Sara Poletti

Summary

Affiliation: San Raffaele Scientific Institute
Country: Italy

Publications

  1. doi request reprint Th17 cells correlate positively to the structural and functional integrity of the brain in bipolar depression and healthy controls
    Sara Poletti
    Department of Clinical Neurosciences, Scientific Institute Ospedale San Raffaele, Milano, Italy C E R M A C Centro di Eccellenza Risonanza Magnetica ad Alto Campo, University Vita Salute San Raffaele, Milano, Italy Electronic address
    Brain Behav Immun . 2016
  2. doi request reprint Brain-derived Neurotrophic Factor (BDNF) and gray matter volume in bipolar disorder
    S Poletti
    Department of Clinical Neurosciences, CERMAC Centro di Eccellenza Risonanza Magnetica ad Alto Campo, Scientific Institute, University Vita Salute San Raffaele, Milan, Italy Department of Immunology, Erasmus University Medical Centre, Rotterdam, The Netherlands Electronic address
    Eur Psychiatry 40:33-37. 2016
  3. doi request reprint SREBF-2 polymorphism influences white matter microstructure in bipolar disorder
    Sara Poletti
    Scientific Institute and University Vita Salute San Raffaele, Department of Clinical Neurosciences, Milan, Italy C E R M A C Centro di Eccellenza Risonanza Magnetica ad Alto Campo, University Vita Salute San Raffaele, Milan, Italy Electronic address
    Psychiatry Res 257:39-46. 2016
  4. ncbi request reprint Kynurenine pathway and white matter microstructure in bipolar disorder
    Sara Poletti
    Department of Clinical Neurosciences, San Raffaele Turro, Istituto Scientifico Ospedale San Raffaele, University Vita Salute San Raffaele, Via Stamira d Ancona 20, Milan, Italy
    Eur Arch Psychiatry Clin Neurosci . 2016
  5. doi request reprint Adverse childhood experiences associate to reduced glutamate levels in the hippocampus of patients affected by mood disorders
    Sara Poletti
    Department of Clinical Neurosciences, Scientific Institute Ospedale San Raffaele, Milano, Italy C E R M A C Centro di Eccellenza Risonanza Magnetica ad Alto Campo, University Vita Salute San Raffaele, Milano, Italy Electronic address
    Prog Neuropsychopharmacol Biol Psychiatry 71:117-22. 2016
  6. doi request reprint Adverse childhood experiences influence the detrimental effect of bipolar disorder and schizophrenia on cortico-limbic grey matter volumes
    Sara Poletti
    Scientific Institute and University Vita Salute San Raffaele, Department of Clinical Neurosciences, Milan, Italy C E R M A C Centro di Eccellenza Risonanza Magnetica ad Alto Campo, University Vita Salute San Raffaele, Milan, Italy Electronic address
    J Affect Disord 189:290-7. 2016
  7. doi request reprint Adverse childhood experiences influence white matter microstructure in patients with schizophrenia
    Sara Poletti
    Department of Clinical Neurosciences, Scientific Institute Ospedale San Raffaele, Milan, Italy C E R M A C Centro di Eccellenza Risonanza Magnetica ad Alto Campo, University Vita Salute San Raffaele, Milan, Italy Electronic address
    Psychiatry Res 234:35-43. 2015
  8. doi request reprint Neural correlates of anxiety sensitivity in panic disorder: A functional magnetic resonance imaging study
    Sara Poletti
    Department of Clinical Neurosciences, Scientific Institute and University Vita Salute San Raffaele, Milan, Italy C E R M A C Centro di Eccellenza Risonanza Magnetica ad Alto Campo, University Vita Salute San Raffaele, Milan, Italy Electronic address
    Psychiatry Res 233:95-101. 2015
  9. doi request reprint Cognitive performances associate with measures of white matter integrity in bipolar disorder
    Sara Poletti
    Scientific Institute and University Vita Salute San Raffaele, Department of Clinical Neurosciences, Via Stamira d Ancona 20, San Raffaele Turro Milan, Italy Electronic address
    J Affect Disord 174:342-52. 2015
  10. doi request reprint Adverse childhood experiences worsen cognitive distortion during adult bipolar depression
    Sara Poletti
    Scientific Institute and University Vita Salute San Raffaele, Department of Clinical Neurosciences, Milan, Italy Electronic address
    Compr Psychiatry 55:1803-8. 2014

Detail Information

Publications43

  1. doi request reprint Th17 cells correlate positively to the structural and functional integrity of the brain in bipolar depression and healthy controls
    Sara Poletti
    Department of Clinical Neurosciences, Scientific Institute Ospedale San Raffaele, Milano, Italy C E R M A C Centro di Eccellenza Risonanza Magnetica ad Alto Campo, University Vita Salute San Raffaele, Milano, Italy Electronic address
    Brain Behav Immun . 2016
    ..Since the CCL20-CCR6 axis is an important entry to the brain we differentiated the various T helper cell subpopulations on the basis of their chemokine receptor expression...
