Affiliation: Telethon Institute of Genetics and Medicine
- Genomic analysis of the TRIM family reveals two groups of genes with distinct evolutionary propertiesMarco Sardiello
Telethon Institute of Genetics and Medicine, Via P, Castellino 111, 80131 Naples, Italy
BMC Evol Biol 8:225. 2008..TRIM genes are involved in ubiquitylation and are implicated in a variety of human pathologies, from Mendelian inherited disorders to cancer, and are also involved in cellular response to viral infection...
- Identification of microRNA-regulated gene networks by expression analysis of target genesVincenzo Alessandro Gennarino
Telethon Institute of Genetics and Medicine, Naples, Italy
Genome Res 22:1163-72. 2012..Based on these findings, we formalize and propose co-expression analysis as a general paradigm for second-generation procedures to recognize bona fide targets and infer biological roles and network communities of miRNAs...
- A novel view of the transcriptome revealed from gene trapping in mouse embryonic stem cellsGuglielmo Roma
Telethon Institute of Genetics and Medicine, 80131 Napoli, Italy
Genome Res 17:1051-60. 2007..Although gene trapping was initially devised as an insertional mutagenesis technique, our study demonstrates its impact on the discovery of a substantial and unprecedented portion of the transcriptome...
- Physical and functional characterization of the genetic locus of IBtk, an inhibitor of Bruton's tyrosine kinase: evidence for three protein isoforms of IBtkCarmen Spatuzza
Department of Experimental and Clinical Medicine, University of Catanzaro Magna Graecia, 88100 Catanzaro, Italy
Nucleic Acids Res 36:4402-16. 2008..These results provide the first characterization of the human IBTK locus and may assist in understanding the in vivo function of IBtk...
- A comparative study of the porin genes encoding VDAC, a voltage-dependent anion channel protein, in Anopheles gambiae and Drosophila melanogasterMarco Sardiello
Dipartimento di Anatomia Patologica e di Genetica, Sezione di Genetica, Universita di Bari, Via Amendola 165 A, Bari 70126, Italy
Gene 317:111-5. 2003..Our results suggest that, while in yeast, plants, and mammals, VDAC isoforms are encoded by small multigene families and are able to compensate for each other at least partially, in A. gambiae a single gene encodes the VDAC protein...