Daniele Torella

Summary

Affiliation: Magna Graecia University
Country: Italy

Publications

  1. ncbi request reprint Coated stents: a novel approach to prevent in-stent restenosis
    Antonio Curcio
    Division of Cardiology, Magna Graecia University, Catanzaro, Naples, Italy
    Ital Heart J 3:16S-19S. 2002
  2. ncbi request reprint Cardiac stem and progenitor cell biology for regenerative medicine
    Daniele Torella
    Division of Cardiology, Magna Graecia University, Catanzaro, Italy
    Trends Cardiovasc Med 15:229-36. 2005
  3. ncbi request reprint Cardiac stem cell-based myocardial regeneration: towards a translational approach
    Daniele Torella
    Laboratory of Molecular, and Cellular Cardiology, Department of Experimental and Clinical Medicine, Magna Graecia University, Magna Graecia University, Catanaro 88100, Catanzaro 88100, Italy
    Cardiovasc Hematol Agents Med Chem 6:53-9. 2008
  4. doi request reprint MicroRNA-133 controls vascular smooth muscle cell phenotypic switch in vitro and vascular remodeling in vivo
    Daniele Torella
    Cardiovascular Institute, Laboratory of Molecular and Cellular Cardiology, Department of Experimental and Clinical Medicine, Magna Graecia University, Germaneto, Catanzaro, Italy
    Circ Res 109:880-93. 2011
  5. doi request reprint Differential regulation of vascular smooth muscle and endothelial cell proliferation in vitro and in vivo by cAMP/PKA-activated p85alphaPI3K
    Daniele Torella
    Laboratory of Molecular and Cellular Cardiology, Magna Graecia University, Campus S Venuta, Viale Europa Germaneto, Catanzaro 88100, Italy
    Am J Physiol Heart Circ Physiol 297:H2015-25. 2009
  6. ncbi request reprint Fludarabine prevents smooth muscle proliferation in vitro and neointimal hyperplasia in vivo through specific inhibition of STAT-1 activation
    Daniele Torella
    Laboratory of Molecular and Cellular Cardiology, Magna Graecia University, Catanzaro, Italy
    Am J Physiol Heart Circ Physiol 292:H2935-43. 2007
  7. ncbi request reprint Resident human cardiac stem cells: role in cardiac cellular homeostasis and potential for myocardial regeneration
    Daniele Torella
    Laboratory of Molecular and Cellular Cardiology, Department of Experimental and Clinical Medicine, Magna Graecia University, Catanzaro, Italy
    Nat Clin Pract Cardiovasc Med 3:S8-13. 2006
  8. ncbi request reprint Mechanisms of smooth muscle cell proliferation and endothelial regeneration after vascular injury and stenting: approach to therapy
    Antonio Curcio
    Division of Cardiology, Department of Experimental and Clinical Medicine, University Magna Graecia, Catanzaro, Italy
    Circ J 75:1287-96. 2011
  9. ncbi request reprint Physical training increases eNOS vascular expression and activity and reduces restenosis after balloon angioplasty or arterial stenting in rats
    Ciro Indolfi
    Division of Cardiology, Magna Graecia University, Catanzaro, Italy
    Circ Res 91:1190-7. 2002
  10. doi request reprint Mitogen-activated protein kinases activation in T lymphocytes of patients with acute coronary syndromes
    Ciro Indolfi
    Division of Cardiology, Laboratory of Molecular and Cellular Cardiology, University Magna Graecia, Viale Europa, Campus S Venuta di Germaneto, Catanzaro, Italy
    Basic Res Cardiol 106:667-79. 2011

Collaborators

Detail Information

Publications47

  1. ncbi request reprint Coated stents: a novel approach to prevent in-stent restenosis
    Antonio Curcio
    Division of Cardiology, Magna Graecia University, Catanzaro, Naples, Italy
    Ital Heart J 3:16S-19S. 2002
  2. ncbi request reprint Cardiac stem and progenitor cell biology for regenerative medicine
    Daniele Torella
    Division of Cardiology, Magna Graecia University, Catanzaro, Italy
    Trends Cardiovasc Med 15:229-36. 2005
    ..This will enable us to design better protocols for the regeneration of functional contractile mass after myocardial injury...
