Manuela Aragno

Summary

Affiliation: University of Turin
Country: Italy

Publications

  1. ncbi request reprint Dehydroepiandrosterone modulates nuclear factor-kappaB activation in hippocampus of diabetic rats
    Manuela Aragno
    Department of Experimental Medicine and Oncology, General Pathology Section, University of Turin, Turin 10126, Italy
    Endocrinology 143:3250-8. 2002
  2. pmc Obestatin induced recovery of myocardial dysfunction in type 1 diabetic rats: underlying mechanisms
    Manuela Aragno
    Department of Experimental Medicine and Oncology, University of Turin, Corso Raffaello 30, Turin, 10125, Italy
    Cardiovasc Diabetol 11:129. 2012
  3. ncbi request reprint Up-regulation of advanced glycated products receptors in the brain of diabetic rats is prevented by antioxidant treatment
    Manuela Aragno
    Department of Experimental Medicine and Oncology, General Pathology Section, University of Turin, Italy
    Endocrinology 146:5561-7. 2005
  4. doi request reprint SREBP-1c in nonalcoholic fatty liver disease induced by Western-type high-fat diet plus fructose in rats
    Manuela Aragno
    Department of Experimental Medicine and Oncology, University of Turin, 10125 Turin, Italy
    Free Radic Biol Med 47:1067-74. 2009
  5. doi request reprint Cardiac impairment in rabbits fed a high-fat diet is counteracted by dehydroepiandrosterone supplementation
    M Aragno
    Department of Experimental Medicine and Oncology, University of Turin, Corso Raffaello 30, Turin, Italy
    Life Sci 85:77-84. 2009
  6. pmc Pioglitazone improves lipid and insulin levels in overweight rats on a high cholesterol and fructose diet by decreasing hepatic inflammation
    Massimo Collino
    Department of Anatomy, Pharmacology and Forensic Medicine, University of Turin, Turin, Italy
    Br J Pharmacol 160:1892-902. 2010
  7. pmc Insulin reduces cerebral ischemia/reperfusion injury in the hippocampus of diabetic rats: a role for glycogen synthase kinase-3beta
    Massimo Collino
    Department of Anatomy, Pharmacology, and Forensic Medicine, University of Turin, Turin, Italy
    Diabetes 58:235-42. 2009
  8. doi request reprint Treatment with the glycogen synthase kinase-3beta inhibitor, TDZD-8, affects transient cerebral ischemia/reperfusion injury in the rat hippocampus
    Massimo Collino
    Department of Anatomy, Pharmacology and Forensic Medicine, University of Turin, Turin, Italy
    Shock 30:299-307. 2008
  9. ncbi request reprint Oxidative stress-dependent impairment of cardiac-specific transcription factors in experimental diabetes
    Manuela Aragno
    Department of Experimental Medicine and Oncology, General Pathology Section, University of Turin, 10126 Turin, Italy
    Endocrinology 147:5967-74. 2006
  10. doi request reprint Dysregulation of SREBP2 induces BACE1 expression
    Raffaella Mastrocola
    Department of Experimental Medicine and Oncology, University of Turin, Italy
    Neurobiol Dis 44:116-24. 2011

Collaborators

Detail Information

Publications43

  1. ncbi request reprint Dehydroepiandrosterone modulates nuclear factor-kappaB activation in hippocampus of diabetic rats
    Manuela Aragno
    Department of Experimental Medicine and Oncology, General Pathology Section, University of Turin, Turin 10126, Italy
    Endocrinology 143:3250-8. 2002
    ..Results indicate that DHEA might protect hippocampus from chronic activation of NF-kappaB-dependent genes by reducing NF-kappaB nuclear translocation. This could result in protection from diabetes-dependent brain damage...
  2. pmc Obestatin induced recovery of myocardial dysfunction in type 1 diabetic rats: underlying mechanisms
    Manuela Aragno
    Department of Experimental Medicine and Oncology, University of Turin, Corso Raffaello 30, Turin, 10125, Italy
    Cardiovasc Diabetol 11:129. 2012
    ..The aim of this study was to investigate whether obestatin (OB), a peptide mediator encoded by the ghrelin gene exerting a protective effect in ischemic reperfused heart, is able to reduce cardiac dysfunctions in adult diabetic rats...
  3. ncbi request reprint Up-regulation of advanced glycated products receptors in the brain of diabetic rats is prevented by antioxidant treatment
    Manuela Aragno
    Department of Experimental Medicine and Oncology, General Pathology Section, University of Turin, Italy
    Endocrinology 146:5561-7. 2005
    ....
