Claudio Doglioni

Summary

Affiliation: San Raffaele Scientific Institute
Country: Italy

Publications

  1. pmc FOXP1 and TP63 involvement in the progression of myelodysplastic syndrome with 5q- and additional cytogenetic abnormalities
    Alberto L'Abbate
    Department of Biology, University of Bari, Via G, Amendola 165 A, Bari 70126, Italy
    BMC Cancer 14:396. 2014
  2. doi Gastric lymphoma: the histology report
    Claudio Doglioni
    Department of Pathology, Scientific Institute San Raffaele, Milan, Italy
    Dig Liver Dis 43:S310-8. 2011
  3. doi Preoperative chemotherapy does not adversely affect pancreatic structure and short-term outcome after pancreatectomy
    Nicolò Pecorelli
    Department of Surgery, Vita Salute San Raffaele University, Via Olgettina 60, 20132, Milan, Italy
    J Gastrointest Surg 17:488-93. 2013
  4. doi The optimal rebiopsy prostatic scheme depends on patient clinical characteristics: results of a recursive partitioning analysis based on a 24-core systematic scheme
    Vincenzo Scattoni
    Department of Urology, University Vita Salute, Scientific Institute San Raffaele, Milan, Italy
    Eur Urol 60:834-41. 2011
  5. pmc A reappraisal of the diagnostic and therapeutic management of uncommon histologies of primary ocular adnexal lymphoma
    Maurilio Ponzoni
    Unit of Lymphoid Malignancies, Department of Onco Hematology, San Raffaele Scientific Institute, Milan, Italy
    Oncologist 18:876-84. 2013
  6. pmc Autologous pancreatic islet transplantation in human bone marrow
    Paola Maffi
    Islet Transplantation Unit, Diabetes Research Institute, Ospedale San Raffaele, Milan, Italy
    Diabetes 62:3523-31. 2013
  7. doi Tumor-mediated liver X receptor-alpha activation inhibits CC chemokine receptor-7 expression on dendritic cells and dampens antitumor responses
    Eduardo J Villablanca
    Cancer Gene Therapy Unit, Program of Immunology and Bio Immuno Gene Therapy of Cancer, Division of Molecular Oncology, Scientific Institute San Raffaele, Milan, Italy
    Nat Med 16:98-105. 2010
  8. doi Chlamydial infection: the link with ocular adnexal lymphomas
    Andres J M Ferreri
    Unit of Lymphoid Malignancies, San Raffaele Scientific Institute, Milan, Italy
    Nat Rev Clin Oncol 6:658-69. 2009
  9. doi Does cytotechnician training influence the accuracy of EUS-guided fine-needle aspiration of pancreatic masses?
    Maria Chiara Petrone
    Division of Gastroenterology and Gastrointestinal Endoscopy, Vita Salute San Raffaele University, Scientific Institute San Raffaele, Milan, Italy
    Dig Liver Dis 44:311-4. 2012
  10. doi (Ir)relevance of Metformin Treatment in Patients with Metastatic Pancreatic Cancer: An Open-Label, Randomized Phase II Trial
    Michele Reni
    Department of Medical Oncology, IRCCS San Raffaele Scientific Institute, Milan, Italy
    Clin Cancer Res 22:1076-85. 2016

Detail Information

Publications78

  1. pmc FOXP1 and TP63 involvement in the progression of myelodysplastic syndrome with 5q- and additional cytogenetic abnormalities
    Alberto L'Abbate
    Department of Biology, University of Bari, Via G, Amendola 165 A, Bari 70126, Italy
    BMC Cancer 14:396. 2014
    ..Single additional alterations to del(5q) by balanced chromosome rearrangements were rarely found in myelodysplasia. In particular, balanced alterations involving TP63 and FOXP1 genes were never reported in the literature...
  2. doi Gastric lymphoma: the histology report
    Claudio Doglioni
    Department of Pathology, Scientific Institute San Raffaele, Milan, Italy
    Dig Liver Dis 43:S310-8. 2011
    ..This paper aims at giving the histopathologist a general knowledge about the state of art of this disease and its management. The diagnostic process leading to a complete and competent report is then described step by step...
  3. doi Preoperative chemotherapy does not adversely affect pancreatic structure and short-term outcome after pancreatectomy
    Nicolò Pecorelli
    Department of Surgery, Vita Salute San Raffaele University, Via Olgettina 60, 20132, Milan, Italy
    J Gastrointest Surg 17:488-93. 2013
    ..The objective of this study is to assess the impact of PCHT on pancreatic structure and short-term outcome after surgical resection...
