Alessandro Federico

Summary

Affiliation: Second University of Naples
Country: Italy

Publications

  1. doi Silymarin/Silybin and Chronic Liver Disease: A Marriage of Many Years
    Alessandro Federico
    Department of Clinical and Experimental Medicine, Second University of Naples, 80131 Naples, Italy
    Molecules 22:. 2017
  2. ncbi The epidemiology of non-alcoholic fatty liver disease and its connection with cardiovascular disease: role of endothelial dysfunction
    A Federico
    Division of Hepato Gastroenterology, Department of Clinical and Experimental Medicine, Second University of Naples, Naples, Italy
    Eur Rev Med Pharmacol Sci 20:4731-4741. 2016
  3. doi Reactivation of hepatitis B virus in cancer patients treated with chemotherapy for solid tumors. Is the prophylaxis really required?
    Alessandro Federico
    Division of Hepatogastroenterology, Second University of Naples, Naples, Italy Electronic address
    Dig Liver Dis 49:197-201. 2017
  4. ncbi Gastrointestinal Hormones, Intestinal Microbiota and Metabolic Homeostasis in Obese Patients: Effect of Bariatric Surgery
    Alessandro Federico
    Division of Hepatogastroenterology, Second University of Naples, Naples, Italy
    In Vivo 30:321-30. 2016
  5. ncbi A pilot study on the ability of clinoptilolite to absorb ethanol in vivo in healthy drinkers: effect of gender
    A Federico
    Department of Clinical and Experimental Medicine, Second University of Naples, Naples, Italy
    J Physiol Pharmacol 66:441-7. 2015
  6. ncbi Silybin-Phosphatidylcholine Complex Protects Human Gastric and Liver Cells from Oxidative Stress
    Alessandro Federico
    Department of Clinical and Experimental Medicine, Second University of Naples, Naples, Italy
    In Vivo 29:569-75. 2015
  7. ncbi The effect of a new symbiotic formulation on plasma levels and peripheral blood mononuclear cell expression of some pro-inflammatory cytokines in patients with ulcerative colitis: a pilot study
    A Federico
    Division of Gastroenterology, 2nd University of Naples, Naples, Italy
    Eur Rev Med Pharmacol Sci 13:285-93. 2009
  8. ncbi Heat shock protein 27 expression in patients with chronic liver damage
    Alessandro Federico
    Centro Interuniversitario per Ricerche su Alimenti, Nutrizione e Apparato Digerente CIRANAD, Cattedra di Gastroenterologia, II Universita di Napoli, Via Pansini 5, Napoli, Italy
    Immunobiology 209:729-35. 2005
  9. ncbi Treatment of patients with non-alcoholic fatty liver disease: current views and perspectives
    A Federico
    2nd University of Naples, Gastroenterology Unit, Via Pansini 5, Naples 80131, Italy
    Dig Liver Dis 38:789-801. 2006
  10. ncbi Emerging drugs for non-alcoholic fatty liver disease
    Alessandro Federico
    Via Alcide De Gasperi 80, 84018 Scafati SA, Italy
    Expert Opin Emerg Drugs 13:145-58. 2008

Collaborators

Detail Information

Publications50

  1. doi Silymarin/Silybin and Chronic Liver Disease: A Marriage of Many Years
    Alessandro Federico
    Department of Clinical and Experimental Medicine, Second University of Naples, 80131 Naples, Italy
    Molecules 22:. 2017
    ..Therefore, the aim of this review is to examine scientific studies concerning the effects derived from silymarin/silybin use in chronic liver diseases, cirrhosis and hepatocellular carcinoma...
  2. ncbi The epidemiology of non-alcoholic fatty liver disease and its connection with cardiovascular disease: role of endothelial dysfunction
    A Federico
    Division of Hepato Gastroenterology, Department of Clinical and Experimental Medicine, Second University of Naples, Naples, Italy
    Eur Rev Med Pharmacol Sci 20:4731-4741. 2016
    ..For this reason, the scientific community may research new therapeutic strategies for non-alcoholic fatty liver disease, by intervening on the early stage of the pathology and blocking endothelial dysfunction...
