M Grigioni

Summary

Affiliation: Istituto Superiore di Sanit
Country: Italy

Publications

  1. ncbi request reprint Endovascular stents: market vigilance and risk factors
    M Grigioni
    Laboratory of Biomedical Engineering, Istituto Superiore di Sanita, Roma, Italy
    Int J Artif Organs 27:45-54. 2004
  2. ncbi request reprint The patterns of flow in the total extracardiac cavopulmonary connection
    Antonio Amodeo
    Department of Paediatric Cardiology and Cardiac Surgery of the Bambino Gesù Hospital, Rome, Italy
    Cardiol Young 14:53-6. 2004
  3. ncbi request reprint Prosthetic heart valves' mechanical loading of red blood cells in patients with hereditary membrane defects
    Mauro Grigioni
    Department of Technology and Health, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    J Biomech 38:1557-65. 2005
  4. ncbi request reprint Beat to beat analysis of mechanical heart valves by means of return map
    M Grigioni
    Technology and Health Department, Istituto Superiore di Sanita, Viale Regina Elena, Rome, 299, 00161, Italy
    J Med Eng Technol 31:94-100. 2007
  5. ncbi request reprint The role of the ISS in the Italian Health Service, and the need for medical device market surveillance
    Mauro Grigioni
    Laboratory of Biomedical Engineering, ISS, Rome, Italy
    J Heart Valve Dis 13:S14-7. 2004
  6. ncbi request reprint Pulsatile flow and atherogenesis: results from in vivo studies
    M Grigioni
    Laboratory of Biomedical Engineering, Istituto Superiore di Sanita, Rome, Italy
    Int J Artif Organs 24:784-92. 2001
  7. ncbi request reprint The power-law mathematical model for blood damage prediction: analytical developments and physical inconsistencies
    Mauro Grigioni
    Laboratory of Biomedical Engineering, Istituto Superiore di Sanita, Rome, Italy
    Artif Organs 28:467-75. 2004
  8. ncbi request reprint Proposal for a quantitative description of blood spiral flow in medical devices
    M Grigioni
    Laboratory of Biomedical Engineering, Istituto Superiore di Sanita, Rome, Italy
    Int J Artif Organs 27:231-42. 2004
  9. ncbi request reprint Potential mechanical blood trauma in vascular access devices: a comparison of case studies
    M Grigioni
    Int J Artif Organs 25:882-91. 2002
  10. ncbi request reprint Computational model of the fluid dynamics of a cannula inserted in a vessel: incidence of the presence of side holes in blood flow
    M Grigioni
    Laboratory of Biomedical Engineering, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161, Roma, Italy
    J Biomech 35:1599-612. 2002

Collaborators

Detail Information

Publications57

  1. ncbi request reprint Endovascular stents: market vigilance and risk factors
    M Grigioni
    Laboratory of Biomedical Engineering, Istituto Superiore di Sanita, Roma, Italy
    Int J Artif Organs 27:45-54. 2004
    ..Another critical point is the reliability of the device which must guarantee an adequate safety level when it is used according to the instructions...
  2. ncbi request reprint The patterns of flow in the total extracardiac cavopulmonary connection
    Antonio Amodeo
    Department of Paediatric Cardiology and Cardiac Surgery of the Bambino Gesù Hospital, Rome, Italy
    Cardiol Young 14:53-6. 2004
  3. ncbi request reprint Prosthetic heart valves' mechanical loading of red blood cells in patients with hereditary membrane defects
    Mauro Grigioni
    Department of Technology and Health, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    J Biomech 38:1557-65. 2005
    ..The clinical data support the relevance of the proposed global parameter as erythrocyte trauma predictor with regard to the fluid dynamics of artificial organs...
  4. ncbi request reprint Beat to beat analysis of mechanical heart valves by means of return map
    M Grigioni
    Technology and Health Department, Istituto Superiore di Sanita, Viale Regina Elena, Rome, 299, 00161, Italy
    J Med Eng Technol 31:94-100. 2007
    ..The methodology proposed here could be regarded as an alternative non-invasive tool to investigate the dynamic behaviour of prosthetic heart valves, especially in the case of their suspected failure...
