S Menard

Summary

Affiliation: Istituto Nazionale Tumori
Country: Italy

Publications

  1. pmc Role of hormonal risk factors in HER2-positive breast carcinomas
    A Balsari
    Istituto Nazionale Tumori, Milano, Italy
    Br J Cancer 88:1032-4. 2003
  2. ncbi request reprint Biologic and therapeutic role of HER2 in cancer
    Sylvie Menard
    Molecular Targeting Unit, Department of Experimental Oncology, Istituto Nazionale Tumori, 20133 Milan, Italy
    Oncogene 22:6570-8. 2003
  3. ncbi request reprint Role of HER2/neu in tumor progression and therapy
    S Menard
    Molecular Targeting Unit, Department of Experimental Oncology, Istituto Nazionale Tumori, Via Venezian 1, 20133 Milano, Italy
    Cell Mol Life Sci 61:2965-78. 2004
  4. doi request reprint Biology, prognosis and response to therapy of breast carcinomas according to HER2 score
    S Menard
    Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    Ann Oncol 19:1706-12. 2008
  5. ncbi request reprint Pathobiologic identification of two distinct breast carcinoma subsets with diverging clinical behaviors
    S Menard
    Department of Experimental Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    Breast Cancer Res Treat 55:169-77. 1999
  6. ncbi request reprint Role of exon-16-deleted HER2 in breast carcinomas
    F Castiglioni
    Molecular Targeting Unit, Department of Experimental Oncology, Istituto Nazionale Tumori, Via Venezian 1, 20133 Milan, Italy
    Endocr Relat Cancer 13:221-32. 2006
  7. ncbi request reprint Production and characterization of monoclonal antibodies directed against the laminin receptor precursor
    S Buto
    Division of Experimental Oncology E, Istituto Nazionale Tumori, Milano, Italy
    Int J Biol Markers 12:1-5. 1997
  8. ncbi request reprint Cooperative effects of Mycobacterium tuberculosis Ag38 gene transduction and interleukin 12 in vaccination against spontaneous tumor development in proto-neu transgenic mice
    L Sfondrini
    Department of Experimental Oncology, Istituto Nazionale Tumori, Milan, Italy
    Cancer Res 60:3777-81. 2000
  9. ncbi request reprint HER2 as a prognostic factor in breast cancer
    S Menard
    Istituto Nazionale Tumori and Institute of Pathology, University of Milan, Milan, Italy
    Oncology 61:67-72. 2001
  10. pmc Effect of adjuvant trastuzumab treatment in conventional clinical setting: an observational retrospective multicenter Italian study
    M Campiglio
    Molecular Targeting Unit, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Amadeo 42, 20133 Milan, Italy
    Breast Cancer Res Treat 141:101-10. 2013

Collaborators

Detail Information

Publications49

  1. pmc Role of hormonal risk factors in HER2-positive breast carcinomas
    A Balsari
    Istituto Nazionale Tumori, Milano, Italy
    Br J Cancer 88:1032-4. 2003
    ..The findings suggest a difference in the protective role of hormone-related risk factors between HER2-positive and -negative tumours...
  2. ncbi request reprint Biologic and therapeutic role of HER2 in cancer
    Sylvie Menard
    Molecular Targeting Unit, Department of Experimental Oncology, Istituto Nazionale Tumori, 20133 Milan, Italy
    Oncogene 22:6570-8. 2003
    ....
  3. ncbi request reprint Role of HER2/neu in tumor progression and therapy
    S Menard
    Molecular Targeting Unit, Department of Experimental Oncology, Istituto Nazionale Tumori, Via Venezian 1, 20133 Milano, Italy
    Cell Mol Life Sci 61:2965-78. 2004
    ..Despite the fact that many pathways interacting with HER2 are still not fully understood, this tyrosine kinase receptor is, to date, a promising molecule for targeted therapy...
  4. doi request reprint Biology, prognosis and response to therapy of breast carcinomas according to HER2 score
    S Menard
    Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    Ann Oncol 19:1706-12. 2008
    ..The standardization of the HER2 score and recent changes in therapeutic modalities points to the need for a reevaluation of the role of HER2 in recently diagnosed breast carcinoma...
  5. ncbi request reprint Pathobiologic identification of two distinct breast carcinoma subsets with diverging clinical behaviors
    S Menard
    Department of Experimental Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    Breast Cancer Res Treat 55:169-77. 1999
    ..These data suggest that breast carcinoma consists of two different subsets that can be identified on the basis of pathobiologic features...