  3. ncbi request reprint Cardiac stem cell-based myocardial regeneration: towards a translational approach
    Daniele Torella
    Laboratory of Molecular, and Cellular Cardiology, Department of Experimental and Clinical Medicine, Magna Graecia University, Magna Graecia University, Catanaro 88100, Catanzaro 88100, Italy
    Cardiovasc Hematol Agents Med Chem 6:53-9. 2008
    ..The present review highlights current knowledge on the biology of CSCs and the prospects of CSC activation in situ, without the need for cell expansion in vitro and consequent transplantation...
  4. doi request reprint MicroRNA-133 controls vascular smooth muscle cell phenotypic switch in vitro and vascular remodeling in vivo
    Daniele Torella
    Cardiovascular Institute, Laboratory of Molecular and Cellular Cardiology, Department of Experimental and Clinical Medicine, Magna Graecia University, Germaneto, Catanzaro, Italy
    Circ Res 109:880-93. 2011
    ..MicroRNA (miR)-1 and -133 play a crucial role in skeletal and cardiac muscle biology and pathophysiology. However, their expression and regulation in vascular cell physiology and disease is currently unknown...
  5. doi request reprint Differential regulation of vascular smooth muscle and endothelial cell proliferation in vitro and in vivo by cAMP/PKA-activated p85alphaPI3K
    Daniele Torella
    Laboratory of Molecular and Cellular Cardiology, Magna Graecia University, Campus S Venuta, Viale Europa Germaneto, Catanzaro 88100, Italy
    Am J Physiol Heart Circ Physiol 297:H2015-25. 2009
    ..By reducing neointimal hyperplasia without inhibiting endothelial regeneration, it exerts a protective effect against restenosis after balloon injury...
  6. ncbi request reprint Fludarabine prevents smooth muscle proliferation in vitro and neointimal hyperplasia in vivo through specific inhibition of STAT-1 activation
    Daniele Torella
    Laboratory of Molecular and Cellular Cardiology, Magna Graecia University, Catanzaro, Italy
    Am J Physiol Heart Circ Physiol 292:H2935-43. 2007
    ..Fludarabine-eluting stents are feasible and effective in reducing in-stent restenosis in rabbits...
  7. ncbi request reprint Resident human cardiac stem cells: role in cardiac cellular homeostasis and potential for myocardial regeneration
    Daniele Torella
    Laboratory of Molecular and Cellular Cardiology, Department of Experimental and Clinical Medicine, Magna Graecia University, Catanzaro, Italy
    Nat Clin Pract Cardiovasc Med 3:S8-13. 2006
    ....
  8. ncbi request reprint Mechanisms of smooth muscle cell proliferation and endothelial regeneration after vascular injury and stenting: approach to therapy
    Antonio Curcio
    Division of Cardiology, Department of Experimental and Clinical Medicine, University Magna Graecia, Catanzaro, Italy
    Circ J 75:1287-96. 2011
    ..Particular emphasis will be placed on the concept that endothelial regeneration might be pursued as well as reduction of VSMC proliferation to allow stable successful revascularization after DES deployment...
  9. ncbi request reprint Physical training increases eNOS vascular expression and activity and reduces restenosis after balloon angioplasty or arterial stenting in rats
    Ciro Indolfi
    Division of Cardiology, Magna Graecia University, Catanzaro, Italy
    Circ Res 91:1190-7. 2002
    ..Increase in eNOS expression and activity might contribute to the potential beneficial effects of exercise on the vessel wall after vascular injury...
  10. doi request reprint Mitogen-activated protein kinases activation in T lymphocytes of patients with acute coronary syndromes
    Ciro Indolfi
    Division of Cardiology, Laboratory of Molecular and Cellular Cardiology, University Magna Graecia, Viale Europa, Campus S Venuta di Germaneto, Catanzaro, Italy
    Basic Res Cardiol 106:667-79. 2011
    ..These data could represent a valuable new molecular signature to be used as specific biomarkers for the diagnosis of unstable angina within ACS...
