- Interaction of carbon monoxide with transition metals: evolutionary insights into drug target discoveryRoberta Foresti
Department of Drug Discovery and Development, Italian Institute of Technology, Via Morego 30, 16163 Genoa, Italy
Curr Drug Targets 11:1595-604. 2010..This review will look back at evolution to analyze and argue that a dynamic interaction of CO with specific intracellular metal centers is the common denominator for the diversified beneficial effects mediated by this gaseous molecule...
- Theoretical insights into the mechanism of carbon monoxide (CO) release from CO-releasing moleculesSai Vikrama Chaitanya Vummaleti
Department of Drug Discovery and Development, Istituto Italiano di Tecnologia via Morego 30, 16163 Genova, Italy
Chemistry 18:9267-75. 2012..The analysis revealed that different L'-exchange reactions were spontaneous in all the CO-RMs. Finally, the calculated second dissociation energies could explain the stoichiometry obtained with the Mb assay experiments...
- A carbon monoxide-releasing molecule (CORM-3) uncouples mitochondrial respiration and modulates the production of reactive oxygen speciesLuisa Lo Iacono
Department of Drug Discovery and Development, Italian Institute of Technology, 16163 Genoa, Italy
Free Radic Biol Med 50:1556-64. 2011..These findings disclose a counterintuitive action of CORM-3 suggesting that CO at low levels acts as an important regulator of mitochondrial respiration...
- CORM-3, a carbon monoxide-releasing molecule, alters the inflammatory response and reduces brain damage in a rat model of hemorrhagic strokeAndriy Yabluchanskiy
Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex, UK
Crit Care Med 40:544-52. 2012..We assessed the effect of CORM-3, a water-soluble carbon monoxide-releasing molecule possessing anti-inflammatory properties, on inflammation and brain injury after intracerebral hemorrhage...