R Bei

Summary

Affiliation: University of Rome Tor Vergata
Country: Italy

Publications

  1. ncbi request reprint Effects of omega-3 polyunsaturated fatty acids on cardiac myocyte protection
    Roberto Bei
    Department of Experimental Medicine and Biochemical Sciences, University of Rome, Tor Vergata, Rome, Italy
    Front Biosci (Landmark Ed) 16:1833-43. 2011
  2. pmc Potential prognostic and diagnostic application of a novel monoclonal antibody against keratinocyte growth factor receptor
    Simona Ceccarelli
    Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161, Rome, Italy
    Mol Biotechnol 56:939-52. 2014
  3. pmc Intratumoral delivery of recombinant vaccinia virus encoding for ErbB2/Neu inhibits the growth of salivary gland carcinoma cells
    Laura Masuelli
    Department of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, Rome, Italy
    J Transl Med 12:122. 2014
  4. ncbi request reprint Poxvirus-based vaccines for cancer immunotherapy: new insights from combined cytokines/co-stimulatory molecules delivery and "uncommon" strains
    Valerio Izzi
    Department of Clinical Sciences and Translational Medicine, Faculty of Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Building F Sud, 2nd Floor, Room 222
    Anticancer Agents Med Chem 14:183-9. 2014
  5. pmc West Nile alternative open reading frame (N-NS4B/WARF4) is produced in infected West Nile Virus (WNV) cells and induces humoral response in WNV infected individuals
    Giovanni Faggioni
    Histology and Molecular Biology Section, Army Medical and Veterinary Research Center Via Santo Stefano Rotondo, 4 00184 Rome, Italy
    Virol J 9:283. 2012
  6. ncbi request reprint Carcinoembryonic antigen (CEA)-based cancer vaccines: recent patents and antitumor effects from experimental models to clinical trials
    Mario Turriziani
    Department of Clinical Sciences and Translational Medicine Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Recent Pat Anticancer Drug Discov 7:265-96. 2012
  7. doi request reprint Long-lasting tissue inflammatory processes trigger autoimmune responses to extracellular matrix molecules
    Roberto Bei
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy
    Int Rev Immunol 27:137-75. 2008
  8. doi request reprint A common repertoire of autoantibodies is shared by cancer and autoimmune disease patients: Inflammation in their induction and impact on tumor growth
    R Bei
    Department of Experimental Medicine and Biochemical Sciences, University Tor Vergata, Rome, Italy
    Cancer Lett 281:8-23. 2009
  9. pmc TAA polyepitope DNA-based vaccines: a potential tool for cancer therapy
    Roberto Bei
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, 00133, Rome, Italy
    J Biomed Biotechnol 2010:102758. 2010
  10. ncbi request reprint The ribosomal P0 protein induces a spontaneous immune response in patients with head and neck advanced stage carcinoma that is not dependent on its overexpression in carcinomas
    Roberto Bei
    Department of Experimental Medicine and Biochemical Sciences, University Tor Vergata, I 00133, Rome, Italy
    Int J Oncol 31:1301-8. 2007

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Effects of omega-3 polyunsaturated fatty acids on cardiac myocyte protection
    Roberto Bei
    Department of Experimental Medicine and Biochemical Sciences, University of Rome, Tor Vergata, Rome, Italy
    Front Biosci (Landmark Ed) 16:1833-43. 2011
    ..This review provides a summary of the in vitro and in vivo effects of omega-3 PUFAs on cardiac myocytes health and reports the outcome of a number of clinical trials in patients consuming omega-3 PUFAs...
  2. pmc Potential prognostic and diagnostic application of a novel monoclonal antibody against keratinocyte growth factor receptor
    Simona Ceccarelli
    Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161, Rome, Italy
    Mol Biotechnol 56:939-52. 2014
    ..SC-101 mAb might represent a useful tool for basic research applications, and it could also contribute to improve the accuracy of diagnosis and prognosis of epithelial tumors. ..
  3. pmc Intratumoral delivery of recombinant vaccinia virus encoding for ErbB2/Neu inhibits the growth of salivary gland carcinoma cells
    Laura Masuelli
    Department of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, Rome, Italy
    J Transl Med 12:122. 2014
    ....
