R Testa

Summary

Affiliation: Neurobiology of Aging Laboratory
Country: Italy

Publications

  1. pmc The Possible Role of Flavonoids in the Prevention of Diabetic Complications
    Roberto Testa
    Experimental models in Clinical Pathology, INRCA IRCCS National Institute, Ancona I 60127, Italy
    Nutrients 8:. 2016
  2. doi In the light of the metabolic memory theory, should not all aged people with dysglycemia be treated?
    Roberto Testa
    Metabolic and Nutrition Research Centre on Diabetes, INRCA IRCCS, Ancona, Italy
    Rejuvenation Res 13:599-605. 2010
  3. doi The Pro/Pro genotype of the p53 codon 72 polymorphism modulates PAI-1 plasma levels in ageing
    Roberto Testa
    Department of Gerontological Research, Diabetology Unit, INRCA IRCCS, Polytechnic University of Marche, Ancona, Italy
    Mech Ageing Dev 130:497-500. 2009
  4. ncbi C-reactive protein is directly related to plasminogen activator inhibitor type 1 (PAI-1) levels in diabetic subjects with the 4G allele at position -675 of the PAI-1 gene
    R Testa
    Department of Gerontological Research, Diabetology Unit, INRCA Hospital, Via della Montagnola 81, I 60131 Ancona, Italy
    Nutr Metab Cardiovasc Dis 18:220-6. 2008
  5. ncbi Interleukin-6-174 G > C polymorphism affects the association between IL-6 plasma levels and insulin resistance in type 2 diabetic patients
    R Testa
    Diabetology Unit, INRCA, Via della Montagnola, 81, I 60131, Ancona, Italy
    Diabetes Res Clin Pract 71:299-305. 2006
  6. ncbi Effect of 4G/5G PAI-1 polymorphism on the response of PAI-1 activity to vitamin E supplementation in Type 2 diabetic patients
    R Testa
    INRCA, Italian National Research Center on Aging, Ancona, Italy
    Diabetes Nutr Metab 17:217-21. 2004
  7. ncbi Effect of etanercept on insulin sensitivity in nine patients with psoriasis
    M Marra
    Diabetology Unit, INRCA, Ancona, Italy
    Int J Immunopathol Pharmacol 20:731-6. 2007
  8. ncbi Smoking is associated with reduced serum levels of the antioxidant enzyme, paraoxonase, in Type 2 diabetic patients
    M Boemi
    Diabetology Unit, Istituto Nazionale Ricovero e Cura per Anziani INRCA, Ancona, Italy
    Diabet Med 21:423-7. 2004
  9. ncbi Age-dependent changes of serum oxygen radical scavenger capacity and haemoglobin glycosylation in non-insulin-dependent diabetic patients
    C Pieri
    Center of Cytology, Gerontological Research Department of INRCA N Masera, Ancona, Italy
    Gerontology 47:88-92. 2001
  10. doi Leukocyte telomere length is associated with complications of type 2 diabetes mellitus
    R Testa
    Metabolic and Nutrition Research Centre on Diabetes, INRCA Ancona, Italy
    Diabet Med 28:1388-94. 2011

