Patrizia Rovere-Querini

Summary

Affiliation: San Raffaele Scientific Institute
Country: Italy

Publications

  1. ncbi request reprint Signals of cell death and tissue turnover during physiological pregnancy, pre-eclampsia, and autoimmunity
    Patrizia Rovere-Querini
    Clinical Immunology Unit, H San Raffaele Scientific Institute, Universita Vita Salute San Raffaele, Milano, Italy
    Autoimmunity 40:290-4. 2007
  2. ncbi request reprint Release of high mobility group box 1 by dendritic cells controls T cell activation via the receptor for advanced glycation end products
    Ingrid E Dumitriu
    Cancer Immunotherapy and Gene Therapy Program, Clinical Immunology Unit, H San Raffaele Scientific Institute, Milan, Italy
    J Immunol 174:7506-15. 2005
  3. ncbi request reprint TNF-alpha coupled to membrane of apoptotic cells favors the cross-priming to melanoma antigens
    Valerie S Zimmermann
    Cancer Immunotherapy and Gene Therapy Program, H San Raffaele Scientific Institute and San Raffaele Vita Salute University, Milano, Italy
    J Immunol 172:2643-50. 2004
  4. ncbi request reprint Requirement of HMGB1 and RAGE for the maturation of human plasmacytoid dendritic cells
    Ingrid E Dumitriu
    H San Raffaele Scientific Institute, Milan, Italy
    Eur J Immunol 35:2184-90. 2005
  5. ncbi request reprint HMGB1: guiding immunity from within
    Ingrid E Dumitriu
    Cancer Immunotherapy and Gene Therapy Program, Clinical Immunology Unit, H San Raffaele Scientific Institute, Via Olgettina 58, Milano 20132, Italy
    Trends Immunol 26:381-7. 2005
  6. ncbi request reprint Cell death: tipping the balance of autoimmunity and tissue repair
    Patrizia Rovere-Querini
    H San Raffaele Scientific Institute, 20132 Milano, Italy
    Curr Pharm Des 14:269-77. 2008
  7. ncbi request reprint The tissue pentraxin PTX3 limits C1q-mediated complement activation and phagocytosis of apoptotic cells by dendritic cells
    Paramita Baruah
    Clinical Immunology Unit, H San Raffaele Scientific Institute, Via Olgettina 58, Milano 20132, Italy
    J Leukoc Biol 80:87-95. 2006
  8. doi request reprint Inflammatory and alternatively activated human macrophages attract vessel-associated stem cells, relying on separate HMGB1- and MMP-9-dependent pathways
    Karine Lolmede
    Clinical Cardiovascular Biology Research Center, H San Raffaele Scientific Institute, Milano, Italy
    J Leukoc Biol 85:779-87. 2009
  9. doi request reprint Melanoma and lymphoma rejection associated with eosinophil infiltration upon intratumoral injection of dendritic and NK/LAK cells
    Annalisa Capobianco
    Department of Oncology, Cancer Immunotherapy and Gene Therapy Program, Clinical Immunology Unit, H San Raffaele Scientific Institute and Università Vita Salute San Raffaele, Milano, Italy
    J Immunother 31:458-65. 2008
  10. ncbi request reprint The secretion of HMGB1 is required for the migration of maturing dendritic cells
    Ingrid E Dumitriu
    Clinical Immunology Unit, H San Raffaele Scientific Institute and Università Vita Salute San Raffaele, Via Olgettina 58, Milano 20132, Italy
    J Leukoc Biol 81:84-91. 2007

Collaborators

Detail Information

Publications45

  1. ncbi request reprint Signals of cell death and tissue turnover during physiological pregnancy, pre-eclampsia, and autoimmunity
    Patrizia Rovere-Querini
    Clinical Immunology Unit, H San Raffaele Scientific Institute, Universita Vita Salute San Raffaele, Milano, Italy
    Autoimmunity 40:290-4. 2007
    ....
