A Belfiore

Summary

Affiliation: Magna Graecia University
Country: Italy

Publications

  1. pmc PPAR-γ agonists and their effects on IGF-I receptor signaling: Implications for cancer
    A Belfiore
    Endocrinology Unit, Department of Clinical and Experimental Medicine, University of Catanzaro, 88100 Catanzaro, Italy
    PPAR Res 2009:830501. 2009
  2. pmc The role of metformin in the management of NAFLD
    Angela Mazza
    Endocrinology Unit, Department of Clinical and Experimental Medicine, University Magna Graecia of Catanzaro, Campus Universitario, località Germaneto, Viale Europa, 88100 Catanzaro, Italy
    Exp Diabetes Res 2012:716404. 2012
  3. pmc The insulin receptor: a new target for cancer therapy
    Roberta Malaguarnera
    Endocrinology Unit, Department of Clinical and Experimental Medicine, University Magna Graecia of Catanzaro Catanzaro, Italy
    Front Endocrinol (Lausanne) 2:93. 2011
  4. pmc Nonalcoholic Fatty liver: a possible new target for type 2 diabetes prevention and treatment
    Barbara Fruci
    Endocrinology, Department of Health Sciences, University Magna Graecia of Catanzaro, Catanzaro 88100, Italy
    Int J Mol Sci 14:22933-66. 2013
  5. doi request reprint Increased mortality in patients with differentiated thyroid cancer associated with Graves' disease
    Gabriella Pellegriti
    Endocrinology Unit, Department of Clinical and Molecular Biomedicine, University of Catania, 95100 Catania, Italy
    J Clin Endocrinol Metab 98:1014-21. 2013
  6. doi request reprint Proinsulin binds with high affinity the insulin receptor isoform A and predominantly activates the mitogenic pathway
    Roberta Malaguarnera
    Department of Health, Endocrinology, University of Catanzaro, Campus Universitario, località Germaneto, 88100 Catanzaro, Italy
    Endocrinology 153:2152-63. 2012
  7. ncbi request reprint Fine-needle aspiration biopsy of the thyroid
    A Belfiore
    Cattedra di Endocrinologia, Dipartimento di Medicina Clinica e Sperimentale, Policlinico Mater Domini, University of Catanzaro, Catanzaro, Italy
    Endocrinol Metab Clin North Am 30:361-400. 2001
  8. doi request reprint Insulin receptor and cancer
    Antonino Belfiore
    Endocrinology Unit, Department of Clinical and Experimental Medicine, University Magna Graecia of Catanzaro, Campus Universitario, località Germaneto, 88100 Catanzaro, Italy
    Endocr Relat Cancer 18:R125-47. 2011
  9. doi request reprint Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease
    Antonino Belfiore
    Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, Ospedale Garibaldi Nesima, 95122 Catania, Italy
    Endocr Rev 30:586-623. 2009
  10. doi request reprint IGF and insulin receptor signaling in breast cancer
    Antonino Belfiore
    Endocrinology, Department of Clinical and Experimental Medicine, University of Catanzaro, 88100, Catanzaro, Italy
    J Mammary Gland Biol Neoplasia 13:381-406. 2008

Collaborators

  • Renato Baserga
  • R Vigneri
  • Alessandra Aloisi
  • D Giuffrida
  • P Scalia
  • I D Goldfine
  • M Loda
  • S Filetti
  • D Russo
  • C Giordano
  • C Giordano Galluzzo
  • P Comoglio
  • Gabriella Castoria
  • Haim Werner
  • Liliane Goetsch
  • Giuseppe Pandini
  • Roberta Malaguarnera
  • Laura Sciacca
  • Francesco Frasca
  • Rossana Mineo
  • Marco Genua
  • Veronica Vella
  • A Mazza
  • Barbara Fruci
  • R Malaguarnera
  • Angela Mazza
  • Alaide Morcavallo
  • Antonella Sacco
  • F Frasca
  • S Trapasso
  • V Vella
  • Gabriella Pellegriti
  • Stefania Giuliano
  • B Fruci
  • G A Garinis
  • Aurora Aiello
  • G Pellegriti
  • Enrico Conte
  • Enzo Medico
  • E Allegra
  • A Garozzo
  • A Fava
  • P Guzzi
  • B D'Orrico
  • P Veltri