Collaborators

Detail Information

Publications22

  1. pmc The Possible Role of Flavonoids in the Prevention of Diabetic Complications
    Roberto Testa
    Experimental models in Clinical Pathology, INRCA IRCCS National Institute, Ancona I 60127, Italy
    Nutrients 8:. 2016
    ..In this review, we seek to highlight the most recent papers focusing on the relationship between flavonoids and main diabetic complications. ..
  2. doi In the light of the metabolic memory theory, should not all aged people with dysglycemia be treated?
    Roberto Testa
    Metabolic and Nutrition Research Centre on Diabetes, INRCA IRCCS, Ancona, Italy
    Rejuvenation Res 13:599-605. 2010
    ..This new evidence could allow us to hypothesize that a treatment of dysglycemia in aged people could remodel their glucose "trajectory" during aging toward a more optimal one, leading to successful aging...
  3. doi The Pro/Pro genotype of the p53 codon 72 polymorphism modulates PAI-1 plasma levels in ageing
    Roberto Testa
    Department of Gerontological Research, Diabetology Unit, INRCA IRCCS, Polytechnic University of Marche, Ancona, Italy
    Mech Ageing Dev 130:497-500. 2009
    ..In particular, our results indicate that Pro/Pro genotype plays a pivotal role in determining PAI-1 levels in aged subjects, while in Arg carriers PAI-1 levels are associated to the known insulin related determinants...
  4. ncbi C-reactive protein is directly related to plasminogen activator inhibitor type 1 (PAI-1) levels in diabetic subjects with the 4G allele at position -675 of the PAI-1 gene
    R Testa
    Department of Gerontological Research, Diabetology Unit, INRCA Hospital, Via della Montagnola 81, I 60131 Ancona, Italy
    Nutr Metab Cardiovasc Dis 18:220-6. 2008
    ....
  5. ncbi Interleukin-6-174 G > C polymorphism affects the association between IL-6 plasma levels and insulin resistance in type 2 diabetic patients
    R Testa
    Diabetology Unit, INRCA, Via della Montagnola, 81, I 60131, Ancona, Italy
    Diabetes Res Clin Pract 71:299-305. 2006
    ..The identification of two categories of diabetic patients may, therefore, lead to different therapeutic strategies in the management of insulin resistance...
  6. ncbi Effect of 4G/5G PAI-1 polymorphism on the response of PAI-1 activity to vitamin E supplementation in Type 2 diabetic patients
    R Testa
    INRCA, Italian National Research Center on Aging, Ancona, Italy
    Diabetes Nutr Metab 17:217-21. 2004
    ....
  7. ncbi Effect of etanercept on insulin sensitivity in nine patients with psoriasis
    M Marra
    Diabetology Unit, INRCA, Ancona, Italy
    Int J Immunopathol Pharmacol 20:731-6. 2007
    ..We conclude that Etanercept, probably acting on inflammation, improves insulin sensitivity in psoriatic subjects...
  8. ncbi Smoking is associated with reduced serum levels of the antioxidant enzyme, paraoxonase, in Type 2 diabetic patients
    M Boemi
    Diabetology Unit, Istituto Nazionale Ricovero e Cura per Anziani INRCA, Ancona, Italy
    Diabet Med 21:423-7. 2004
    ..To analyse the association of smoking with paraoxonase (PON1) in Type 2 diabetic patients...
  9. ncbi Age-dependent changes of serum oxygen radical scavenger capacity and haemoglobin glycosylation in non-insulin-dependent diabetic patients
    C Pieri
    Center of Cytology, Gerontological Research Department of INRCA N Masera, Ancona, Italy
    Gerontology 47:88-92. 2001
    ..Contradictory results have been reported in the literature concerning the correlation between glycosylated haemoglobin (HbA1c) and peroxidation level in serum of diabetic patients...
  10. doi Leukocyte telomere length is associated with complications of type 2 diabetes mellitus
    R Testa
    Metabolic and Nutrition Research Centre on Diabetes, INRCA Ancona, Italy
    Diabet Med 28:1388-94. 2011
    ..As a consequence, this study aimed to verify whether leukocyte telomere length is associated with the presence and the number of diabetic complications in a sample of patients with Type 2 diabetes...
  11. ncbi Relationship between lipoprotein(a) levels, oxidative stress, and blood pressure levels in patients with essential hypertension
    R Antonicelli
    National Institute for Gerontological Research, Ancona, Italy
    Clin Exp Med 1:145-50. 2001
    ..Apo(a) isoform size did not affect these relationships. Our data suggest that Lp(a) and peroxidative stress may be involved as cofactors in essential hypertension, with a mechanism that remains to be elucidated...
  12. doi Telomere/telomerase system impairment in circulating angiogenic cells of geriatric patients with heart failure
    F Olivieri
    Department of Molecular Pathology and Innovative Therapies, Universita Politecnica delle Marche, Ancona, Italy