  6. ncbi request reprint Role of exon-16-deleted HER2 in breast carcinomas
    F Castiglioni
    Molecular Targeting Unit, Department of Experimental Oncology, Istituto Nazionale Tumori, Via Venezian 1, 20133 Milan, Italy
    Endocr Relat Cancer 13:221-32. 2006
    ..Specific inhibitors of HER2 catalytic activity represent a promising approach to therapy of HER2-overexpressing tumors...
  7. ncbi request reprint Production and characterization of monoclonal antibodies directed against the laminin receptor precursor
    S Buto
    Division of Experimental Oncology E, Istituto Nazionale Tumori, Milano, Italy
    Int J Biol Markers 12:1-5. 1997
    ..MPLRs are thus a new powerful tool which could help in the characterization of the still enigmatic 67LR molecule...
  8. ncbi request reprint Cooperative effects of Mycobacterium tuberculosis Ag38 gene transduction and interleukin 12 in vaccination against spontaneous tumor development in proto-neu transgenic mice
    L Sfondrini
    Department of Experimental Oncology, Istituto Nazionale Tumori, Milan, Italy
    Cancer Res 60:3777-81. 2000
    ..tuberculosis gene and low doses of IL-12 in a model of stochastic development of mammary tumors. This adjuvant approach may represent a promising immunotherapeutic strategy for cancer immunization...
  9. ncbi request reprint HER2 as a prognostic factor in breast cancer
    S Menard
    Istituto Nazionale Tumori and Institute of Pathology, University of Milan, Milan, Italy
    Oncology 61:67-72. 2001
    ..The first type of IDC occurs in older patients, progresses slowly due to estrogen dependency but is aggressive long term. The other type progresses rapidly, is HER2 positive and is more likely to occur in young patients...
  10. pmc Effect of adjuvant trastuzumab treatment in conventional clinical setting: an observational retrospective multicenter Italian study
    M Campiglio
    Molecular Targeting Unit, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Amadeo 42, 20133 Milan, Italy
    Breast Cancer Res Treat 141:101-10. 2013
    ..89 vs. 14.28 %, p = 0.0240); no significant differences were observed in recurrences in the other recorded body sites, raising the possibility that the protection exerted by trastuzumab is lower in bone metastases...
  11. ncbi request reprint The 67 kDa laminin receptor increases tumor aggressiveness by remodeling laminin-1
    V Berno
    Molecular Targeting Unit, Department of Experimental Oncology, Istituto Nazionale Tumori, Via Venezian 1 20133 Milan, Italy
    Endocr Relat Cancer 12:393-406. 2005
    ....
  12. ncbi request reprint HER2 overexpression in various tumor types, focussing on its relationship to the development of invasive breast cancer
    S Menard
    The Molecular Targeting Unit, Istituto Nazional Tumori, Milan, Italy
    Ann Oncol 12:S15-9. 2001
    ..It is anticipated that the emerging wealth of standardized data for HER2 status will help to elucidate the role of HER2 in tumor progression...
  13. ncbi request reprint Production of a monoclonal antibody directed against the recombinant SEL1L protein
    R Orlandi
    Department of Experimental Oncology, Istituto Nazionale Tumori, Milan, Italy
    Int J Biol Markers 17:104-11. 2002
    ..MSel1 is able to recognize SEL1L even on archival tumor specimens and is therefore particularly appropriate to study SEL1L involvement in tumor progression...
  14. ncbi request reprint Binding-induced activation of overexpressed p185HER2 is essential in triggering neuronal differentiation of PC12 cells
    R Orlandi
    Division of Experimental Oncology E, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    J Cell Biochem 67:316-26. 1997
    ..PC12-HER2 cells represent a suitable system for selection of p185HER2-activating ligands (peptides, phage-displayed peptides or proteins) or specific inhibitors of its tyrosine kinase activity...
  15. pmc Immunodetection of bone marrow micrometastases in breast carcinoma patients and its correlation with primary tumour prognostic features
    S Menard
    Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    Br J Cancer 69:1126-9. 1994
    ..Thus, the presence of immunoreactive cells in bone marrow correlates with the expression in the primary tumour of a marker of the metastatic potential of the tumour, the 67 kDa laminin receptor...