  11. doi request reprint The instantaneous wave-free ratio (iFR) for evaluation of non-culprit lesions in patients with acute coronary syndrome and multivessel disease
    Ciro Indolfi
    Division of Cardiology, Department of Medical and Surgical Sciences, Magna Graecia University, Catanzaro, Italy URT CNR, Magna Graecia University, Catanzaro, Italy Electronic address
    Int J Cardiol 178:46-54. 2015
    ....
  12. pmc The duration of balloon inflation affects the luminal diameter of coronary segments after bioresorbable vascular scaffolds deployment
    Sabato Sorrentino
    Division of Cardiology, Department of Medical and Surgical Sciences, Magna Graecia University, Catanzaro, Italy
    BMC Cardiovasc Disord 15:169. 2015
    ..However, since no evidences are available demonstrating the superiority of a longer balloon dilatation time, the implantation technique is highly variable among different centers...
  13. doi request reprint Administration of a loading dose has no additive effect on platelet aggregation during the switch from ongoing clopidogrel treatment to ticagrelor in patients with acute coronary syndrome
    Gianluca Caiazzo
    From the Division of Cardiology, Department of Medical and Surgical Sciences G C, S D R, D T, C S, A M, S G, M M, C I and Clinical Pathology Unit, Department of Health Sciences E P, E G, Magna Graecia University of Catanzaro, Catanzaro, Italy and URT CNR, Department of Medicine, Consiglio Nazionale delle Ricerche, Catanzaro, Italy C I
    Circ Cardiovasc Interv 7:104-12. 2014
    ....
  14. ncbi request reprint The present and future of drug-eluting stents
    Ciro Indolfi
    Division of Cardiology, Department of Experimental and Clinical Medicine, Magna Graecia University, Catanzaro, Italy
    Ital Heart J 6:498-506. 2005
    ..e., nanotechnology) that will improve DES performance allowing other future clinical applications in patients with ST-elevation myocardial infarction, vulnerable plaques, insulin-dependent diabetes mellitus, etc...
  15. pmc Modulation of Circulating MicroRNAs Levels during the Switch from Clopidogrel to Ticagrelor
    Annarita Carino
    Division of Cardiology, Department of Medical and Surgical Sciences, Magna Græcia University, 88100 Catanzaro, Italy
    Biomed Res Int 2016:3968206. 2016
    ..If confirmed in larger, independent cohorts, our results pave the way for the use of circulating microRNAs as biomarkers of platelets activity in response to specific pharmacological treatments. ..
  16. pmc Delayed sudden radial artery rupture after left transradial coronary catheterization: a case report
    Ciro Indolfi
    From the Division of Cardiology CI, FP, AM, CS, DT, SS, AP, VE, AC, SDR, Department of Medical and Surgical Sciences, Magna Graecia University and URT CNR CI, Department of Medicine, Consiglio Nazionale delle Ricerche, Catanzaro, Italy
    Medicine (Baltimore) 94:e634. 2015
    ..After prompt surgical hemostasis, negative pressure wound therapy was very helpful in favoring healing of the large and deep wound...
  17. pmc Carbonic anhydrase activation is associated with worsened pathological remodeling in human ischemic diabetic cardiomyopathy
    Daniele Torella
    Molecular and Cellular Cardiology, Department of Medical and Surgical Sciences, Magna Graecia University, Catanzaro, Italy
    J Am Heart Assoc 3:e000434. 2014
    ..Recently, carbonic anhydrases (CAs) have been shown to play a major role in diabetic microangiopathy but their role in the diabetic cardiomyopathy is still unknown...
  18. ncbi request reprint Hydroxymethylglutaryl coenzyme A reductase inhibitor simvastatin prevents cardiac hypertrophy induced by pressure overload and inhibits p21ras activation
    Ciro Indolfi
    Division of Cardiology, Magna Graecia University, Catanzaro, Italy
    Circulation 106:2118-24. 2002
    ..The aims of the study were to assess the in vivo effects of simvastatin (SIM) on cardiac hypertrophy and on Ras signaling in rats with ascending aorta banding...