  • Marco Russo
  • Ilenia Marturano
  • Rosa Terranova
  • Celestina Mannarino
  • Giorgia Anna Garinis
  • A Ippolito
  • S Giuliano
  • Concetta Voci
  • A Morcavallo
  • Aldo Garozzo
  • Angela Palummo
  • Fiorenza Gianì
  • Marco Gaspari
  • Giovanni Cuda
  • Martin R Larsen
  • V Ventura
  • L Abenavoli
  • S Abenavoli
  • M Greco
  • L Sciacca
  • M De Siena
  • R Mineo
  • Rive Sarfstein
  • E Gulletta
  • G Pandini
  • Guidalberto Manfioletti
  • Diego Sisci
  • Marcello Maggiolini
  • M Stella
  • M Attard
  • P Gangemi
  • F Trimarchi
  • C Nucera
  • E Mazzon
  • Angelo Mandarino
  • Rosa Linda Messina
  • Barbara Akla
  • Nathalie Corvaia
  • Thierry Wurch
  • Sebastiano Squatrito
  • Marco Marcelli
  • Charles T Roberts
  • Simona Russo
  • Angela Costantino
  • Emanuela Mazzon

Detail Information

Publications43

  1. pmc PPAR-γ agonists and their effects on IGF-I receptor signaling: Implications for cancer
    A Belfiore
    Endocrinology Unit, Department of Clinical and Experimental Medicine, University of Catanzaro, 88100 Catanzaro, Italy
    PPAR Res 2009:830501. 2009
    ..In light of these evidences, TZDs or other PPAR-γ agonists may be exploited in those tumors "addicted" to the IGF signaling and/or in tumors occurring in hyperinsulinemic patients...
  2. pmc The role of metformin in the management of NAFLD
    Angela Mazza
    Endocrinology Unit, Department of Clinical and Experimental Medicine, University Magna Graecia of Catanzaro, Campus Universitario, località Germaneto, Viale Europa, 88100 Catanzaro, Italy
    Exp Diabetes Res 2012:716404. 2012
    ..Moreover, metformin could have beneficial tissue-specific effects in NAFLD patients irrespective of its effects as insulin sensitizer...
  3. pmc The insulin receptor: a new target for cancer therapy
    Roberta Malaguarnera
    Endocrinology Unit, Department of Clinical and Experimental Medicine, University Magna Graecia of Catanzaro Catanzaro, Italy
    Front Endocrinol (Lausanne) 2:93. 2011
    ..Only few drugs co-targeting the IR and IGF-IR are currently available. Ideally, future IR targeting strategies should be able to selectively inhibit the tumor promoting effects of IR without impairing its metabolic effects...
  4. pmc Nonalcoholic Fatty liver: a possible new target for type 2 diabetes prevention and treatment
    Barbara Fruci
    Endocrinology, Department of Health Sciences, University Magna Graecia of Catanzaro, Catanzaro 88100, Italy
    Int J Mol Sci 14:22933-66. 2013
    ..The heterogeneity of these studies and the small number of patients do not allow for firm conclusions about treatment guidelines, and further randomized, controlled studies are needed. ..
  5. doi request reprint Increased mortality in patients with differentiated thyroid cancer associated with Graves' disease
    Gabriella Pellegriti
    Endocrinology Unit, Department of Clinical and Molecular Biomedicine, University of Catania, 95100 Catania, Italy
    J Clin Endocrinol Metab 98:1014-21. 2013
    ..Subsequent studies on this issue reached controversial conclusions. Genetic and environmental factors, as well as the lack of appropriate control subjects and/or inadequate patient follow-up, may account for these discrepancies...
  6. doi request reprint Proinsulin binds with high affinity the insulin receptor isoform A and predominantly activates the mitogenic pathway
    Roberta Malaguarnera
    Department of Health, Endocrinology, University of Catanzaro, Campus Universitario, località Germaneto, 88100 Catanzaro, Italy
    Endocrinology 153:2152-63. 2012
    ..In conclusion, proinsulin is a selective IR-A ligand and may induce biological effects through this IR isoform...
