Roberto Motterlini

Summary

Country: Italy

Publications

  1. ncbi request reprint Interaction of carbon monoxide with transition metals: evolutionary insights into drug target discovery
    Roberta Foresti
    Department of Drug Discovery and Development, Italian Institute of Technology, Via Morego 30, 16163 Genoa, Italy
    Curr Drug Targets 11:1595-604. 2010
  2. doi request reprint Theoretical insights into the mechanism of carbon monoxide (CO) release from CO-releasing molecules
    Sai Vikrama Chaitanya Vummaleti
    Department of Drug Discovery and Development, Istituto Italiano di Tecnologia via Morego 30, 16163 Genova, Italy
    Chemistry 18:9267-75. 2012
  3. doi request reprint A carbon monoxide-releasing molecule (CORM-3) uncouples mitochondrial respiration and modulates the production of reactive oxygen species
    Luisa Lo Iacono
    Department of Drug Discovery and Development, Italian Institute of Technology, 16163 Genoa, Italy
    Free Radic Biol Med 50:1556-64. 2011
  4. doi request reprint CORM-3, a carbon monoxide-releasing molecule, alters the inflammatory response and reduces brain damage in a rat model of hemorrhagic stroke
    Andriy Yabluchanskiy
    Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex, UK
    Crit Care Med 40:544-52. 2012

Collaborators

  • Andrea Cavalli
  • Roberta Foresti
  • Sai Vikrama Chaitanya Vummaleti
  • Andriy Yabluchanskiy
  • Luisa Lo Iacono
  • Davide Branduardi
  • Philip Sawle
  • Shervanthi Homer-Vanniasinkam
  • Matteo Masetti
  • Marco De Vivo
  • Colin J Green
  • Jorge Boczkowski
  • Issam Salouage
  • Roland Zini
  • Alain Berdeaux
  • Didier Morin

Detail Information

Publications4

  1. ncbi request reprint Interaction of carbon monoxide with transition metals: evolutionary insights into drug target discovery
    Roberta Foresti
    Department of Drug Discovery and Development, Italian Institute of Technology, Via Morego 30, 16163 Genoa, Italy
    Curr Drug Targets 11:1595-604. 2010
    ..This review will look back at evolution to analyze and argue that a dynamic interaction of CO with specific intracellular metal centers is the common denominator for the diversified beneficial effects mediated by this gaseous molecule...
  2. doi request reprint Theoretical insights into the mechanism of carbon monoxide (CO) release from CO-releasing molecules
    Sai Vikrama Chaitanya Vummaleti
    Department of Drug Discovery and Development, Istituto Italiano di Tecnologia via Morego 30, 16163 Genova, Italy
    Chemistry 18:9267-75. 2012
    ..The analysis revealed that different L'-exchange reactions were spontaneous in all the CO-RMs. Finally, the calculated second dissociation energies could explain the stoichiometry obtained with the Mb assay experiments...
  3. doi request reprint A carbon monoxide-releasing molecule (CORM-3) uncouples mitochondrial respiration and modulates the production of reactive oxygen species
    Luisa Lo Iacono
    Department of Drug Discovery and Development, Italian Institute of Technology, 16163 Genoa, Italy
    Free Radic Biol Med 50:1556-64. 2011
    ..These findings disclose a counterintuitive action of CORM-3 suggesting that CO at low levels acts as an important regulator of mitochondrial respiration...
  4. doi request reprint CORM-3, a carbon monoxide-releasing molecule, alters the inflammatory response and reduces brain damage in a rat model of hemorrhagic stroke
    Andriy Yabluchanskiy
    Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex, UK
    Crit Care Med 40:544-52. 2012
    ..We assessed the effect of CORM-3, a water-soluble carbon monoxide-releasing molecule possessing anti-inflammatory properties, on inflammation and brain injury after intracerebral hemorrhage...