  16. ncbi request reprint Characterization of two monoclonal antibodies directed against the 67 kDa high affinity laminin receptor and application for the study of breast carcinoma progression
    S Martignone
    Istituto Nazionale Tumori, Milan, Italy
    Clin Exp Metastasis 10:379-86. 1992
    ..In metastatic lesions MLuC5 reactivity was only found in 11% of the samples tested, independently of the site of origin of the lesion...
  17. ncbi request reprint Response to cyclophosphamide, methotrexate, and fluorouracil in lymph node-positive breast cancer according to HER2 overexpression and other tumor biologic variables
    S Menard
    Molecular Targeting Unit, Department of Experimental Oncology, Scientific Direction, Istituto Nazionale Tumori, Milan, Italy
    J Clin Oncol 19:329-35. 2001
    ..In this study, we investigated this issue in the 386 breast cancer patients in the first CMF controlled clinical trial with a 20-year follow-up...
  18. ncbi request reprint Tamoxifen chemoprevention of a hormone-independent tumor in the proto-neu transgenic mice model
    S Menard
    Department of Experimental Oncology, Istituto Nazionale Tumori, Milan, Italy
    Cancer Res 60:273-5. 2000
    ..In conclusion, TAM can prevent the occurrence of hormone-independent breast carcinoma if given early enough to inhibit normal cells...
  19. ncbi request reprint Formation of the 67-kDa laminin receptor by acylation of the precursor
    S Buto
    Division of Experimental Oncology E, Istituto Nazionale Tumori, Milan, Italy
    J Cell Biochem 69:244-51. 1998
    ..These data suggest that the 67LR is a heterodimer stabilized by strong intramolecular hydrophobic interactions, carried by fatty acids bound to the 37LRP and to a galectin3 cross-reacting molecule...
  20. ncbi request reprint Combination of a CpG-oligodeoxynucleotide and a topoisomerase I inhibitor in the therapy of human tumour xenografts
    A Balsari
    Institute of Pathology, University of Milan, 20133 Milan, Italy
    Eur J Cancer 40:1275-81. 2004
    ..Administration sequence was critical to the combination toxicity: the complete regimen of the cytotoxic drug followed by repeated administrations of the immunomodulator seemed the most promising for further investigations...
  21. ncbi request reprint Heregulin beta1 induces the down regulation and the ubiquitin-proteasome degradation pathway of p185HER2 oncoprotein
    A Magnifico
    Division of Experimental Oncology E, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    FEBS Lett 422:129-31. 1998
    ..Ubiquitinated p185HER2 was degradated by the 26S proteasome proteolytic pathway. Kinetics and inhibition experiments indicated that endocytosis of the receptor occurs downstream of the initiation of the degradation process...
  22. ncbi request reprint Production of a monoclonal antibody directed against the high-affinity nerve growth factor receptor
    E Tagliabue
    Department of Experimental Oncology, Istituto Nazionale Tumori, Milano, Italy
    Int J Biol Markers 14:68-72. 1999
    ..This new reagent appears to be an appropriate tool for analyzing the expression of high-affinity nerve growth factor receptor in tumors of different origin and for elucidating its involvement in tumor progression...
  23. ncbi request reprint Selection of monoclonal antibodies which induce internalization and phosphorylation of p185HER2 and growth inhibition of cells with HER2/NEU gene amplification
    E Tagliabue
    Division of Experimental Oncology E, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    Int J Cancer 47:933-7. 1991
    ..These results indicate that MGR3 is directed against a determinant located in the p185HER2 ligand binding site and may compete with the p185HER2 ligand, but is incapable of inducing a complete mitotic signal...
  24. ncbi request reprint Prevention of spontaneous neu-expressing mammary tumor development in mice transgenic for rat proto-neu by DNA vaccination
    S M Pupa
    Molecular Targeting Unit, Department of Experimental Oncology, Istituto Nazionale Tumori, Milano, Italy
    Gene Ther 8:75-9. 2001
    ....
  25. ncbi request reprint Nerve growth factor cooperates with p185(HER2) in activating growth of human breast carcinoma cells
    E Tagliabue
    Molecular Targeting Unit, Department of Experimental Oncology, Istituto Nazionale Tumori, 20133 Milan, Italy
    J Biol Chem 275:5388-94. 2000
    ....