  7. ncbi request reprint Fine-needle aspiration biopsy of the thyroid
    A Belfiore
    Cattedra di Endocrinologia, Dipartimento di Medicina Clinica e Sperimentale, Policlinico Mater Domini, University of Catanzaro, Catanzaro, Italy
    Endocrinol Metab Clin North Am 30:361-400. 2001
    ....
  8. doi request reprint Insulin receptor and cancer
    Antonino Belfiore
    Endocrinology Unit, Department of Clinical and Experimental Medicine, University Magna Graecia of Catanzaro, Campus Universitario, località Germaneto, 88100 Catanzaro, Italy
    Endocr Relat Cancer 18:R125-47. 2011
    ..Future anticancer therapies need to target the IR-A pathway in order to inhibit the tumor promoting effect of IR without impairing the metabolic effect of insulin...
  9. doi request reprint Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease
    Antonino Belfiore
    Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, Ospedale Garibaldi Nesima, 95122 Catania, Italy
    Endocr Rev 30:586-623. 2009
    ..The functional characteristics of such hybrid receptors and their role in physiology, in diabetes, and in malignant cells are not yet fully understood. These receptors seem to enhance cell responsiveness to IGFs...
  10. doi request reprint IGF and insulin receptor signaling in breast cancer
    Antonino Belfiore
    Endocrinology, Department of Clinical and Experimental Medicine, University of Catanzaro, 88100, Catanzaro, Italy
    J Mammary Gland Biol Neoplasia 13:381-406. 2008
    ..Moreover, in addition to the IGF-IR, both IR-A and HRs should be also considered as molecular targets for anti-cancer therapies...
  11. ncbi request reprint The role of insulin receptor isoforms and hybrid insulin/IGF-I receptors in human cancer
    Antonino Belfiore
    Department of Clinical and Experimental Medicine, Endocrine Unit, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy
    Curr Pharm Des 13:671-86. 2007
    ..IR-A isoform and hybrid receptors should be regarded, therefore, as potential molecular targets for novel anti-cancer therapies...
  12. pmc The IGF system in thyroid cancer: new concepts
    V Vella
    Cattedra di Endocrinologia, Istituto di Medicina Interna, Malattie Endocrine e del Metabolismo, University of Catania, Ospedale Garibaldi, Catania, Italy
    Mol Pathol 54:121-4. 2001
    ..These data indicate that both IR/IGF-I-R hybrids and IR-A play an important role in the overactivation of the IGF system in thyroid cancer and in IGF-I mitogenic signalling in these tumours. J Clin PATHOL: Mol Pathol..
  13. pmc Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells
    F Frasca
    Istituto di Medicina Interna, Malattie Endocrine e del Metabolismo, University of Catania, Ospedale Garibaldi, 95123 Catania, Italy
    Mol Cell Biol 19:3278-88. 1999
    ..These data indicate, therefore, that there are two receptors for IGF-II, both IGF-I-R and IR-A. Further, they suggest that interaction of IGF-II with IR-A may play a role both in fetal growth and cancer biology...
  14. ncbi request reprint Negative/low expression of the Met/hepatocyte growth factor receptor identifies papillary thyroid carcinomas with high risk of distant metastases
    A Belfiore
    Cattedra di Endocrinologia, University of Catania, Italy
    J Clin Endocrinol Metab 82:2322-8. 1997
    ..99; P = 0.0099), and vascular invasion (hazard ratio = 3.19; P = 0.0358). These findings suggest a role for Met/HGF-R in papillary thyroid cancer and its clinical use to select patients with a high risk of distant metastases...
  15. ncbi request reprint Immunostaining for Met/HGF receptor may be useful to identify malignancies in thyroid lesions classified suspicious at fine-needle aspiration biopsy
    A Ippolito
    Istituto di Medicina Interna e di Malattie Endocrine e del Metabolismo, University of Catania, Italy
    Thyroid 11:783-7. 2001
    ..These data suggest that Met immunostaining of suspicious cytological smears are useful for identifying malignant lesions, especially those with a papillary histotype...