  19. pmc MicroRNA-1 downregulation increases connexin 43 displacement and induces ventricular tachyarrhythmias in rodent hypertrophic hearts
    Antonio Curcio
    Division of Cardiology, Laboratory of Molecular and Cellular Cardiology, Department of Medical and Surgical Sciences, University Magna Graecia, Catanzaro, Italy
    PLoS ONE 8:e70158. 2013
    ..Treatment of pressure overload-induced myocyte hypertrophy reduces the risk of life-threatening VT by normalizing miR-1 expression levels with the consequent stabilization of Cx43 expression and activity within the gap junction. ..
  20. doi request reprint Adult c-kit(pos) cardiac stem cells are necessary and sufficient for functional cardiac regeneration and repair
    Georgina M Ellison
    Stem Cell and Regenerative Biology Unit BioStem, Liverpool John Moores University, Liverpool L3 3AF, UK
    Cell 154:827-42. 2013
    ..These data show that c-kit(pos) eCSCs are necessary and sufficient for the regeneration and repair of myocardial damage...
  21. ncbi request reprint Molecular mechanisms of in-stent restenosis and approach to therapy with eluting stents
    Ciro Indolfi
    Division of Cardiology, Magna Graecia University, Catanzaro, Italy
    Trends Cardiovasc Med 13:142-8. 2003
    ..Finally, the new concept of local drugs that elute directly to the site of vascular injury from coated stents and the available clinical results obtained with rapamycin or paclitaxel-eluting stents are discussed...
  22. ncbi request reprint Growth-factor-mediated cardiac stem cell activation in myocardial regeneration
    Daniele Torella
    Magna Graecia University, Catanzaro, Italy
    Nat Clin Pract Cardiovasc Med 4:S46-51. 2007
    ..Here, we discuss the properties of endogenous myocardial stem cells that might be exploited to produce clinical myocardial regeneration without the need for cell transplantation...
  23. doi request reprint Left radial access for percutaneous coronary procedures: from neglected to performer? A meta-analysis of 14 studies including 7,603 procedures
    Salvatore De Rosa
    Division of Cardiology, Department of Medical and Surgical Sciences, Magna Graecia University, Catanzaro, Italy
    Int J Cardiol 171:66-72. 2014
    ..For this reason, the aim of the present meta-analysis was to compare procedural performance of left and right radial artery access for percutaneous coronary interventions...
  24. ncbi request reprint Proteomics reveals high levels of vitamin D binding protein in myocardial infarction
    Cosimo Gasparri
    Division of Cardiology, Magna Graecia University, Catanzaro, Italy
    Front Biosci (Elite Ed) 2:796-804. 2010
    ..Moreover, fresh thrombotic plaques, obtained during primary angioplasty, showed high expression of VDB protein. Mechanistically, VDB protein reduces platelet aggregation and prolongs coagulation time ex vivo...
  25. doi request reprint Routine ganglionic plexi ablation during Maze procedure improves hospital and early follow-up results of mitral surgery
    Francesco Onorati
    Cardiac Surgery Unit, Magna Graecia University of Catanzaro, Catanzaro, Italy
    J Thorac Cardiovasc Surg 136:408-18. 2008
    ..Ganglionic plexi are claimed to be potentially responsible for atrial fibrillation. We evaluated whether ganglionic plexi isolation improves the results of the Maze procedure during mitral valve surgery...
  26. ncbi request reprint Rat carotid artery dilation by PTCA balloon catheter induces neointima formation in presence of IEL rupture
    Ciro Indolfi
    Division of Cardiology, Magna Graecia University, Via Tommaso Campanella 115, 88100 Catanzaro, Italy
    Am J Physiol Heart Circ Physiol 283:H760-7. 2002
    ..In conclusion, our inexpensive animal model of restenosis after angioplasty may have great relevance toward a better understanding of the mechanisms and toward assessment of new therapeutical strategies for this phenomenon...
  27. doi request reprint OFFgel-based multidimensional LC-MS/MS approach to the cataloguing of the human platelet proteome for an interactomic profile
    Shibu Krishnan
    Laboratory of Proteomics and Mass Spectrometry and Department of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, Catanzaro, Italy
    Electrophoresis 32:686-95. 2011
    ..Moreover, toxicity pathway in agreement with network analysis, supports the concept that platelet life span is governed by an apoptotic mechanism...