  4. ncbi request reprint Poxvirus-based vaccines for cancer immunotherapy: new insights from combined cytokines/co-stimulatory molecules delivery and "uncommon" strains
    Valerio Izzi
    Department of Clinical Sciences and Translational Medicine, Faculty of Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Building F Sud, 2nd Floor, Room 222
    Anticancer Agents Med Chem 14:183-9. 2014
    ..Special attention will be devoted to the new poxvirus strains that are currently under consideration for tumour therapy; the current knowledge on clinical trials and outcomes will also be reviewed...
  5. pmc West Nile alternative open reading frame (N-NS4B/WARF4) is produced in infected West Nile Virus (WNV) cells and induces humoral response in WNV infected individuals
    Giovanni Faggioni
    Histology and Molecular Biology Section, Army Medical and Veterinary Research Center Via Santo Stefano Rotondo, 4 00184 Rome, Italy
    Virol J 9:283. 2012
    ..The purpose of this study was to demonstrate the in vitro production of WARF4 protein following WNV infection of cultured VERO cells and its immunity in WNV infected individuals...
  6. ncbi request reprint Carcinoembryonic antigen (CEA)-based cancer vaccines: recent patents and antitumor effects from experimental models to clinical trials
    Mario Turriziani
    Department of Clinical Sciences and Translational Medicine Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Recent Pat Anticancer Drug Discov 7:265-96. 2012
    ..This review also discusses relevant patents relating to the use of CEA as a cancer vaccine...
  7. doi request reprint Long-lasting tissue inflammatory processes trigger autoimmune responses to extracellular matrix molecules
    Roberto Bei
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy
    Int Rev Immunol 27:137-75. 2008
    ....
  8. doi request reprint A common repertoire of autoantibodies is shared by cancer and autoimmune disease patients: Inflammation in their induction and impact on tumor growth
    R Bei
    Department of Experimental Medicine and Biochemical Sciences, University Tor Vergata, Rome, Italy
    Cancer Lett 281:8-23. 2009
    ....
  9. pmc TAA polyepitope DNA-based vaccines: a potential tool for cancer therapy
    Roberto Bei
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, 00133, Rome, Italy
    J Biomed Biotechnol 2010:102758. 2010
    ..This review will discuss the rationale for using the TAA polyepitope DNA-based vaccination strategy and recent results corroborating the usefulness of DNA encoding polyepitope vaccines as a potential tool for cancer therapy...
  10. ncbi request reprint The ribosomal P0 protein induces a spontaneous immune response in patients with head and neck advanced stage carcinoma that is not dependent on its overexpression in carcinomas
    Roberto Bei
    Department of Experimental Medicine and Biochemical Sciences, University Tor Vergata, I 00133, Rome, Italy
    Int J Oncol 31:1301-8. 2007
    ....
  11. ncbi request reprint Alpha fetoprotein is more than a hepatocellular cancer biomarker: from spontaneous immune response in cancer patients to the development of an AFP-based cancer vaccine
    R Bei
    Department of Experimental Medicine and Biochemical Sciences, Faculty of Medicine, University of Rome Tor Vergata, 00133 Rome, Italy
    Curr Mol Med 11:564-81. 2011
    ..This review will discuss the rationale for using the AFP-based vaccination strategy and recent results corroborating the usefulness of AFP vaccines as a potential tool for cancer therapy...
  12. ncbi request reprint Dietary flavonoids: molecular mechanisms of action as anti- inflammatory agents
    Laura Marzocchella
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Recent Pat Inflamm Allergy Drug Discov 5:200-20. 2011
    ..This report reviews the current knowledge on the molecular mechanisms of action of flavonoids as anti-inflammatory agents and also discusses the relevant patents...
  13. ncbi request reprint Immunity to extracellular matrix antigens is associated with ultrastructural alterations of the stroma and stratified epithelium basement membrane in the skin of Hashimotos thyroiditis patients
    R Bei
    Department of Experimental Medicine and Biochemical Sciences, University, Tor Vergata, Rome, Italy
    Int J Immunopathol Pharmacol 19:661-74. 2006
    ..Our findings suggest that autoantibodies to ECM molecules might contribute to the development of asymptomatic extra-thyroid skin diseases in HT patients...