  3. doi Reactivation of hepatitis B virus in cancer patients treated with chemotherapy for solid tumors. Is the prophylaxis really required?
    Alessandro Federico
    Division of Hepatogastroenterology, Second University of Naples, Naples, Italy Electronic address
    Dig Liver Dis 49:197-201. 2017
    ..Reactivation of hepatitis B virus during cancer chemotherapy for non-hematological tumors is not fully clear...
  4. ncbi Gastrointestinal Hormones, Intestinal Microbiota and Metabolic Homeostasis in Obese Patients: Effect of Bariatric Surgery
    Alessandro Federico
    Division of Hepatogastroenterology, Second University of Naples, Naples, Italy
    In Vivo 30:321-30. 2016
    ..In order to evaluate dietary intake, nutritional assessment and plasma levels of gastrointestinal peptides, we enrolled severely obese patients before and after bariatric surgery...
  5. ncbi A pilot study on the ability of clinoptilolite to absorb ethanol in vivo in healthy drinkers: effect of gender
    A Federico
    Department of Clinical and Experimental Medicine, Second University of Naples, Naples, Italy
    J Physiol Pharmacol 66:441-7. 2015
    ..Our study highlights and confirms the ability of clinoptilolite to decrease the absorption of ingested ethanol by reducing blood alcohol levels. This effect was statistically significant at a dose of 5 g. ..
  6. ncbi Silybin-Phosphatidylcholine Complex Protects Human Gastric and Liver Cells from Oxidative Stress
    Alessandro Federico
    Department of Clinical and Experimental Medicine, Second University of Naples, Naples, Italy
    In Vivo 29:569-75. 2015
    ....
  7. ncbi The effect of a new symbiotic formulation on plasma levels and peripheral blood mononuclear cell expression of some pro-inflammatory cytokines in patients with ulcerative colitis: a pilot study
    A Federico
    Division of Gastroenterology, 2nd University of Naples, Naples, Italy
    Eur Rev Med Pharmacol Sci 13:285-93. 2009
    ..During intestinal inflammation white blood cells are recruited from the blood, and they represent the major contributors to tissue perpetuation of inflammation via their production of chemokines and proinflammatory cytokines...
  8. ncbi Heat shock protein 27 expression in patients with chronic liver damage
    Alessandro Federico
    Centro Interuniversitario per Ricerche su Alimenti, Nutrizione e Apparato Digerente CIRANAD, Cattedra di Gastroenterologia, II Universita di Napoli, Via Pansini 5, Napoli, Italy
    Immunobiology 209:729-35. 2005
    ..The present data are the first showing that, particularly in conditions of enhanced oxidative stress, lymphomonocytes from liver disease patients present an increased expression of HSP27...
  9. ncbi Treatment of patients with non-alcoholic fatty liver disease: current views and perspectives
    A Federico
    2nd University of Naples, Gastroenterology Unit, Via Pansini 5, Naples 80131, Italy
    Dig Liver Dis 38:789-801. 2006
    ....
  10. ncbi Emerging drugs for non-alcoholic fatty liver disease
    Alessandro Federico
    Via Alcide De Gasperi 80, 84018 Scafati SA, Italy
    Expert Opin Emerg Drugs 13:145-58. 2008
    ..This last form may evolve to cirrhosis and hepatocellular carcinoma...
  11. ncbi Chronic inflammation and oxidative stress in human carcinogenesis
    Alessandro Federico
    Division of Gastroenterology, F Magrassi and A Lanzara Medical Surgical Department, Second University of Naples, Naples, Italy
    Int J Cancer 121:2381-6. 2007
    ..This review focalizes some of these intricate events by discussing the relationships occurring among oxidative/nitrosative/metabolic stress, inflammation and cancer...
  12. pmc Platelet aggregation is affected by nitrosothiols in patients with chronic hepatitis: in vivo and in vitro studies
    A Federico
    Inter University Research Centre on Foods, Nutrition and Gastrointestinal Tract, Gastroenterology School, 2nd University of Naples, Via Alcide De Gasperi 80, 84018 Scafati, Italy
    World J Gastroenterol 13:3677-83. 2007
    ....