  16. ncbi request reprint Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved
    Giuseppe Pandini
    Istituto di Medicina Interna, Malattie Endocrine e del Metabolismo, University of Catania, Ospedale Garibaldi, 95123 Catania, Italy
    J Biol Chem 277:39684-95. 2002
    ..The relative abundance of IR isoforms therefore affects IGF system activation through Hybrid-Rs, with important consequences for tissue-specific responses to both insulin and IGFs...
  17. ncbi request reprint Thyroid cancer development and progression: emerging role of cancer stem cells
    R Malaguarnera
    Endocrinology Unit, Department of Health, University Magna Graecia of Catanzaro, Catanzaro, Italy
    Minerva Endocrinol 37:103-15. 2012
    ..More effective protocols for the identification and isolation of thyroid cancer stem cells will allow us to specifically and safely target these cells with the aim to definitely eradicate aggressive thyroid cancers...
  18. doi request reprint BRAF(V600E) mutation and the biology of papillary thyroid cancer
    F Frasca
    Endocrinologia, Dipartimento di Medicina Interna e Medicina Specialistica, University of Catania, PO Garibaldi Nesima, Via Palermo 636, Catania, Italy
    Endocr Relat Cancer 15:191-205. 2008
    ..These results indicate that BRAF((V600E)) mutation is a marker of aggressive disease in both micro- and macro-PTCs. Moreover, for the first time, a possible link between BRAF((V600E)) mutation and environmental carcinogens is suggested...
  19. doi request reprint Evaluation of the CD44 isoform v-6 (sCD44var, v6) in the saliva of patients with laryngeal carcinoma and its prognostic role
    S Trapasso
    Department of Otolaryngology, University Magna Graecia of Catanzaro, Catanzaro, Italy
    Cancer Biomark 16:275-80. 2016
    ....
  20. doi request reprint Metformin versus dietary treatment in nonalcoholic hepatic steatosis: a randomized study
    G A Garinis
    Endocrinology Unit, Department of Clinical and Experimental Medicine, University Magna Graecia of Catanzaro, Catanzaro, Italy
    Int J Obes (Lond) 34:1255-64. 2010
    ..We aimed at evaluating whether the addition of low-dose metformin to dietary treatment could be an effective approach in nondiabetic patients with nonalcoholic fatty liver disease (NAFLD)...
  21. doi request reprint In PCOS patients the addition of low-dose spironolactone induces a more marked reduction of clinical and biochemical hyperandrogenism than metformin alone
    A Mazza
    Department of Health Sciences, Endocrinology, University Magna Graecia of Catanzaro, Campus Universitario, località Germaneto, 88100 Catanzaro, Italy
    Nutr Metab Cardiovasc Dis 24:132-9. 2014
    ..We investigated whether therapy with metformin plus low-dose spironolactone is more effective than metformin alone in PCOS patients...
  22. ncbi request reprint Differentiated thyroid cancer in children and adolescents
    D Giuffrida
    Medical Oncology Unit, S Luigi Hospital, University of Catania, Italy
    J Endocrinol Invest 25:18-24. 2002
    ..For this reason, although the prognosis is usually good in these patients, we believe that total or near total thyroidectomy with lymphadenectomy is always the required initial surgical treatment...
  23. ncbi request reprint A novel autocrine loop involving IGF-II and the insulin receptor isoform-A stimulates growth of thyroid cancer
    Veronica Vella
    Istituto di Medicina Interna e di Malattie Endocrine e del Metabolismo, Cattedra di Endocrinologia, University of Catania, Ospedale Garibaldi, 95123 Catania, Italy
    J Clin Endocrinol Metab 87:245-54. 2002
    ..A growth-promoting autocrine loop is activated, therefore, and may affect thyroid cancer biology...
  24. ncbi request reprint In IGF-I receptor-deficient leiomyosarcoma cells autocrine IGF-II induces cell invasion and protection from apoptosis via the insulin receptor isoform A
    Laura Sciacca
    Dipartimento di Medicina Interna e Medicina Specialistica, University of Catania, Ospedale Garibaldi, 95123 Catania, Italy
    Oncogene 21:8240-50. 2002
    ..In SKUT-1 leiomyoma cells this fetal IR isoform may vicariate the IGF-IR for cell response to both insulin and IGF-II. Acting on the same IR-A receptor IGF-II is more potent than insulin in stimulating cancer cell migration...
