Vincenzo Barnaba

Summary

Affiliation: University of Rome La Sapienza
Country: Italy

Publications

  1. pmc The ambiguity in immunology
    Vincenzo Barnaba
    Dipartimento di Medicina Interna e Specialita Mediche, Sapienza Università di Roma Rome, Italy
    Front Immunol 3:18. 2012
  2. pmc Chloroquine enhances human CD8+ T cell responses against soluble antigens in vivo
    Daniele Accapezzato
    Fondazione Andrea Cesalpino, Dipartimento di Medicina Interna, Universita degli Studi di Roma La Sapienza, Rome, Italy
    J Exp Med 202:817-28. 2005
  3. pmc Increased CD8+ T cell responses to apoptotic T cell-associated antigens in multiple sclerosis
    Francesco Lolli
    Dipartimento di Scienze Biomediche, Sperimentali e Cliniche and Neurofarba, Università of Firenze, Azienda Ospedaliera di Careggi, Largo Brambilla 6, 50134 Firenze, Italy
    J Neuroinflammation 10:94. 2013
  4. doi request reprint Induction, control, and plasticity of Treg cells: the immune regulatory network revised?
    Vincenzo Barnaba
    Dipartimento di Medicina Interna e Specialita Mediche, Sapienza Universita di Roma, Rome, Italy
    Eur J Immunol 43:318-22. 2013
  5. doi request reprint Tuning cross-presentation of apoptotic T cells in immunopathology
    Vincenzo Barnaba
    Policlinico Umberto I, Dipartimento di Medicina Interna e Specialita Mediche, Sapienza Universita di Roma, Viale del Policlinico 155, Rome, 00161, Italy
    Adv Exp Med Biol 785:27-35. 2013
  6. doi request reprint Hepatitis C virus infection: a "liaison a trois" amongst the virus, the host, and chronic low-level inflammation for human survival
    Vincenzo Barnaba
    Departimento of Medicina Interna, Sapienza Universita di Roma, Fondazione Andrea Cesalpino, Fondazione Cenci Bolognetti, Italy
    J Hepatol 53:752-61. 2010
  7. ncbi request reprint Subversion of effector CD8+ T cell differentiation in acute hepatitis C virus infection: the role of the virus
    Daniele Accapezzato
    Fondazione Andrea Cesalpino and Dipartimento di Medicina Interna, Universita degli Studi di Roma La Sapienza, Rome, Italy
    Eur J Immunol 34:438-46. 2004
  8. pmc PD-L1 negatively regulates CD4+CD25+Foxp3+ Tregs by limiting STAT-5 phosphorylation in patients chronically infected with HCV
    Debora Franceschini
    Dipartimento di Medicina Interna, Sapienza Universita di Roma, Policlinico Umberto I, Viale del Policlinico 155, Rome, Italy
    J Clin Invest 119:551-64. 2009
  9. doi request reprint IFN-α enhances cross-presentation in human dendritic cells by modulating antigen survival, endocytic routing, and processing
    Francesca Spadaro
    Department of Cell Biology and Neurosciences, Section of Experimental Immunotherapy, Istituto Superiore di Sanita, Viale Regina Elena 299, Rome, Italy
    Blood 119:1407-17. 2012
  10. ncbi request reprint Cross-presentation of caspase-cleaved apoptotic self antigens in HIV infection
    Pisana Moroni Rawson
    Fondazione Andrea Cesalpino Dipartimento di Medicina Interna, Sapienza Universita di Roma, 00161 Rome, Italy
    Nat Med 13:1431-9. 2007