  2. doi request reprint Brain-derived Neurotrophic Factor (BDNF) and gray matter volume in bipolar disorder
    S Poletti
    Department of Clinical Neurosciences, CERMAC Centro di Eccellenza Risonanza Magnetica ad Alto Campo, Scientific Institute, University Vita Salute San Raffaele, Milan, Italy Department of Immunology, Erasmus University Medical Centre, Rotterdam, The Netherlands Electronic address
    Eur Psychiatry 40:33-37. 2016
    ..The aim of our study was to investigate if serum levels of BDNF are associated with GM volumes in BD patients and healthy controls (HC)...
  3. doi request reprint SREBF-2 polymorphism influences white matter microstructure in bipolar disorder
    Sara Poletti
    Scientific Institute and University Vita Salute San Raffaele, Department of Clinical Neurosciences, Milan, Italy C E R M A C Centro di Eccellenza Risonanza Magnetica ad Alto Campo, University Vita Salute San Raffaele, Milan, Italy Electronic address
    Psychiatry Res 257:39-46. 2016
    ..These results seem to suggest an involvement of SREBF-2 in the integrity of white matter tracts in BD and therefore a possible role of SREBP pathway in CNS myelination processes...
  4. ncbi request reprint Kynurenine pathway and white matter microstructure in bipolar disorder
    Sara Poletti
    Department of Clinical Neurosciences, San Raffaele Turro, Istituto Scientifico Ospedale San Raffaele, University Vita Salute San Raffaele, Via Stamira d Ancona 20, Milan, Italy
    Eur Arch Psychiatry Clin Neurosci . 2016
    ..Reduced levels of these metabolites in BD thus seem to confirm a crucial role of serotonin turnover in BD pathophysiology...
  5. doi request reprint Adverse childhood experiences associate to reduced glutamate levels in the hippocampus of patients affected by mood disorders
    Sara Poletti
    Department of Clinical Neurosciences, Scientific Institute Ospedale San Raffaele, Milano, Italy C E R M A C Centro di Eccellenza Risonanza Magnetica ad Alto Campo, University Vita Salute San Raffaele, Milano, Italy Electronic address
    Prog Neuropsychopharmacol Biol Psychiatry 71:117-22. 2016
    ..Abnormalities of glutamatergic signaling could then possibly underpin the structural and functional abnormalities observed in patients affected by mood disorders. ..
  6. doi request reprint Adverse childhood experiences influence the detrimental effect of bipolar disorder and schizophrenia on cortico-limbic grey matter volumes
    Sara Poletti
    Scientific Institute and University Vita Salute San Raffaele, Department of Clinical Neurosciences, Milan, Italy C E R M A C Centro di Eccellenza Risonanza Magnetica ad Alto Campo, University Vita Salute San Raffaele, Milan, Italy Electronic address
    J Affect Disord 189:290-7. 2016
    ..The aim of this study is to measure the effect of diagnosis and ACE on GM volume in a sample of patients with BD or SCZ compared with healthy controls (HC)...
  7. doi request reprint Adverse childhood experiences influence white matter microstructure in patients with schizophrenia
    Sara Poletti
    Department of Clinical Neurosciences, Scientific Institute Ospedale San Raffaele, Milan, Italy C E R M A C Centro di Eccellenza Risonanza Magnetica ad Alto Campo, University Vita Salute San Raffaele, Milan, Italy Electronic address
    Psychiatry Res 234:35-43. 2015
    ....