  2. ncbi request reprint Release of high mobility group box 1 by dendritic cells controls T cell activation via the receptor for advanced glycation end products
    Ingrid E Dumitriu
    Cancer Immunotherapy and Gene Therapy Program, Clinical Immunology Unit, H San Raffaele Scientific Institute, Milan, Italy
    J Immunol 174:7506-15. 2005
    ..The use of an ancient signal of necrosis, HMGB1, by dendritic cells to sustain their own maturation and for activation of T lymphocytes represents a profitable evolutionary mechanism...
  3. ncbi request reprint TNF-alpha coupled to membrane of apoptotic cells favors the cross-priming to melanoma antigens
    Valerie S Zimmermann
    Cancer Immunotherapy and Gene Therapy Program, H San Raffaele Scientific Institute and San Raffaele Vita Salute University, Milano, Italy
    J Immunol 172:2643-50. 2004
    ....
  4. ncbi request reprint Requirement of HMGB1 and RAGE for the maturation of human plasmacytoid dendritic cells
    Ingrid E Dumitriu
    H San Raffaele Scientific Institute, Milan, Italy
    Eur J Immunol 35:2184-90. 2005
    ..These results reveal HMGB1 and RAGE as the first known autocrine loop modulating the maturation of PDC, and suggest that antagonists of HMGB1/RAGE might have therapeutic potential for the treatment of systemic human diseases...
  5. ncbi request reprint HMGB1: guiding immunity from within
    Ingrid E Dumitriu
    Cancer Immunotherapy and Gene Therapy Program, Clinical Immunology Unit, H San Raffaele Scientific Institute, Via Olgettina 58, Milano 20132, Italy
    Trends Immunol 26:381-7. 2005
    ..The role of HMGB1 as an endogenous molecule that facilitates immune responses and has an important role in tissue homeostasis and disease will be highlighted here...
  6. ncbi request reprint Cell death: tipping the balance of autoimmunity and tissue repair
    Patrizia Rovere-Querini
    H San Raffaele Scientific Institute, 20132 Milano, Italy
    Curr Pharm Des 14:269-77. 2008
    ....
  7. ncbi request reprint The tissue pentraxin PTX3 limits C1q-mediated complement activation and phagocytosis of apoptotic cells by dendritic cells
    Paramita Baruah
    Clinical Immunology Unit, H San Raffaele Scientific Institute, Via Olgettina 58, Milano 20132, Italy
    J Leukoc Biol 80:87-95. 2006
    ....
  8. doi request reprint Inflammatory and alternatively activated human macrophages attract vessel-associated stem cells, relying on separate HMGB1- and MMP-9-dependent pathways
    Karine Lolmede
    Clinical Cardiovascular Biology Research Center, H San Raffaele Scientific Institute, Milano, Italy
    J Leukoc Biol 85:779-87. 2009
    ..Moreover, they open the possibility of novel strategies, aimed at interfering selectively with signals that recruit blood-derived stem cells toward pro- or anti-inflammatory macrophages...
  9. doi request reprint Melanoma and lymphoma rejection associated with eosinophil infiltration upon intratumoral injection of dendritic and NK/LAK cells
    Annalisa Capobianco
    Department of Oncology, Cancer Immunotherapy and Gene Therapy Program, Clinical Immunology Unit, H San Raffaele Scientific Institute and Università Vita Salute San Raffaele, Milano, Italy
    J Immunother 31:458-65. 2008
    ..The response associated to the preferential recruitment within tumors of eosinophils. The simultaneous injection in solid tumors of DCs and NK/LAK cells represents an attractive approach for antineoplastic immunotherapeutic strategies...
  10. ncbi request reprint The secretion of HMGB1 is required for the migration of maturing dendritic cells
    Ingrid E Dumitriu
    Clinical Immunology Unit, H San Raffaele Scientific Institute and Università Vita Salute San Raffaele, Via Olgettina 58, Milano 20132, Italy
    J Leukoc Biol 81:84-91. 2007
    ..Our data suggest that the autocrine/paracrine release of HMGB1 and the integrity of the HMGB1/RAGE pathway are required for the migratory function of DC...
