Maria Rapicetta

Summary

Affiliation: Istituto Superiore di Sanit
Country: Italy

Publications

  1. doi request reprint New perspectives for hepatitis B vaccines and immunization
    Maria Rapicetta
    Viral Hepatitis Unit, Department of Infectious, Parasitic and Immune Mediated Disease, Istituto Superiore di Sanita, Rome, Italy
    Vaccine 27:3271-5. 2009
  2. ncbi request reprint Rapid emergence of a viral resistant mutant in WHV chronically infected woodchucks treated with lamivudine and a pre-S/S CHO-derived hepatitis B virus vaccine
    Loreta A Kondili
    Viral Hepatitis Unit, Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Rome, Italy
    Vaccine 25:4895-902. 2007
  3. ncbi request reprint A pre-S/S CHO-derived hepatitis B virus vaccine protects woodchucks from WHV productive infection
    Claudio Argentini
    Viral Hepatitis Unit, Department of Infectious, Parasitic, and Immune Mediated Disease, Istituto Superiore di Sanita, Viale Regina Elena, 00161 Rome, Italy
    Vaccine 23:3649-56. 2005
  4. doi request reprint Hepatitis B, C and Delta virus infections in Albanian patients with chronic liver disease: evaluation of possible changes during the last 10 years
    Loreta A Kondili
    Viral Hepatitis Unit, Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanità Rome 00161, Italy
    Eur J Gastroenterol Hepatol 22:167-71. 2010
  5. doi request reprint Identification of low HBV-DNA levels by nucleic acid amplification test (NAT) in blood donors
    Stefano Dettori
    Viral Hepatitis Unit, Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, 00161 Rome, Italy
    J Infect 59:128-33. 2009
  6. doi request reprint Nucleic acid testing (NAT) for HCV RNA in Italian transfusion centres: an external quality assessment
    Angela Candido
    Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    J Clin Virol 41:277-82. 2008
  7. ncbi request reprint Lack of WHV integration nearby N-myc2 and in the downstream b3n and win loci in a considerable fraction of liver tumors with activated N-myc2 from naturally infected wild woodchucks
    Roberto Bruni
    Department of Infectious, Parasitic and Immunomediated Diseases, Viral Hepatitis Unit, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Virology 345:258-69. 2006
  8. doi request reprint Effect of an immunogenic complex containing WHV viral particles and non-neutralizing anti-HBs antibodies on the outcome of WHV infection in woodchucks
    Emilio D'Ugo
    Viral Hepatitis Unit, Department of Infectious, Parasitic and Immune Mediated Diseases, Italian Instituter of Health, Rome, Italy
    J Med Virol 83:178-86. 2011
  9. pmc Microarray analysis identifies a common set of cellular genes modulated by different HCV replicon clones
    Anna Rita Ciccaglione
    Department of Infectious, Parasitic and Immunomediated Diseases, Istituto Superiore di Sanita, Rome, Italy
    BMC Genomics 9:309. 2008
  10. ncbi request reprint Rare HVR1-HCV genotype 1b variants in patients with B non Hodgkin's lymphoma. Comparison with viral sequences detected in cases of lymphoproliferative disorders and B cell compartmentalisation
    Stefano Dettori
    Viral Hepatitis Unit, Department of Infectious, Parasitic and Immune Mediated Disease, Istituto Superiore di Sanita, Rome
    New Microbiol 30:265-70. 2007

