Anna Mondino

Summary

Affiliation: San Raffaele Scientific Institute
Country: Italy

Publications

  1. pmc Cytosolic sequestration of Prep1 influences early stages of T cell development
    Dmitry Penkov
    Molecular Genetics Unit, San Raffaele Scientific Institute and Universita Vita Salute San Raffaele, Milan, Italy
    PLoS ONE 3:e2424. 2008
  2. pmc Redirecting the immune response: role of adoptive T cell therapy
    Anna Mondino
    Division of Immunology, Transplantation, and Infectious Diseases, San Raffaele Scientific Institute, 20132 Milan, Italy
    Hum Gene Ther 21:533-41. 2010
  3. doi request reprint Antigen-experienced CD4(+) T cells limit naïve T-cell priming in response to therapeutic vaccination in vivo
    Chris Schiering
    Program in Immunology and Bio Immunotherapy of Cancer, Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy
    Cancer Res 70:6161-70. 2010
  4. doi request reprint IL-7 is superior to IL-2 for ex vivo expansion of tumour-specific CD4(+) T cells
    Stefano Caserta
    Program in Immunology and Bio Immuno gene therapy of Cancer PIBIC, Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy
    Eur J Immunol 40:470-9. 2010
  5. ncbi request reprint Tumors hamper the immunogenic competence of CD4+ T cell-directed dendritic cell vaccination
    Valerie S Zimmermann
    Cancer Immunotherapy and Gene Therapy Program, Department of Biotechnology, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
    J Immunol 179:2899-909. 2007
  6. doi request reprint Vaccine-instructed intratumoral IFN-γ enables regression of autochthonous mouse prostate cancer in allogeneic T-cell transplantation
    Rodrigo Hess Michelini
    Lymphocyte Activation Unit, Cellular Immunology Unit, Division of Immunology, Transplantation and Infectious Disease, Department of Pathology, San Raffaele Scientific Institute Università Vita Salute San Raffaele, Milan, Italy
    Cancer Res 73:4641-52. 2013
  7. doi request reprint Concurrent allorecognition has a limited impact on posttransplant vaccination
    Teresa Manzo
    Program in Immunology and Bio Immuno gene therapy of Cancer, Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, 20132 Milan, Italy
    J Immunol 186:1361-8. 2011
  8. doi request reprint Concomitant tumor and minor histocompatibility antigen-specific immunity initiate rejection and maintain remission from established spontaneous solid tumors
    Rodrigo Hess Michelini
    Lymphocyte Activation Unit, Cellular Immunology Unit, Pathology Unit, Experimental Hematology, San Raffaele Scientific Institute, and Universita Vita Salute San Raffaele, Milan, Italy
    Cancer Res 70:3505-14. 2010
  9. doi request reprint Synthetic CD4+ T cell-targeted antigen-presenting cells elicit protective antitumor responses
    Stefano Caserta
    Cancer Immunotherapy and Gene Therapy Program, San Raffaele Scientific Institute, Milan, Italy
    Cancer Res 68:3010-8. 2008
  10. doi request reprint IL-7 and IL-15 allow the generation of suicide gene-modified alloreactive self-renewing central memory human T lymphocytes
    Shin Kaneko
    Experimental Hematology Unit, Cancer Immunotherapy and Gene Therapy Program, Department of Oncology, San Raffaele Scientific Institute, Milano, Italy
    Blood 113:1006-15. 2009

