1165-7. 2004
  34. ncbi Nerve growth factor involvement in the visual system: implications in allergic and neurodegenerative diseases
    Alessandra Micera
    CIR Laboratorio di Oftalmologia, Campus Bio Medico and Fondazione GB Bietti, Rome, Italy
    Cytokine Growth Factor Rev 15:411-7. 2004
    ..The present review of experimental and clinical studies will highlight old and recent strategies for treating ocular surface and tear disorders with NGF...
  35. ncbi The hygiene hypothesis: does it function worldwide?
    Megon Bresciani
    IRCCS San Raffaele Pisana, Research Center, Rome, Italy
    Curr Opin Allergy Clin Immunol 5:147-51. 2005
    ....
  36. ncbi CD34-positive cells in human umbilical cord blood express nerve growth factor and its specific receptor TrkA
    Luisa Bracci-Laudiero
    Institute of Neurobiology and Molecular Medicine, CNR, Viale Marx 15 43, 00137 Rome, Italy
    J Neuroimmunol 136:130-9. 2003
    ..Our findings suggest that NGF may play a role in the differentiation of hematopoietic progenitors and indicate a different requirement for NGF by immune cells, depending on their state of maturity...
  37. ncbi Expression of Toll-like receptors in healthy and allergic conjunctiva
    Stefano Bonini
    CIR Laboratory of Ophthalmology, Campus Bio Medico and G B Bietti Eye Foundation, Rome, Italy
    Ophthalmology 112:1528; discussion 1548-9. 2005
    ..To investigate the expression of toll-like receptors (TLRs) in healthy and active vernal keratoconjunctivitis (VKC) conjunctiva...
  38. ncbi Allergic conjunctivitis: the forgotten disease
    Sergio Bonini
    Chair Allergology and Clinical Immunology, Second University of Naples and IRCCS San Raffaele, Rome, Italy
    Chem Immunol Allergy 91:110-20. 2006
    ..In particular, the classification of the various forms of a 'red eye' of allergic origin appears inadequate to answer the progress achieved in their multifactorial pathogenesis...
  39. ncbi Nerve growth factor effect on human primary fibroblastic-keratocytes: possible mechanism during corneal healing
    Alessandra Micera
    CIR Laboratory of Ophthalmology, University Campus Bio Medico and G B Bietti, Foundation, Via Emilio Longoni 83, 00155 Rome, Italy
    Exp Eye Res 83:747-57. 2006
    ..To sum up, the findings of this study indicate that NGF can modulate some functional activities of fibroblastic-keratocytes, thus substantiating the healing effects of NGF on corneal wound-healing...
  40. ncbi Hyperosmolar conjunctival provocation for the evaluation of nonspecific hyperreactivity in healthy patients and patients with allergy
    Marta Sacchetti
    Department of Ophthalmology, University of Rome, Campus Bio Medico, Italy
    J Allergy Clin Immunol 118:872-7. 2006
    ..Tissue hyperreactivity of target organs to nonspecific stimuli is known to be an important factor in influencing the clinical picture of allergic disease...
  41. ncbi Natural killer cells in vernal keratoconjunctivitis
    Alessandro Lambiase
    Interdisciplinary Center for Biomedical Research CIR, Laboratory of Ophthalmology, University Campus Bio Medico of Rome, Italy
    Mol Vis 13:1562-7. 2007
    ..The aim of this study was to evaluate NK in the blood and the conjunctiva of patients with vernal keratoconjunctivitis (VKC)...