  13. ncbi Beneficial effects of a probiotic VSL#3 on parameters of liver dysfunction in chronic liver diseases
    Carmela Loguercio
    Department of Internistica Clinica e Sperimentale F Magrassi e A Lanzara, Inter University Research Center on Foods, Nutrition, and Gastrointestinal Tract CIRANAD, Second University of Naples, Naples, Italy
    J Clin Gastroenterol 39:540-3. 2005
    ..To evaluate whether chronic therapy with probiotics affects plasma levels of cytokines and oxidative/nitrosative stress parameters, as well as liver damage, in patients with various types of chronic liver disease...
  14. doi Symbiotic formulation in experimentally induced liver fibrosis in rats: intestinal microbiota as a key point to treat liver damage?
    Giuseppe D'Argenio
    Gastroenterologia, Universita Federico II, Napoli, Italy
    Liver Int 33:687-97. 2013
    ..The aim of our research was the detection and evaluation of the effects of chronic treatment with a symbiotic formulation on CCl4 -induced rat liver fibrosis...
  15. pmc Coeliac disease and C virus-related chronic hepatitis: a non association
    Antonietta Gerarda Gravina
    Department of Clinical and Experimental Medicine and Surgery F Magrassi e A Lanzara Hepato Gastroenterology Division and C I R A N A D, Second University of Naples, Via Pansini 5, Naples 80131, Italy
    BMC Res Notes 5:533. 2012
    ....
  16. doi Efficacy of 5-day levofloxacin-containing concomitant therapy in eradication of Helicobacter pylori infection
    Alessandro Federico
    Dipartimento Medico Chirurgico di Internistica Clinica e Sperimentale ed UOC di Gastroenterologia e, Napoli, Italy
    Gastroenterology 143:55-61.e1; quize e13-4. 2012
    ....
  17. ncbi The effect of a silybin-vitamin e-phospholipid complex on nonalcoholic fatty liver disease: a pilot study
    Carmela Loguercio
    Interuniversity Research Center on Foods, Nutrition and Gastrointestinal Tract CIRANAD, Unit of Gastroenterology, Second University of Naples, Naples, Italy
    Dig Dis Sci 52:2387-95. 2007
    ..Our data suggest that silybin conjugated with vitamin E and phospholipids could be used as a complementary approach to the treatment of patients with chronic liver damage...
  18. doi Intestinal permeability in patients with chronic liver diseases: Its relationship with the aetiology and the entity of liver damage
    Rita Cariello
    Department of Experimental Medicine, Second University of Naples, Italy
    Dig Liver Dis 42:200-4. 2010
    ..Alteration in intestinal permeability may be an important factor in the pathogenesis of both the progression of some chronic liver diseases and the onset of some complications in patients with liver cirrhosis...
  19. pmc Focus on emerging drugs for the treatment of patients with non-alcoholic fatty liver disease
    Alessandro Federico
    Alessandro Federico, Claudio Zulli, Ilario de Sio, Anna Del Prete, Marcello Dallio, Carmela Loguercio, Department of Clinical and Experimental Medicine F Magrassi e A Lanzara, Hepatogastroenterology Division, Interuniversity Research Centre on Food, Nutrition and the Gastrointestinal Tract CIRANAD Second University of Naples, 80131 Naples, Italy
    World J Gastroenterol 20:16841-57. 2014
    ..Urgently, new pharmacological approaches are needed. Here, we will focus on the challenges facing actual therapeutic strategies and the most recent investigated molecules. ..
  20. pmc Fat: a matter of disturbance for the immune system
    Alessandro Federico
    Section of Clinical Immunology, Department of Clinical and Experimental Medicine, Second University of Naples, Napoli, Italy
    World J Gastroenterol 16:4762-72. 2010
    ..This review discusses the role of fat as "a matter of disturbance for the immune system" with a focus on hepatic steatosis...
  21. ncbi Epidemiology and Natural History of Alcoholic Liver Disease
    Mario Masarone
    Internal Medicine and Hepatology Division, Department of Medicine, University of Medicine of Salerno, Salerno, Via Alessandro Manzoni 26b, 80123, Naples, Italy
    Rev Recent Clin Trials 11:167-74. 2016
    ..In this brief review we will report on the global burden of ALD, the principal factors influencing its prevalence among populations and the different presentations of its natural history. ..