Collaborators

Detail Information

Publications29

  1. pmc The ambiguity in immunology
    Vincenzo Barnaba
    Dipartimento di Medicina Interna e Specialita Mediche, Sapienza Università di Roma Rome, Italy
    Front Immunol 3:18. 2012
    ..All these plans participate principally to maintain a state of chronic low-level inflammation during persisting infections, and ultimately to favor the species survival...
  2. pmc Chloroquine enhances human CD8+ T cell responses against soluble antigens in vivo
    Daniele Accapezzato
    Fondazione Andrea Cesalpino, Dipartimento di Medicina Interna, Universita degli Studi di Roma La Sapienza, Rome, Italy
    J Exp Med 202:817-28. 2005
    ..Our results suggest that chloroquine treatment improves CD8 immunity during vaccination...
  3. pmc Increased CD8+ T cell responses to apoptotic T cell-associated antigens in multiple sclerosis
    Francesco Lolli
    Dipartimento di Scienze Biomediche, Sperimentali e Cliniche and Neurofarba, Università of Firenze, Azienda Ospedaliera di Careggi, Largo Brambilla 6, 50134 Firenze, Italy
    J Neuroinflammation 10:94. 2013
    ..Here, we evaluated the hypothesis that CD8+ T cell responses to caspase-cleaved antigens derived from effector T cells undergoing apoptosis, may contribute to multiple sclerosis (MS) immunopathology...
  4. doi request reprint Induction, control, and plasticity of Treg cells: the immune regulatory network revised?
    Vincenzo Barnaba
    Dipartimento di Medicina Interna e Specialita Mediche, Sapienza Universita di Roma, Rome, Italy
    Eur J Immunol 43:318-22. 2013
    ....
  5. doi request reprint Tuning cross-presentation of apoptotic T cells in immunopathology
    Vincenzo Barnaba
    Policlinico Umberto I, Dipartimento di Medicina Interna e Specialita Mediche, Sapienza Universita di Roma, Viale del Policlinico 155, Rome, 00161, Italy
    Adv Exp Med Biol 785:27-35. 2013
    ..and the progression towards chronic inflammatory diseases...
  6. doi request reprint Hepatitis C virus infection: a "liaison a trois" amongst the virus, the host, and chronic low-level inflammation for human survival
    Vincenzo Barnaba
    Departimento of Medicina Interna, Sapienza Universita di Roma, Fondazione Andrea Cesalpino, Fondazione Cenci Bolognetti, Italy
    J Hepatol 53:752-61. 2010
    ....
  7. ncbi request reprint Subversion of effector CD8+ T cell differentiation in acute hepatitis C virus infection: the role of the virus
    Daniele Accapezzato
    Fondazione Andrea Cesalpino and Dipartimento di Medicina Interna, Universita degli Studi di Roma La Sapienza, Rome, Italy
    Eur J Immunol 34:438-46. 2004
    ..Therefore, the strength of CTL activation is dependent on the balance between the threshold of stimulatory signals and the viral interference capacities provided during priming...
  8. pmc PD-L1 negatively regulates CD4+CD25+Foxp3+ Tregs by limiting STAT-5 phosphorylation in patients chronically infected with HCV
    Debora Franceschini
    Dipartimento di Medicina Interna, Sapienza Universita di Roma, Policlinico Umberto I, Viale del Policlinico 155, Rome, Italy
    J Clin Invest 119:551-64. 2009
    ..Notably, PD-L1 blockade upregulated STAT-5 phosphorylation in Tregs ex vivo. These data suggest that PD-L1 negatively regulates Tregs at sites of chronic inflammation by controlling STAT-5 phosphorylation...
  9. doi request reprint IFN-α enhances cross-presentation in human dendritic cells by modulating antigen survival, endocytic routing, and processing
    Francesca Spadaro
    Department of Cell Biology and Neurosciences, Section of Experimental Immunotherapy, Istituto Superiore di Sanita, Viale Regina Elena 299, Rome, Italy
    Blood 119:1407-17. 2012
    ....
  10. ncbi request reprint Cross-presentation of caspase-cleaved apoptotic self antigens in HIV infection
    Pisana Moroni Rawson
    Fondazione Andrea Cesalpino Dipartimento di Medicina Interna, Sapienza Universita di Roma, 00161 Rome, Italy
    Nat Med 13:1431-9. 2007
    ..These findings demonstrate a previously undescribed role for caspases in immunopathology...
