Cristina Scielzo

Summary

Affiliation: San Raffaele Scientific Institute
Country: Italy

Publications

  1. doi How the microenvironment shapes chronic lymphocytic leukemia: the cytoskeleton connection
    Cristina Scielzo
    Unit of Lymphoid Malignancies, Division of Molecular Oncology, Istituto Scientifico San Raffaele, Milan, Italy
    Leuk Lymphoma 51:1371-4. 2010
  2. doi HS1 has a central role in the trafficking and homing of leukemic B cells
    Cristina Scielzo
    Unit of Lymphoid Malignancies, Division of Molecular Oncology, San Raffaele Scientific Institute, Via Olgettina 58, Milan, Italy
    Blood 116:3537-46. 2010
  3. doi Targeting the LYN/HS1 signaling axis in chronic lymphocytic leukemia
    Elisa ten Hacken
    Division of Molecular Oncology, Unit of Lymphoid Malignancies, San Raffaele Scientific Institute, Milan, Italy
    Blood 121:2264-73. 2013
  4. doi Targeting B-cell anergy in chronic lymphocytic leukemia
    Benedetta Apollonio
    Division of Molecular Oncology, San Raffaele Scientific Institute, Milano, Italy
    Blood 121:3879-88, S1-8. 2013
  5. pmc Establishment and Characterization of PCL12, a Novel CD5+ Chronic Lymphocytic Leukaemia Cell Line
    Andreas Agathangelidis
    IRCCS San Raffaele Scientific Institute, Division of Experimental Oncology, Unit of Lymphoid Malignancies, Milano, Italy IRCCS San Raffaele Scientific Institute, Division of Experimental Oncology, Unit of B Cell Neoplasia, Milano, Italy
    PLoS ONE 10:e0130195. 2015
  6. doi MicroRNA and proliferation control in chronic lymphocytic leukemia: functional relationship between miR-221/222 cluster and p27
    Michela Frenquelli
    Department of Oncology, Unit and Laboratory of Lymphoid Malignancies, San Raffaele Scientific Institute and Universita Vita Salute San Raffaele, Milan, Italy
    Blood 115:3949-59. 2010
  7. doi Constitutive activation of distinct BCR-signaling pathways in a subset of CLL patients: a molecular signature of anergy
    Marta Muzio
    Department of Oncology, Unit and Laboratory of Lymphoid Malignancies, Università Vita Salute San Raffaele and Istituto Scientifico San Raffaele, Milan, Italy
    Blood 112:188-95. 2008
  8. doi Targeting Macrophages Sensitizes Chronic Lymphocytic Leukemia to Apoptosis and Inhibits Disease Progression
    Giovanni Galletti
    Unit of Lymphoid Malignancies, Division of Experimental Oncology, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy Vita Salute San Raffaele University, 20132 Milan, Italy
    Cell Rep 14:1748-60. 2016
  9. doi General population low-count CLL-like MBL persists over time without clinical progression, although carrying the same cytogenetic abnormalities of CLL
    Claudia Fazi
    Laboratory of B Cell Neoplasia, Division of Molecular Oncology, Istituto Scientifico San Raffaele, Via Olgettina 60, Milan, Italy
    Blood 118:6618-25. 2011
  10. ncbi From normal to clonal B cells: Chronic lymphocytic leukemia (CLL) at the crossroad between neoplasia and autoimmunity
    Paolo Ghia
    Unit of Lymphoid Malignancies, Department of Oncology, Università Vita Salute San Raffaele and Istituto Scientifico San Raffaele, Milano, Italy
    Autoimmun Rev 7:127-31. 2007