  4. doi request reprint SREBP-1c in nonalcoholic fatty liver disease induced by Western-type high-fat diet plus fructose in rats
    Manuela Aragno
    Department of Experimental Medicine and Oncology, University of Turin, 10125 Turin, Italy
    Free Radic Biol Med 47:1067-74. 2009
    ..DHEA supplementation of the HF-F diet reduced de novo lipogenesis and delayed progression of nonalcoholic fatty liver disease, demonstrating a relationship between oxidative stress and nonalcoholic fatty liver disease via SREBP-1c...
  5. doi request reprint Cardiac impairment in rabbits fed a high-fat diet is counteracted by dehydroepiandrosterone supplementation
    M Aragno
    Department of Experimental Medicine and Oncology, University of Turin, Corso Raffaello 30, Turin, Italy
    Life Sci 85:77-84. 2009
    ..The biochemical and structural cardiac oxidative-dependent damage induced by high-fat (HF) diet was examined in a rabbit model, together with the role of dehydroepiandrosterone (DHEA) in contrasting tissue damage...
  6. pmc Pioglitazone improves lipid and insulin levels in overweight rats on a high cholesterol and fructose diet by decreasing hepatic inflammation
    Massimo Collino
    Department of Anatomy, Pharmacology and Forensic Medicine, University of Turin, Turin, Italy
    Br J Pharmacol 160:1892-902. 2010
    ..This study aimed to investigate the hepatic signalling pathway activated by PPARgamma activation in a non-genetic insulin-resistant animal model...
  7. pmc Insulin reduces cerebral ischemia/reperfusion injury in the hippocampus of diabetic rats: a role for glycogen synthase kinase-3beta
    Massimo Collino
    Department of Anatomy, Pharmacology, and Forensic Medicine, University of Turin, Turin, Italy
    Diabetes 58:235-42. 2009
    ..Insulin is a well-known inhibitor of glycogen synthase kinase-3beta (GSK-3beta). Here, we investigate the role of GSK-3beta inhibition on I/R-induced cerebral injury in a rat model of insulinopenic diabetes...
  8. doi request reprint Treatment with the glycogen synthase kinase-3beta inhibitor, TDZD-8, affects transient cerebral ischemia/reperfusion injury in the rat hippocampus
    Massimo Collino
    Department of Anatomy, Pharmacology and Forensic Medicine, University of Turin, Turin, Italy
    Shock 30:299-307. 2008
    ..The present study demonstrates that TDZD-8 protects the brain against I/R injury by inhibiting GSK-3beta activity. Collectively, our data may contribute to focus the role of GSK-3beta in cerebral I/R...
  9. ncbi request reprint Oxidative stress-dependent impairment of cardiac-specific transcription factors in experimental diabetes
    Manuela Aragno
    Department of Experimental Medicine and Oncology, General Pathology Section, University of Turin, 10126 Turin, Italy
    Endocrinology 147:5967-74. 2006
    ....
  10. doi request reprint Dysregulation of SREBP2 induces BACE1 expression
    Raffaella Mastrocola
    Department of Experimental Medicine and Oncology, University of Turin, Italy
    Neurobiol Dis 44:116-24. 2011
    ....
  11. ncbi request reprint Oxidative stress triggers cardiac fibrosis in the heart of diabetic rats
    Manuela Aragno
    Department of Experimental Medicine and Oncology, University of Turin, Via Genova 3, 10126 Turin, Italy
    Endocrinology 149:380-8. 2008
    ..Structural and ultrastructural changes and impairment of muscle function induced by experimental diabetes were minimized by DHEA treatment...
  12. ncbi request reprint Pro-inflammatory cytokines and oxidative stress/antioxidant parameters characterize the bio-humoral profile of early cachexia in lung cancer patients
    Nicoletta Fortunati
    Oncological Endocrinology, ASO San Giovanni Battista, Turin, Italy
    Oncol Rep 18:1521-7. 2007
    ..Moreover, the evaluation of gene expression in patient PBMC was helpful in differentiating tumour vs host factors, therefore being useful in the study of pathogenetic mechanisms in neoplastic cachectic patients...
  13. ncbi request reprint Oxidative stress and inflammatory response evoked by transient cerebral ischemia/reperfusion: effects of the PPAR-alpha agonist WY14643
    Massimo Collino
    Department of Anatomy, Pharmacology, and Forensic Medicine, University of Turin, 10125 Turin, Italy
    Free Radic Biol Med 41:579-89. 2006
    ..We propose that WY14643 protects the brain against excessive oxidative stress and inflammation and may thus be useful in treating stroke...