  11. doi request reprint Redox remodeling: a candidate regulator of HMGB1 function in injured skeletal muscle
    Michela Vezzoli
    Innate Immunity and Tissue Remodeling Unit, San Raffaele Scientific Institute, Milano, Italy
    Ann N Y Acad Sci 1209:83-90. 2010
    ..Moreover, data suggest a potential role for infiltrating alternatively activated macrophages to influence the outcome of inflammatory responses to sterile skeletal muscle necrosis...
  12. pmc Magnetic resonance imaging at 7T reveals common events in age-related sarcopenia and in the homeostatic response to muscle sterile injury
    Antonio Esposito
    Department of Radiology and Preclinical MR and US Facility of Experimental Imaging Center, San Raffaele Scientific Institute, Milano, Italy
    PLoS ONE 8:e59308. 2013
    ..A. as common events reflecting inflammatory infiltration and muscle regeneration in the transient response of the tissue to acute injury and in the persistent adaptation to aging...
  13. ncbi request reprint Plasma and tissue expression of the long pentraxin 3 during normal pregnancy and preeclampsia
    Patrizia Rovere-Querini
    Clinical Immunology Unit, Division of Pathology, H San Raffaele Scientific Institute and Università Vita Salute San Raffaele, Milano, Italy
    Obstet Gynecol 108:148-55. 2006
    ..We examined whether PTX3 is expressed during pregnancy and possibly involved in the development of preeclampsia...
  14. pmc Inhibition of phosphatidylserine recognition heightens the immunogenicity of irradiated lymphoma cells in vivo
    Attilio Bondanza
    Clinical Immunology Unit, Cancer Immunotherapy and Gene Therapy Program, H San Raffaele Institute, DIBIT 3A1, Via Olgettina 58, 20132 Milano, Italy
    J Exp Med 200:1157-65. 2004
    ..Finally, AxV-coupled irradiated cells induced the regression of growing tumors. These data indicate that endogenous adjuvants that bind to dying tumor cells can be exploited to target tumors for immune rejection...
  15. doi request reprint Oxidative stress elicits platelet/leukocyte inflammatory interactions via HMGB1: a candidate for microvessel injury in sytemic sclerosis
    Norma Maugeri
    1 Division of Regenerative Medicine, Stem Cells and Gene Therapy, and Department of Medicine, San Raffaele Scientific Institute, Milano, Italy
    Antioxid Redox Signal 20:1060-74. 2014
    ..Here we investigate whether oxidative stress regulates the cross-talk between leukocytes and platelets via HMGB1, thus contributing to vessel inflammation in SSc...
  16. ncbi request reprint Requirement for dendritic cells in the establishment of anti-phospholipid antibodies
    Attilio Bondanza
    H San Raffaele Scientific Institute, Universita Vita Salute, Milano, Italy
    Autoimmunity 40:302-6. 2007
    ..Little is known about the regulation of the immune response against soluble autoantigens targeted in these diseases...
  17. ncbi request reprint Maturing dendritic cells depend on RAGE for in vivo homing to lymph nodes
    Angelo A Manfredi
    Clinical Immunology Unit, H San Raffaele Scientific Institute and Università Vita Salute San Raffaele, Via Olgettina 48, Milan, Italy
    J Immunol 180:2270-5. 2008
    ..Thus the HMGB1-RAGE pathway is a checkpoint in DC maturation and function and a candidate for targeted therapies...
  18. ncbi request reprint Nitric oxide boosts chemoimmunotherapy via inhibition of acid sphingomyelinase in a mouse model of melanoma
    Cristiana Perrotta
    H San Raffaele Scientific Institute, Italy
    Cancer Res 67:7559-64. 2007
    ....
  19. pmc Leukocytes recruited by tumor-derived HMGB1 sustain peritoneal carcinomatosis
    Lucia Cottone
    Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, Milano, Italy Vita Salute San Raffaele University, School of Medicine, Milano, Italy
    Oncoimmunology 5:e1122860. 2016
    ..Our findings provide a preclinical proof of principle that strategies based on preventing HMGB1-driven recruitment of leukocytes could be used for treating peritoneal carcinomatosis. ..