  22. ncbi Alcoholic Liver Disease and Hepatitis C Chronic Infection
    Alessandro Federico
    Division of Hepatogastroenterology, Department of Clinical and Experimental Medicine, Second University of Naples, Via Pansini 5, 80131 Naples, Italy
    Rev Recent Clin Trials 11:201-7. 2016
    ..Finally we paid attention to the oncogenetic mechanisms inducing hepatocellular carcinoma and variability of response to antiviral therapy that derives from alcohol abuse in a subject affected by C hepatitis. ..
  23. doi Ultrasound-guided percutaneous biopsy for diagnosis of gastrointestinal lesions
    Ilario de Sio
    Department of Clinical and Experimental Medicine Magrassi Lanzara, Gastroenterology Unit, Second University of Naples, Naples, Italy Electronic address
    Dig Liver Dis 45:816-9. 2013
    ..Endoscopical examination is not always sufficient for the diagnosis of gastrointestinal masses. This study assessed the diagnostic accuracy and safety of ultrasound-guided percutaneous biopsy of gastrointestinal lesions...
  24. pmc Secondary Extramedullary Plasmacytoma of the Duodenum: An Unusual Endoscopic Presentation
    Antonietta Gerarda Gravina
    Department of Clinical and Experimental Medicine, Gastroenterology Unit, Second University of Naples, Italy These authors contributed equally to this work
    Gastroenterology Res 6:110-111. 2013
    ..The final diagnosis was multiple myeloma IgA lambda, stage II A, with secondary duodenal EMP. To our knowledge this is the first report showing duodenal involvement by EMP with the aspect of multiple non-polypoid lesions...
  25. doi Urotensin-II receptor is over-expressed in colon cancer cell lines and in colon carcinoma in humans
    Alessandro Federico
    Gastroenterology Unit, Department of Clinical and Experimental Medicine and Surgery, Second University of Naples, Naples, Italy
    Eur J Clin Invest 44:285-94. 2014
    ..Urotensin (U)-II receptor (UTR) has been previously reported to be over-expressed in a number of tumours. Whether UTR-related pathway plays a role in colon carcinogenesis is unknown...
  26. pmc Serum oxidative stress markers and lipidomic profile to detect NASH patients responsive to an antioxidant treatment: a pilot study
    Paola Stiuso
    Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, Via De Crecchio 7, 80138 Naples, Italy
    Oxid Med Cell Longev 2014:169216. 2014
    ..Conclusion. These data suggest that lipidomic and/or oxidative status of serum from patients with NASH could be useful as prognostic markers of response to an antioxidant treatment...
  27. pmc Eradication of Helicobacter pylori infection: which regimen first?
    Alessandro Federico
    Alessandro Federico, Antonietta Gerarda Gravina, Agnese Miranda, Carmela Loguercio, Marco Romano, Department of Clinical and Experimental Medicine, Gastroenterology Unit, Second University of Naples, 80131 Naples, Italy
    World J Gastroenterol 20:665-72. 2014
    ..A first-line eradication regimen should be based on what works best in a defined geographical area and must take into account the prevalence of antimicrobial resistance in that region. ..
  28. doi Silybin combined with phosphatidylcholine and vitamin E in patients with nonalcoholic fatty liver disease: a randomized controlled trial
    Carmela Loguercio
    Department F Magrassi e A Lanzara, Second University of Naples, 80131 Napoli, Italy
    Free Radic Biol Med 52:1658-65. 2012
    ..Treatment with RA but not P for 12 months was associated with improvement in liver enzymes, insulin resistance, and liver histology, without increases in body weight. These findings warrant further investigation...
  29. doi The impact of diet on liver fibrosis and on response to interferon therapy in patients with HCV-related chronic hepatitis
    Carmela Loguercio
    Department of Internal Medicine and Hepatogastroenterology, Second University of Naples, Naples, Italy
    Am J Gastroenterol 103:3159-66. 2008
    ..The aim of this study was to evaluate whether dietary composition affects the severity of liver damage and response to therapy in patients with HCV-related chronic hepatitis...