  14. pmc High sugar intake and development of skeletal muscle insulin resistance and inflammation in mice: a protective role for PPAR- δ agonism
    Elisa Benetti
    Department of Drug Science and Technology, University of Turin, Via Giuria 9, 10125 Torino, Italy
    Mediators Inflamm 2013:509502. 2013
    ..Overall, here we show that PPAR- δ activation protects the skeletal muscle against the metabolic abnormalities caused by chronic HFCS exposure by affecting multiple levels of the insulin and inflammatory cascades...
  15. doi request reprint The up-regulation of BACE1 mediated by hypoxia and ischemic injury: role of oxidative stress and HIF1alpha
    Michela Guglielmotto
    Department of Experimental Medicine and Oncology, University of Turin, Italy
    J Neurochem 108:1045-56. 2009
    ..Our study strengthens the hypothesis that oxidative stress is a basic common mechanism of amyloid-beta accumulation...
  16. doi request reprint Reversal of the deleterious effects of chronic dietary HFCS-55 intake by PPAR-δ agonism correlates with impaired NLRP3 inflammasome activation
    Massimo Collino
    Department of Drug Science and Technology, University of Turin, Turin, Italy
    Biochem Pharmacol 85:257-64. 2013
    ....
  17. ncbi request reprint Pro-oxidant effect of dehydroepiandrosterone in rats is mediated by PPAR activation
    Raffaella Mastrocola
    Department of Experimental Medicine and Oncology, General Pathology Section, Corso Raffaello 30, University of Turin, 10125 Turin, Italy
    Life Sci 73:289-99. 2003
    ..This latter result confirms the antioxidant effects of DHEA at low doses, as already previously documented...
  18. doi request reprint AGEs/RAGE complex upregulates BACE1 via NF-κB pathway activation
    Michela Guglielmotto
    Department of Experimental Medicine and Oncology, University of Turin, Turin, Italy
    Neurobiol Aging 33:196.e13-27. 2012
    ..Our findings demonstrate that activation of the AGEs/RAGE axis, by upregulating the key enzyme for amyloid-β production, provides a pathologic link between diabetes mellitus and AD...
  19. ncbi request reprint Oxidative stress and kidney dysfunction due to ischemia/reperfusion in rat: attenuation by dehydroepiandrosterone
    Manuela Aragno
    Department of Experimental Medicine and Oncology, General Pathology Section, University of Turin, Turin, Italy
    Kidney Int 64:836-43. 2003
    ..This in vivo study investigates the effect of dehydroepiandrosterone (DHEA), a physiologic steroid with antioxidant properties, on oxidative balance and renal dysfunctions induced by monolateral I/R...
  20. ncbi request reprint Prevention of severe toxic liver injury and oxidative stress in MCP-1-deficient mice
    Elena Zamara
    Dipartimento di Medicina e Oncologia Sperimentale, University of Turin, Italy
    J Hepatol 46:230-8. 2007
    ..In this study, we investigated the development of acute toxic damage in mice lacking monocyte chemoattractant protein-1 (MCP-1), a chemokine which recruits monocytes and activated lymphocytes...
  21. doi request reprint Peroxisome proliferator-activated receptor β/δ agonism protects the kidney against ischemia/reperfusion injury in diabetic rats
    Massimo Collino
    Department of Anatomy, Pharmacology, and Forensic Medicine, University of Turin, Turin, Italy
    Free Radic Biol Med 50:345-53. 2011
    ..Thus, we report herein that PPARβ/δ activation protects the diabetic kidney against I/R injury by a mechanism that may involve changes in renal expression of SOCS-3 resulting in a reduced local inflammatory response...
  22. ncbi request reprint Modulation of the oxidative stress and inflammatory response by PPAR-gamma agonists in the hippocampus of rats exposed to cerebral ischemia/reperfusion
    Massimo Collino
    Department of Anatomy, Pharmacology and Forensic Medicine, University of Turin, Torino, Italy
    Eur J Pharmacol 530:70-80. 2006
    ..Taken together, the results provide convincing evidence that PPAR-gamma agonists exert protective effects in a rat model of mild forebrain ischemia/reperfusion injury by inhibiting oxidative stress and excessive inflammatory response...
  23. ncbi request reprint Muscle wasting in diabetic and in tumor-bearing rats: role of oxidative stress
    Raffaella Mastrocola
    Department of Experimental Medicine and Oncology, University of Turin, Corso Raffaello 30, 10125 Turin, Italy
    Free Radic Biol Med 44:584-93. 2008
    ..Moreover, despite oxidative stress being detectable in both experimental models, its contribution to muscle wasting is not comparable...