  20. doi request reprint Anti-TNFα agents curb platelet activation in patients with rheumatoid arthritis
    Angelo A Manfredi
    Università Vita Salute San Raffaele and IRCCS San Raffaele Scientific Institute, Milano, Italy
    Ann Rheum Dis 75:1511-20. 2016
    ..We investigated whether (1) TNFα activates human platelets and (2) TNFα pharmacological blockade modulates the platelet-leucocyte reciprocal activation in RA...
  21. ncbi request reprint Innate responses to Aspergillus: role of C1q and pentraxin 3 in nasal polyposis
    Paramita Baruah
    Cancer Immunotherapy and Gene Therapy Program, Clinical Immunology Unit, H San Raffaele Scientific Institute, Via Olgettina 58, Milano, Italy
    Am J Rhinol 21:224-30. 2007
    ....
  22. doi request reprint Requirement of HMGB1 for stromal cell-derived factor-1/CXCL12-dependent migration of macrophages and dendritic cells
    Lara Campana
    Innate Immunity and Tissue Remodeling Unit, H San Raffaele Scientific Institute, Milano 20132, Italy
    J Leukoc Biol 86:609-15. 2009
    ....
  23. ncbi request reprint Melanoma cells interfere with the interaction of dendritic cells with NK/LAK cells
    Annalisa Capobianco
    Department of Oncology, Cancer Immunotherapy and Gene Therapy Program, Clinical Immunology Unit, H San Raffaele Scientific Institute and Vita Salute San Raffaele University, Milano, Italy
    Int J Cancer 119:2861-9. 2006
    ..Interference with the NK/DC interaction possibly represents a mechanism used by growing tumors to evade the immune response...
  24. pmc The clearance of cell remnants and the regeneration of the injured muscle depend on soluble pattern recognition receptor PTX3
    Michela Vezzoli
    Division of Immunology, Transplantation and Infectious Disease, San Raffaele Scientific Institute, Milano, Italy
    Mol Med 22:. 2016
    ..The signals causing the resolution of muscle inflammation are only partially characterized. The long pentraxin PTX3, which modulates leukocyte recruitment and activation, could contribute...
  25. doi request reprint 5-Fluorouracil causes leukocytes attraction in the peritoneal cavity by activating autophagy and HMGB1 release in colon carcinoma cells
    Lucia Cottone
    Division of Regenerative Medicine, San Raffaele Scientific Institute, Milano, Italy School of Medicine, Vita Salute San Raffaele University, Milano, Italy
    Int J Cancer 136:1381-9. 2015
    ..Our results identify autophagy induction and HMGB1 release in colon carcinoma cells as key events responsible for 5-FU elicited leukocyte attraction and define a novel rate-limiting target for combinatorial therapies. ..
  26. ncbi request reprint Characterisation of functional biotinylated TNF-alpha targeted to the membrane of apoptotic melanoma cells
    Valerie S Zimmermann
    Cancer Immunotherapy and Gene Therapy Programme, H San Raffaele Scientific Institute, Via Olgettina 58, 20132, Milan, Italy
    J Immunol Methods 276:79-87. 2003
    ..Therefore the bridging of TNF-alpha potentiates its biological function and influences the outcome of the phagocytic clearance of apoptotic tumor cells...
  27. doi request reprint Adjuvant role for cell death during chemo- and radiotherapy of cancer?
    Patrizia Rovere-Querini
    Laboratory of Clinical Immunology, San Raffaele Scientific Institute, DIBIT 3A1, Via Olgettina 58, 20132 Milano, Italy
    Expert Rev Clin Immunol 4:27-32. 2008
    ..Larger studies on various therapeutic regimens are needed to evaluate the general relevance of this observation...
  28. doi request reprint The immune system and the repair of skeletal muscle
    Silvia Brunelli
    Stem Cell Research Institute, San Raffaele Scientific Institute, DIBIT, Via Olgettina 58, 20132 Milano, Italy
    Pharmacol Res 58:117-21. 2008
    ....