  28. doi request reprint HMGA1 is a novel candidate gene for myocardial infarction susceptibility
    Salvatore De Rosa
    Division of Cardiology, Department of Medical and Surgical Sciences, Magna Graecia University, Catanzaro, Italy
    Int J Cardiol . 2016
    ..An association of the HMGA1 rs146052672 variant with T2DM has been recently reported. Thus, our aim was to evaluate whether this variant was also associated with AMI...
  29. doi request reprint Intracoronary abciximab reduces death and major adverse cardiovascular events in acute coronary syndromes: a meta-analysis of clinical trials
    Salvatore De Rosa
    Division of Cardiology, Magna Graecia University of Catanzaro, Italy
    Int J Cardiol 168:1298-305. 2013
    ..However clinical trials have shown conflicting results. The aim of the present study was to compare IC with IV abciximab administration on mortality and MACEs in patients with ACS undergoing PCI...
  30. pmc Intense myocyte formation from cardiac stem cells in human cardiac hypertrophy
    Konrad Urbanek
    Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Proc Natl Acad Sci U S A 100:10440-5. 2003
    ..Their presence is consistent with the notion that myocyte hyperplasia significantly contributes to cardiac hypertrophy and accounts for the subpopulation of cycling myocytes...
  31. ncbi request reprint Cardiac stem cells possess growth factor-receptor systems that after activation regenerate the infarcted myocardium, improving ventricular function and long-term survival
    Konrad Urbanek
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Circ Res 97:663-73. 2005
    ..In conclusion, the heart has an endogenous reserve of CSCs-ECCs that can be activated to reconstitute dead myocardium and recover cardiac function...
  32. ncbi request reprint Adult cardiac stem cells are multipotent and support myocardial regeneration
    Antonio P Beltrami
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Cell 114:763-76. 2003
    ..The existence of these cells opens new opportunities for myocardial repair...
  33. ncbi request reprint Effect of stent coating alone on in vitro vascular smooth muscle cell proliferation and apoptosis
    Antonio Curcio
    Div of Cardiology, Dept of Experimental and Clinical Medicine, Magna Graecia Univ, Via Tommaso Campanella 115, 88100 Catanzaro, Italy
    Am J Physiol Heart Circ Physiol 286:H902-8. 2004
    ..This effect should be taken in account when evaluating an association of this coating with antiproliferative agents for in-stent restenosis prevention...
  34. ncbi request reprint Cardiac stem cell and myocyte aging, heart failure, and insulin-like growth factor-1 overexpression
    Daniele Torella
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Circ Res 94:514-24. 2004
    ..The differential response of TG mice to chronological age may result from preservation of functional CSCs undergoing myocyte commitment. In conclusion, senescence of CSCs and myocytes conditions the development of an aging myopathy...
  35. ncbi request reprint Aging exacerbates negative remodeling and impairs endothelial regeneration after balloon injury
    Daniele Torella
    Div of Cardiology, Magna Graecia Univ, Via Tommaso Campanella, 115, 88100 Catanzaro, Italy
    Am J Physiol Heart Circ Physiol 287:H2850-60. 2004
    ..The molecular mechanisms underlying these responses seem to be a reduced Akt and eNOS activity...
  36. ncbi request reprint Bone marrow cells differentiate in cardiac cell lineages after infarction independently of cell fusion
    Jan Kajstura
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Circ Res 96:127-37. 2005
    ..In conclusion, BMCs adopt the cardiac cell lineages and have an important therapeutic impact on ischemic heart failure...
  37. pmc Cardiac stem cells delivered intravascularly traverse the vessel barrier, regenerate infarcted myocardium, and improve cardiac function
    Buddhadeb Dawn
    Institute of Molecular Cardiology, University of Louisville, Louisville, KY 40202, USA
    Proc Natl Acad Sci U S A 102:3766-71. 2005
    ..The results establish CSCs as candidates for cardiac regeneration and support an approach in which the heart's own stem cells could be collected, expanded, and stored for subsequent therapeutic repair...