  4. doi The optimal rebiopsy prostatic scheme depends on patient clinical characteristics: results of a recursive partitioning analysis based on a 24-core systematic scheme
    Vincenzo Scattoni
    Department of Urology, University Vita Salute, Scientific Institute San Raffaele, Milan, Italy
    Eur Urol 60:834-41. 2011
    ..The most beneficial number and the location of prostate biopsies remain matters of debate, especially after an initial negative biopsy...
  5. pmc A reappraisal of the diagnostic and therapeutic management of uncommon histologies of primary ocular adnexal lymphoma
    Maurilio Ponzoni
    Unit of Lymphoid Malignancies, Department of Onco Hematology, San Raffaele Scientific Institute, Milan, Italy
    Oncologist 18:876-84. 2013
    ..This review covers the prevalence, clinical presentation, behavior, and histological and molecular features of uncommon forms of primary OAL and provides practical recommendations for therapeutic management. ..
  6. pmc Autologous pancreatic islet transplantation in human bone marrow
    Paola Maffi
    Islet Transplantation Unit, Diabetes Research Institute, Ospedale San Raffaele, Milan, Italy
    Diabetes 62:3523-31. 2013
    ..Moreover, this is the first unequivocal example of successful engraftment of endocrine tissue in the BM in humans. ..
  7. doi Tumor-mediated liver X receptor-alpha activation inhibits CC chemokine receptor-7 expression on dendritic cells and dampens antitumor responses
    Eduardo J Villablanca
    Cancer Gene Therapy Unit, Program of Immunology and Bio Immuno Gene Therapy of Cancer, Division of Molecular Oncology, Scientific Institute San Raffaele, Milan, Italy
    Nat Med 16:98-105. 2010
    ..The manipulation of this pathway could restore antitumor immunity in individuals with cancer...
  8. doi Chlamydial infection: the link with ocular adnexal lymphomas
    Andres J M Ferreri
    Unit of Lymphoid Malignancies, San Raffaele Scientific Institute, Milan, Italy
    Nat Rev Clin Oncol 6:658-69. 2009
    ..Available data on the epidemiology, biology and pathogenesis of this association are analyzed and new investigative and clinical approaches are discussed...
  9. doi Does cytotechnician training influence the accuracy of EUS-guided fine-needle aspiration of pancreatic masses?
    Maria Chiara Petrone
    Division of Gastroenterology and Gastrointestinal Endoscopy, Vita Salute San Raffaele University, Scientific Institute San Raffaele, Milan, Italy
    Dig Liver Dis 44:311-4. 2012
    ..The aim of this study was to evaluate the effect of formal cytotechnician training on the diagnostic accuracy of EUS-FNA of pancreatic masses...
  10. doi (Ir)relevance of Metformin Treatment in Patients with Metastatic Pancreatic Cancer: An Open-Label, Randomized Phase II Trial
    Michele Reni
    Department of Medical Oncology, IRCCS San Raffaele Scientific Institute, Milan, Italy
    Clin Cancer Res 22:1076-85. 2016
    ....
  11. doi Chlamydophila psittaci eradication with doxycycline as first-line targeted therapy for ocular adnexae lymphoma: final results of an international phase II trial
    Andres J M Ferreri
    San Raffaele Scientific Institute, Milan, Italy
    J Clin Oncol 30:2988-94. 2012
    ..To our knowledge, this is the first international phase II trial aimed at clarifying Cp prevalence and activity of first-line doxycycline in a homogeneous series of consecutive patients with newly diagnosed stage I OAMZL...
  12. doi Mucin expression pattern in pancreatic diseases: findings from EUS-guided fine-needle aspiration biopsies
    Silvia Carrara
    Division of Gastroenterology and Gastrointestinal Endoscopy, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Milan, Italy
    Am J Gastroenterol 106:1359-63. 2011
    ..This study assessed the feasibility of evaluating MUC expression from material obtained by EUS-FNA and studied the profile of MUC expression in benign and malignant pancreatic lesions...
  13. doi Methotrexate in refractory bilateral juvenile temporal arteritis: Report of a case
    Corrado Campochiaro
    a Unit of Medicine and Clinical Immunology, Vita Salute San Raffaele University, San Raffaele Scientific Institute, Milan, Italy
    Mod Rheumatol 26:276-7. 2016
    ..Methotrexate, added as a steroid-sparing agent, resulted in a good disease control. ..
  14. doi Anti-metastatic activity of the tumor vascular targeting agent NGR-TNF
    Paola Di Matteo
    Molmed SpA, Via Olgettina 58, 20132, Milan, Italy
    Clin Exp Metastasis 32:289-300. 2015
    ....