  14. ncbi request reprint Curcumin induces apoptosis in breast cancer cell lines and delays the growth of mammary tumors in neu transgenic mice
    L Masuelli
    Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy
    J Biol Regul Homeost Agents 27:105-19. 2013
    ..These findings support further studies on the therapeutic potential of CUR in combination with standard therapies in breast cancer patients...
  15. ncbi request reprint Recombinant erythropoietin differently affects proliferation of mesothelioma cells but not sensitivity to cisplatin and pemetrexed
    Camilla Palumbo
    Department of Experimental Medicine and Biochemical Sciences, Universita degli Studi di Roma Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Cancer Chemother Pharmacol 61:893-901. 2008
    ..According to the presented findings, rHuEpo appears to have an overall limited impact on cell growth and no effect on MM sensitivity to chemotherapy...
  16. ncbi request reprint Molecular targets and targeted therapies for malignant mesothelioma
    Camilla Palumbo
    Department of Experimental Medicine and Biochemical Sciences, Tor Vergata University, Via Montpellier 1, Rome, Italy
    Curr Med Chem 15:855-67. 2008
    ..A recombinant immunotoxin targeted to the membrane antigen mesothelin is an additional agent whose activity is being evaluated in mesothelioma patients...
  17. ncbi request reprint Placenta growth factor is a survival factor for human malignant mesothelioma cells
    L Albonici
    Department of Experimental Medicine and Biochemical Sciences, Tor Vergata University, Rome, Italy
    Int J Immunopathol Pharmacol 22:389-401. 2009
    ..This evidence could help the rational design of new therapeutic interventions for this aggressive tumor...
  18. ncbi request reprint HMBA induces cell death and potentiates doxorubicin toxicity in malignant mesothelioma cells
    Camilla Palumbo
    Department of Experimental Medicine and Biochemical Sciences, Tor Vergata University, Rome, Italy
    Cancer Chemother Pharmacol 54:398-406. 2004
    ..The aim of the present study was to evaluate the cytotoxic efficacy of the hybrid polar compound hexamethylene bisacetamide(HMBA), either as a single agent or in combination with the anthracycline doxorubicin (DOX), against MM cells...
  19. ncbi request reprint Inhibition of Mek 1/2 kinase activity and stimulation of melanogenesis by 5,7-dimethoxycoumarin treatment of melanoma cells
    Daniela Alesiani
    Department of Biology, University of Rome Tor Vergata, I 00133 Rome, Italy
    Int J Oncol 34:1727-35. 2009
    ....
  20. ncbi request reprint Frequent overexpression of multiple ErbB receptors by head and neck squamous cell carcinoma contrasts with rare antibody immunity in patients
    Roberto Bei
    Department of Experimental Medicine and Biochemical Sciences, University Tor Vergata, Rome, Italy
    J Pathol 204:317-25. 2004
    ..Based on upregulation of several known immunosuppressive molecules, scarcity of ErbB-specific antibodies is consistent with attenuation of natural tumour-specific immune responses in HNSCC...
  21. ncbi request reprint Changes in serum levels of TNF-alpha, IL-6, OPG, RANKL and their correlation with radiographic and clinical assessment in fragility fractures and high energy fractures
    M G Giganti
    Dept of Clinical Sciences and Translational Medicine, University of Rome, Rome, Italy
    J Biol Regul Homeost Agents 26:671-80. 2012
    ..These findings suggest that serum levels of IL-6, TNF-alpha, RANKL and OPG might be used to monitor the stages of fracture repair. Further studies will be needed to confirm the role of these cytokines in fracture repair...
  22. ncbi request reprint Co-localization of multiple ErbB receptors in stratified epithelium of oral squamous cell carcinoma
    R Bei
    Department of Experimental Medicine and Pathology, University 'La Sapienza, Rome, Italy
    J Pathol 195:343-8. 2001
    ....
  23. pmc Local delivery of recombinant vaccinia virus encoding for neu counteracts growth of mammary tumors more efficiently than systemic delivery in neu transgenic mice
    Laura Masuelli
    Department of Experimental Medicine, University of Rome Sapienza, Rome, Italy
    Cancer Immunol Immunother 59:1247-58. 2010
    ..This study may have important implications for the design of cancer vaccine protocols for the treatment of breast cancer and of accessible tumors using recombinant vaccinia virus...