  8. doi request reprint Neural correlates of anxiety sensitivity in panic disorder: A functional magnetic resonance imaging study
    Sara Poletti
    Department of Clinical Neurosciences, Scientific Institute and University Vita Salute San Raffaele, Milan, Italy C E R M A C Centro di Eccellenza Risonanza Magnetica ad Alto Campo, University Vita Salute San Raffaele, Milan, Italy Electronic address
    Psychiatry Res 233:95-101. 2015
    ..Our data seem to confirm that anxiety sensitivity is an important component of panic disorder. Accordingly, the neural underpinnings of anxiety sensitivity could be an interesting focus for treatment and further research. ..
  9. doi request reprint Cognitive performances associate with measures of white matter integrity in bipolar disorder
    Sara Poletti
    Scientific Institute and University Vita Salute San Raffaele, Department of Clinical Neurosciences, Via Stamira d Ancona 20, San Raffaele Turro Milan, Italy Electronic address
    J Affect Disord 174:342-52. 2015
    ..We hypothesized that neuropsychological performances could correlate with WM integrity in a sample of bipolar patients in core WM tracts...
  10. doi request reprint Adverse childhood experiences worsen cognitive distortion during adult bipolar depression
    Sara Poletti
    Scientific Institute and University Vita Salute San Raffaele, Department of Clinical Neurosciences, Milan, Italy Electronic address
    Compr Psychiatry 55:1803-8. 2014
    ..Nevertheless, little research has been carried out on possible associations between adverse childhood experiences (ACEs) and cognitive distortion, and whether any gender differences exist...
  11. doi request reprint Effect of glutamate transporter EAAT2 gene variants and gray matter deficits on working memory in schizophrenia
    S Poletti
    Department of Clinical Neurosciences, Scientific Institute and University Vita Salute San Raffaele, Milan, Italy Centro di Eccellenza Risonanza Magnetica ad Alto Campo CERMAC, University Vita Salute San Raffaele, Milan, Italy Electronic address
    Eur Psychiatry 29:219-25. 2014
    ..The differential effect of EAAT2 observed between good and poor performers suggests that the effect of EEAT2 on gray matter might reveal in the presence of a pathological process affecting gray matter. ..
  12. doi request reprint Effect of early stress on hippocampal gray matter is influenced by a functional polymorphism in EAAT2 in bipolar disorder
    Sara Poletti
    Department of Clinical Neurosciences, Scientific Institute and University Vita Salute San Raffaele, Milan, Italy Electronic address
    Prog Neuropsychopharmacol Biol Psychiatry 51:146-52. 2014
    ....
  13. doi request reprint Neuropsychological deficits in bipolar depression persist after successful antidepressant treatment
    Sara Poletti
    Scientific Institute and University Vita Salute San Raffaele Turro, Department of Clinical Neurosciences, Stamira d Ancona 20, Milano, Italy Electronic address
    J Affect Disord 156:144-9. 2014
    ....
  14. doi request reprint Catechol-O-methyltransferase (COMT) genotype biases neural correlates of empathy and perceived personal distress in schizophrenia
    Sara Poletti
    Department of Clinical Neurosciences, San Raffaele Scientific Institute and University Vita Salute, Milan, Italy
    Compr Psychiatry 54:181-6. 2013
    ..Empathy is an essential element of human behavior, requires the ability to adopt another person's perspective, and has been found to be dysfunctional in schizophrenia...
  15. doi request reprint Computer-aided neurocognitive remediation in schizophrenia: durability of rehabilitation outcomes in a follow-up study
    Sara Poletti
    CERMAC Centro di Eccellenza Risonanza Magnetica ad Alto Campo, University Vita Salute San Raffaele, Milan, Italy
    Neuropsychol Rehabil 20:659-74. 2010
    ..In conclusion improvements in cognitive functions and daily functioning achieved through the association of CRT and standard rehabilitation treatment persist over time after the conclusion of the training period...
  16. doi request reprint Self-awareness of cognitive functioning in schizophrenia: patients and their relatives
    Sara Poletti
    Department of Clinical Neurosciences, Scientific Institute and University Vita Salute San Raffaele, Milan, Italy
    Psychiatry Res 198:207-11. 2012
    ..When both patients and relatives are unaware of the patients' cognitive deficits, this could affect adherence to remediation treatment and need to be specifically addressed in future rehabilitation strategies...