Collaborators

Detail Information

Publications30

  1. doi request reprint New perspectives for hepatitis B vaccines and immunization
    Maria Rapicetta
    Viral Hepatitis Unit, Department of Infectious, Parasitic and Immune Mediated Disease, Istituto Superiore di Sanita, Rome, Italy
    Vaccine 27:3271-5. 2009
    ..Future studies on treatment of HBV chronic infection should be addressed to the evaluation of therapies combined with antivirals, vaccines and immunomodulatory compounds...
  2. ncbi request reprint Rapid emergence of a viral resistant mutant in WHV chronically infected woodchucks treated with lamivudine and a pre-S/S CHO-derived hepatitis B virus vaccine
    Loreta A Kondili
    Viral Hepatitis Unit, Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Rome, Italy
    Vaccine 25:4895-902. 2007
    ..The woodchuck remains a useful model for characterising the biology and kinetics of the emergence of drug-resistant variants and could be used for pre-clinical studies of combinations of new antiviral drugs...
  3. ncbi request reprint A pre-S/S CHO-derived hepatitis B virus vaccine protects woodchucks from WHV productive infection
    Claudio Argentini
    Viral Hepatitis Unit, Department of Infectious, Parasitic, and Immune Mediated Disease, Istituto Superiore di Sanita, Viale Regina Elena, 00161 Rome, Italy
    Vaccine 23:3649-56. 2005
    ..In the vaccinated animals, there was evidence of abortive infection. The results demonstrate that a human vaccine is able to protect woodchucks from WHV infection...
  4. doi request reprint Hepatitis B, C and Delta virus infections in Albanian patients with chronic liver disease: evaluation of possible changes during the last 10 years
    Loreta A Kondili
    Viral Hepatitis Unit, Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanità Rome 00161, Italy
    Eur J Gastroenterol Hepatol 22:167-71. 2010
    ....
  5. doi request reprint Identification of low HBV-DNA levels by nucleic acid amplification test (NAT) in blood donors
    Stefano Dettori
    Viral Hepatitis Unit, Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, 00161 Rome, Italy
    J Infect 59:128-33. 2009
    ..To evaluate the presence of HBV-DNA in 22,765 consecutive blood donors, who donated blood in the period from January 2006 to August 2007 at a transfusion centre in Lazio, a region in central Italy with low HBV endemicity...
  6. doi request reprint Nucleic acid testing (NAT) for HCV RNA in Italian transfusion centres: an external quality assessment
    Angela Candido
    Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    J Clin Virol 41:277-82. 2008
    ..We conducted an external quality assessment of the results obtained in Italian transfusion centre laboratories employing nucleic acid testing (NAT) for detection of HCV RNA in donated blood...
  7. ncbi request reprint Lack of WHV integration nearby N-myc2 and in the downstream b3n and win loci in a considerable fraction of liver tumors with activated N-myc2 from naturally infected wild woodchucks
    Roberto Bruni
    Department of Infectious, Parasitic and Immunomediated Diseases, Viral Hepatitis Unit, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Virology 345:258-69. 2006
    ....
  8. doi request reprint Effect of an immunogenic complex containing WHV viral particles and non-neutralizing anti-HBs antibodies on the outcome of WHV infection in woodchucks
    Emilio D'Ugo
    Viral Hepatitis Unit, Department of Infectious, Parasitic and Immune Mediated Diseases, Italian Instituter of Health, Rome, Italy
    J Med Virol 83:178-86. 2011
    ..The results of this study indicate that the IGC could be useful for breaking the tolerance in hepadnaviral infection and for boosting the host's innate and adoptive immune response...
  9. pmc Microarray analysis identifies a common set of cellular genes modulated by different HCV replicon clones
    Anna Rita Ciccaglione
    Department of Infectious, Parasitic and Immunomediated Diseases, Istituto Superiore di Sanita, Rome, Italy
    BMC Genomics 9:309. 2008
    ..Thus, we analysed the expression profiles of different clones of human hepatoma-derived Huh-7 cells carrying a self-replicating HCV RNA which express all viral proteins (HCV replicon system)...
  10. ncbi request reprint Rare HVR1-HCV genotype 1b variants in patients with B non Hodgkin's lymphoma. Comparison with viral sequences detected in cases of lymphoproliferative disorders and B cell compartmentalisation
    Stefano Dettori
    Viral Hepatitis Unit, Department of Infectious, Parasitic and Immune Mediated Disease, Istituto Superiore di Sanita, Rome
    New Microbiol 30:265-70. 2007
    ..In conclusion, the HCV predominants circulating in B-NHL cases seem to be associated with clonal selection of rare variants...
