Barbara Rinaldi

Summary

Affiliation: Second University of Naples
Country: Italy

Publications

  1. ncbi request reprint ETA endothelin receptors are involved in the ouabain-induced haemodynamic effects in the periaqueductal gray area of rats
    Michele D'Amico
    Department of Experimental Medicine, Section of Pharmacology L Donatelli, Centre of Excellence for Cardiovascular Diseases, Faculty of Medicine and Surgery, 2nd University of Naples, Via Costantinopoli 16 80138 Naples, Italy
    Life Sci 72:2211-8. 2003
  2. pmc Effects of sildenafil on the gastrocnemius and cardiac muscles of rats in a model of prolonged moderate exercise training
    Barbara Rinaldi
    Department of Experimental Medicine, Section of Pharmacology L Donatelli, Centre of Excellence for Cardiovascular Diseases, Second University of Naples, Naples, Italy
    PLoS ONE 8:e69954. 2013
  3. pmc Anti-inflammatory effect of simvastatin in an experimental model of spinal cord trauma: involvement of PPAR-α
    Emanuela Esposito
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, 98125 Messina, Italy
    J Neuroinflammation 9:81. 2012
  4. pmc PPARα mediates the anti-inflammatory effect of simvastatin in an experimental model of zymosan-induced multiple organ failure
    Barbara Rinaldi
    Department of Experimental Medicine, Section of Pharmacology L Donatelli, Excellence Centre for Cardiovascular Diseases, Second University of Naples, Italy
    Br J Pharmacol 163:609-23. 2011
  5. pmc Inflammatory events in a vascular remodeling model induced by surgical injury to the rat carotid artery
    Barbara Rinaldi
    Department of Experimental Medicine, Excellence Centre on Cardiovascular Diseases, Second University of Naples, Via Costantinopoli 16, 80138 Naples, Italy
    Br J Pharmacol 147:175-82. 2006
  6. ncbi request reprint Exercise training affects age-induced changes in SOD and heat shock protein expression in rat heart
    Barbara Rinaldi
    Department of Experimental Medicine and Excellence Center of Cardiovascular Disease, Second University of Naples, Naples 80138, Italy
    Exp Gerontol 41:764-70. 2006
  7. doi request reprint Rosiglitazone reduces the inflammatory response in a model of vascular injury in rats
    Barbara Rinaldi
    Department of Experimental Medicine, Excellence Centre for Cardiovascular Diseases, Second University of Naples, Naples, Italy
    Shock 32:638-44. 2009
  8. doi request reprint Hyperbaric oxygen therapy reduces the toll-like receptor signaling pathway in multiple organ failures
    Barbara Rinaldi
    Department of Experimental Medicine, Excellence Center for Cardiovascular Diseases, Second University of Naples, Via De Crecchio 7, 80138, Naples, Italy
    Intensive Care Med 37:1110-9. 2011
  9. ncbi request reprint Chronic peripheral ouabain treatment affects the brain endothelin system of rats
    Clara Di Filippo
    Department of Experimental Medicine, Section of Pharmacology Leonardo Donatelli, Research Centre for Cardiovascular Diseases, Faculty of Medicine and Surgery, 2nd University of Naples, Italy
    J Hypertens 21:747-53. 2003
  10. ncbi request reprint Hyperbaric oxygen therapy prevents coagulation disorders in an experimental model of multiple organ failure syndrome
    Francesco Imperatore
    Department of Experimental Medicine, Section of Pharmacology L Donatelli, Faculty of Medicine, Second University of Naples, via Michele Tenore 14, 80137, Naples, Italy
    Intensive Care Med 32:1881-8. 2006