  26. ncbi request reprint Role of HER2 gene overexpression in breast carcinoma
    S Menard
    Molecular Targeting Unit, Department of Experimental Oncology, Istituto Nazionale Tumori, Milan, Italy
    J Cell Physiol 182:150-62. 2000
    ....
  27. ncbi request reprint Protection of adjuvant trastuzumab in sites of early relapses
    M Campiglio
    Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy Dipartimento di Morfologia Umana e Scienze Biomediche Città Studi, Universita degli Studi di Milano, Milan, Italy
    J Clin Oncol 29:619. 2011
    ....
  28. ncbi request reprint Characterization of a monoclonal antibody directed against the epidermal growth factor receptor binding site
    R Pellegrini
    Division of Experimental Oncology E, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    Cancer Immunol Immunother 34:37-42. 1991
    ..MGR1 therefore seems to be an adequate reagent for the development of immunotherapeutical approaches suitable for the treatment of tumours with EGF-R overexpression...
  29. ncbi request reprint p185 HER2/neu epitope mapping with murine monoclonal antibodies
    F Centis
    Division of Experimental Oncology E, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    Hybridoma 11:267-76. 1992
    ..Epitope-5, recognized by the MGR9 MAb, on the contrary to the other epitopes, was prevalently localized at the basal membrane level of the tumor nodule...
  30. ncbi request reprint Co-regulation and physical association of the 67-kDa monomeric laminin receptor and the alpha6beta4 integrin
    E Ardini
    Division of Experimental Oncology E, Istituto Nazionale Tumori, 20133 Milan, Italy
    J Biol Chem 272:2342-5. 1997
    ....
  31. ncbi request reprint The 67 kDa laminin receptor as a prognostic factor in human cancer
    S Menard
    Division of Experimental Oncology E, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    Breast Cancer Res Treat 52:137-45. 1998
    ..In particular, therapeutic approaches that downregulate expression of the receptor on tumor cells might lead to decreased tumor aggressiveness...
  32. ncbi request reprint Cooperative inhibitory effect of ZD1839 (Iressa) in combination with trastuzumab (Herceptin) on human breast cancer cell growth
    N Normanno
    Oncologia Sperimentale D, Istituto Tumori Milano, Milan, Italy
    Ann Oncol 13:65-72. 2002
    ..Co-expression of the epidermal growth factor receptor (EGFR) and of ErbB-2 is found in a subset of primary human breast cancer...
  33. ncbi request reprint Antibody response after vaccination with antigen-pulsed dendritic cells
    F Battaini
    Molecular Targeting Unit, Istituto Nazionale Tumori, University of Milan, Milan Italy
    Int J Biol Markers 19:213-20. 2004
    ..The obtained results indicate that antigen-pulsed DCs can induce an antibody response and that adding CpG after antigen pulsing greatly increases anti-HER2 antibody production...
  34. ncbi request reprint Prognostic value of alpha 6 beta 4 integrin expression in breast carcinomas is affected by laminin production from tumor cells
    E Tagliabue
    Division of Experimental Oncology, Istituto Nazionale Tumori, Milan, Italy
    Clin Cancer Res 4:407-10. 1998
    ....
  35. pmc Prognosis based on primary breast carcinoma instead of pathological nodal status
    S Menard
    Department of Experimental Oncology E, Istituto Nazionale Tumori, Milan, Italy
    Br J Cancer 70:709-12. 1994
    ..Our data suggest that the primary tumour score provides more reliable prognostic information than pathological nodal status, and that axillary dissection can be avoided in a large number of patients...
  36. ncbi request reprint New insights into the metastasis-associated 67 kD laminin receptor
    S Menard
    Division of Experimental Oncology E, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    J Cell Biochem 67:155-65. 1997
    ..Downregulation of the receptor expression on tumor cells might open new therapeutic approaches to decrease tumor aggressiveness...
  37. ncbi request reprint c-erbB-2 expression in primary breast cancer
    E Tagliabue
    Division of Experimental Oncology E, Istituto Nazionale Tumori, Milan, Italy
    Int J Biol Markers 14:16-26. 1999
    ..Few studies have looked at changes in c-erbB-2 on therapy. Those that have seem to show no significant change on either tamoxifen or chemotherapy...
  38. ncbi request reprint Prognostic significance of the CaMBr1 antigen on breast carcinoma: relevance of the type of recognised glycoconjugate
    F Perrone
    Division of Experimental Oncology E, PRESTCO, Milan, Italy
    Eur J Cancer 29:2113-7. 1993
    ..05) and lobular histotype (P < 0.01), but failed to predict survival, although a trend for longer DFS was observed for positive cases...