  11. ncbi request reprint Immunization of woodchucks with adjuvanted sHDAg (p24): immune response and outcome following challenge
    Emilio D'Ugo
    Laboratory of Virology, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Vaccine 22:457-66. 2004
    ..Overall, the results suggest that the MF59/p24 vaccine better controls the infection in terms of viral replication and survival...
  12. doi request reprint Historical study of acute hepatitis B in subjects with or without hepatitis C infection
    Tommaso Stroffolini
    Tropical Diseases Unit, Policlinico Umberto I, Rome, Italy
    Eur J Intern Med 23:e146-9. 2012
    ..The aim of the study was to evaluate during time the epidemiological features of acute hepatitis B cases referred to an Infectious Disease Unit in North-East of Italy between 1978 and 1995...
  13. pmc A computational approach identifies two regions of Hepatitis C Virus E1 protein as interacting domains involved in viral fusion process
    Roberto Bruni
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Rome, Italy
    BMC Struct Biol 9:48. 2009
    ....
  14. doi request reprint HCV genetic variability: from quasispecies evolution to genotype classification
    Claudio Argentini
    Viral Hepatitis Unit, Department of Infectious, Parasitic and Immune Mediated Disease, Istituto Superiore di Sanita, Viale Regina Elena 299, Rome, Italy
    Future Microbiol 4:359-73. 2009
    ..The features and biological implications of HCV variability and of quasispecies dynamics in infection transmission, mechanisms of chronicity and resistance to antiviral therapy are discussed...
  15. doi request reprint Evaluation of the effects of human leukocyte IFN-alpha on the immune response to the HBV vaccine in healthy unvaccinated individuals
    Paola Rizza
    Section of Experimental Immunotherapy, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Viale Regina Elena, 299, 00161Rome, Italy
    Vaccine 26:1038-49. 2008
    ..We conclude that, under the conditions used in this trial, natural IFN-alpha does not act as an adjuvant of the HBV vaccine in healthy unvaccinated individuals...
  16. pmc A cohort study to evaluate persistence of hepatitis B immunogenicity after administration of hexavalent vaccines
    Cristina Giambi
    Communicable Disease Epidemiology Unit, National Centre for Epidemiology, Surveillance and Health Promotion, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    BMC Infect Dis 8:100. 2008
    ..The objectives of this study were to evaluate the persistence of antibodies to anti-HBs, in children in the third year of life, and to investigate the response to a booster dose of hepatitis B vaccine...
  17. doi request reprint A unique HAV strain circulated in patients with acute HAV infection with different risk exposures in Tuscany, Italy
    Stefania Taffon
    Istituto Superiore di Sanita, Department of Infectious, Parasitic and Immune Mediated Disease, Rome, Italy
    J Clin Virol 50:142-7. 2011
    ..Acute Hepatitis A Virus (HAV) is reported to be an emergent problem in several developed countries...
  18. doi request reprint Evidence for the presence of autochthonous (locally acquired) cases of acute hepatitis E virus infections in Italy since the 80s
    Tommaso Stroffolini
    Department of Infectious and Tropical Diseases, Policlinico Umberto I, Rome, Italy
    Eur J Intern Med 26:348-50. 2015
    ..Autochthonous (locally acquired) cases of acute hepatitis E virus have been recently reported in several developed countries...
  19. doi request reprint Woodchuck hepatitis virus core gene deletions and proliferative responses of peripheral blood mononuclear cells stimulated by an immunodominant epitope: a viral immune escape in the woodchuck model of chronic hepatitis B?
    Stefania Taffon
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161, Rome, Italy
    Arch Virol 160:1065-73. 2015
    ....
  20. doi request reprint The woodchuck hepatitis B virus infection model for the evaluation of HBV therapies and vaccine therapies
    Emilio D'Ugo
    Viral Hepatitis Unit, Department of Infectious, Parasitic and Immune Mediated Infections, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy 39 06 49903233 39 06 49902662
    Expert Opin Drug Discov 5:1153-62. 2010
    ..These may also include specifically targeted immunocomplexes. Such therapies could constitute new frontiers for the treatment of HBV chronic disease...
  21. doi request reprint Switched memory B cells maintain specific memory independently of serum antibodies: the hepatitis B example
    M Manuela Rosado
    Research Center Ospedale Pediatrico Bambino Gesù, IRCSS, Laboratory of Flow Cytometry and B Cell Development, Rome, Italy
    Eur J Immunol 41:1800-8. 2011
