Maria Costantini

Summary

Affiliation: Stazione Zoologica Anton Dohrn
Country: Italy

Publications

  1. pmc Genealogy of an ancient protein family: the Sirtuins, a family of disordered members
    Susan Costantini
    Pascale Foundation National Cancer Institute Cancer Research Center CROM, via Ammiraglio Bianco, 83013, Mercogliano, Italy
    BMC Evol Biol 13:60. 2013
  2. ncbi request reprint An analysis of sponge genomes
    Maria Costantini
    Laboratorio di Evoluzione Molecolare, Stazione Zoologica Anton Dohrn, Villa Comunale, Napoli 80121, Italy
    Gene 342:321-5. 2004
  3. doi request reprint Extrapolating ENCODE data to the whole human genome
    Maria Costantini
    Laboratory of Molecular Evolution, Stazione Zoologica Anton Dohrn, 80121 Naples, Italy
    Gene 419:66-9. 2008
  4. pmc Mapping insertions, deletions and SNPs on Venter's chromosomes
    Maria Costantini
    Stazione Zoologica Anton Dohrn, Naples, Italy
    PLoS ONE 4:e5972. 2009
  5. pmc The evolution of isochore patterns in vertebrate genomes
    Maria Costantini
    Stazione Zoologica Anton Dohrn, Naples, Italy
    BMC Genomics 10:146. 2009
  6. ncbi request reprint Isochore pattern and gene distribution in the chicken genome
    Maria Costantini
    Laboratory of Molecular Evolution, Stazione Zoologica Anton Dohrn, 80121 Naples, Italy
    Gene 400:9-15. 2007
  7. ncbi request reprint Isochore patterns and gene distributions in fish genomes
    Maria Costantini
    Laboratory of Molecular Evolution, Stazione Zoologica Anton Dohrn, 80121 Naples, Italy
    Genomics 90:364-71. 2007
  8. ncbi request reprint Human chromosomal bands: nested structure, high-definition map and molecular basis
    Maria Costantini
    Laboratory of Molecular Evolution, Stazione Zoologica Anton Dohrn, Naples, Italy
    Chromosoma 116:29-40. 2007
  9. doi request reprint Correlations between coding and contiguous non-coding sequences in isochore families from vertebrate genomes
    Maria Costantini
    Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy
    Gene 410:241-8. 2008
  10. doi request reprint Diatom-derived oxylipins induce cell death in sea urchin embryos activating caspase-8 and caspase 3/7
    Nadia Ruocco
    Department of Biology and Evolution of Marine Organisms, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Napoli, Italy
    Aquat Toxicol 176:128-40. 2016