Collaborators

Detail Information

Publications27

  1. ncbi request reprint ETA endothelin receptors are involved in the ouabain-induced haemodynamic effects in the periaqueductal gray area of rats
    Michele D'Amico
    Department of Experimental Medicine, Section of Pharmacology L Donatelli, Centre of Excellence for Cardiovascular Diseases, Faculty of Medicine and Surgery, 2nd University of Naples, Via Costantinopoli 16 80138 Naples, Italy
    Life Sci 72:2211-8. 2003
    ..These results indicate that PAG-ET-1 system via an action on ETA receptors is involved in the OUA effects...
  2. pmc Effects of sildenafil on the gastrocnemius and cardiac muscles of rats in a model of prolonged moderate exercise training
    Barbara Rinaldi
    Department of Experimental Medicine, Section of Pharmacology L Donatelli, Centre of Excellence for Cardiovascular Diseases, Second University of Naples, Naples, Italy
    PLoS ONE 8:e69954. 2013
    ..This report may impact on the use of sildenafil as a substance able to influence sports performance. ..
  3. pmc Anti-inflammatory effect of simvastatin in an experimental model of spinal cord trauma: involvement of PPAR-α
    Emanuela Esposito
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, 98125 Messina, Italy
    J Neuroinflammation 9:81. 2012
    ..Moreover, previous results suggest that PPAR-α plays a role in control of secondary inflammatory process associated with spinal cord injury (SCI)...
  4. pmc PPARα mediates the anti-inflammatory effect of simvastatin in an experimental model of zymosan-induced multiple organ failure
    Barbara Rinaldi
    Department of Experimental Medicine, Section of Pharmacology L Donatelli, Excellence Centre for Cardiovascular Diseases, Second University of Naples, Italy
    Br J Pharmacol 163:609-23. 2011
    ..We used a zymosan-induced non-septic shock experimental model to investigate the role of PPARα in the anti-inflammatory effects of simvastatin...
  5. pmc Inflammatory events in a vascular remodeling model induced by surgical injury to the rat carotid artery
    Barbara Rinaldi
    Department of Experimental Medicine, Excellence Centre on Cardiovascular Diseases, Second University of Naples, Via Costantinopoli 16, 80138 Naples, Italy
    Br J Pharmacol 147:175-82. 2006
    ..Dendritic-like cells were for the first time identified as a novel component of tissue repair consequent to acute arterial injury...
  6. ncbi request reprint Exercise training affects age-induced changes in SOD and heat shock protein expression in rat heart
    Barbara Rinaldi
    Department of Experimental Medicine and Excellence Center of Cardiovascular Disease, Second University of Naples, Naples 80138, Italy
    Exp Gerontol 41:764-70. 2006
    ..These findings suggest that the beneficial effects on aged-related cardiovascular changes could be connected to the "anti-oxidant" effects of prolonged exercise training...
  7. doi request reprint Rosiglitazone reduces the inflammatory response in a model of vascular injury in rats
    Barbara Rinaldi
    Department of Experimental Medicine, Excellence Centre for Cardiovascular Diseases, Second University of Naples, Naples, Italy
    Shock 32:638-44. 2009
    ..In conclusion, rosiglitazone negatively regulated the inflammatory events involved in tissue repair at molecular and cellular levels. These results suggest that rosiglitazone plays a protective role in inflammatory vascular diseases...
  8. doi request reprint Hyperbaric oxygen therapy reduces the toll-like receptor signaling pathway in multiple organ failures
    Barbara Rinaldi
    Department of Experimental Medicine, Excellence Center for Cardiovascular Diseases, Second University of Naples, Via De Crecchio 7, 80138, Naples, Italy
    Intensive Care Med 37:1110-9. 2011
    ..The aim of this study was to investigate the effect of HBO exposure on TLR2 and TLR4 signal transduction and organ dysfunction during MODS induced by zymosan in the rat...
  9. ncbi request reprint Chronic peripheral ouabain treatment affects the brain endothelin system of rats
    Clara Di Filippo
    Department of Experimental Medicine, Section of Pharmacology Leonardo Donatelli, Research Centre for Cardiovascular Diseases, Faculty of Medicine and Surgery, 2nd University of Naples, Italy
    J Hypertens 21:747-53. 2003
    ..However, the pattern of central changes induced by chronic infusion of ouabain is not completely understood...
  10. ncbi request reprint Hyperbaric oxygen therapy prevents coagulation disorders in an experimental model of multiple organ failure syndrome