  29. ncbi request reprint Neuroendocrine modulation induced by selective blockade of TNF-alpha in rheumatoid arthritis
    Gabriele Di Comite
    Clinical Immunology and Rheumatology Unit, CIGTP, H San Raffaele Scientific Institute DIBIT and Vita Salute University, 3A1 Lab 3, Via Olgettina 58, 20132 Milan, Italy
    Ann N Y Acad Sci 1069:428-37. 2006
    ....
  30. ncbi request reprint Environmental adjuvants, apoptosis and the censorship over autoimmunity
    Patrizia Rovere-Querini
    H San Raffaele Scientific Institute and Vita Salute San Raffaele University, DIBIT 3A1, Via Olgettina 58, 20132 Milano, Italy
    Autoimmun Rev 4:555-60. 2005
    ..Novel tools for drug development will derive from the molecular identification of the constraints that prevent autoimmunity in normal subjects...
  31. pmc Disruption of a Regulatory Network Consisting of Neutrophils and Platelets Fosters Persisting Inflammation in Rheumatic Diseases
    Norma Maugeri
    San Raffaele Scientific Institute, Universita Vita Salute San Raffaele, Milano, Italy
    Front Immunol 7:182. 2016
    ..HMGB1 could represent a player in the pathogenesis of rheumatic diseases and an attractive target for molecular interventions. ..
  32. ncbi request reprint Cutting edge: dissociation between autoimmune response and clinical disease after vaccination with dendritic cells
    Attilio Bondanza
    Cancer Immunotherapy and Gene Therapy Program, Clinical Immunology and Rheumatology Unit, H San Raffaele Scientific Institute, and Universita Vita Salute San Raffaele, Milan, Italy
    J Immunol 170:24-7. 2003
    ..The data suggest that DC vaccination consistently triggers autoimmune responses. However, clinical autoimmunity develops in susceptible subjects only...
  33. pmc An intense and short-lasting burst of neutrophil activation differentiates early acute myocardial infarction from systemic inflammatory syndromes
    Norma Maugeri
    Università Vita Salute San Raffaele and San Raffaele Scientific Institute, Milano, Italy
    PLoS ONE 7:e39484. 2012
    ..Neutrophils are involved in thrombus formation. We investigated whether specific features of neutrophil activation characterize patients with acute coronary syndromes (ACS) compared to stable angina and to systemic inflammatory diseases...
  34. pmc The role of platelets in the pathogenesis of systemic sclerosis
    Giuseppe A Ramirez
    Department of Immunology, San Raffaele Scientific Institute, Universita Vita Salute San Raffaele, Milano, Italy
    Front Immunol 3:160. 2012
    ..As a consistent circulating source of bioactive compounds platelets contribute to the development of many characteristic phenomena of SSc, such as fibrosis and impaired vascular tone...
  35. ncbi request reprint Tumor destruction and in situ delivery of antigen presenting cells promote anti-neoplastic immune responses: implications for the immunotherapy of pancreatic cancer
    Patrizia Rovere-Querini
    Cancer Immunotherapy and Gene Therapy Program, Clinical Immunology Unit, H San Raffaele Scientific Institute and Vita Salute San Raffaele University Milan, Italy
    JOP 5:308-14. 2004
    ....
  36. ncbi request reprint Requirement of dying cells and environmental adjuvants for the induction of autoimmunity
    Attilio Bondanza
    H San Raffaele Scientific Institute and University, Via Olgettina 58, Milan 20132, Italy
    Arthritis Rheum 50:1549-60. 2004
    ..However, dying cells are a potential initiating stimulus for systemic lupus erythematosus (SLE). Our goal was to verify whether immune adjuvants influence the autoimmunity induction that ensues following in vivo injection of dying cells...