  5. ncbi request reprint The role of the ISS in the Italian Health Service, and the need for medical device market surveillance
    Mauro Grigioni
    Laboratory of Biomedical Engineering, ISS, Rome, Italy
    J Heart Valve Dis 13:S14-7. 2004
  6. ncbi request reprint Pulsatile flow and atherogenesis: results from in vivo studies
    M Grigioni
    Laboratory of Biomedical Engineering, Istituto Superiore di Sanita, Rome, Italy
    Int J Artif Organs 24:784-92. 2001
    ..This result could be useful in minimizing the negative consequences of clinical interventions such as graft and/or stent implantation...
  7. ncbi request reprint The power-law mathematical model for blood damage prediction: analytical developments and physical inconsistencies
    Mauro Grigioni
    Laboratory of Biomedical Engineering, Istituto Superiore di Sanita, Rome, Italy
    Artif Organs 28:467-75. 2004
    ....
  8. ncbi request reprint Proposal for a quantitative description of blood spiral flow in medical devices
    M Grigioni
    Laboratory of Biomedical Engineering, Istituto Superiore di Sanita, Rome, Italy
    Int J Artif Organs 27:231-42. 2004
    ..The results obtained in this test case investigation, confirm the effectiveness of the proposed function for a quantitative analysis of spiral flow in medical devices...
  9. ncbi request reprint Potential mechanical blood trauma in vascular access devices: a comparison of case studies
    M Grigioni
    Int J Artif Organs 25:882-91. 2002
    ....
  10. ncbi request reprint Computational model of the fluid dynamics of a cannula inserted in a vessel: incidence of the presence of side holes in blood flow
    M Grigioni
    Laboratory of Biomedical Engineering, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161, Roma, Italy
    J Biomech 35:1599-612. 2002
    ..g. on the fluid dynamics establishing in the free luminal space left, in the vessel, by the inserted cannula...
  11. ncbi request reprint Evaluation of the surface-averaged load exerted on a blood element by the Reynolds shear stress field provided by artificial cardiovascular devices
    Mauro Grigioni
    Laboratory of Biomedical Engineering, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161, Roma, Italy
    J Biomech 35:1613-22. 2002
    ..A new parameter is thus proposed, which can be correlated with prosthetic devices complications...
  12. ncbi request reprint Pathological patient in protocol definition for bench testing of mechanical cardiac support system
    M Grigioni
    Laboratory of Biomedical Engineering, Istituto Superiore di Sanita, Roma, Italy
    Int J Artif Organs 26:64-72. 2003
    ..Thus the results of this experimentation can be useful to clinicians in forecasting the response of the heart affected by a cardiac disease and to set appropriate parameters for suitable assistance...
  13. ncbi request reprint Numerical simulation of a realistic total cavo-pulmonary connection: effect of unbalanced pulmonary resistances on hydrodynamic performance
    M Grigioni
    Laboratory of Biomedical Engineering, Istituto Superiore di Sanita, Rome, Italy
    Int J Artif Organs 26:1005-14. 2003
    ....
  14. ncbi request reprint Morphological analysis of in vivo velocity field in the alteration of the vasomotor tone
    M Grigioni
    Laboratory of Biomedical Engineering, Istituto Superiore di Sanita, Rome Italy
    Int J Artif Organs 27:868-81. 2004
    ..The present study confirms the feasibility of the proposed analysis to follow vascular pathology evolution, distiguishing between an in progress and a static situation...
  15. ncbi request reprint Evolutive algorithms for beat-by-beat estimation of left ventricular mechanics
    Mauro Grigioni
    Dipartimento Tecnologie e Salute, Istituto Superiore di Sanita, Roma
    Ann Ist Super Sanita 40:401-9. 2004
    ..Future studies will approach the reduction in GAs computational costs, for a real time in vivo application...
  16. ncbi request reprint Power dissipation associated with surgical operations' hemodynamics: critical issues and application to the total cavopulmonary connection
    Mauro Grigioni
    Cardiovascular Bioengineering, Technology and Health Department, Istituto Superiore di Sanita, Rome, Italy
    J Biomech 39:1583-94. 2006
    ..5 l/min total cardiac output). The proposed approach should be adopted in order to improve the accuracy of the hydrodynamical performance's assessment of surgical connections (e.g., TCPC) or implantable devices (e.g., valved conduit)...