  38. pmc Myocardial regeneration by activation of multipotent cardiac stem cells in ischemic heart failure
    Konrad Urbanek
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Proc Natl Acad Sci U S A 102:8692-7. 2005
    ..The loss of functionally competent CSCs in chronic ischemic cardiomyopathy may underlie the progressive functional deterioration and the onset of terminal failure...
  39. pmc Stem cells in the dog heart are self-renewing, clonogenic, and multipotent and regenerate infarcted myocardium, improving cardiac function
    Axel Linke
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Proc Natl Acad Sci U S A 102:8966-71. 2005
    ..These results suggest that strategies capable of activating the growth reserve of the myocardium may be important in cardiac repair after ischemic injury...
  40. ncbi request reprint Resident progenitors and bone marrow stem cells in myocardial renewal and repair
    Simon Mendez-Ferrer
    Cardiovascular Institute and Center for Cardiovascular Health, Mount Sinai School of Medicine, New York, NY 10029, USA
    Nat Clin Pract Cardiovasc Med 3:S83-9. 2006
    ..Here, we briefly review the use of bone-marrow-derived and cardiac-derived stem/progenitor cells in myocardial regeneration studies and discuss their significance for the future of the field of myocardial regeneration...
  41. ncbi request reprint Testing regeneration of human myocardium without knowing the identity and the number of effective bone marrow cells transplanted: are the results meaningful?
    Daniele Torella
    J Am Coll Cardiol 48:417; author reply 417-8. 2006
  42. ncbi request reprint [Cardiovascular regenerative medicine at the crossroads. Clinical trials of cellular therapy must now be based on reliable experimental data from animals with characteristics similar to human's]
    Bernardo Nadal-Ginard
    The Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Rev Esp Cardiol 59:1175-89. 2006
    ..Without it, we run the risk of holding back the field for decades, as happened with the first human heart transplants and with trials of gene therapy...
  43. ncbi request reprint Myocyte death and renewal: modern concepts of cardiac cellular homeostasis
    Georgina M Ellison
    Cardiovascular Institute and Center for Cardiovascular Health, Mount Sinai School of Medicine, New York, NY 10029, USA
    Nat Clin Pract Cardiovasc Med 4:S52-9. 2007
    ..In this article, we review the developments in cardiac cell biology that might, in our opinion, have a broad impact on cardiovascular medicine...
  44. ncbi request reprint Increased vascular endothelial growth factor expression but impaired vascular endothelial growth factor receptor signaling in the myocardium of type 2 diabetic patients with chronic coronary heart disease
    Ferdinando Carlo Sasso
    Department of Geriatrics and Metabolic Disease, Second University of Naples, Naples, Italy
    J Am Coll Cardiol 46:827-34. 2005
    ..The aim of the present study was to evaluate the expression and the activity of vascular endothelial growth factor (VEGF) in the hearts of diabetic patients with chronic coronary heart disease (CHD)...
  45. ncbi request reprint Nuclear targeting of Akt enhances kinase activity and survival of cardiomyocytes
    Isao Shiraishi
    The Children s Hospital Research Foundation, Division of Molecular Cardiovascular Biology Cincinnati, Ohio, USA
    Circ Res 94:884-91. 2004
    ....
  46. pmc Acute beta-adrenergic overload produces myocyte damage through calcium leakage from the ryanodine receptor 2 but spares cardiac stem cells
    Georgina M Ellison
    Zena and Michael A Wiener Cardiovascular Institute and Marie Josee and Henry R Kravis Center for Cardiovascular Health, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 282:11397-409. 2007
    ..The latter could contribute to the ability of the myocardium to rapidly recover from acute hyperadrenergic damage...
  47. ncbi request reprint Senescence and death of primitive cells and myocytes lead to premature cardiac aging and heart failure
    Cristina Chimenti
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Vosburgh Pavilion, Room 302, Valhalla, NY 10595, USA
    Circ Res 93:604-13. 2003
    ..In conclusion, telomere erosion, cellular senescence, and death characterize aged diseased hearts and the development of cardiac failure in humans...