  25. doi request reprint Differential signaling activation by insulin and insulin-like growth factors I and II upon binding to insulin receptor isoform A
    Antonella Sacco
    Endocrinology Unit, Department of Clinical and Experimental Medicine, University of Catanzaro, 88100 Catanzaro, Italy
    Endocrinology 150:3594-602. 2009
    ..These results underline the role of IR-A in physiology and disease...
  26. ncbi request reprint Differential gene expression induced by insulin and insulin-like growth factor-II through the insulin receptor isoform A
    Giuseppe Pandini
    Dipartimento di Medicina Interna e di Medicine Specialistiche, Cattedra di Endocrinologia, University of Catania, USL 34, Ospedale Garibaldi, 95123 Catania, Italy
    J Biol Chem 278:42178-89. 2003
    ....
  27. ncbi request reprint Detection of an activating mutation of the thyrotropin receptor in a case of an autonomously hyperfunctioning thyroid insular carcinoma
    D Russo
    Dipartimento di Medicina Sperimentale e Clinica, Cattedra di Endocrinologia, University of Reggio Calabria, Catanzaro, Italy
    J Clin Endocrinol Metab 82:735-8. 1997
    ..This is the first description of an activating TSH receptor mutation in a thyroid hyperfunctioning carcinoma in which an aggressive malignant phenotype coexisted with activation of the cAMP cascade and differentiated thyroid functions...
  28. ncbi request reprint Functional responses and in vivo anti-tumour activity of h7C10: a humanised monoclonal antibody with neutralising activity against the insulin-like growth factor-1 (IGF-1) receptor and insulin/IGF-1 hybrid receptors
    Giuseppe Pandini
    Dipartimento di Medicina Interna e Medicine Specialistiche, Ospedale Garibaldi, University of Catania, Italy
    Eur J Cancer 43:1318-27. 2007
    ..The herewith described neutralising properties of h7C10 as potent inhibitor of both IGF-1R and Hybrid-Rs are likely to participate in its anti-tumoural activities and maybe of interest for therapeutic applications...
  29. pmc Research resource: New and diverse substrates for the insulin receptor isoform A revealed by quantitative proteomics after stimulation with IGF-II or insulin
    Alaide Morcavallo
    Department of Clinical and Experimental Medicine, University Magna Graecia of Catanzaro, Catanzaro, Italy
    Mol Endocrinol 25:1456-68. 2011
    ..These findings indicate that IR-A activation by IGF-II elicits a unique signaling pathway that may play a distinct role in physiology and in disease...
  30. doi request reprint Insulin receptor isoforms and insulin-like growth factor receptor in human follicular cell precursors from papillary thyroid cancer and normal thyroid
    Roberta Malaguarnera
    Department of Clinical and Experimental Medicine, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy
    J Clin Endocrinol Metab 96:766-74. 2011
    ..Thyroid cancer cells are responsive to insulin and IGF-I and IGF-II and often overexpress the insulin receptor (IR) and the IGF-I receptor (IGF-IR)...
  31. ncbi request reprint Interleukin-4 stimulates papillary thyroid cancer cell survival: implications in patients with thyroid cancer and concomitant Graves' disease
    Veronica Vella
    Istituto di Medicina Interna e di Malattie Endocrine e del Metabolismo, Cattedra di Endocrinologia, University of Catania, Ospedale Garibaldi, Italy
    J Clin Endocrinol Metab 89:2880-9. 2004
    ..Taken together, these findings suggest that thyroid cancer cells receive significant protection from apoptosis by IL-4 produced in the thyroid gland by activated T lymphocytes when concomitant Graves' disease is present...
  32. ncbi request reprint Signaling differences from the A and B isoforms of the insulin receptor (IR) in 32D cells in the presence or absence of IR substrate-1
    Laura Sciacca
    Dipartimento di Medicina Interna e Medicina Specialistica, University of Catania, Ospedale Garibaldi, 95123 Catania, Italy
    Endocrinology 144:2650-8. 2003
    ..The results confirm that the A isoform responds to IGF-II and preferentially sends mitogenic, antiapoptotic signals, whereas the B form, poorly responsive to IGF-II, tends to send differentiation signals...