  39. ncbi request reprint Role of p53 in HER2-induced proliferation or apoptosis
    P Casalini
    Molecular Targeting Unit, Department of Experimental Oncology, Istituto Nazionale Tumori, 20133 Milano, Italy
    J Biol Chem 276:12449-53. 2001
    ..By contrast, growth factors stimulation of HER2 transfectants with mutated-p53 induced progression through the cell cycle. Together, our data point to a regulatory role for p53 in HER2 signaling...
  40. ncbi request reprint Role of Toll-like receptor 9 (TLR-9) in acute graft-versus-host disease
    A Balsari
    University of Milan, Milan, Italy National Cancer Institute, Milan, Italy
    J Clin Oncol 26:7037. 2008
    ..Using knockout mice, we evaluated the role of TLR4 and TLR9 in the GVHD associated with allogeneic bone marrow transplantation...
  41. ncbi request reprint Oral administration of anti-doxorubicin monoclonal antibody prevents chemotherapy-induced gastrointestinal toxicity in mice
    D Morelli
    Division of Experimental Oncology E, Istituto Nazionale Tumori, Milan, Italy
    Cancer Res 56:2082-5. 1996
    ..This type of treatment may be useful in preventing anthracycline-induced gastrointestinal mucositis in cancer patients...
  42. ncbi request reprint Innate immunity in breast carcinoma
    L Sfondrini
    Molecular Targeting Unit, Department of Experimental Oncology, Istituto Nazionale Tumori, Via Venezian 1, 20133 Milan, Italy
    Endocr Relat Cancer 10:301-8. 2003
    ....
  43. ncbi request reprint In vivo and in vitro growth of SCLC cells derived from biopsies
    S Giani
    Experimental Oncology E, Istituto Nazionale Tumori, Milano, Italy
    Tumori 75:570-5. 1989
    ..These data suggest that only some tumors, presumably with peculiar biological characteristics, can efficiently grow in these artificial systems...
  44. ncbi request reprint Antigenic and immunogenic mimicry of the HER2/neu oncoprotein by phage-displayed peptides
    R Orlandi
    Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    Eur J Immunol 24:2868-73. 1994
    ....
  45. ncbi request reprint Study of the expression and function of the tumour-associated antigen CaMBr1 in small cell lung carcinomas
    S Martignone
    Istituto Nazionale Tumori, Milan, Italy
    Eur J Cancer 29:2020-5. 1993
    ..The increase of MBr1 reactivity after neuraminidase treatment suggests that the CaMBr1 epitope expressed in the SCLC cell line is carried by a sialoglycoprotein...
  46. ncbi request reprint Polarization of the alpha 6 beta 4 integrin in ovarian carcinomas
    C Bottini
    Division of Experimental Oncology E, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    Int J Cancer 54:261-7. 1993
    ....
  47. ncbi request reprint N-(4-hydroxyphenyl)retinamide induces apoptosis of malignant hemopoietic cell lines including those unresponsive to retinoic acid
    D Delia
    Division of Experimental Oncology, Istituto Nazionale Tumori, Milan, Italy
    Cancer Res 53:6036-41. 1993
    ..The clinical use of HPR, particularly in retinoic acid-unresponsive acute promyelocytic leukemia patients, is suggested...
  48. ncbi request reprint Allelic polymorphisms in the transcriptional regulatory region of human SEL1L
    M Cattaneo
    Institute of Advanced Biomedical Technologies, National Research Council, Via Fratelli Cervi 93, Segrate, 20090, Milan, Italy
    Mutat Res 458:71-6. 2001
    ..The functional effects of this polymorphism was analysed by transient transfection assay which resulted in a significant increase in the transcriptional activity of the gene...
  49. ncbi request reprint Expression of protein tyrosine phosphatase alpha (RPTPalpha) in human breast cancer correlates with low tumor grade, and inhibits tumor cell growth in vitro and in vivo
    E Ardini
    Division of Experimental Oncology, Molecular Targeting Unit, Istituto Nazionale Tumori, Via Venezian 1, 20133 Milan, Italy
    Oncogene 19:4979-87. 2000
    ..To our knowledge, this is the first example of a study correlating expression level of a specific bona fide PTP with neoplastic disease status in humans...