  17. ncbi request reprint Multiresolution analysis of heart rate variability as investigational tool in experimental fetal cardiac surgery
    Mauro Grigioni
    Cardiovascular Bioengineering, Technology and Health Department, Istituto Superiore di Sanita, Rome, Italy
    Ann Biomed Eng 34:799-809. 2006
    ..Multiresolution analysis could give more insights on fetal hypoxemia and could also represent a minimally invasive monitoring tool to limit the damage to the fetoplacental unit during experimental fetal cardiac surgery...
  18. ncbi request reprint Innovative technologies for the assessment of cardiovascular medical devices: state-of-the-art techniques for artificial heart valve testing
    Mauro Grigioni
    Cardiovascular Bioengineering, Technology and Health Department, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161, Rome, Italy
    Expert Rev Med Devices 1:81-93. 2004
    ..It can be realistically expected that this characterization will help designers in improving PHV performance...
  19. ncbi request reprint A novel formulation for blood trauma prediction by a modified power-law mathematical model
    Mauro Grigioni
    Cardiovascular Bioengineering Unit, Technology and Health Department, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Biomech Model Mechanobiol 4:249-60. 2005
    ..To date, the necessity to design further experiments to validate the proposed damage function clashes with the limitations inherent to current systems to get the time-varying shear stress completely under control...
  20. ncbi request reprint Critical issues in studies of flow through the Fontan circuit after 10 years of investigation
    Mauro Grigioni
    Cardiovascular Bioengineering, Technology and Health Department, Istituto Superiore di Sanita, Rome, Italy
    Cardiol Young 15:68-73. 2005
  21. ncbi request reprint A mathematical description of blood spiral flow in vessels: application to a numerical study of flow in arterial bending
    Mauro Grigioni
    Laboratory of Biomedical Engineering, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161, Rome, Italy
    J Biomech 38:1375-86. 2005
    ..The proposed method quantified spiral motion, and revealed the progression in the degree of stenosis, in the presented case study. In the future, it could be used as a synthetic tool to approach specific clinical complications...
  22. ncbi request reprint On the monodimensional approach to the estimation of the highest reynolds shear stress in a turbulent flow
    M Grigioni
    Laboratory of Biomedical Engineering, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161, Roma, Italy
    J Biomech 33:701-8. 2000
    ....
  23. ncbi request reprint Extracorporeal circulation in ewe's foetus: towards a reliable foetal cardiac surgery protocol. A comparison of two cases
    M Grigioni
    Laboratory of Biomedical Engineering, Istituto Superiore di Sanita, Roma Italy
    Int J Artif Organs 23:189-98. 2000
    ..In particular, we assessed the foetal placental reactivity to prolonged cardiac bypass in steady-flow conditions...
  24. ncbi request reprint Hemodynamic performance of small-size bileaflet valves: pressure drop and laser Doppler anemometry study comparison of three prostheses
    M Grigioni
    Istituto Superiore di Sanita, Laboratory of Biomedical Engineering, Rome, Italy
    Artif Organs 24:959-65. 2000
    ..This study can provide insights into a PHV's local flow structure and global hemodynamical parameters...
  25. ncbi request reprint Laser Doppler anemometry study of bidimensional flows downstream of three 19 mm bileaflet valves in the mitral position, under kinematic similarity
    M Grigioni
    Laboratory of Biomedical Engineering, Istituto Superiore di Sanita, Roma, Italy
    Ann Biomed Eng 28:194-203. 2000
    ..The three prosthetic heart valves (PHVs) tested show many differences as for their turbulence properties, although they are similarly constructed...
  26. ncbi request reprint Time dependent non-Newtonian numerical study of the flow field in a realistic model of aortic arch
    C Del Gaudio
    Cardiovascular Bioengineering, Technology and Health Department, Istituto Superiore di Sanita, Rome, Italy
    Int J Artif Organs 29:709-18. 2006
    ..The resulting complex fluid dynamics, established in the aortic arch and in its branches, can be related to the possible endothelium response to mechanical stimuli, induced by wall shear stress, in the promotion of inflammatory events...