  17. doi request reprint Computer-aided neurocognitive remediation as an enhancing strategy for schizophrenia rehabilitation
    Roberto Cavallaro
    Department of Clinical Neurosciences, San Raffaele Universitary Scientific Institute Hospital, Vita Salute San Raffaele University, Milano, Italy
    Psychiatry Res 169:191-6. 2009
    ..Results confirmed that cognitive remediation added to the SRT of schizophrenia enhanced its neuropsychological effects and increased the effects of a long-term rehabilitation programme in terms of functional outcomes...
  18. doi request reprint Functional and structural brain correlates of theory of mind and empathy deficits in schizophrenia
    Francesco Benedetti
    Department of Clinical Neurosciences, Scientific Institute and University Vita Salute San Raffaele, Milan, Italy
    Schizophr Res 114:154-60. 2009
    ..Brain imaging studies suggested that ToM and Emp depend on the activation of brain networks mainly localized at the superior temporal lobe and temporo-parietal junction...
  19. pmc Lithium and GSK3-β promoter gene variants influence white matter microstructure in bipolar disorder
    Francesco Benedetti
    Istituto Scientifico Ospedale San Raffaele, Department of Clinical Neurosciences, Scientific Institute and University Vita Salute, San Raffaele Turro, Milan, Italy
    Neuropsychopharmacology 38:313-27. 2013
    ....
  20. doi request reprint Gene-gene interaction of glycogen synthase kinase 3-β and serotonin transporter on human antidepressant response to sleep deprivation
    Francesco Benedetti
    Department of Clinical Neurosciences, Scientific Institute San Raffaele and University Vita Salute, Milano, Italy
    J Affect Disord 136:514-9. 2012
    ..In animals the knockout of GSK3-β counteracts the depressive-like behavioral effects of 5-HT inhibition...
  21. doi request reprint Lithium and GSK-3β promoter gene variants influence cortical gray matter volumes in bipolar disorder
    Francesco Benedetti
    Department of Clinical Neurosciences, Scientific Institute and University Vita Salute San Raffaele, Milan, Italy
    Psychopharmacology (Berl) 232:1325-36. 2015
    ..GSK-3β gene variants and lithium can influence brain gray and white matter structure in psychiatric conditions, so we studied their combined effect in BD...
  22. doi request reprint Rapid treatment response of suicidal symptoms to lithium, sleep deprivation, and light therapy (chronotherapeutics) in drug-resistant bipolar depression
    Francesco Benedetti
    Istituto Scientifico Universitario Ospedale San Raffaele, Dipartimento di Neuroscienze Cliniche, San Raffaele Turro, Via Stamira d Ancona 20, 20127 Milan, Italy
    J Clin Psychiatry 75:133-40. 2014
    ..The efficacy of antidepressants on suicidality has been questioned. Total sleep deprivation and light therapy prompt a rapid and stable antidepressant response in bipolar disorder...
  23. doi request reprint Association of the C(-1019)G 5-HT1A promoter polymorphism with exposure to stressors preceding hospitalization for bipolar depression
    Francesco Benedetti
    Department of Clinical Neurosciences, San Raffaele Scientific Institute and University Vita Salute, Milan, Italy
    J Affect Disord 132:297-300. 2011
    ..In humans, the G variant of the C(-1019)G 5-HT1A receptor promoter gene polymorphism (rs6295) has been associated with higher expression of 5-HT1A receptors, increased depression, and lower stress preceding completed suicide...
  24. doi request reprint Stem Cell Factor (SCF) is a putative biomarker of antidepressant response
    Francesco Benedetti
    Department of Clinical Neurosciences, Scientific Institute Ospedale San Raffaele, 20127, San Raffaele Turro, Via Stamira d Ancona 20, Milan, Italy
    J Neuroimmune Pharmacol 11:248-58. 2016
    ..SCF may be a candidate growth factor that contributes to neurotrophic and immune effects that are involved in the process of remission/recovery from depression. ..