    Int J Cardiol 164:99-105. 2013
    ..However, the underlying mechanisms are only partly unraveled. No data are currently available regarding telomere/telomerase system in CACs of CHF patients...
  13. ncbi Helicobacter pylori masks differences in homocysteine plasma levels between controls and type 2 diabetic patients
    S Cenerelli
    Institute of Internal Medicine, University of Ancona, INRCA, Via Birarelli 8, I 60121 Ancona, Italy
    Eur J Clin Invest 32:158-62. 2002
    ..Starting from these findings we wanted to verify whether differences in homocysteine levels exist between a type 2 diabetic population and a control group, taking into account the presence/absence of Helicobacter pylori...
  14. ncbi Apolipoprotein E polymorphisms and mortality in Italian type 2 diabetic patients
    M Boemi
    Instituto Nazionale Ricoveroe Cura per Anziani, Ancona, Italy
    Eur J Clin Invest 33:296-300. 2003
    ..To determine if apolipoprotein E polymorphism is associated with cardiovascular or all-cause mortality in Italian Type 2 diabetic patients...
  15. doi Diabetes-related quality of life is enhanced by glycaemic improvement in older people
    A M Abbatecola
    Scientific Direction, Italian National Research Centre on Aging, Ancona, Italy
    Diabet Med 32:243-9. 2015
    ..To investigate the validity and reliability of the Audit of Diabetes-Dependent Quality of Life instrument in older Italians with diabetes and to test the association of diabetes-related quality of life with glycaemic control over time...
  16. ncbi The effect of different glucose endovenous administrations on amylin and insulin blood concentration in healthy subjects
    I Testa
    University of Ancona
    Boll Soc Ital Biol Sper 72:103-8. 1996
    ..The highest increases of IAPP concentrations were found when there was a rapid glucose decrease in the blood. These findings suggest a significant role of IAPP in regulating the rapid decreases of glycemia...
  17. ncbi Vitamin E intake reduces plasminogen activator inhibitor type 1 in T2DM patients
    A R Bonfigli
    Gerontological Research Department, University of Ancona, Italy
    Diabetes Nutr Metab 14:71-7. 2001
    ....
  18. ncbi Cytokine gene polymorphisms in recurrent pregnancy loss of unknown cause
    Norma Prigoshin
    Histocompatibility and Immunogenetics Section, Diagnostic Department, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina
    Am J Reprod Immunol 52:36-41. 2004
    ..Significantly different levels of Th1/Th2 cytokines are produced by normal pregnant women compared with women with RPL of unknown cause...
  19. ncbi Increased levels of gammaGT suggest the presence of bile duct lesions in patients with chronic hepatitis C: absence of influence of HCV genotype, HCV-RNA serum levels, and HGV infection on this histological damage
    E Giannini
    Department of Internal Medicine, University of Genoa, Italy
    Dig Dis Sci 46:524-9. 2001
    ..Viral factors such as HCV genotype and RNA levels as well as HGV-RNA positivity are probably not the main cause of this histological damage...
  20. doi +647 A/C and +1245 MT1A polymorphisms in the susceptibility of diabetes mellitus and cardiovascular complications
    R Giacconi
    Immunology Center Section Nutrition, Immunity and Ageing, Research Department INRCA, Via Birarelli 8, 60121 Ancona, Italy
    Mol Genet Metab 94:98-104. 2008
    ..Moreover, C+ carriers in DCVD patients presented a worse glycemic control, a reduced iZnR and a higher MT levels, suggesting a possible role of MT in diabetic cardiovascular complications...
  21. ncbi Liver iron accumulation in chronic hepatitis C patients without HFE mutations: relationships with histological damage, viral load and genotype and alpha-glutathione S-transferase levels
    E Giannini
    Gastroenterology Unit, Department of Internal Medicine, University of Genoa, Italy
    Eur J Gastroenterol Hepatol 13:1355-61. 2001
    ..Moreover, higher staging is associated with mesenchymal or mixed iron deposition. In these patients, higher alpha-glutathione S-transferase levels seem to reflect more complex damage...
  22. ncbi Impairment of cytochrome P-450-dependent liver activity in cirrhotic patients with Helicobacter pylori infection
    E Giannini
    Gastroenterology Unit and Postgraduate School of Gastroenterology and Digestive Endoscopy, Department of Internal Medicine, University of Genoa, Italy
    Aliment Pharmacol Ther 15:1967-73. 2001
    ..Tumour necrosis factor-alpha does not seem to be the mediator of this impairment. Further studies are needed to evaluate the impact of H. pylori eradication on parameters of liver function...