Collaborators

Detail Information

Publications22

  1. pmc Genealogy of an ancient protein family: the Sirtuins, a family of disordered members
    Susan Costantini
    Pascale Foundation National Cancer Institute Cancer Research Center CROM, via Ammiraglio Bianco, 83013, Mercogliano, Italy
    BMC Evol Biol 13:60. 2013
    ..Aim of this work is to understand what structural properties are shared among members of this family in humans as well as in other organisms...
  2. ncbi request reprint An analysis of sponge genomes
    Maria Costantini
    Laboratorio di Evoluzione Molecolare, Stazione Zoologica Anton Dohrn, Villa Comunale, Napoli 80121, Italy
    Gene 342:321-5. 2004
    ..cydonium and Suberites domuncula. It was shown that DNAs from both sponges are characterized by unimodal CsCl profiles, additional peaks being due to contaminating prokaryotic and eukaryotic microorganisms...
  3. doi request reprint Extrapolating ENCODE data to the whole human genome
    Maria Costantini
    Laboratory of Molecular Evolution, Stazione Zoologica Anton Dohrn, 80121 Naples, Italy
    Gene 419:66-9. 2008
    ..This unbalanced representativity of ENCODE can, however, be corrected by multiplying ENCODE data by a G/E factor (the ratio of whole genome data over ENCODE data), so amplifying the potential interest of ENCODE...
  4. pmc Mapping insertions, deletions and SNPs on Venter's chromosomes
    Maria Costantini
    Stazione Zoologica Anton Dohrn, Naples, Italy
    PLoS ONE 4:e5972. 2009
    ..The very recent availability of fully sequenced individual human genomes is a major revolution in biology which is certainly going to provide new insights into genetic diseases and genomic rearrangements...
  5. pmc The evolution of isochore patterns in vertebrate genomes
    Maria Costantini
    Stazione Zoologica Anton Dohrn, Naples, Italy
    BMC Genomics 10:146. 2009
    ..g., between amphibians and mammals); and (v) isochores are tightly linked to a number of basic biological properties, such as gene density, gene expression, replication timing and recombination...
  6. ncbi request reprint Isochore pattern and gene distribution in the chicken genome
    Maria Costantini
    Laboratory of Molecular Evolution, Stazione Zoologica Anton Dohrn, 80121 Naples, Italy
    Gene 400:9-15. 2007
    ..This raises important questions about genome evolution in vertebrates...
  7. ncbi request reprint Isochore patterns and gene distributions in fish genomes
    Maria Costantini
    Laboratory of Molecular Evolution, Stazione Zoologica Anton Dohrn, 80121 Naples, Italy
    Genomics 90:364-71. 2007
    ..Moreover, in each genome the GC-poorest isochore families comprised a group of "long isochores" (2-20 Mb in size), which were the lowest in GC and varied in size distribution and relative amount from one genome to the other...
  8. ncbi request reprint Human chromosomal bands: nested structure, high-definition map and molecular basis
    Maria Costantini
    Laboratory of Molecular Evolution, Stazione Zoologica Anton Dohrn, Naples, Italy
    Chromosoma 116:29-40. 2007
    ....
  9. doi request reprint Correlations between coding and contiguous non-coding sequences in isochore families from vertebrate genomes
    Maria Costantini
    Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy
    Gene 410:241-8. 2008
    ....
  10. doi request reprint Diatom-derived oxylipins induce cell death in sea urchin embryos activating caspase-8 and caspase 3/7
    Nadia Ruocco
    Department of Biology and Evolution of Marine Organisms, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Napoli, Italy
    Aquat Toxicol 176:128-40. 2016
    ..lividus) genes, detected by Real Time qPCR. These findings have interesting implications from the ecological point of view, given the importance of diatom blooms in nutrient-rich aquatic environments. ..
  11. doi request reprint The distributions of "new" and "old" Alu sequences in the human genome: the solution of a "mystery"
    Maria Costantini
    Laboratory of Cellular and Developmental Biology, Stazione Zoologica Anton Dohrn, Naples, Italy
    Mol Biol Evol 29:421-7. 2012
    ....
  12. pmc Replication timing, chromosomal bands, and isochores
    Maria Costantini
    Laboratory of Molecular Evolution, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy
    Proc Natl Acad Sci U S A 105:3433-7. 2008
    ..Finally, we show that our results should be representative for the whole human genome and thus help to predict replication timing zones in all chromosomes...
  13. pmc The isochore patterns of invertebrate genomes
    Rosalia Cammarano
    Stazione Zoologica Anton Dohrn, Naples, Italy
    BMC Genomics 10:538. 2009
    ..A question raised by these results concerned how far back in evolution an isochore organization of the eukaryotic genome arose...
  14. pmc An isochore map of human chromosomes
    Maria Costantini
    Laboratory of Molecular Evolution, Stazione Zoologica Anton Dohrn, 80121 Naples, Italy
    Genome Res 16:536-41. 2006
    ....
  15. doi request reprint Polysaccharides from the Marine Environment with Pharmacological, Cosmeceutical and Nutraceutical Potential
    Nadia Ruocco
    Department of Biology and Evolution of Marine Organisms, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Napoli, Italy
    Molecules 21:. 2016
    ..Research in this field is opening new doors for harnessing the potential of marine natural products. ..
  16. pmc Compositional patterns in the genomes of unicellular eukaryotes
    Maria Costantini
    Laboratory of Animal Physiology and Evolution, Stazione Zoologica Anton Dohrn, Villa Comunale, Naples 80121, Italy
    BMC Genomics 14:755. 2013
    ..A question raised by these basic results concerns how far back in evolution the compartmentalized organization of the eukaryotic genomes arose...
  17. pmc The short-sequence designs of isochores from the human genome
    Maria Costantini
    Laboratory of Molecular Evolution, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy
    Proc Natl Acad Sci U S A 105:13971-6. 2008
    ....
  18. pmc Blue-Print Autophagy: Potential for Cancer Treatment
    Nadia Ruocco
    Department of Biology and Evolution of Marine Organisms, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Napoli, Italy
    Mar Drugs 14:. 2016
    ..In conclusion, this blue-print autophagy (so defined because it is induced and/or inhibited by marine natural products) represents a new strategy for the future of biomedicine and of biotechnology in cancer treatment. ..
  19. pmc The Anolis Lizard Genome: An Amniote Genome without Isochores?
    Maria Costantini
    Department of Biology and Evolution of Marine Organisms, Stazione Zoologica Anton Dohrn, Naples, Italy
    Genome Biol Evol 8:1048-55. 2016
    ..In conclusion, the Anolis genome is no exception to the general rule of an isochore organization in the genomes of vertebrates (and other eukaryotes). ..
  20. pmc New insights into negative effects of lithium on sea urchin Paracentrotus lividus embryos
    Nadia Ruocco
    Department of Biology and Evolution of Marine Organisms, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Napoli, Italy
    Sci Rep 6:32157. 2016
    ..The findings may also have relevance outside the world of marine organisms since lithium is widely prescribed for the treatment of human bipolar disorders. ..
  21. pmc Toxic Diatom Aldehydes Affect Defence Gene Networks in Sea Urchins
    Stefano Varrella
    Department of Biology and Evolution of Marine Organisms, Stazione Zoologica Anton Dohrn, Villa Comunale, Napoli, Italy
    PLoS ONE 11:e0149734. 2016
    ..This represents the first report on gene networks affected by PUAs, opening new perspectives in understanding the cellular mechanisms underlying the response of benthic organisms to diatom exposure. ..
  22. doi request reprint Structure-function relationship and evolutionary history of the human selenoprotein M (SelM) found over-expressed in hepatocellular carcinoma
    Stefano Guariniello
    Biochemistry, Biophysics and General Pathology Department and Computational Biology Doctorate, Second University of Naples, Naples, Italy
    Biochim Biophys Acta 1844:447-56. 2014
    ..Moreover, we modeled some of its mutants to obtain structural information helpful for structure-based drug design. ..