  15. pmc The oxysterol-CXCR2 axis plays a key role in the recruitment of tumor-promoting neutrophils
    Laura Raccosta
    Cancer Gene Therapy Unit, Program of Immunology and Bio Immuno Gene Therapy of Cancer, Division of Molecular Oncology, Scientific Institute San Raffaele, Milan, Italy
    J Exp Med 210:1711-28. 2013
    ..These results identify an unanticipated protumor function of the oxysterol-CXCR2 axis and a possible target for cancer therapy. ..
  16. doi Gastroenteric neuroendocrine neoplasms classification: comparison of prognostic models
    Anna Dolcetta-Capuzzo
    Department of Endocrinology and Internal Medicine, Endocrine Tumors Unit, San Raffaele Scientific Institute, Milan, Italy
    Cancer 119:36-44. 2013
    ..In the current study, the authors evaluated the prognostic significance of these models and compared their efficacy in describing patients' long-term survival to assess the best prognostic model currently available for clinicians...
  17. ncbi Carcinoembryonic antigen-specific but not antiviral CD4+ T cell immunity is impaired in pancreatic carcinoma patients
    Elena Tassi
    Tumor Immunology Unit, Universita Vita Salute San Raffaele, Milan, Italy
    J Immunol 181:6595-603. 2008
    ..Collectively, these results demonstrate that Th2-immune deviation in pancreatic cancer is not generalized but tumor related and suggests that the skew might be possibly due to factor(s) present at the tumor site...
  18. ncbi Ex vivo gene therapy with lentiviral vectors rescues adenosine deaminase (ADA)-deficient mice and corrects their immune and metabolic defects
    Alessandra Mortellaro
    Via Olgettina 58, 20132, Milan, Italy
    Blood 108:2979-88. 2006
    ..Overall, this study demonstrates the efficacy of LV gene transfer in correcting both the immunological and metabolic phenotypes of ADA-SCID and supports the future clinical use of this approach...
  19. ncbi High syndecan-1 expression in breast carcinoma is related to an aggressive phenotype and to poorer prognosis
    Mattia Barbareschi
    Department of Pathology, Santa Chiara Hospital, Trento, Italy
    Cancer 98:474-83. 2003
    ..Syndecan-1 is a transmembrane heparan sulphate proteoglycan that is involved in cell-cell adhesion, organization of cell-matrix adhesion, and regulation of growth factor signaling...
  20. pmc Enhanced expression of CD13 in vessels of inflammatory and neoplastic tissues
    Paola Di Matteo
    Molmed SpA, Milan, Italy
    J Histochem Cytochem 59:47-59. 2011
    ..This finding may be relevant for CD13-mediated vascular targeting therapies...
  21. doi Revertant T lymphocytes in a patient with Wiskott-Aldrich syndrome: analysis of function and distribution in lymphoid organs
    Sara Trifari
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Milan, Italy
    J Allergy Clin Immunol 125:439-448.e8. 2010
    ..Secondary mutations leading to re-expression of WAS protein (WASP) are relatively frequent in patients with WAS...
  22. doi Renal sinus fat invasion in pT3a clear cell renal cell carcinoma affects outcomes of patients without nodal involvement or distant metastases
    Roberto Bertini
    Department of Urology, Vita Salute University San Raffaele, Milan, Italy
    J Urol 181:2027-32. 2009
    ..We analyzed the impact of sinus fat invasion on cancer specific survival in a cohort of patients with pT3a clear cell renal cell carcinoma...
  23. doi Biopsy schemes with the fewest cores for detecting 95% of the prostate cancers detected by a 24-core biopsy
    Vincenzo Scattoni
    Department of Urology, University Vita Salute, Scientific Institute San Raffaele, Milan, Italy
    Eur Urol 57:1-8. 2010
    ..The most efficient number and location of prostate biopsies remains a matter of debate...
  24. pmc Ex vivo enrichment of circulating anti-tumor T cells from both cutaneous and ocular melanoma patients: clinical implications for adoptive cell transfer therapy
    Tonia Mazzarella
    Unit of Immuno biotherapy of Melanoma and Solid Tumors, Division of Molecular Oncology, San Raffaele Scientific Institute, Via Olgettina 58, Milan, Italy
    Cancer Immunol Immunother 61:1169-82. 2012
    ..Thus, anti-tumor circulating PBMC-derived T cells could be efficiently isolated from melanoma patients by our novel ex vivo enrichment protocol. This protocol appears suitable for ACT studies of cutaneous and ocular melanoma patients...
  25. pmc Prevalence of Borrelia burgdorferi infection in a series of 98 primary cutaneous lymphomas
    Maurilio Ponzoni
    Pathology Unit, Department of Onco Hematology, San Raffaele Scientific Institute, Milan, Italy
    Oncologist 16:1582-8. 2011
    ..burgdorferi in primary cutaneous B- and T-cell lymphomas from areas nonendemic for this microorganism and the consequent rationale for the adoption of antibiotic therapy in these patients...