  25. doi request reprint Influence of an interaction between lithium salts and a functional polymorphism in SLC1A2 on the history of illness in bipolar disorder
    Sara Dallaspezia
    Department of Clinical Neurosciences, Istituto Scientifico Ospedale San Raffaele, San Raffaele Turro, Milan, Italy
    Mol Diagn Ther 16:303-9. 2012
    ..This T-to-G (DNA forward strand) polymorphism, commonly known as SLC1A2 -181A>C, affects transporter expression, with the variant G allele inducing a 30% reduction in promoter activity compared with the T allele...
  26. doi request reprint The Brief Assessment of Cognition in Schizophrenia. Normative data for the Italian population
    Simona Anselmetti
    Department of Clinical Neurosciences, Vita Salute San Raffaele University Scientific Hospital, Via Stamira d Ancona 20, 20127, Milan, Italy
    Neurol Sci 29:85-92. 2008
    ..To provide normative values for the Italian population for the Brief Assessment of Cognition in Schizophrenia (BACS), a recent brief neuropsychological instrument for the assessment of cognition in patients with schizophrenia...
  27. doi request reprint Widespread changes of white matter microstructure in obsessive-compulsive disorder: effect of drug status
    Francesco Benedetti
    Department of Clinical Neurosciences, Scientific Institute and University Vita Salute San Raffaele, Milano, Italy
    Eur Neuropsychopharmacol 23:581-93. 2013
    ..Changes of DTI measures in drug-treated OCD patients could reflect pathophysiological underpinnings of OCD, or a yet unexplored part of the mechanism of action of drugs...
  28. doi request reprint Tract-specific white matter structural disruption in patients with bipolar disorder
    Francesco Benedetti
    Department of Clinical Neurosciences, Scientific Institute and University Vita Salute San Raffaele, Milano, Italy
    Bipolar Disord 13:414-24. 2011
    ....
  29. ncbi request reprint Influence of catechol-O-methyltransferase Val158Met polymorphism on neuropsychological and functional outcomes of classical rehabilitation and cognitive remediation in schizophrenia
    Marta Bosia
    Department of Neuropsychiatric Sciences, San Raffaele Universitary Scientific Institute Hospital, Vita Salute San Raffaele University, Milano, Italy
    Neurosci Lett 417:271-4. 2007
    ....
  30. ncbi request reprint Clock genes associate with white matter integrity in depressed bipolar patients
    Irene Bollettini
    a Department of Clinical Neurosciences, Scientific Institute and University Vita Salute San Raffaele, Milan, Italy
    Chronobiol Int . 2016
    ..Thus, it may be suggested that CLOCK rs1801260*C and PER34/4 influence myelination processes by regulating sleep quality and quantity...
  31. doi request reprint Successful antidepressant chronotherapeutics enhance fronto-limbic neural responses and connectivity in bipolar depression
    Benedetta Vai
    Department of Clinical Neurosciences, Scientific Institute Ospedale San Raffaele, Milan, Italy C E R M A C Centro di Eccellenza Risonanza Magnetica ad Alto Campo, Universita Vita Salute San Raffaele, Italy Department of Human Studies, Libera Università Maria Ss Assunta, Roma, Italy Electronic address
    Psychiatry Res 233:243-53. 2015
    ....
  32. doi request reprint The serotonin transporter genotype modulates the relationship between early stress and adult suicidality in bipolar disorder
    Francesco Benedetti
    Department of Clinical Neurosciences, Scientific Institute Ospedale San Raffaele and University Vita Salute, Milano, Italy
    Bipolar Disord 16:857-66. 2014
    ....
  33. doi request reprint Disruption of white matter integrity in bipolar depression as a possible structural marker of illness
    Francesco Benedetti
    Department of Clinical Neurosciences, Scientific Institute and University Vita Salute San Raffaele, Milano, Italy
    Biol Psychiatry 69:309-17. 2011
    ..Literature suggests that WM integrity could be altered in bipolar disorder. Heterogeneity of brain imaging methods, the studied samples, and drug treatments make localization, nature, and severity of the WM abnormalities unclear...
  34. doi request reprint Inflammatory cytokines influence measures of white matter integrity in Bipolar Disorder
    Francesco Benedetti
    Department of Clinical Neurosciences, Scientific Institute Ospedale San Raffaele, Milano, University Vita Salute San Raffaele, Milano, Italy C E R M A C Centro di Eccellenza Risonanza Magnetica ad Alto Campo, University Vita Salute San Raffaele, Milano, Italy Electronic address
    J Affect Disord 202:1-9. 2016
    ..Consistent findings in animal models link WM damage in inflammatory diseases of the brain and serum levels of cytokines...