  33. doi request reprint HMGA1 protein is a positive regulator of the insulin-like growth factor-I receptor gene
    Aurora Aiello
    Department of Clinical and Experimental Medicine, Endocrinology, University of Catanzaro, 88100 Catanzaro, Italy
    Eur J Cancer 46:1919-26. 2010
    ..Our data indicate, therefore, that HMGA1 protein is a positive regulator of IGF-IR expression and that HMGA1 overexpression may contribute to IGF-IR dysregulation in cancer cells...
  34. ncbi request reprint Activation of the hepatocyte growth factor (HGF)-Met system in papillary thyroid cancer: biological effects of HGF in thyroid cancer cells depend on Met expression levels
    Rossana Mineo
    Dipartimento di Medicina Sperimentale e Clinica, Policlinico Mater Domini, University of Catanzaro Magna Graecia, Via Tommaso Campanella 115, 88100 Catanzaro, Italy
    Endocrinology 145:4355-65. 2004
    ....
  35. doi request reprint Role of cyclic AMP response element-binding protein in insulin-like growth factor-i receptor up-regulation by sex steroids in prostate cancer cells
    Marco Genua
    Endocrinology, Department of Internal Medicine and Medical Specialties, University of Catania, Catania, Italy
    Cancer Res 69:7270-7. 2009
    ..In conclusion, we describe a novel mechanism of IGF-IR up-regulation and promoter activity by CREB activation, induced by sex steroids, through a nongenotropic signaling...
  36. doi request reprint Sex steroids upregulate the IGF-1R in prostate cancer cells through a nongenotropic pathway
    Giuseppe Pandini
    Dipartimento di Medicina Interna e Medicine Specialistiche, Endocrine Unit, Universita di Catania, Catania, Italy
    Ann N Y Acad Sci 1155:263-7. 2009
    ..Inhibition of the IGF-1R or the Src-ERK pathway should be considered, therefore, as an adjuvant therapy in PCa...
  37. ncbi request reprint Androgens up-regulate the insulin-like growth factor-I receptor in prostate cancer cells
    Giuseppe Pandini
    Dipartimento di Medicina Interna e di Medicina Specialistica, Cattedra di Endocrinologia, University of Catania, Ospedale Garibaldi, Catania, Italy
    Cancer Res 65:1849-57. 2005
    ..Anti-androgen therapy may be only partially effective, or almost ineffective, in blocking important biological effects of androgens, such as activation of the IGF system...
  38. ncbi request reprint 17beta-estradiol up-regulates the insulin-like growth factor receptor through a nongenotropic pathway in prostate cancer cells
    Giuseppe Pandini
    Endocrinologia, Dipartimento di Medicina Interna e Medicina Specialistica, University of Catania, Ospedale Garibaldi Nesima, Catania, Italy
    Cancer Res 67:8932-41. 2007
    ..Estrogens may have a role, therefore, in tumor progression to androgen independence. Inhibition of the IGF-IR or the Src-ERK pathway should be considered, therefore, as an adjuvant therapy in prostate cancer...
  39. ncbi request reprint Role of c-Abl in directing metabolic versus mitogenic effects in insulin receptor signaling
    Francesco Frasca
    Endocrinologia, Dipartimento di Medicina Interna e di Medicina Specialistica, Universita di Catania, Ospedale Garibaldi, Nesima, 95122 Catania, Italy
    J Biol Chem 282:26077-88. 2007
    ..Taken together these results suggest that c-Abl activation by insulin, via a modification of FAK response, may play an important role in directing mitogenic versus metabolic insulin receptor signaling...
  40. ncbi request reprint IGF-II binding to insulin receptor isoform A induces a partially different gene expression profile from insulin binding
    Giuseppe Pandini
    Dipartimento di Medicina Interna e di Medicine Specialistiche, Universita di Cantania, Italy
    Ann N Y Acad Sci 1028:450-6. 2004
    ..These findings provide a molecular basis in clarifying the biological role of IR-A in embryonic/fetal life and in cancer...