  26. doi A prognostic score to predict major complications after pancreaticoduodenectomy
    Marco Braga
    Department of Surgery, Vita Salute San Raffaele University, Milan, Italy
    Ann Surg 254:702-7; discussion 707-8. 2011
    ..To develop and validate a simple prognostic score to predict major postoperative complications after pancreaticoduodenectomy (PD)...
  27. ncbi Maturing dendritic cells depend on RAGE for in vivo homing to lymph nodes
    Angelo A Manfredi
    Clinical Immunology Unit, H San Raffaele Scientific Institute and Università Vita Salute San Raffaele, Via Olgettina 48, Milan, Italy
    J Immunol 180:2270-5. 2008
    ..Thus the HMGB1-RAGE pathway is a checkpoint in DC maturation and function and a candidate for targeted therapies...
  28. doi Interleukin-6 in ANCA-associated vasculitis: Rationale for successful treatment with tocilizumab
    Alvise Berti
    Vita Salute San Raffaele University, Milan, Italy Unit of Medicine and Clinical Immunology, IRCCS San Raffaele Scientific Institute, Milan, Italy Electronic address
    Semin Arthritis Rheum 45:48-54. 2015
    ..The aim of the present study is to evaluate a potential role of interleukin (IL)-6 and its pathway in the pathogenesis of AAV and to review previous evidence of IL-6 in MPA and GPA...
  29. doi Interobserver agreement among pathologists regarding core tissue specimens obtained with a new endoscopic ultrasound histology needle; a prospective multicentre study in 50 cases
    Maria Chiara Petrone
    Gastroenterology and Gastrointestinal Endoscopy Unit, Vita Salute San Raffaele University, Scientific Institute San Raffaele, Milan, Italy
    Histopathology 62:602-8. 2013
    ..To evaluate the interobserver agreement among pathologists in grading the quality of specimens obtained with a new 19-gauge endoscopic ultrasound histology needle...
  30. pmc Absence of Rac1 and Rac3 GTPases in the nervous system hinders thymic, splenic and immune-competence development
    Veronica Basso
    Lymphocyte Activation Unit, Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy
    Eur J Immunol 41:1410-9. 2011
    ..Our results support a role for neuronal Rac1 and Rac3 in dictating proper lymphoid organ development, and suggest the existence of lymphoid-extrinsic mechanisms linking neural defects to the loss of immune-competence...
  31. pmc Evidence for long-term efficacy and safety of gene therapy for Wiskott-Aldrich syndrome in preclinical models
    Francesco Marangoni
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Milan, Italy
    Mol Ther 17:1073-82. 2009
    ..Demonstration of long-term efficacy and safety of WAS gene therapy mediated by a clinically applicable LV is a key step toward the implementation of a gene therapy clinical trial for WAS...
  32. ncbi A virtual tissue bank for primary central nervous system lymphomas in immunocompetent individuals
    Maurilio Ponzoni
    Division of Pathology, Department of Oncology, San Raffaele Scientific Institute, Milan, Italy
    Pathobiology 74:264-9. 2007
    ..ielsg.org. Only anonymous data are centralized at the website of the International Extranodal Lymphoma Study Group, whilst the pathologic material is maintained at the local pathology institutes...
  33. doi US-guided application of a new hybrid probe in human pancreatic adenocarcinoma: an ex vivo study
    Maria Chiara Petrone
    Division of Gastroenterology and Gastrointestinal Endoscopy, Vita Salute San Raffaele University, Scientific Institute San Raffaele, 20132 Milan, Italy
    Gastrointest Endosc 71:1294-7. 2010
    ..A new flexible bipolar ablation device (Cryotherm probe [CTP]) was developed combining radiofrequency and cryotechnology...
  34. doi HER2 testing in gastric cancer
    Luca Albarello
    Department of Pathology, Universita Vita Salute San Raffaele, San Raffaele Scientific Institute, Via Olgettina 60, Milan, Italy
    Adv Anat Pathol 18:53-9. 2011
    ....
  35. pmc Immunobiological characterization of cancer stem cells isolated from glioblastoma patients
    Tiziano Di Tomaso
    Department of Pathology, San Raffaele Foundation Scientific Institute, Milan, Italy
    Clin Cancer Res 16:800-13. 2010
    ..The aims of this study were the immunobiological characterization of GBM CSCs and the assessment of whether these cells represent suitable targets for immunotherapy...