  37. ncbi request reprint Dendritic cells and the shadow line between autoimmunity and disease
    Angelo A Manfredi
    Arthritis Rheum 52:11-5. 2005
  38. ncbi request reprint Conversation galante: how the immune and the neuroendocrine systems talk to each other
    Gabriele Di Comite
    H San Raffaele Scientific Institute and Università Vita Salute San Raffaele, Via Olgettina 58, 20132 Milano, Italy
    Autoimmun Rev 7:23-9. 2007
    ..A better molecular dissection of this finely regulated inter-system cross-talk, in physiological conditions and during self-sustaining inflammatory diseases, might enable more rational therapeutic approaches...
  39. ncbi request reprint Activation of acid sphingomyelinase and its inhibition by the nitric oxide/cyclic guanosine 3',5'-monophosphate pathway: key events in Escherichia coli-elicited apoptosis of dendritic cells
    Sestina Falcone
    Vita Salute University and Stem Cell Research Institute, San Raffaele, Milan, Italy
    J Immunol 173:4452-63. 2004
    ..Thus, A-SMase plays a central role in E. coli/LPS-induced DC apoptosis and its inhibition by NO, and it might be a target of new therapeutic approaches to sepsis...
  40. ncbi request reprint The pattern recognition receptor PTX3 is recruited at the synapse between dying and dendritic cells, and edits the cross-presentation of self, viral, and tumor antigens
    Paramita Baruah
    Cancer Immunotherapy and Gene Therapy Program, H San Raffaele Institute, Milan, Italy
    Blood 107:151-8. 2006
    ..These data suggest that PTX3 acts as a third-party agent between microbial stimuli and dying cells, contributing to limit tissue damage under inflammatory conditions and the activation of autoreactive T cells...
  41. doi request reprint Human recombinant heat shock protein 70 affects the maturation pathways of dendritic cells in vitro and has an in vivo adjuvant activity
    Barbara Valentinis
    MolMed S p A, Via Olgettina 58, 20132 Milan, Italy
    J Leukoc Biol 84:199-206. 2008
    ..No activation of p38 was induced in the same experimental conditions. Our data suggest that the IkappaB-alpha/NF-kappaB pathway has a critical role in the partial maturation of DCs induced by rHSP70...
  42. pmc HMGB1 is an endogenous immune adjuvant released by necrotic cells
    Patrizia Rovere-Querini
    Cancer Immunotherapy and Gene Therapy Program, Clinical Immunology Unit H San Raffaele Scientific Institute and Vita Salute San Raffaele University, DIBIT 3A1, Chromatin Dynamics Unit, Via Olgettina 58, 20132 Milano, Italy
    EMBO Rep 5:825-30. 2004
    ..In vivo, HMGB1 enhances the primary antibody responses to soluble antigens and transforms poorly immunogenic apoptotic lymphoma cells into efficient vaccines...
  43. ncbi request reprint The prototypic tissue pentraxin PTX3, in contrast to the short pentraxin serum amyloid P, inhibits phagocytosis of late apoptotic neutrophils by macrophages
    Andre P van Rossum
    University Hospital Groningen, Groningen, The Netherlands
    Arthritis Rheum 50:2667-74. 2004
    ..We undertook this study to test our hypothesis that PTX3 inhibits phagocytosis of late apoptotic PMNs by macrophages, thereby leading to their accumulation in the vessel wall...
  44. ncbi request reprint Nitric oxide confers therapeutic activity to dendritic cells in a mouse model of melanoma
    Cristiana Perrotta
    Department of Pharmaco Biology, University of Calabria, Rende
    Cancer Res 64:3767-71. 2004
    ..All of the effects of DETA-NO were mediated through cGMP generation. NO and NO-generating drugs may therefore be used to increase the anticancer efficacy of DCs...
  45. ncbi request reprint Synergism of nitric oxide and maturation signals on human dendritic cells occurs through a cyclic GMP-dependent pathway
    Clara Paolucci
    Department Neuroscience, DIBIT H San Raffaele Institute, Via Olgettina 58, 20132 Milan, Italy
    J Leukoc Biol 73:253-62. 2003
    ..These results provide the first evidence that NO acts as a cosignaling molecule regulating human DC response to maturation stimuli...