  30. ncbi Oxidative stress in viral and alcoholic hepatitis
    Carmela Loguercio
    Gastroenterology School, 2nd University of Naples, and Inter University Research Center of Alimentary Intake, Nutrition and Digestive Tract CIRANAD, Naples, Italy
    Free Radic Biol Med 34:1-10. 2003
    ..By enhancing the antioxidant ability of hepatocytes, through transgene vectors, one could counteract oxidative/nitrosative stress and, in this way, contribute to blocking the progression of liver disease...
  31. ncbi Alcoholic beverages and gastric epithelial cell viability: effect on oxidative stress-induced damage
    C Loguercio
    Centro Interuniversitario di Ricerca su Alimenti, Nutrizione e Apparato Digerente Dipartimento Medico Chirurgico di Internistica Clinica e Sperimentale F Magrassi e A Lanzara, Seconda Universita di Napoli, Italia
    J Physiol Pharmacol 60:87-92. 2009
    ..Pre-treatment with red wine, but not with dealcoholate red wine, significantly and time-dependently prevented oxidative stress-induced cell damage...
  32. ncbi [Effects of a new pharmacological complex (silybin + vitamin-E + phospholipids) on some markers of the metabolic syndrome and of liver fibrosis in patients with hepatic steatosis. Preliminary study]
    M Trappoliere
    Interuniversity Research Center on Foods Nutrition and Gastrointestinal Tract CIRANAD, Unit of Gastroenterology, 2nd University of Naples, Naples, Italy
    Minerva Gastroenterol Dietol 51:193-9. 2005
    ....
  33. pmc Gut-Brain Axis in Gastric Mucosal Damage and Protection
    Dolores Sgambato
    Division of Hepato Gastroenterology, Department of Clinical and Experimental Medicine, Second University of Naples, Via Pansini 5, 80131 Naples, Italy
    Curr Neuropharmacol 14:959-966. 2016
    ..Also, existing evidence indicates that nitric oxide, prostaglandins and calcitonin gene-related peptide play a role as final effectors of gastric protection...
  34. doi Clinical trial on the efficacy of a new symbiotic formulation, Flortec, in patients with irritable bowel syndrome: a multicenter, randomized study
    Angelo Andriulli
    Division of Gastroenterology, Casa Sollievo della Sofferenza Hospital, IRCCS, San Giovanni Rotondo, Italy
    J Clin Gastroenterol 42:S218-23. 2008
    ..Efficacy of symbiotics in patients with irritable bowel syndrome (IBS) remains unknown...
  35. ncbi Telaprevir may induce adverse cutaneous reactions by a T cell immune-mediated mechanism
    Alessandro Federico
    Department of Clinical and Experimental Medicine, Second University of Naples, Naples, Italy
    Ann Hepatol 14:420-4. 2015
    ..05). In conclusion, adverse cutaneous reactions of our patient were caused by a telaprevir-induced T-cell dependent immune mechanism. ..
  36. ncbi Non alcoholic fatty liver: epidemiology and natural history
    Mario Masarone
    Via Alessandro Manzoni 26b, 80123, Naples, Italy
    Rev Recent Clin Trials 9:126-33. 2014
    ..In this review we will report on the global and regional prevalence of NAFLD, the principal risk factors and the natural history of its different presentations. ..
  37. pmc Herbal products: benefits, limits, and applications in chronic liver disease
    Anna Del Prete
    Department of Clinical and Experimental Medicine, Interuniversity Research Centre on Food, Nutrition and the Gastrointestinal Tract CIRANAD, 2nd University of Naples, 80131 Naples, Italy
    Evid Based Complement Alternat Med 2012:837939. 2012
    ....
  38. doi Empirical levofloxacin-containing versus clarithromycin-containing sequential therapy for Helicobacter pylori eradication: a randomised trial
    Marco Romano
    Dipartimento Medico, AziendaOspedaliera Universitaria, Seconda Universita di Napoli, Napoli, Italy
    Gut 59:1465-70. 2010
    ....