  27. ncbi request reprint A mathematical model of the fetal cardiovascular system based on genetic algorithms as identification technique
    M Grigioni
    Laboratory of Biomedical Engineering, Istituto Superiore di Sanita, Rome, Italy
    Int J Artif Organs 24:286-96. 2001
    ....
  28. ncbi request reprint ET(A)/ET(B) receptor antagonist bosentan inhibits neointimal development in collared carotid arteries of rabbits
    G Marano
    Laboratorio di Farmacologia, Istituto Superiore di Sanita, Rome, Italy
    Life Sci 63:PL259-66. 1998
    ....
  29. ncbi request reprint Particle image velocimetry analysis of the flow field in the total cavopulmonary connection
    M Grigioni
    Istituto Superiore di Sanita, Laboratory of Biomedical Engineering, Rome, Italy
    Artif Organs 24:946-52. 2000
    ..The effect of different loading conditions, which realistically can be found in vivo, is studied with a high spatial resolution, showing the possibility to use pulmonary resistance as a parameter in designing the surgical geometry...
  30. ncbi request reprint Effects of isoflurane on cardiovascular system and sympathovagal balance in New Zealand white rabbits
    G Marano
    Laboratorio di Farmacologia, Istituto Superiore di Sanita, Rome, Italy
    J Cardiovasc Pharmacol 28:513-8. 1996
    ....
  31. ncbi request reprint The role of usable length in the compliance measurement of vascular prostheses
    M Grigioni
    Laboratory of Biomedical Engineering, Istituto Superiore di Sanita, Roma, Italy
    Int J Artif Organs 22:837-42. 1999
    ..The results provide an indication of the influence of usable length on the compliance and diameter mismatch at the anasthomosis between graft and host artery...
  32. ncbi request reprint 19 mm sized bileaflet valve prostheses' flow field investigated by bidimensional laser Doppler anemometry (part I: velocity profiles)
    V Barbaro
    Laboratory of Biomedical Engineering, Istituto Superiore di Sanita, Rome, Italy
    Int J Artif Organs 20:622-8. 1997
    ..Results concern velocity profiles during the peak flow systolic phase, at high cardiac output regime, highlighting the different flow field features downstream of the four small-sized cardiac valves...
  33. ncbi request reprint The influence of the leaflets' curvature on the flow field in two bileaflet prosthetic heart valves
    M Grigioni
    Laboratory of Biomedical Engineering, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161, Roma, Italy
    J Biomech 34:613-21. 2001
    ..In particular, the concept of curved wake leads to conclude that the curvature of the leaflets' surface must be identified as an important parameter, which deserves careful attention in PHV design and development...
  34. ncbi request reprint Treatment of pulmonary artery stenosis after arterial switch operation: stent implantation vs. balloon angioplasty
    R Formigari
    Pediatric Cardiology and Cardiac Surgery, Ospedale Bambino Gesu, Rome, Italy
    Catheter Cardiovasc Interv 50:207-11. 2000
    ..Balloon dilation should be considered in selected cases unsuitable for treatment with endovascular stents...
  35. ncbi request reprint A discussion on the threshold limit for hemolysis related to Reynolds shear stress
    M Grigioni
    Istituto Superiore di Sanita, Laboratory of Biomedical Engineering, Roma, Italy
    J Biomech 32:1107-12. 1999
    ..This result, obtained on the basis of the study of RBCs' response to a turbulent environment, indicates that blood particles are probably more resistant to short-time shear stresses than it was thought...
  36. ncbi request reprint Effects of isoflurane versus halothane on myocardial contractility in rabbits: assessment with transthoracic two-dimensional echocardiography
    G Marano
    Laboratorio di Farmacologia, Istituto Superiore di Sanita, Rome, Italy
    Lab Anim 31:144-50. 1997
    ..Isoflurane should therefore be preferred over halothane, especially in cases of prolonged anaesthetic procedures...