  24. ncbi request reprint Cell cycle arrest and differentiation induction by 5,7-dimethoxycoumarin in melanoma cell lines
    Daniela Alesiani
    Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 1 00133 Rome, Italy
    Int J Oncol 32:425-34. 2008
    ..These findings suggest that 5,7-dimethoxycoumarin should be further investigated through studies both in vitro, to identify the binding partners for this compound, and in preclinical animal models...
  25. ncbi request reprint The use of temozolomide for the treatment of malignant tumors: clinical evidence and molecular mechanisms of action
    Roberto Bei
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome 00133, Italy
    Recent Pat Anticancer Drug Discov 5:172-87. 2010
    ....
  26. ncbi request reprint Gene-specific inhibition of breast carcinoma in BALB-neuT mice by active immunization with rat Neu or human ErbB receptors
    Laura Masuelli
    Department of Experimental Medicine and Pathology, University La Sapienza, Rome, Italy
    Int J Oncol 30:381-92. 2007
    ..Our findings indicated that targeted inhibition of neu oncogene-mediated mammary carcinogenesis is conditional upon the immunization schedule and discrete immunogenic epitopes shared to a variable extent by different ErbB receptors...
  27. ncbi request reprint Topical use of sucralfate in epithelial wound healing: clinical evidences and molecular mechanisms of action
    Laura Masuelli
    Department of Experimental Medicine, University of Rome Sapienza, Rome, Italy
    Recent Pat Inflamm Allergy Drug Discov 4:25-36. 2010
    ....
  28. ncbi request reprint A polyepitope DNA vaccine targeted to Her-2/ErbB-2 elicits a broad range of human and murine CTL effectors to protect against tumor challenge
    Antonio Scardino
    Institut National de la Santé et de la Recherche Médicale U753, Institut Gustave Roussy, Villejuif, France
    Cancer Res 67:7028-36. 2007
    ..These data indicate that the pVax1/pet-neu cDNA vaccine coding for a poly-ErbB-2 epitope is able to generate simultaneous ErbB-2-specific antitumor responses against dominant and cryptic multiple epitopes...
  29. ncbi request reprint Suppression of the functionally coupled cyclooxygenase-2/prostaglandin E synthase as a basis of simvastatin-dependent plaque stabilization in humans
    Francesco Cipollone
    Department of Medicine and Aging, School of Medicine, University of Chieti G D Annunzio, Chieti, Italy
    Circulation 107:1479-85. 2003
    ..The aim of this study was to characterize the effect of simvastatin on inflammatory infiltration and the expression of COX-2/mPGES and MMPs in human carotid plaques...
  30. ncbi request reprint Blockade of the angiotensin II type 1 receptor stabilizes atherosclerotic plaques in humans by inhibiting prostaglandin E2-dependent matrix metalloproteinase activity
    Francesco Cipollone
    G d Annunzio University of Chieti and the G d Annunzio University Foundation, Chieti, Italy
    Circulation 109:1482-8. 2004
    ..Thus, the aim of this study was to characterize the effect of the angiotensin II type 1 (AT1) receptor antagonist irbesartan on the inflammatory infiltration and expression of COX-2/mPGES-1 and MMPs in human carotid plaques...
  31. ncbi request reprint The receptor RAGE as a progression factor amplifying arachidonate-dependent inflammatory and proteolytic response in human atherosclerotic plaques: role of glycemic control
    Francesco Cipollone
    University of Chieti G D Annunzio School of Medicine, Chieti, Italy
    Circulation 108:1070-7. 2003
    ..The aim of this study was to characterize RAGE expression in human plaques and to correlate it with the inflammatory infiltration, COX-2/mPGES-1 and MMP expression, and with clinical evidence of diabetes...
  32. ncbi request reprint Overexpression of ErbB2 and ErbB3 receptors in Schwann cells of patients with Charcot-Marie-tooth disease type 1A
    Roberto Massa
    Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Via Montpellier 1, I 00133 Roma, Italy
    Muscle Nerve 33:342-9. 2006
    ..The upregulation of these receptors may play a role in the inhibition of myelination or in the promotion of recurrent demyelination and axonal damage...