  39. ncbi Relationship of blood trace elements to liver damage, nutritional status, and oxidative stress in chronic nonalcoholic liver disease
    C Loguercio
    Centro Interuniversitario di Ricerche su Alimenti, Nutrizione e Apparato Digerente, , , Naples, Italy
    Biol Trace Elem Res 81:245-54. 2001
    ..The plasma Br level was higher in cirrhotics with respect to the control and chronic hepatitis groups...
  40. doi The patterns of reflux can affect regression of non-dysplastic and low-grade dysplastic Barrett's esophagus after medical and surgical treatment: a prospective case-control study
    Salvatore Tolone
    Division of General and Bariatric Surgery, Department of Surgery, Second University of Naples, Via Pansini, 5, 80131, Naples, NA, Italy
    Surg Endosc 29:648-57. 2015
    ..We aimed to analyze pattern of reflux and regression of ND- or LGD-BE after medical and surgical treatment...
  41. doi Targeting gut-liver axis for the treatment of nonalcoholic steatohepatitis: translational and clinical evidence
    Alessandro Federico
    Division of Hepatogastroenterology, Department of Clinical and Experimental Medicine, Second University of Naples, Naples, Italy
    Transl Res 167:116-24. 2016
    ..In this review, we summarized the evidence regarding the role of gut-liver axis in the pathogenesis of NASH and discussed the potential therapeutic role of gut microbiota modulation in the clinical setting...
  42. ncbi Drinking habits and risk of altered liver enzymes in the general population of a rural area in Southern Italy
    C Loguercio
    Interuniversity Research Center on Foods, Nutrition and Gastrointestinal Tract CIRANAD, Unit of Gastroenterology, 2nd University of Naples, Naples, Italy
    Dig Liver Dis 39:748-52. 2007
    ....
  43. pmc Humerus Metastasis From Cholangiocarcinoma: A Case Report
    Alessandro Federico
    Gastroenterology Division, Department of Clinical and Experimental Medicine, Second University of Naples, Naples, Italy
    Gastroenterology Res 6:39-41. 2013
    ..We present a case of elderly patient with a severe and progressive pain due to a pathologic fracture of humerus. The medical investigations revealed the presence of an intrahepatic cholangiocarcinoma...
  44. ncbi Polydatin administration improves serum biochemical parameters and oxidative stress markers during chronic alcoholism: a pilot study
    Maria Caterina Pace
    Department of Anesthesiological, Surgical and Emergency Sciences, Second University of Naples, Naples, Italy
    In Vivo 29:405-8. 2015
    ....
  45. ncbi Non-alcoholic fatty liver disease: a multicentre clinical study by the Italian Association for the Study of the Liver
    C Loguercio
    School of Gastroenterology, Second University of Naples, Naples, Italy
    Dig Liver Dis 36:398-405. 2004
    ..To define the characteristics of the Italian patient presenting non-alcoholic fatty liver disease...
  46. ncbi Can dietary intake influence plasma levels of amino acids in liver cirrhosis?
    C Loguercio
    Interuniversity Research Centre on alimentary intake, Nutrition and Gastrointestinal Tract, Gastrointestinal School, Faculty of Medicine, 2nd University of Naples, Italy
    Dig Liver Dis 32:611-6. 2000
    ..Modifications in plasma amino acid patterns in cirrhotics are attributed to impaired liver function, being more evident in alcoholic than in viral cirrhosis...
  47. ncbi Alteration of haemostasis in non-metastatic gastric cancer
    P Di Micco
    Division of General Medicine and Hepatology, Second University of Naples, Italy
    Dig Liver Dis 33:546-50. 2001
    ..Cancer is one of the most common acquired causes of venous thromboembolism...
  48. ncbi Effects of selenium and zinc supplementation on nutritional status in patients with cancer of digestive tract
    A Federico
    Semeiotics and Clinical Methodology, II University of Naples, Naples, Italy
    Eur J Clin Nutr 55:293-7. 2001
    ..To evaluate the effect of oral administration of selenium and zinc tablets in patients with cancer of the digestive tract during chemotherapy...
  49. ncbi Gut-liver axis: a new point of attack to treat chronic liver damage?
    Carmela Loguercio
    Am J Gastroenterol 97:2144-6. 2002