  37. doi request reprint Improved management of systemic venous anomalies in a single ventricle: New rationale
    Antonio Amodeo
    Cardiac Surgery Service of the Medical Surgical Department of Paediatric Cardiology, Bambino Gesù Paediatric Hospital, Piazza S Onofrio 4, Rome, Italy
    J Thorac Cardiovasc Surg 138:1154-9. 2009
    ..Two innovative surgical approaches addressing systemic venous anomalies in single-ventricle patients are evaluated...
  38. ncbi request reprint Monodimensional estimation of maximum Reynolds shear stress in the downstream flow field of bileaflet valves
    Mauro Grigioni
    Laboratory of Biomedical Engineering, Istituto Superiore di Sanita, Rome, Italy
    J Heart Valve Dis 11:392-401. 2002
    ..The present study aimed to derive the maximum Reynolds shear stress (RSS) in three commercially available prosthetic heart valves (PHVs) of wide diffusion, starting with monodimensional data provided in vivo by echo Doppler...
  39. ncbi request reprint Three-dimensional numeric simulation of flow through an aortic bileaflet valve in a realistic model of aortic root
    Mauro Grigioni
    Technology and Health Department, Istituto Superiore di Sanita, Roma, Italy
    ASAIO J 51:176-83. 2005
    ..The results of this simulation furnished a reasonable indication (in terms of fluid dynamics) parameters downstream of the prosthetic device, especially in Valsalva sinuses, the role of which is proven to affect the valve's performance...
  40. doi request reprint Electromyographic audio biofeedback for telerehabilitation in hospital
    Marco Rogante
    Dipartiemnto di Tecnologie e Salute, Istituto Superiore di Sanita, Viale Regina Elena 299, Rome, Italy
    J Telemed Telecare 16:204-6. 2010
    ..Wireless technology would reduce the complexity of the tasks required of the patient...
  41. ncbi request reprint Virtual microscopy and digital cytology: state of the art
    Daniele Giansanti
    Dipartimento di Tecnologie e Salute, Istituto Superiore di Sanita, Rome, Italy
    Ann Ist Super Sanita 46:115-22. 2010
    ..The work enlightens future scenarios of actions relevant for the introduction of the technology...
  42. ncbi request reprint Electrospun bioresorbable heart valve scaffold for tissue engineering
    C Del Gaudio
    Cardiovascular Bioengineering, Technology and Health Department, National Institute of Health, Rome Italy
    Int J Artif Organs 31:68-75. 2008
    ..This preliminary study suggests a successful perspective for the proposed approach in designing a novel tissue engineered bioresorbable heart valve...
  43. ncbi request reprint Endothelin and mechanical properties of the carotid artery in Wistar-Kyoto and spontaneously hypertensive rats
    G Marano
    Laboratorio di Farmacologia, Istituto Superiore di Sanita, Rome, Italy
    Cardiovasc Res 41:701-7. 1999
    ....
  44. ncbi request reprint SWIFT (sequence-wide investigation with Fourier transform): a software tool for identifying proteins of a given class from the unannotated genome sequence
    G D'Avenio
    Department of Technologies and Health, Parasitic and Immune Mediated Diseases Istituto Superiore di Sanità, Rome, Italy
    Bioinformatics 21:2943-9. 2005
    ..The ever increasing number of sequenced genomes calls for new analysis techniques, which can benefit from the methodologies developed in the field of signal processing...
  45. ncbi request reprint A novel method for measuring the torque on implantable cardiovascular devices in MR static fields
    Rossella Canese
    Department of Technology and Health, Istituto Superiore di Sanita, Rome, Italy
    J Magn Reson Imaging 26:1368-74. 2007
    ..To propose a novel quantitative method for measuring the torque acting on mechanical heart valve prostheses subjected to a high static magnetic field in a MR scanner...
  46. doi request reprint Fluid dynamics studies of cardiovascular medical devices and blood damage prediction
    Mauro Grigioni
    Department of Technology and Health, ISS, Rome, Italy
    Conf Proc IEEE Eng Med Biol Soc 2008:1419-22. 2008
    ....