  36. doi Chlamydophila psittaci is viable and infectious in the conjunctiva and peripheral blood of patients with ocular adnexal lymphoma: results of a single-center prospective case-control study
    Andres J M Ferreri
    Unit of Lymphoid Malignancies, San Raffaele Scientific Institute, Milan, Italy
    Int J Cancer 123:1089-93. 2008
    ..Cp infection is common in OAML patients and exceptional in blood donors. Epidemiological data of OAML patients (prolonged contact with household animals and chronic conjunctivitis) are consistent with Cp exposure risk...
  37. doi Central nervous system marginal zone B-cell lymphoma associated with Chlamydophila psittaci infection
    Maurilio Ponzoni
    Pathology Unit, San Raffaele Scientific Institute, 20132 Milan, Italy
    Hum Pathol 42:738-42. 2011
    ..This observation points toward the opportunity to investigate the prevalence of C psittaci infection in central nervous system lymphomas, particularly in those with low-grade histologic features...
  38. ncbi Bacteria-eradicating therapy with doxycycline in ocular adnexal MALT lymphoma: a multicenter prospective trial
    Andres J M Ferreri
    Medical Oncology Unit, Department of Oncology, San Raffaele H Scientific Institute, Via Olgettina 60, 20132 Milan, Italy
    J Natl Cancer Inst 98:1375-82. 2006
    ..The effectiveness of doxycycline treatment in Cp-negative OAL has not been tested...
  39. ncbi Plasma and tissue expression of the long pentraxin 3 during normal pregnancy and preeclampsia
    Patrizia Rovere-Querini
    Clinical Immunology Unit, Division of Pathology, H San Raffaele Scientific Institute and Università Vita Salute San Raffaele, Milano, Italy
    Obstet Gynecol 108:148-55. 2006
    ..We examined whether PTX3 is expressed during pregnancy and possibly involved in the development of preeclampsia...
  40. ncbi Pilot study on the correlation of optical coherence tomography with histology in celiac disease and normal subjects
    Enzo Masci
    Gastroenterology and Gastrointestinal Endoscopy Unit, Vita Salute San Raffaele University IRCCS San Raffaele Hospital, Milan, Italy
    J Gastroenterol Hepatol 22:2256-60. 2007
    ..The aim of the present study was to test the utility of OCT in patients undergoing esophagogastroduodenoscopy (EGD) for histological diagnosis...
  41. ncbi Regression of ocular adnexal lymphoma after Chlamydia psittaci-eradicating antibiotic therapy
    Andres J M Ferreri
    Department of Radiochemotherapy, San Raffaele H Scientific Institute, Via Olgettina 60, 20132 Milan, Italy
    J Clin Oncol 23:5067-73. 2005
    ..The present pilot study was carried out to assess whether C psittaci-eradicating antibiotic therapy is associated with tumor regression in ocular adnexal lymphomas...
  42. doi Chlamydia infection and lymphomas: association beyond ocular adnexal lymphomas highlighted by multiple detection methods
    Maurilio Ponzoni
    Pathology Unit, San Raffaele Scientific Institute, Milano, Italy
    Clin Cancer Res 14:5794-800. 2008
    ..Herein, we used multiple Chlamydia detection tools to identify Cp elementary bodies-containing cell and to assess Cp prevalence in both nodal and extranodal lymphomas...
  43. ncbi Prognostic factors and analysis of microsatellite instability in resected pulmonary metastases from colorectal carcinoma
    Giulio Melloni
    Department of Thoracic Surgery, Scientific Institute H San Raffaele, Milan, Italy
    Ann Thorac Surg 81:2008-13. 2006
    ..The aims were to search for factors influencing prognosis and to investigate the presence of microsatellite instability in the primary tumors and the corresponding lung metastases...
  44. pmc The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy
    Eugenio Montini
    San Raffaele Telethon Institute for Gene Therapy, Via Olgettina 58, 20132 Milan, Italy
    J Clin Invest 119:964-75. 2009
    ..Our findings strongly support the use of SIN viral vector platforms and show that ISS can substantially modulate genotoxicity...
  45. doi Bone marrow histopathology in the diagnostic evaluation of splenic marginal-zone and splenic diffuse red pulp small B-cell lymphoma: a reliable substitute for spleen histopathology?
    Maurilio Ponzoni
    Pathology Unit, Department of Oncology, San Raffaele Scientific Institute, Milan, Italy
    Am J Surg Pathol 36:1609-18. 2012
    ..However, presently it is not possible to distinguish SMZL from SDRL on the basis of BMB evaluation alone; hence, histopathologic examination of the spleen remains the "gold standard" approach...