  24. ncbi request reprint Dehydroepiandrosterone administration counteracts oxidative imbalance and advanced glycation end product formation in type 2 diabetic patients
    Enrico Brignardello
    Oncological Endocrinology Unit, San Giovanni Battista Hospital, Turin, Italy
    Diabetes Care 30:2922-7. 2007
    ..This study aimed to evaluate the effects of DHEA administration on oxidative stress, pentosidine concentration, and tumor necrosis factor (TNF)-alpha/TNF-alpha receptor system activity in patients with type 2 diabetes...
  25. ncbi request reprint Ischaemic preconditioning modulates the activity of Kupffer cells during in vivo reperfusion injury of rat liver
    Barbara Cavalieri
    Laboratory of Experimental Liver Pathology, Department of Clinical and Biological Sciences, University of Turin, 10043 Orbassano, Turin, Italy
    Cell Biochem Funct 21:299-305. 2003
    ....
  26. ncbi request reprint Oxidative stress impairs skeletal muscle repair in diabetic rats
    Manuela Aragno
    Department of Experimental Medicine and Oncology, University of Turin, Turin, Italy
    Diabetes 53:1082-8. 2004
    ..Vitamin E administration to STZ-induced diabetic rats reverses oxidative imbalance and improves muscle gene transcription, reinforcing the suggestion that oxidative stress may play a role in diabetes-related impaired muscle repair...
  27. pmc Targeting the NLRP3 inflammasome to reduce diet-induced metabolic abnormalities in mice
    Fausto Chiazza
    Dipartimento di Scienza e Tecnologia del Farmaco, Universita di Torino, Turin, Italy
    Mol Med . 2015
    ....
  28. pmc Oxidative stress activates a positive feedback between the gamma- and beta-secretase cleavages of the beta-amyloid precursor protein
    Elena Tamagno
    Department of Experimental Medicine and Oncology, University of Torino, Torino, Italy
    J Neurochem 104:683-95. 2008
    ..Our findings suggest a mechanism by which OS induces BACE1 transcription, thereby promoting production of pathological levels of amyloid beta in AD...
  29. ncbi request reprint Neutral endopeptidase (EC 3.4.24.11) in cirrhotic liver: a new target to treat portal hypertension?
    Giovanni Sansoè
    Gastroenterology Unit, Gradenigo Hospital, Turin, Italy
    J Hepatol 43:791-8. 2005
    ..We determined the effects of NEP inhibition by candoxatrilat on hormonal status, liver function and arterial and portal pressures in rats with CCl4-induced cirrhosis...
  30. pmc Accumulation of advanced glycation end-products and activation of the SCAP/SREBP Lipogenetic pathway occur in diet-induced obese mouse skeletal muscle
    Raffaella Mastrocola
    Department of Clinical and Biological Sciences, University of Turin, Turin, Italy
    PLoS ONE 10:e0119587. 2015
    ....
  31. ncbi request reprint 4-Hydroxynonenal as a selective pro-fibrogenic stimulus for activated human hepatic stellate cells
    Elena Zamara
    Dipartimento di Medicina e Oncologia Sperimentale, Universita di Torino, Corso Raffaello 30, 10125 Turin, Italy
    J Hepatol 40:60-8. 2004
    ..This study has been performed to evaluate its 'in vivo' levels in injured liver and whether HNE may induce apoptosis and/or affect selected phenotypic responses in activated human hepatic stellate cells (HSC/MF)...
  32. pmc Pharmacological Inhibition of NLRP3 Inflammasome Attenuates Myocardial Ischemia/Reperfusion Injury by Activation of RISK and Mitochondrial Pathways
    Raffaella Mastrocola
    Department of Clinical and Biological Sciences, University of Turin, Torino, Italy
    Oxid Med Cell Longev 2016:5271251. 2016
    ....
  33. pmc Maladaptive Modulations of NLRP3 Inflammasome and Cardioprotective Pathways Are Involved in Diet-Induced Exacerbation of Myocardial Ischemia/Reperfusion Injury in Mice
    Raffaella Mastrocola
    Department of Clinical and Biological Sciences, University of Turin, Regione Gonzole 10, Orbassano, 10043 Torino, Italy
    Oxid Med Cell Longev 2016:3480637. 2016
    ..The common mechanisms of damage here reported lead to a better understanding of the cross-talk among prosurvival and detrimental pathways leading to the development of cardiovascular disorders associated with metabolic diseases. ..