  47. ncbi request reprint Electrospun bioresorbable trileaflet heart valve prosthesis for tissue engineering: in vitro functional assessment of a pulmonary cardiac valve design
    Costantino Del Gaudio
    Dipartimento di Tecnologie e Salute, Istituto Superiore di Sanita, Rome, Italy
    Ann Ist Super Sanita 44:178-86. 2008
    ..Further studies and design changes are needed in order to optimize the final scaffold to bear arterial hemodynamic conditions...
  48. ncbi request reprint Early primary Kawashima operation combined with direct hepatic vein-to-azygos vein connection: a new logical approach
    Antonio Amodeo
    Division of Pediatric Cardiac Surgery, Bambino Gesu Hospital, Istituto Superiore di Sanita, Rome, Italy
    J Thorac Cardiovasc Surg 129:949-50. 2005
  49. ncbi request reprint Picture archiving and communication systems in digital cytology
    Sandra Morelli
    Dipartimento di Tecnologie e Salute, Istituto Superiore di Sanita, Rome, Italy
    Ann Ist Super Sanita 46:130-7. 2010
    ..the PACS in D-CYT are not standardized from manufacturers. The study makes a proposal of a useful software architecture to improve the PACS integration for D-CYT applications, with potentialities in the HIS...
  50. ncbi request reprint Inflammatory response to cardiac bypass in ewe fetuses: effects of steroid administration or continuous hemodiafiltration
    Adriano Carotti
    Department of Pediatric Cardiology and Cardiac Surgery, Ospedale Bambino Gesu, Rome, Italy
    J Thorac Cardiovasc Surg 126:1839-50. 2003
    ....
  51. ncbi request reprint Genetic algorithms for parameter estimation in mathematical modeling of glucose metabolism
    Umberto Morbiducci
    Laboratory of Biomedical Engineering, Istituto Superiore di Sanita, Rome, Italy
    Comput Biol Med 35:862-74. 2005
    ..To overcome these limitations, Genetic algorithms (GAs) were tested on a group of 49 subjects. The stochastic nature of GAs allowed overcoming the initialization problem. Moreover, GAs significantly improved the accuracy of fit...
  52. ncbi request reprint The beneficial vortex and best spatial arrangement in total extracardiac cavopulmonary connection
    Antonio Amodeo
    Department of Cardiac Surgery, Bambino Gesu Hospital, and the Laboratory of Biomedical Engineering, Trieste, Italy
    J Thorac Cardiovasc Surg 124:471-8. 2002
    ....
  53. ncbi request reprint 3-D simulation of the St. Jude Medical bileaflet valve opening process: fluid-structure interaction study and experimental validation
    Alberto Redaelli
    Department of Bioengineering, Politecnico of Milan, Milan
    J Heart Valve Dis 13:804-13. 2004
    ..The present study offers a computational approach to the simulation of valve leaflet motion during the opening process, together with an experimental set-up for validation of the model...
  54. doi request reprint Numerical simulation of the dynamics of a bileaflet prosthetic heart valve using a fluid-structure interaction approach
    Matteo Nobili
    Department of Bioengineering, Politecnico di Milano, P za Leonardo Da Vinci, 32, 20133 Milano, Italy
    J Biomech 41:2539-50. 2008
    ....
  55. ncbi request reprint Helical flow as fluid dynamic signature for atherogenesis risk in aortocoronary bypass. A numeric study
    Umberto Morbiducci
    Department of Mechanics, Universita Politecnica delle Marche, Ancona, Italy
    J Biomech 40:519-34. 2007
    ....
  56. ncbi request reprint Biological fate of tissue-engineered porcine valvular conduits xenotransplanted in the sheep thoracic aorta
    Maria Teresa Conconi
    Department of Pharmaceutical Sciences, University of Padua, I 35121 Padua, Italy
    Int J Mol Med 14:1043-8. 2004
    ....
  57. ncbi request reprint Optical vibrocardiography: a novel tool for the optical monitoring of cardiac activity
    Umberto Morbiducci
    Department of Mechanics, Universita Politecnica delle Marche, Via Brecce Bianche, 60100 Ancona, Italy
    Ann Biomed Eng 35:45-58. 2007
    ..The technique may be used also to monitor subjects, e.g., severely burned, for which contact with the skin needs to be minimized...