  46. doi Peripheral blood lymphocytes genetically modified to express the self/tumor antigen MAGE-A3 induce antitumor immune responses in cancer patients
    Raffaella Fontana
    Cancer Gene Therapy Unit, Cancer Immunotherapy and Gene Therapy Program, Department of Oncology, Scientific Institute San Raffaele, Milan, Italy
    Blood 113:1651-60. 2009
    ..Clinical studies on a larger group of patients are needed to evaluate the clinical efficacy of such a strategy...
  47. ncbi Therapeutic management of ocular adnexal MALT lymphoma
    Andres J M Ferreri
    Medical Oncology Unit, Department of Oncology, San Raffaele Scientific Institute, Via Olgettina 6020132, Milan, Italy
    Expert Opin Pharmacother 8:1073-83. 2007
    ..In this review, the authors analyze related literature and propose therapeutic guidelines for the management of ocular adnexal lymphoma of MALT-type...
  48. ncbi Identification of proangiogenic TIE2-expressing monocytes (TEMs) in human peripheral blood and cancer
    Mary Anna Venneri
    San Raffaele Telethon Institute for Gene Therapy, Milan, Italy
    Blood 109:5276-85. 2007
    ..Human TEMs may provide a novel, biologically relevant marker of angiogenesis and represent a previously unrecognized target of cancer therapy...
  49. ncbi Chronic lymphocytic leukemia: the pathologist's view of lymph node microenvironment
    Maurilio Ponzoni
    Pathology Unit, Department of Oncology, University Scientific Institute San Raffaele, Milan, Italy
    Semin Diagn Pathol 28:161-6. 2011
    ..Special attention is devoted to analyzing the properties of both neoplastic and nonneoplastic bystander cells within proliferation centers, the mysterious structures that likely represent the actual proliferative compartment...
  50. doi Cardiotoxicity after low-dose chloroquine antimalarial therapy
    Gabriele Fragasso
    Clinical Cardiology, Heart Failure Clinic, Istituto Scientifico San Raffaele, Milan, Italy
    Heart Vessels 24:385-7. 2009
    ....
  51. ncbi Association between Helicobacter pylori infection and MALT-type lymphoma of the ocular adnexa: clinical and therapeutic implications
    Andrés Jm Ferreri
    Medical Oncology Unit, San Raffaele H Scientific Institute, Milan, Italy
    Hematol Oncol 24:33-7. 2006
    ....
  52. doi Improved histologic and clinicopathologic criteria for prognostic evaluation of pancreatic endocrine tumors
    Stefano La Rosa
    Department of Pathology, Ospedale di Circolo, 21100 Varese, Italy
    Hum Pathol 40:30-40. 2009
    ..The TNM system proved to be highly predictive of patient outcome and easy to combine with histologic and clinicopathologic parameters to classify pancreatic endocrine tumors into groups of increasing malignant potential...
  53. ncbi Characterization of t(6;11)(p21;q12) in a renal-cell carcinoma of an adult patient
    Lorenza Pecciarini
    Department of Pathology, Scientific Institute San Raffaele Hospital, Milano, Italy
    Genes Chromosomes Cancer 46:419-26. 2007
    ..Our data contribute to define better this rare RCC type, which is typical not only of childhood but can also be found in adulthood...
  54. doi Clinical signature and pathogenetic factors of diabetes associated with pancreas disease (T3cDM): a prospective observational study in surgical patients
    Gianpaolo Balzano
    Department of Surgery, IRCCS San Raffaele Scientific Institute, Milan, Italy
    Acta Diabetol 51:801-11. 2014
    ..Classical risk factors for type 2 diabetes were associated with the onset of diabetes after surgery. T3cDM appeared as a heterogeneous entity strongly overlapped with type 2 diabetes. ..
  55. pmc Human IL2RA null mutation mediates immunodeficiency with lymphoproliferation and autoimmunity
    Kevin Goudy
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Scientific Institute, Milan, Italy
    Clin Immunol 146:248-61. 2013
    ..Thus, the complex pathogenesis of CD25 deficiency provides invaluable insight into the role of IL2/IL-2RA-dependent regulation in autoimmunity and inflammatory diseases...
  56. doi The vasostatin-1 fragment of chromogranin A preserves a quiescent phenotype in hypoxia-driven endothelial cells and regulates tumor neovascularization
    Lorenzo Veschini
    Myeloma Unit, San Raffaele Scientific Institute, Milan, Italy
    FASEB J 25:3906-14. 2011
    ..Our findings highlight a previously undescribed function of VS-1 as a regulator of tumor vascularization...
  57. ncbi Plasma cell granuloma of the thyroid gland: a challenging diagnostic problem
    Anna Cremonini
    San Raffaele Scientific Institute, Milan, Italy
    Int J Surg Pathol 20:500-6. 2012
    ..In view of these considerations, a contemporary diagnostic approach to thyroid plasma cell granuloma is therefore discussed here...