  34. doi request reprint Effect of n-3 fatty acids on patients with advanced lung cancer: a double-blind, placebo-controlled study
    Concetta Finocchiaro
    Department of Clinical Nutrition, San Giovanni Battista Hospital, Turin, Italy
    Br J Nutr 108:327-33. 2012
    ..Our data confirm that the continual assumption of EPA plus DHA determined an anti-inflammatory and anti-oxidative action which could be considered a preliminary goal in anti-cachectic therapy...
  35. doi request reprint High-fructose intake as risk factor for neurodegeneration: Key role for carboxy methyllysine accumulation in mice hippocampal neurons
    Raffaella Mastrocola
    Department of Clinical and Biological Sciences, University of Turin, Turin, Italy Electronic address
    Neurobiol Dis 89:65-75. 2016
    ....
  36. pmc Variability in myosteatosis and insulin resistance induced by high-fat diet in mouse skeletal muscles
    Massimo Collino
    Department of Drug Science and Technology, University of Turin, Via Giuria 9, 10125 Turin, Italy
    Biomed Res Int 2014:569623. 2014
    ..Overall, these results show that adaptive responses to dietary manipulation occur in a muscle-specific pattern. ..
  37. ncbi request reprint Ischemic preconditioning attenuates the oxidant-dependent mechanisms of reperfusion cell damage and death in rat liver
    Barbara Cavalieri
    Laboratory of Experimental Liver Pathology, the Department of Clinical and Biological Sciences, University of Turin, Italy
    Liver Transpl 8:990-9. 2002
    ....
  38. ncbi request reprint Valproic acid, a histone deacetylase inhibitor, enhances sensitivity to doxorubicin in anaplastic thyroid cancer cells
    Maria G Catalano
    Department of Clinical Pathophysiology, University of Turin, Via Genova 3, 10126 Turin, Italy
    J Endocrinol 191:465-72. 2006
    ..These results might offer a rationale for clinical studies of a new combined therapy in an effort to improve the outcome of patients with anaplastic thyroid cancer...
  39. ncbi request reprint Modulations of the calcineurin/NF-AT pathway in skeletal muscle atrophy
    Paola Costelli
    Dipartimento di Medicina e Oncologia Sperimentale, Universita di Torino, Italy
    Biochim Biophys Acta 1770:1028-36. 2007
    ..These results suggest that modulations of calcineurin activity may be involved in the pathogenesis of muscle wasting in diabetes though not in cancer cachexia...
  40. doi request reprint Study of the photocatalytic transformation of synephrine: a biogenic amine relevant in anti-doping analysis
    Claudio Medana
    Department of Molecular Biotechnology and Health Sciences, University of Turin, Torino, Italy
    Anal Bioanal Chem 405:1105-13. 2013
    ..On the contrary, we demonstrate the inconsistency of this reaction in both rat and human in vivo determinations, resulting in forensic importance...
  41. doi request reprint Multiple courses of G-CSF in patients with decompensated cirrhosis: consistent mobilization of immature cells expressing hepatocyte markers and exploratory clinical evaluation
    Silvia Gaia
    Department of Gastro Hepatology, A O Città della Salute e della Scienza, S Giovanni Battista Hospital, University of Turin, C Bramante 88, 10126, Turin, Italy
    Hepatol Int 7:1075-83. 2013
    ..A phase II prospective trial was carried out for evaluation of BMC mobilization induced by multiple courses of G-CSF in cirrhotic patients...
  42. ncbi request reprint Selective up-regulation of tumor necrosis factor receptor I in tumor-bearing rats with cancer-related cachexia
    Maria G Catalano
    Laboratorio di Endocrinologia Oncologica, Dipartimenti di Fisiopatologia Clinica and Oncologia, Universita di Torino, I 10126 Turin, Italy
    Int J Oncol 23:429-36. 2003
    ..This is the first demonstration of a selective up-regulation of TNF-RI in cancer cachexia and suggests that local production of TNF-alpha and IL-6 is a corner-stone in the induction/maintenance of this syndrome...
  43. ncbi request reprint Development of a new class of potential antiatherosclerosis agents: NO-donor antioxidants
    Clara Cena
    Dipartimento di Scienza e Tecnologia del Farmaco, via P Giuria 9, I 10125 Torino, Italy
    Bioorg Med Chem Lett 14:5971-4. 2004
    ..All the compounds proved to inhibit the ferrous salt/ascorbate induced lipidic peroxidation of membrane lipids of rat hepatocytes. They were also capable of dilating rat aorta strips precontracted with phenylephrine...