Collaborators

Detail Information

Publications15

  1. doi How the microenvironment shapes chronic lymphocytic leukemia: the cytoskeleton connection
    Cristina Scielzo
    Unit of Lymphoid Malignancies, Division of Molecular Oncology, Istituto Scientifico San Raffaele, Milan, Italy
    Leuk Lymphoma 51:1371-4. 2010
    ..We hypothesize that hematopoietic cell-specific Lyn substrate 1 (HS1), a putative prognostic marker in CLL that interacts with distinct cytoskeleton adapters in leukemic B-lymphocytes, could regulate the CLL cell cytoskeleton...
  2. doi HS1 has a central role in the trafficking and homing of leukemic B cells
    Cristina Scielzo
    Unit of Lymphoid Malignancies, Division of Molecular Oncology, San Raffaele Scientific Institute, Via Olgettina 58, Milan, Italy
    Blood 116:3537-46. 2010
    ..These findings show that HS1 is a central regulator of cytoskeleton remodeling that controls lymphocyte trafficking and homing and significantly influences the tissue invasion and infiltration in CLL...
  3. doi Targeting the LYN/HS1 signaling axis in chronic lymphocytic leukemia
    Elisa ten Hacken
    Division of Molecular Oncology, Unit of Lymphoid Malignancies, San Raffaele Scientific Institute, Milan, Italy
    Blood 121:2264-73. 2013
    ..Thus LYN/HS1 axis marks distinct signaling profiles and cytoskeletal-related features that may represent valuable targets for cytoskeleton-targeted therapeutic intervention in CLL...
  4. doi Targeting B-cell anergy in chronic lymphocytic leukemia
    Benedetta Apollonio
    Division of Molecular Oncology, San Raffaele Scientific Institute, Milano, Italy
    Blood 121:3879-88, S1-8. 2013
    ....
  5. pmc Establishment and Characterization of PCL12, a Novel CD5+ Chronic Lymphocytic Leukaemia Cell Line
    Andreas Agathangelidis
    IRCCS San Raffaele Scientific Institute, Division of Experimental Oncology, Unit of Lymphoid Malignancies, Milano, Italy IRCCS San Raffaele Scientific Institute, Division of Experimental Oncology, Unit of B Cell Neoplasia, Milano, Italy
    PLoS ONE 10:e0130195. 2015
    ..Finally, they grow rapidly and localize in all lymphoid organs when xenotrasplanted in Rag2-/-γc-/- mice. PCL12 represents a suitable preclinical model for testing pharmacological agents. ..
  6. doi MicroRNA and proliferation control in chronic lymphocytic leukemia: functional relationship between miR-221/222 cluster and p27
    Michela Frenquelli
    Department of Oncology, Unit and Laboratory of Lymphoid Malignancies, San Raffaele Scientific Institute and Universita Vita Salute San Raffaele, Milan, Italy
    Blood 115:3949-59. 2010
    ..These data indicate that the miR-221/222 cluster modulates the expression of p27 protein in CLL cells and lead to suggest that miR-221/222 and p27 may represent a regulatory loop that helps maintaining CLL cells in a resting condition...
  7. doi Constitutive activation of distinct BCR-signaling pathways in a subset of CLL patients: a molecular signature of anergy
    Marta Muzio
    Department of Oncology, Unit and Laboratory of Lymphoid Malignancies, Università Vita Salute San Raffaele and Istituto Scientifico San Raffaele, Milan, Italy
    Blood 112:188-95. 2008
    ..CLL cases with this signature may be taken as a human model of anergic B cells aberrantly expanded...
  8. doi Targeting Macrophages Sensitizes Chronic Lymphocytic Leukemia to Apoptosis and Inhibits Disease Progression
    Giovanni Galletti
    Unit of Lymphoid Malignancies, Division of Experimental Oncology, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy Vita Salute San Raffaele University, 20132 Milan, Italy
    Cell Rep 14:1748-60. 2016
    ..These results establish the important role of macrophages in CLL and suggest therapeutic strategies based on interfering with leukemia-macrophage interactions. ..
  9. doi General population low-count CLL-like MBL persists over time without clinical progression, although carrying the same cytogenetic abnormalities of CLL
    Claudia Fazi
    Laboratory of B Cell Neoplasia, Division of Molecular Oncology, Istituto Scientifico San Raffaele, Via Olgettina 60, Milan, Italy
    Blood 118:6618-25. 2011
    ....
  10. ncbi From normal to clonal B cells: Chronic lymphocytic leukemia (CLL) at the crossroad between neoplasia and autoimmunity
    Paolo Ghia
    Unit of Lymphoid Malignancies, Department of Oncology, Università Vita Salute San Raffaele and Istituto Scientifico San Raffaele, Milano, Italy
    Autoimmun Rev 7:127-31. 2007
    ..The crucial issues have become to what extent this deleterious binding capacity is central to the natural history of the disease and how it relates to the malignant transformation of the cell...
  11. ncbi Age-dependent accumulation of monoclonal CD4+CD8+ double positive T lymphocytes in the peripheral blood of the elderly
    Paolo Ghia
    Laboratory and Unit of Lymphoid Malignancies, Department of Oncology, Universita Vita Salute San Raffaele, Milano and Istituto Scientifico San Raffaele, Milano, Italy
    Br J Haematol 139:780-90. 2007
    ..The similarities between DP clones and MBL in the elderly may help to better understand the mechanisms of immunosenescence and their relationships with the development of lymphoproliferative disorders...
  12. doi CLL-like monoclonal B-cell lymphocytosis: are we all bound to have it?
    Lydia Scarfo
    Laboratory of B Cell Neoplasia, Division of Molecular Oncology, San Raffaele Scientific Institute, Via Olgettina 58, Milan, Italy
    Semin Cancer Biol 20:384-90. 2010
    ....
  13. doi A novel Rag2-/-gammac-/--xenograft model of human CLL
    Maria Teresa Sabrina Bertilaccio
    Laboratory of Lymphoid Malignancies, Division of Molecular Oncology, Istituto Scientifico San Raffaele, Milan, Italy
    Blood 115:1605-9. 2010
    ..This model closely resembles aggressive human CLL and could be very useful for evaluating both the biologic basis of CLL growth and dissemination as well as the efficacy of new therapeutic agents...
  14. doi How the microenvironment wires the natural history of chronic lymphocytic leukemia
    Federico Caligaris-Cappio
    San Raffaele Scientific Institute, Division of Molecular Oncology, Unit of Lymphoid Malignancies, Milano, Italy Università Vita Salute San Raffaele, Milano, Italy Electronic address
    Semin Cancer Biol 24:43-8. 2014
    ..Conceivably the host of new non-genotoxic drugs that operate at the forefront between tumor cells and their milieu will modify the present therapeutic perspective by re-shaping the tumor cell/microenvironment cross talk. ..
  15. pmc HS1 protein is differentially expressed in chronic lymphocytic leukemia patient subsets with good or poor prognoses
    Cristina Scielzo
    Department of Oncology, Universita Vita e Salute San Raffaele, Milan, Italy
    J Clin Invest 115:1644-50. 2005
    ..These data indicate a central role for antigen stimulation in CLL and suggest a new therapeutic target for patients with aggressive disease...