  58. doi Two positive nodes represent a significant cut-off value for cancer specific survival in patients with node positive prostate cancer. A new proposal based on a two-institution experience on 703 consecutive N+ patients treated with radical prostatectomy, e
    Alberto Briganti
    Department of Urology, Vita Salute University, Milan, Italy
    Eur Urol 55:261-70. 2009
    ..However, node positive (N+) patients share heterogeneous outcomes according to the extent of lymph node invasion (LNI)...
  59. doi Obesity does not increase the risk of lymph node metastases in patients with clinically localized prostate cancer undergoing radical prostatectomy and extended pelvic lymph node dissection
    Alberto Briganti
    Department of Urology, Vita Salute University, San Raffaele Hospital, Via Olgettina, 60, 20132, Milan, Italy
    Int J Urol 16:676-81. 2009
    ..We hypothesized that obesity, quantified as body mass index (BMI), is associated with a higher risk of lymph node invasion (LNI) in patients undergoing extended pelvic lymph node dissection (ePLND)...
  60. doi Constitutive overexpression of CDC25A in primary human mammary epithelial cells results in both defective DNA damage response and chromosomal breaks at fragile sites
    Maria Giulia Cangi
    Pathology Unit, San Raffaele Scientific Institute, Milan, Italy
    Int J Cancer 123:1466-71. 2008
    ..Our data suggest that CDC25A overexpression, pushing the cell through the cell cycle transitions, induces DDR alterations that might enhance genomic instability...
  61. pmc Immune regulatory neural stem/precursor cells protect from central nervous system autoimmunity by restraining dendritic cell function
    Stefano Pluchino
    Neuroimmunology Unit, San Raffaele Scientific Institute and Università Vita Salute, Milan, Italy
    PLoS ONE 4:e5959. 2009
    ..This study was designed to identify the first candidate that exemplifies and sustains the immune modulatory capacity of transplanted NPCs...
  62. ncbi Expression of TP73L is a helpful diagnostic marker of primary mediastinal large B-cell lymphomas
    Alberto Zamo
    Department of Pathology, University of Verona, Verona, Italy
    Mod Pathol 18:1448-53. 2005
    ..TP73L expression proved a useful diagnostic marker of primary mediastinal large B-cell lymphoma, and gave new insights in to the molecular pathways playing a role in this lymphoma...
  63. doi BRAFV600E-mutation is invariably present and associated to oncogene-induced senescence in Erdheim-Chester disease
    Maria Giulia Cangi
    Unit of Pathology, IRCCS San Raffaele Scientific Institute, Milan, Italy
    Ann Rheum Dis 74:1596-602. 2015
    ..BRAF(V600E) has been associated with oncogene-induced senescence (OIS), a protective mechanism against oncogenic events, characterised by the induction of proinflammatory pathways...
  64. doi Phase II trial of salvage therapy with trabectedin in metastatic pancreatic adenocarcinoma
    Carmen Belli
    Department of Medical Oncology, San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy
    Cancer Chemother Pharmacol 77:477-84. 2016
    ..This phase II trial explored the activity of trabectedin in mPA progressing after gemcitabine-based first-line chemotherapy...
  65. pmc In vivo confocal microscopy in goldenhar syndrome: a case report
    Giacinto Triolo
    Cornea and Ocular Surface Unit, San Raffaele Scientific Institute, Milan, Italy
    BMC Ophthalmol 13:55. 2013
    ..We aimed to (i) describe the in vivo confocal morphology of limbal dermoids in Goldenhar syndrome and (ii) compare these findings with standard light microscopy...
  66. doi Antibodies are forever: a study using 12-26-year-old expired antibodies
    Maria C Argentieri
    Department of Pathology, AO San Gerardo, Monza, Italy
    Histopathology 63:869-76. 2013
    ..The aim of this study was to investigate whether the shelf-life of diagnostic antibodies is longer than the expiry date on the label...
  67. ncbi Definition, diagnosis, and management of intravascular large B-cell lymphoma: proposals and perspectives from an international consensus meeting
    Maurilio Ponzoni
    Unit of Lymphoma Malignancies, Pathology and Oncology Units, Department of Oncology, San Raffaele Scientific Institute, Milan, Italy
    J Clin Oncol 25:3168-73. 2007
    ..Finally, a provisional practical diagnostic approach to hemophagocytosis-associated patients and a proposal for the most useful criteria in the settings of differential diagnosis are included...