    Francesco Imperatore
    Department of Experimental Medicine, Section of Pharmacology L Donatelli, Faculty of Medicine, Second University of Naples, via Michele Tenore 14, 80137, Naples, Italy
    Intensive Care Med 32:1881-8. 2006
    ..To evaluate the effects of hyperbaric oxygen (HBO) therapy on the coagulation cascade using an experimental model of multiple organ failure syndrome (MOFS)...
  11. pmc Effects of chronic treatment with the new ultra-long-acting β2 -adrenoceptor agonist indacaterol alone or in combination with the β1 -adrenoceptor blocker metoprolol on cardiac remodelling
    Barbara Rinaldi
    Centre of Excellence for Cardiovascular Diseases, Second University of Naples, Naples, Italy
    Br J Pharmacol 172:3627-37. 2015
    ....
  12. doi request reprint G-CSF contributes at the healing of tunica media of arteriotomy-injured rat carotids by promoting differentiation of vascular smooth muscle cells
    Barbara Rinaldi
    Department of Experimental Medicine, Section of Pharmacology L Donatelli, Centre of Excellence for Cardiovascular Diseases, Second University of Naples, Naples, Italy
    J Cell Physiol 231:215-23. 2016
    ....
  13. doi request reprint Local inhibition of ornithine decarboxylase reduces vascular stenosis in a murine model of carotid injury
    Amalia Forte
    Dept of Experimental Medicine, Second University of Naples, Italy Excellence Research Centre for Cardiovascular Diseases, Second University of Naples, Italy
    Int J Cardiol 168:3370-80. 2013
    ..We aimed to test the effect of α-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase, on vascular cell pathophysiology in vitro and in a rat model of carotid arteriotomy-induced (re)stenosis...
  14. doi request reprint Stem cell therapy for arterial restenosis: potential parameters contributing to the success of bone marrow-derived mesenchymal stromal cells
    Amalia Forte
    Department of Experimental Medicine, Second University of Naples, Naples, Italy
    Cardiovasc Drugs Ther 26:9-21. 2012
    ..In this study we describe some of the effects subsequent to MSC treatment of rats submitted to carotid arteriotomy and possibly responsible for their antirestenotic effect...
  15. pmc Effect of Prolonged Moderate Exercise on the Changes of Nonneuronal Cells in Early Myocardial Infarction
    Barbara Rinaldi
    Department of Experimental Medicine, Division of Pharmacology, The Second University of Naples, Via Costantinopoli 16, 80138 Naples, Italy
    Neural Plast 2015:265967. 2015
    ..Our data suggest that there is an early brain reaction to myocardial infarction induction, involving nonneuronal cells, that is attenuated by the prolonged exercise. ..
  16. ncbi request reprint Local administration of ETA (but not ETB) blockers into the PAG area of the brain decreases blood pressure of DOCA-salt rats
    Clara Di Filippo
    Department of Experimental Medicine, Section of Pharmacology L Donatelli, Research Center for Cardiovascular Diseases, Faculty of Medicine and Surgery, Second University of Naples, Via Costantinopoli 16, Italy
    Naunyn Schmiedebergs Arch Pharmacol 366:123-6. 2002
    ..PAG-endothelin ETA antagonism can therefore be said to counteract the cardiovascular changes induced by DOCA-salt treatment in rats...
  17. doi request reprint Long-term administration of ranolazine attenuates diastolic dysfunction and adverse myocardial remodeling in a model of heart failure with preserved ejection fraction
    Antonella De Angelis
    Department of Experimental Medicine, Section of Pharmacology, Second University of Naples, Via Costantinopoli 16, 80138 Naples, Italy
    Int J Cardiol 217:69-79. 2016
    ..To investigate the effects of chronic administration of ranolazine (RAN) on experimental model of heart failure with preserved ejection fraction...
  18. pmc Intraperitoneal oxygen/ozone treatment decreases the formation of experimental postsurgical peritoneal adhesions and the levels/activity of the local ubiquitin-proteasome system
    Clara Di Filippo
    Department of Experimental Medicine, Section of Pharmacology L Donatelli, 2nd University of Naples, 80138 Naples, Italy
    Mediators Inflamm 2011:606718. 2011
    ..Oxygen/ozone mixture is potentially useful for approaching the post-surgical peritoneal adhesions, and the UPS system is involved in this...
  19. doi request reprint Novel potential targets for prevention of arterial restenosis: insights from the pre-clinical research