Collaborators

Detail Information

Publications26

  1. pmc Cytosolic sequestration of Prep1 influences early stages of T cell development
    Dmitry Penkov
    Molecular Genetics Unit, San Raffaele Scientific Institute and Universita Vita Salute San Raffaele, Milan, Italy
    PLoS ONE 3:e2424. 2008
    ..To further investigate the role of this homeodomain DNA-binding protein in T cell development, we generated transgenic mice expressing the N-terminal fragment of Pbx1 (Pbx1NT) under the control of the Lck proximal promoter...
  2. pmc Redirecting the immune response: role of adoptive T cell therapy
    Anna Mondino
    Division of Immunology, Transplantation, and Infectious Diseases, San Raffaele Scientific Institute, 20132 Milan, Italy
    Hum Gene Ther 21:533-41. 2010
    ..Here, we review the importance of pretransplantation host conditioning and posttransplantation strategies that have been shown to contribute to the therapeutic efficacy of infused T lymphocytes...
  3. doi request reprint Antigen-experienced CD4(+) T cells limit naïve T-cell priming in response to therapeutic vaccination in vivo
    Chris Schiering
    Program in Immunology and Bio Immunotherapy of Cancer, Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy
    Cancer Res 70:6161-70. 2010
    ....
  4. doi request reprint IL-7 is superior to IL-2 for ex vivo expansion of tumour-specific CD4(+) T cells
    Stefano Caserta
    Program in Immunology and Bio Immuno gene therapy of Cancer PIBIC, Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy
    Eur J Immunol 40:470-9. 2010
    ..Together our data support a unique role for IL-7 in retrieving memory-like CD4(+) T cells suitable for adoptive T-cell therapy...
  5. ncbi request reprint Tumors hamper the immunogenic competence of CD4+ T cell-directed dendritic cell vaccination
    Valerie S Zimmermann
    Cancer Immunotherapy and Gene Therapy Program, Department of Biotechnology, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
    J Immunol 179:2899-909. 2007
    ..Because T cell help is needed for protective immunity, we speculate that the ability of tumors to limit vaccine-induced CD4+ T cell memory could provide a partial explanation for the limited efficacy of current strategies...
  6. doi request reprint Vaccine-instructed intratumoral IFN-γ enables regression of autochthonous mouse prostate cancer in allogeneic T-cell transplantation
    Rodrigo Hess Michelini
    Lymphocyte Activation Unit, Cellular Immunology Unit, Division of Immunology, Transplantation and Infectious Disease, Department of Pathology, San Raffaele Scientific Institute Università Vita Salute San Raffaele, Milan, Italy
    Cancer Res 73:4641-52. 2013
    ..Our findings argue that posttransplant tumor-directed vaccination is critical to effectively direct donor T cells to the tumor site in cooperation with allogeneic hematopoietic cell transplantation...
  7. doi request reprint Concurrent allorecognition has a limited impact on posttransplant vaccination
    Teresa Manzo
    Program in Immunology and Bio Immuno gene therapy of Cancer, Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, 20132 Milan, Italy
    J Immunol 186:1361-8. 2011
    ....
  8. doi request reprint Concomitant tumor and minor histocompatibility antigen-specific immunity initiate rejection and maintain remission from established spontaneous solid tumors
    Rodrigo Hess Michelini
    Lymphocyte Activation Unit, Cellular Immunology Unit, Pathology Unit, Experimental Hematology, San Raffaele Scientific Institute, and Universita Vita Salute San Raffaele, Milan, Italy
    Cancer Res 70:3505-14. 2010
    ....
  9. doi request reprint Synthetic CD4+ T cell-targeted antigen-presenting cells elicit protective antitumor responses
    Stefano Caserta
    Cancer Immunotherapy and Gene Therapy Program, San Raffaele Scientific Institute, Milan, Italy
    Cancer Res 68:3010-8. 2008
    ..Taken together, our data support the use of cell-free, synthetic aAPC as a specific and versatile alternative to expand peptide-specific CD4(+) T cells in adoptive and active immunotherapy...
  10. doi request reprint IL-7 and IL-15 allow the generation of suicide gene-modified alloreactive self-renewing central memory human T lymphocytes
    Shin Kaneko
    Experimental Hematology Unit, Cancer Immunotherapy and Gene Therapy Program, Department of Oncology, San Raffaele Scientific Institute, Milano, Italy
    Blood 113:1006-15. 2009
    ..GVHD was halted through the activation of the suicide gene machinery. These results warrant the use of suicide gene-modified T(CM) cells cultured with IL-7 and IL-15 for the safe exploitation of the alloreactive response against cancer...
  11. doi request reprint A signaling loop of REST, TSC2 and β-catenin governs proliferation and function of PC12 neural cells
    Romana Tomasoni
    Division of Immunology, Transplantation Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy
    J Cell Sci 124:3174-86. 2011
    ..The new REST-TSC2-β-catenin signaling paradigm might have an important role in various aspects of neural cell physiology and pathology, including the regulation of proliferation and neurosecretion...
  12. doi request reprint Targeting TNF-α to neoangiogenic vessels enhances lymphocyte infiltration in tumors and increases the therapeutic potential of immunotherapy
    Arianna Calcinotto
    Cellular Immunology Unit, San Raffaele Scientific Institute, 20132 Milan, Italy
    J Immunol 188:2687-94. 2012
    ..Thus, these findings might be relevant for the design of novel immunotherapeutic approaches for cancer patients...
  13. doi request reprint Rapamycin-sensitive signals control TCR/CD28-driven Ifng, Il4 and Foxp3 transcription and promoter region methylation
    Romana Tomasoni
    Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy
    Eur J Immunol 41:2086-96. 2011
    ....
  14. pmc mTOR at the crossroads of T cell proliferation and tolerance
    Anna Mondino
    San Raffaele Scientific Institute, Milan, Italy
    Semin Immunol 19:162-72. 2007
    ..The role of mTOR as a rheostat capable of integrating extracellular, plasma membrane-associated, and intracellular signals with relevance to T cell priming and tolerance is discussed...
  15. ncbi request reprint Prolonged TCR/CD28 engagement drives IL-2-independent T cell clonal expansion through signaling mediated by the mammalian target of rapamycin
    Sara Colombetti
    Cancer Immunotherapy and Gene Therapy Program, San Raffaele Scientific Institute, Milan, Italy
    J Immunol 176:2730-8. 2006
    ..These data suggest that Ag persistence and the availability of costimulatory signals and of autocrine and paracrine growth factors individually shape T lymphocyte expansion in vivo...
  16. pmc Absence of Rac1 and Rac3 GTPases in the nervous system hinders thymic, splenic and immune-competence development
    Veronica Basso
    Lymphocyte Activation Unit, Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy
    Eur J Immunol 41:1410-9. 2011
    ..Our results support a role for neuronal Rac1 and Rac3 in dictating proper lymphoid organ development, and suggest the existence of lymphoid-extrinsic mechanisms linking neural defects to the loss of immune-competence...
  17. doi request reprint Vascular targeting, chemotherapy and active immunotherapy: teaming up to attack cancer
    Matteo Bellone
    Cancer Immunotherapy and Gene Therapy Program, San Raffaele Scientific Institute, Via Olgettina 58, 20132, Milan, Italy
    Trends Immunol 29:235-41. 2008
    ..This approach has the potential to empower chemoimmunotherapeutic strategies by improving cytotoxic drug penetration into tumors while exploiting the proinflammatory and immunostimulating activities of TNF-alpha and active immunotherapy...
  18. pmc Monoallelic germline TSC1 mutations are permissive for T lymphocyte development and homeostasis in tuberous sclerosis complex individuals
    Karolina Pilipow
    Lymphocyte Activation Unit, Immunology, Transplantation and Infectious Disease Division, San Raffaele Scientific Institute, Milano, Italy Università Vita Salute San Raffaele, Milano, Italy
    PLoS ONE 9:e91952. 2014
    ..Thus, our results indicate that, while one functional TSC1 allele preserves human T lymphocytes development and homeostasis, TSC1 acute down-regulation is detrimental to the survival of both primary and transformed T cells. ..
  19. ncbi request reprint Phenotype and homing of CD4 tumor-specific T cells is modulated by tumor bulk
    Fabio Benigni
    Cancer Immunotherapy and Gene Therapy Program, S Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
    J Immunol 175:739-48. 2005
    ..Thus, the continuous stimulation of tumor-specific CD4 T cells in tumor-bearing mice appears to hinder the systemic accumulation of central memory CD4 T lymphocytes...
  20. doi request reprint The tuberous sclerosis complex: balancing proliferation and survival
    Romana Tomasoni
    Program in Immunology and Bio Immuno gene therapy of Cancer PIBIC, Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, I 20132 Milan, Italy
    Biochem Soc Trans 39:466-71. 2011
    ..In the present paper, we review recent evidence highlighting the notion that the TSC1/2 complex simultaneously controls mTOR-dependent and mTOR-independent signals critical for the balancing of cell proliferation and cell death...
  21. doi request reprint Exploiting cytokines in adoptive T-cell therapy of cancer
    Elisabetta Petrozziello
    Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, Via Olgettina, 58, 20132 Milan, Italy
    Immunotherapy 7:573-84. 2015
    ..Here we review latest developments on the use of cytokines to better direct the nature of the T-cell infusion product, T-cell function and persistence in vivo, as well as to modulate the tumor microenvironment. ..
  22. doi request reprint Adoptive T-cell therapy for cancer: The era of engineered T cells
    Chiara Bonini
    Experimental Hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy
    Eur J Immunol 45:2457-69. 2015
    ..We provide an overview of current strategies aimed at improving the safety and efficacy of these approaches, with an outlook on prospective developments...
  23. ncbi request reprint Immune surveillance and anti-tumor immune responses: an anatomical perspective
    Valerie S Zimmermann
    Cancer Immunotherapy and Gene Therapy Program, San Raffaele Scientific Institute, DIBIT, Via Olgettina 58, 20132 Milan, Italy
    Immunol Lett 98:1-8. 2005
    ..Here, we will review the preclinical studies, which have defined the spatial and temporal organisation of anti-tumor immunity, and discuss the implications of these findings in active immunotherapy...
  24. ncbi request reprint The immunogenicity of dendritic cell-based vaccines is not hampered by doxorubicin and melphalan administration
    Anna Casati
    Cancer Immunotherapy and Gene Therapy Program, San Raffaele Scientific Institute, DIBIT, Milan, Italy
    J Immunol 174:3317-25. 2005
    ..Together our results indicate that Doxorubicin- or Melphalan-based chemotherapy and Ag-specific vaccination can be combined for adjuvant treatments of cancer patients...
  25. ncbi request reprint Critical impact of the kinetics of dendritic cells activation on the in vivo induction of tumor-specific T lymphocytes
    Annalisa Camporeale
    Cancer Immunotherapy and Gene Therapy Program, Istituto Scientifico H San Raffaele, 20132 Milan, Italy
    Cancer Res 63:3688-94. 2003
    ..Our data are relevant for the design of DC-based vaccines...