  11. pmc Hepatic expansion of a virus-specific regulatory CD8(+) T cell population in chronic hepatitis C virus infection
    Daniele Accapezzato
    Fondazione Andrea Cesalpino, Dipartimento di Medicina Interna, Universita degli Studi di Roma La Sapienza, Rome, Italy
    J Clin Invest 113:963-72. 2004
    ....
  12. ncbi request reprint IFN-alpha-conditioned dendritic cells are highly efficient in inducing cross-priming CD8(+) T cells against exogenous viral antigens
    Caterina Lapenta
    Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Rome, Italy
    Eur J Immunol 36:2046-60. 2006
    ..These results suggest that IFN-DC are directly licensed for an efficient CD8(+) T cell priming by mechanisms likely involving enhanced antigen presentation and special attitude to produce IL-12 family cytokines...
  13. pmc Polyfunctional type-1, -2, and -17 CD8⁺ T cell responses to apoptotic self-antigens correlate with the chronic evolution of hepatitis C virus infection
    Debora Franceschini
    Dipartimento di Medicina Interna e Specialita Mediche, Sapienza Universita di Roma, Rome, Italy
    PLoS Pathog 8:e1002759. 2012
    ....
  14. doi request reprint miR-21 is a negative modulator of T-cell activation
    Claudia Carissimi
    Dipartimento di Biotecnologie Cellulari ed Ematologia, Sapienza Universita di Roma, Italy
    Biochimie 107:319-26. 2014
    ..Our results highlight an unexpected function of miR-21 as a negative modulator of signal transduction downstream of TCR in T-lymphocytes. ..
  15. doi request reprint Dendritic cells loaded with apoptotic oligodendrocytes as a source of myelin T-cell epitopes in multiple sclerosis
    Francesca Meloni
    Andrea Cesalpino Foundation and Department of Internal Medicine, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, Italy
    Clin Immunol 129:286-94. 2008
    ..Results suggest that MBP epitopes generated from enzymatic processing of apoptotic glial cells by DCs might be relevant to MS pathogenesis...
  16. doi request reprint Discovery of chemotherapy-associated ovarian cancer antigens by interrogating memory T cells
    Marino Paroli
    Dipartimento di Scienze e Biotecnologie Medico Chirurgiche, Sapienza Universita di Roma, Rome, Italy
    Int J Cancer 134:1823-34. 2014
    ..The T-cell interrogation system represents a strategy of reverse tumor immunology that proposes to identify CAAs, which may then be validated as possible prognostic tumor biomarkers or cancer vaccines. ..
  17. ncbi request reprint Mechanisms inducing or controlling CD8+ T cell responses against self- or non-self-antigens
    Daniele Accapezzato
    Fondazione Andrea Cesalpino, Dipartimento di Medicina Interna, Universita degli Studi di Roma La Sapienza, and Istituto Pasteur Cenci Bolognetti, 00161 Rome, Italy
    Ann N Y Acad Sci 987:99-106. 2003
    ....
  18. ncbi request reprint Subversion of effector CD8+ T cell differentiation in acute hepatitis C virus infection: exploring the immunological mechanisms
    Vittorio Francavilla
    Fondazione Andrea Cesalpino and Dipartimento di Medicina Interna, Universita degli Studi di Roma La Sapienza, Rome, Italy
    Eur J Immunol 34:427-37. 2004
    ..These data are consistent with the possible therapeutic treatment with IL-2 to rebuild the effector T cell pool in these patients...
  19. doi request reprint An emerging player in the adaptive immune response: microRNA-146a is a modulator of IL-2 expression and activation-induced cell death in T lymphocytes
    Graziella Curtale
    Dipartimento di Biotecnologie Cellulari ed Ematologia, Sezione di Genetica Molecolare, Universita di Roma, Rome, Italy
    Blood 115:265-73. 2010
    ..Furthermore, miR-146a enforced expression impairs both activator protein 1 (AP-1) activity and interleukin-2 (IL-2) production induced by TCR engagement, thus suggesting a role of this miRNA in the modulation of adaptive immunity...
  20. ncbi request reprint Mechanisms of CD8+ T cell peripheral tolerance to our own antigens
    Marino Paroli