    Amalia Forte
    Department of Experimental Medicine, Second University of Naples, Via L De Crecchio 7, 80138 Naples, Italy
    Clin Sci (Lond) 127:615-34. 2014
    ..The present review summarizes the most recent and promising therapeutic strategies identified in experimental models of (re)stenosis and potentially translatable to patients subjected to revascularization procedures...
  20. doi request reprint Predictors of mortality in atypical antipsychotic-treated community-dwelling elderly patients with behavioural and psychological symptoms of dementia: a prospective population-based cohort study from Italy
    Concetta Rafaniello
    Department of Experimental Medicine, Regional Centre of Pharmacosurveillance and Pharmacoepidemiology, Second University of Naples, Via De Crecchio 7, 80138, Naples, Italy
    Eur J Clin Pharmacol 70:187-95. 2014
    ....
  21. doi request reprint An open randomized study of the treatment of escitalopram alone and combined with gamma-hydroxybutyric acid and naltrexone in alcoholic patients
    Luigi Stella
    Department of Experimental Medicine, Section of Pharmacology L Donatelli, Faculty of Medicine and Surgery, Second University of Naples, Naples, Italy
    Pharmacol Res 57:312-7. 2008
    ..Finally, in group 4 (NTX+GHB+SSRI), 1 patient relapsed after 3 months and 1 after 6 months, whereas 10 patients remain abstinent. In conclusion, the combination of NTX+GHB+SSRI was the most effective in preventing relapses...
  22. pmc Indomethacin potentiates acetylcholine-induced vasodilation by increasing free radical production
    Antonella De Angelis
    Department of Experimental Medicine, Section of Pharmacology Leonardo Donatelli, Second University of Naples, Naples, Italy
    Br J Pharmacol 142:1233-40. 2004
    ..We cannot judge if indomethacin-induced endothelium-dependent vasodilation damages or protects the cardiovascular system. Here, we show that indomethacin acts on the cardiovascular system regardless of cyclooxygenase inhibition...
  23. doi request reprint Primary and Acquired Resistance of Colorectal Cancer to Anti-EGFR Monoclonal Antibody Can Be Overcome by Combined Treatment of Regorafenib with Cetuximab
    Stefania Napolitano
    Oncologia Medica, Dipartimento Medico Chirurgico di Internistica Clinica e Sperimentale F Magrassi e A Lanzara, Seconda Universita degli Studi di Napoli, Naples, Italy
    Clin Cancer Res 21:2975-83. 2015
    ..We have investigated the role of regorafenib, an oral multikinase inhibitor, in combination with cetuximab, an anti-EGFR mAb, to overcome anti-EGFR resistance...
  24. ncbi request reprint Assessing the viability of long-acting β2-agonists in paediatric asthma patients: a pharmacokinetic/pharmacodynamic perspective
    Maria Gabriella Matera
    a Department of Experimental Medicine, Second University of Naples, Naples, Italy
    Expert Opin Drug Metab Toxicol . 2016
    ....
  25. doi request reprint Safety of attention-deficit/hyperactivity disorder medications in children: an intensive pharmacosurveillance monitoring study
    Simona Ruggiero
    Department of Experimental Medicine, Section of Pharmacology Leonardo Donatelli, Center of Pharmacosurveillance and Pharmacoepidemiology, Faculty of Medicine and Surgery, Second University of Naples, Naples, Italy
    J Child Adolesc Psychopharmacol 22:415-22. 2012
    ....
  26. ncbi request reprint Exercise training promotes SIRT1 activity in aged rats
    Nicola Ferrara
    Department of Health Sciences, Faculty of Medicine, University of Molise, Campobasso, Italy
    Rejuvenation Res 11:139-50. 2008
    ..There was a similar decrease in cyclin D(2), and no changes in GADD45a mRNA expression in adipose tissue. We concluded that exercise training, which significantly increases SIRT1 activity, could counteract age-related systems impairment...
  27. ncbi request reprint Exercise training and beta-blocker treatment ameliorate age-dependent impairment of beta-adrenergic receptor signaling and enhance cardiac responsiveness to adrenergic stimulation
    Dario Leosco
    Department of Internal Medicine, Cardiovascular Sciences and Immunology, University Federico II, Via Pansini 5, Edificio 2, 80131 Naples, Italy
    Am J Physiol Heart Circ Physiol 293:H1596-603. 2007
    ..In conclusion, we demonstrate for the first time that exercise and beta-AR blockade can similarly ameliorate beta-AR signaling in the aged heart, leading to improved beta-AR responsiveness and corresponding LV inotropic reserve...