Affiliation: National Cancer Research Institute
- Tryptophan-derived catabolites are responsible for inhibition of T and natural killer cell proliferation induced by indoleamine 2,3-dioxygenaseGuido Frumento
Immunogenetics Laboratory, National Cancer Research Institute, University of Genoa, Largo Rosanna Benzi 10, 16132 Genoa, Italy
J Exp Med 196:459-68. 2002....
- Survival advantage with KIR ligand incompatibility in hematopoietic stem cell transplantation from unrelated donorsSebastian Giebel
Department of Haematology and Bone Marrow Transplantation, Silesian Medical Academy, Katowice, Poland
Blood 102:814-9. 2003..These data indicate that natural killer (NK) cell alloreactivity is associated with better outcome after URD-HSC transplantation when ATG is used as part of GVHD prophylaxis...
- The tryptophan catabolite L-kynurenine inhibits the surface expression of NKp46- and NKG2D-activating receptors and regulates NK-cell functionMariella Della Chiesa
DIMS Dipartimento di Medicina Sperimentale, Universita di Genova, Genova, Italy
Blood 108:4118-25. 2006..The effect of l-kynurenine, which is effective at both the transcriptional and the protein level, can be reverted, since NK cells were found to recover their functional competence after washing...
- Natural killer cells infiltrating human nonsmall-cell lung cancer are enriched in CD56 bright CD16(-) cells and display an impaired capability to kill tumor cellsPaolo Carrega
Department of Experimental Medicine, University of Genoa, Italy
Cancer 112:863-75. 2008..Despite natural killer (NK) cells being originally identified and named because of their ability to kill tumor cells in vitro, only limited information is available on NK cells infiltrating malignant tumors, especially in humans...
- Arginase 2 is expressed by human lung cancer, but it neither induces immune suppression, nor affects disease progressionRita Rotondo
Department of Translational Oncology, National Institute for Cancer Research, Genoa, Italy
Int J Cancer 123:1108-16. 2008..Our results indicate that ARG2 is expressed in lung cancer, but it does not induce tumor immune escape and does not affect disease progression, most probably due to the lack of concomitant NOS expression...
- Targeting tumor-related immunosuppression for cancer immunotherapyGuido Frumento
Istituto Nazionale per la Ricerca sul Cancro, C o CBA Largo R Benzi 10, 16132 Genoa, Italy
Endocr Metab Immune Disord Drug Targets 6:233-7. 2006..Also strategies aimed at blocking enzyme-based immune-suppressive mechanisms are suitable, as suggested by experimental evidences in mouse tumor models...
- A T-cell epitope encoded by a subset of HLA-DPB1 alleles determines nonpermissive mismatches for hematologic stem cell transplantationElisabetta Zino
HLA Tissue Typing Laboratory, Immunohematology and Transfusion Medicine Service, San Raffaele Telethon Institue for Gene Therapy, Cancer Immunotherapy and Gene Therapy Program, Istituto Scientifico H S Raffaele, Via Olgettina 60, I 20132 Milan, Italy
Blood 103:1417-24. 2004..64, P =.1). These data suggest that biologic characterization of in vivo alloreactivity can be a tool for definition of clinically relevant nonpermissive HLA mismatches for unrelated HSC transplantation...
- Eosinophil granulocytes account for indoleamine 2,3-dioxygenase-mediated immune escape in human non-small cell lung cancerSimonetta Astigiano
Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
Neoplasia 7:390-6. 2005..This finding suggests that the degree of IDO-positive infiltrate could be a prognostic marker in NSCLC...