    ..01) and serum Abs (geometric mean concentration, GMC from 2.9 to 284 mIU/mL), demonstrating that circulating memory B cells effectively respond to Ag challenge even when specific Abs fall under the protective threshold...
  22. ncbi request reprint Correlates of infection and molecular characterization of blood-borne HIV, HCV, and HBV infections in HIV-1 infected inmates in Italy: An observational cross-sectional study
    Nunzia Sanarico
    aNational AIDS Center, Istituto Superiore di Sanita, RomebItalian Ministry of Health, RomecDepartment of Infectious Diseases, Istituto Superiore di Sanita, RomedASL 3 Genovese and Department of Infectious Diseases, Galliera Hospital, GenovaeSpedali Civili, BresciafInfectious Diseases Unit, University of Bari, BarigCentro Medicina del Viaggiatore e delle Migrazioni, Presidio Ospedaliero di Lamezia Terme, Giovanni Paolo II Hospital, Lamezia TermehDepartment of Primary Care AUSL, ModenaiBelcolle Hospital, ASL ViterbojUniversity of Sassari, Sassari, Italy
    Medicine (Baltimore) 95:e5257. 2016
    ....
  23. ncbi request reprint The win locus involved in activation of the distal N-myc2 gene upon WHV integration in woodchuck liver tumors harbors S/MAR elements
    Roberto Bruni
    Viral Hepatitis Unit, Department of Infectious, Parasitic and Immunomediated Diseases, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Virology 329:1-10. 2004
    ..The distribution of previously described WHV insertions relative to the S/MARs reinforces the hypothesis that S/MARs nearby distal WHV insertions might be involved in long-range activation of N-myc2...
  24. doi request reprint The impact of a vaccination campaign against hepatitis B on the further decrease of hepatitis B virus infection in a southern Italian town over 14 years
    Tommaso Stroffolini
    Tropical Diseases Unit, Policlinico Umberto I, Rome, Italy
    Eur J Intern Med 23:e190-2. 2012
    ..The aims of this study were to identify changes, if any, in the epidemiological pattern of HBV infection in a southern Italian town first surveyed in 1996 and to assess the effectiveness of vaccination campaign against hepatitis B...
  25. ncbi request reprint High prevalence of hepatitis B virus infection in B-cell non-Hodgkin's lymphoma
    Fabrizio Marcucci
    Istituto Superiore di Sanita, Rome, Italy
    Haematologica 91:554-7. 2006
    ..75-7.66). HBV/HCV co-infection was found in four cases, but in no controls. The finding of a positive association between HBV infection and B-NHL raises the possibility that HBV may play an etiologic role in the induction of B-NHL...
  26. ncbi request reprint Clinical and molecular characterization of chronic hepatitis B in Albania: a country that is still highly endemic for HBV infection
    L A Kondili
    Department of Infectious, Parasitic, and Immunomediated Diseases, Viral Hepatitis Unit, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    J Med Virol 75:20-6. 2005
    ..In conclusion, the virological and clinical pattern of chronic hepatitis B in Albania is similar to that observed in other Mediterranean countries; it seems to be independent of the HBV endemicity level...
  27. pmc Modulation of RANTES expression by HCV core protein in liver derived cell lines
    Anna Ruggieri
    Viral Hepatitis Unit, Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Rome, Italy
    BMC Gastroenterol 7:21. 2007
    ..Modulation of chemokines, such as RANTES may be part of the virus induced pathogenicity. We examined the effect of core and structural proteins of HCV on RANTES expression in two liver derived cell lines, HepG2 and Chang Liver (CHL)...
  28. ncbi request reprint In vivo transmission and dynamics of deleted genomes after experimental infection of woodchuck hepatitis B virus in adult animals
    Valentina La Sorsa
    Laboratory of Virology, Istituto Superiore di Sanita, Rome, Italy
    Virus Genes 25:147-57. 2002
    ..The characterization of these classes of deleted mutants in woodchuck-WHV model raises new questions on the link between DGs and persistent infections...
  29. pmc Repression of interferon regulatory factor 1 by hepatitis C virus core protein results in inhibition of antiviral and immunomodulatory genes
    Anna R Ciccaglione
    Department of Infectious, Parasitic and Immunomediated Diseases, Istituto Superiore di Sanita, Viale Regina Elena, 299 Rome 00161, Italy
    J Virol 81:202-14. 2007
    ....
  30. ncbi request reprint An outbreak of hepatitis A virus infection with a high case-fatality rate among injecting drug users
    Enea Spada
    Istituto Superiore di Sanita, National Center of Epidemiology, Surveillance and Health Promotion, Clinical Epidemiology Unit, Viale Regina Elena 299, 00161 Rome, Italy
    J Hepatol 43:958-64. 2005
    ..We attempted a thorough evaluation of the outbreak, including epidemiological, clinical and virological analyses...