  68. pmc Co-graft of allogeneic immune regulatory neural stem cells (NPC) and pancreatic islets mediates tolerance, while inducing NPC-derived tumors in mice
    Raffaella Melzi
    San Raffaele Diabetes Research Institute HSR DRI, Division of Immunology, Transplantation and Infectious Disease, San Raffaele Scientific Institute, Milan, Italy
    PLoS ONE 5:e10357. 2010
    ..The aim of this study was to define whether NPC administered in combination with pancreatic islets prevents rejection in a fully mismatched allograft model...
  69. doi Isoaspartate-glycine-arginine: a new tumor vasculature-targeting motif
    Flavio Curnis
    Department of Biological and Technological Research, CIGT Program and IIT Network Research Unit of Molecular Neuroscience, San Raffaele Scientific Institute, Milan, Italy
    Cancer Res 68:7073-82. 2008
    ..These results suggest that isoDGR is a novel tumor vasculature-targeting motif. Peptides containing isoDGR could be exploited as ligands for targeted delivery of drugs, imaging agents, or other compounds to tumor vasculature...
  70. ncbi New transcription factors in diagnostic hematopathology
    Maurilio Ponzoni
    Pathology Unit, Scientific Institute San Raffaele, Milano, Italy
    Adv Anat Pathol 14:25-35. 2007
    ..This field is rapidly evolving, as witnessed by the ongoing growing number of novel TFs with possible diagnostic applications appearing in the literature...
  71. ncbi IFN-gamma produced by human papilloma virus-18 E6-specific CD4+ T cells predicts the clinical outcome after surgery in patients with high-grade cervical lesions
    Samantha Seresini
    Tumor Immunology Unit, Scientific Institute H San Raffaele, Milan, Italy
    J Immunol 179:7176-83. 2007
    ....
  72. doi Peripheral T-cell tolerance associated with prostate cancer is independent from CD4+CD25+ regulatory T cells
    Elena Degl'Innocenti
    Cancer Immunotherapy and Gene Therapy Program, Istituto Scientifico San Raffaele, Milan, Italy
    Cancer Res 68:292-300. 2008
    ..Hence, we conclude that Treg accrual is a phenomenon common to the sites of an ongoing immune response, and in TRAMP mice in particular, Treg are dispensable for induction of tumor-specific tolerance...
  73. ncbi Variations in clinical presentation, frequency of hemophagocytosis and clinical behavior of intravascular lymphoma diagnosed in different geographical regions
    Andres J M Ferreri
    Medical Oncology Unit, Department of Oncology, San Raffaele Scientific Institute, Milan, Italy
    Haematologica 92:486-92. 2007
    ..This study explored variations in the clinical manifestations of intravascular lymphoma (IVL) on the bases of the association with hemophagocytosis and the country where the diagnosis was made...
  74. ncbi Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration
    Eugenio Montini
    San Raffaele Telethon Institute for Gene Therapy, Via Olgettina 58, 20132, Milan, Italy
    Nat Biotechnol 24:687-96. 2006
    ..Our results validate a much-needed platform to assess vector safety and provide direct evidence that prototypical lentiviral vectors have low oncogenic potential, highlighting a major rationale for application to gene therapy...
  75. ncbi Isolated bone marrow occurrence of classic Hodgkin's lymphoma in an HIV-negative patient
    Maurilio Ponzoni
    Pathology Unit, Department of Oncology, San Raffaele H Scientific Institute, Milan, Italy
    Haematologica 91:ECR04. 2006
    ..The impacts of such unusual Hodgkin's Lymphoma manifestation on clinical practice as well as the related diagnostic and therapeutic implications are discussed...
  76. ncbi Optical coherence tomography to detect epithelial lesions of the main pancreatic duct: an Ex Vivo study
    Pier Alberto Testoni
    Division of Gastroenterology, Vita Salute San Raffaele University, IRCCS San Raffaele Hospital, Milan, Italy
    Am J Gastroenterol 100:2777-83. 2005
    ..The probe can be inserted into the main pancreatic duct (MPD) through a standard endoscopic retrograde cholangiopancreatography catheter...
  77. ncbi M-CAM expression as marker of poor prognosis in epithelial ovarian cancer
    Daniela Aldovini
    Department of Pathology, S Chiara Hospital, Trento, Italy
    Int J Cancer 119:1920-6. 2006
    ..In particular, M-CAM expression identifies a subgroup of front-line therapy-responding patients who undergo dramatic relapses, thus helping to better select patients who might benefit from new/alternative therapeutic modalities...
  78. ncbi Abnormal re-epithelialization and lung remodeling in idiopathic pulmonary fibrosis: the role of deltaN-p63
    Marco Chilosi
    Department of Pathology, University of Verona, Verona, Italy
    Lab Invest 82:1335-45. 2002
    ....