  35. doi request reprint Opposite effects of suicidality and lithium on gray matter volumes in bipolar depression
    Francesco Benedetti
    Department of Clinical Neurosciences, Scientific Institute San Raffaele and University Vita Salute, Milan, Italy
    J Affect Disord 135:139-47. 2011
    ..We studied the effect of a positive history of attempted suicide and ongoing lithium treatment on regional GM volumes of patients affected by bipolar depression...
  36. doi request reprint Neural responses to emotional stimuli in comorbid borderline personality disorder and bipolar depression
    Daniele Radaelli
    University Vita Salute San Raffaele, Milan, Italy
    Psychiatry Res 203:61-6. 2012
    ..The present study identifies the neural basis of the interaction between BPD and MD. The lower rate of response to treatment in MD+BPD could be related to a more severe emotional dysregulation syndrome...
  37. doi request reprint The COMT Val158Met polymorphism moderates the association between cognitive functions and white matter microstructure in schizophrenia
    Sara Poletti
    Departments of aClinical Neurosciences bNeuroradiology, Scientific Institute Ospedale San Raffaele cC E R M A C Centro di Eccellenza Risonanza Magnetica ad Alto Campo, University Vita Salute San Raffaele, Milan, Italy
    Psychiatr Genet 26:193-202. 2016
    ..We thus hypothesized that the COMT ValMet genotype would affect the association between cognitive functions and WM microstructure in a sample of schizophrenic patients...
  38. doi request reprint Disruption of white matter integrity marks poor antidepressant response in bipolar disorder
    Irene Bollettini
    Department of Clinical Neurosciences, Scientific Institute and University Vita Salute San Raffaele, Milan, Italy C E R M A C Centro di Eccellenza Risonanza Magnetica ad Alto Campo, University Vita Salute San Raffaele, Milan, Italy PhD Program in Philosophy and Sciences of Mind University Vita Salute San Raffaele, Milan, Italy
    J Affect Disord 174:233-40. 2015
    ....
  39. doi request reprint Caudate gray matter volume in obsessive-compulsive disorder is influenced by adverse childhood experiences and ongoing drug treatment
    Francesco Benedetti
    Department of Clinical Neurosciences, Scientific Institute and University Vita Salute San Raffaele, Milan, Italy
    J Clin Psychopharmacol 32:544-7. 2012
    ..Robust neuroimaging findings associated OCD with corticostriatal dysfunction and with abnormal morphology and metabolism of cortical areas and basal ganglia...
  40. doi request reprint Adverse childhood experiences and gender influence treatment seeking behaviors in obsessive-compulsive disorder
    Francesco Benedetti
    Department of Clinical Neurosciences, Scientific Institute and University Vita Salute, San Raffaele, Milan
    Compr Psychiatry 55:298-301. 2014
    ..ACE could influence the use of psychotropic drugs in adulthood, and treatment seeking behaviors...
  41. doi request reprint Neural correlates of delusion in bipolar depression
    Daniele Radaelli
    Department of Clinical Neurosciences, Scientific Institute, University Vita Salute San Raffaele, Milan, Italy Centro di Eccellenza Risonanza Magnetica ad Alto Campo C E R M A C, University Vita Salute San Raffaele, Milan, Italy Electronic address
    Psychiatry Res 221:1-5. 2014
    ....
  42. doi request reprint Multidimensional cognitive impairment in unipolar and bipolar depression and the moderator effect of adverse childhood experiences
    Sara Poletti
    Division of Clinical Neurosciences, Scientific Institute and University Vita Salute San Raffaele, Milan
    Psychiatry Clin Neurosci . 2016
    ....
  43. doi request reprint Right hemisphere neural activations in the recall of waking fantasies and of dreams
    Francesco Benedetti
    Department of Clinical Neurosciences, Scientific Institute and University Vita Salute San Raffaele, Milan, Italy
    J Sleep Res 24:576-82. 2015
    ..Their degree of activation could parallel the level of logical robustness or inconsistency experienced when integrating information and mental representations in the process of building fantasy and dream narratives. ..