    Andrea Cesalpino Foundation, Department of Internal Medicine, La Sapienza University of Rome, Viale del Policlinico 155, 00161, Rome, Italy
    Front Biosci 10:1628-34. 2005
    ....
  21. doi request reprint IFN-α promotes rapid human Treg contraction and late Th1-like Treg decrease
    Ilenia Pacella
    Dipartimento di Medicina Interna e Specialita Mediche, Sapienza Universita di Roma, Rome, Italy
    J Leukoc Biol 100:613-23. 2016
    ..In summary, our results suggest that IFN-α-driven, early regulatory T cell depletion contributes to the development of antiviral immunity, ultimately resulting in the resolution of type 1 inflammation. ..
  22. pmc Regulatory T cells with multiple suppressive and potentially pro-tumor activities accumulate in human colorectal cancer
    Eleonora Timperi
    Dipartimento di Medicina Interna e Specialita Mediche, Sapienza Universita di Roma, Rome, Italy
    Oncoimmunology 5:e1175800. 2016
    ..Overall, our data indicate that Treg accumulation may contribute through multiple mechanisms to CRC establishment and progression. ..
  23. doi request reprint Divergent effects of type-I interferons on regulatory T cells
    Silvia Piconese
    Dipartimento di Medicina Interna e Specialita Mediche, Sapienza Universita di Roma, Policlinico Umberto I, Viale del Policlinico 155, I 00161 Rome, Italy Electronic address
    Cytokine Growth Factor Rev 26:133-41. 2015
    ....
  24. pmc Characterization of a proteasome and TAP-independent presentation of intracellular epitopes by HLA-B27 molecules
    Adriana Magnacca
    Department of Biology and Biotechnology C Darwin, University of Rome, Rome, Italy
    J Biol Chem 287:30358-67. 2012
    ....
  25. ncbi request reprint Phenotypic and Functional Analysis of the Suppressive Function of Human Regulatory T Cells
    Eleonora Timperi
    Dipartimento di Medicina Interna e Specialita Mediche, Sapienza Universita di Roma, Viale del Policlinico 155, Rome, 00161, Italy
    Methods Mol Biol 1514:139-151. 2017
    ..The immunoregulatory identity of a certain Treg subpopulation may be functionally verified by performing an in vitro suppression assay described here, testing the capability of Tregs to suppress the activation of responder cells...
  26. ncbi request reprint Long-lasting memory-resting and memory-effector CD4+ T cells in human X-linked agammaglobulinemia
    Marino Paroli
    Fondazione Andrea Cesalpino, Dipartimento di Medicina Interna, Universita di Roma La Sapienza, Policlinico Umberto I, Via le del Policlinico 155, 00161 Rome, Italy
    Blood 99:2131-7. 2002
    ..These data strongly suggest that B cells are not an absolute requirement for the generation of effective T-cell memory in humans, nor do they seem to influence T(H)1/T(H)2 balance...
  27. ncbi request reprint Responses of peptide-specific T cells to stimulation with polystyrene beads carrying HLA class I molecules loaded with single peptides
    Alberto Chersi
    Department of Biochemistry, Regina Elena Institute for Cancer Research, Rome, Italy
    J Immunol Methods 291:79-91. 2004
    ....
  28. doi request reprint Stability of Regulatory T Cells Undermined or Endorsed by Different Type-1 Cytokines
    Silvia Piconese
    Dipartimento di Medicina Interna e Specialita Mediche, Sapienza Universita di Roma, Policlinico Umberto I, Viale del Policlinico 155, I 00161, Rome, Italy
    Adv Exp Med Biol 850:17-30. 2015
    ..Such regulation would unleash the development of protective type-1 immunity while constraining exacerbated Th1 responses, possibly causing immunopathology. ..
  29. doi request reprint Human OX40 tunes the function of regulatory T cells in tumor and nontumor areas of hepatitis C virus-infected liver tissue
    Silvia Piconese
    Dipartimento di Medicina Interna e Specialita Mediche, Sapienza Universita di Roma, Policlinico Umberto I, Rome, Italy
    Hepatology 60:1494-507. 2014
    ..However, this signal is counteracted in noncirrhotic liver tissue (showing various levels of inflammation) by high availability of interleukin-12 and IFN-γ, ultimately leading to complete, full Th1-like Treg differentiation...