Luisa Diomede

Summary

Affiliation: Istituto di Ricerche Farmacologiche Mario Negri
Country: Italy

Publications

  1. doi request reprint Cardiac light chain amyloidosis: The role of metal ions in oxidative stress and mitochondrial damage
    Luisa Diomede
    IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Via G La Masa 19, Milano, Italy, 20156
    Antioxid Redox Signal . 2017
  2. doi request reprint The new β amyloid-derived peptide Aβ1-6A2V-TAT(D) prevents Aβ oligomer formation and protects transgenic C. elegans from Aβ toxicity
    Luisa Diomede
    Department of Molecular Biochemistry and Pharmacology, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa 19, 20156 Milan, Italy Electronic address
    Neurobiol Dis 88:75-84. 2016
  3. pmc Expression of A2V-mutated Aβ in Caenorhabditis elegans results in oligomer formation and toxicity
    Luisa Diomede
    Department of Molecular Biochemistry and Pharmacology, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa 19, 20156 Milan, Italy Electronic address
    Neurobiol Dis 62:521-32. 2014
  4. pmc Oleuropein aglycone protects transgenic C. elegans strains expressing Aβ42 by reducing plaque load and motor deficit
    Luisa Diomede
    Department of Molecular Biochemistry and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    PLoS ONE 8:e58893. 2013
  5. doi request reprint Tetracycline and its analogues protect Caenorhabditis elegans from β amyloid-induced toxicity by targeting oligomers
    Luisa Diomede
    Department of Molecular Biochemistry and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Neurobiol Dis 40:424-31. 2010
  6. pmc Specific recognition of biologically active amyloid-β oligomers by a new surface plasmon resonance-based immunoassay and an in vivo assay in Caenorhabditis elegans
    Matteo Stravalaci
    Department of Molecular Biochemistry and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, 20156 Milan, Italy
    J Biol Chem 287:27796-805. 2012
  7. pmc A Caenorhabditis elegans-based assay recognizes immunoglobulin light chains causing heart amyloidosis
    Luisa Diomede
    Department of Molecular Biochemistry and Pharmacology, Istituto di Ricovero e Cura a Carattere Scientifico Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Blood 123:3543-52. 2014
  8. pmc Clusterin Binds to Aβ1-42 Oligomers with High Affinity and Interferes with Peptide Aggregation by Inhibiting Primary and Secondary Nucleation
    Marten Beeg
    From the Department of Molecular Biochemistry and Pharmacology, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, 20156 Milan, Italy
    J Biol Chem 291:6958-66. 2016
  9. ncbi request reprint Structural properties of Gerstmann-Straussler-Scheinker disease amyloid protein
    Mario Salmona
    Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milan, Italy
    J Biol Chem 278:48146-53. 2003
  10. pmc The efficacy of tetracyclines in peripheral and intracerebral prion infection
    Ada De Luigi
    Department of Molecular Biochemistry and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    PLoS ONE 3:e1888. 2008

Collaborators

Detail Information

Publications18

  1. doi request reprint Cardiac light chain amyloidosis: The role of metal ions in oxidative stress and mitochondrial damage
    Luisa Diomede
    IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Via G La Masa 19, Milano, Italy, 20156
    Antioxid Redox Signal . 2017
    ..This is a novel conceptual advance which paves the way for new pharmacological strategies aimed at not only counteracting but totally inhibiting the vicious cycle of redox damage...
  2. doi request reprint The new β amyloid-derived peptide Aβ1-6A2V-TAT(D) prevents Aβ oligomer formation and protects transgenic C. elegans from Aβ toxicity
    Luisa Diomede
    Department of Molecular Biochemistry and Pharmacology, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa 19, 20156 Milan, Italy Electronic address
    Neurobiol Dis 88:75-84. 2016
    ..These observations offer a proof of concept for future pharmacological studies in mouse models of AD, providing a foundation for the design of AβA2V-based peptidomimetic molecules for therapeutic purposes. ..
  3. pmc Expression of A2V-mutated Aβ in Caenorhabditis elegans results in oligomer formation and toxicity
    Luisa Diomede
    Department of Molecular Biochemistry and Pharmacology, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa 19, 20156 Milan, Italy Electronic address
    Neurobiol Dis 62:521-32. 2014
    ....
  4. pmc Oleuropein aglycone protects transgenic C. elegans strains expressing Aβ42 by reducing plaque load and motor deficit
    Luisa Diomede
    Department of Molecular Biochemistry and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    PLoS ONE 8:e58893. 2013
    ....
  5. doi request reprint Tetracycline and its analogues protect Caenorhabditis elegans from β amyloid-induced toxicity by targeting oligomers
    Luisa Diomede
    Department of Molecular Biochemistry and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Neurobiol Dis 40:424-31. 2010
    ..These effects were specific, dose-related and not linked to any antibiotic activity, suggesting that the drugs might offer an effective therapeutic strategy to target soluble Aβ aggregates...
  6. pmc Specific recognition of biologically active amyloid-β oligomers by a new surface plasmon resonance-based immunoassay and an in vivo assay in Caenorhabditis elegans
    Matteo Stravalaci
    Department of Molecular Biochemistry and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, 20156 Milan, Italy
    J Biol Chem 287:27796-805. 2012
    ..The SPR-based immunoassay provides new opportunities for detection of toxic Aβ oligomers in biological samples and could be adapted to study misfolding proteins in other neurodegenerative disorders...
  7. pmc A Caenorhabditis elegans-based assay recognizes immunoglobulin light chains causing heart amyloidosis
    Luisa Diomede
    Department of Molecular Biochemistry and Pharmacology, Istituto di Ricovero e Cura a Carattere Scientifico Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Blood 123:3543-52. 2014
    ..In conclusion, these data indicate that this nematode-based assay is a promising surrogate model for investigating the heart-specific toxicity of amyloidogenic LCs and for a rapid screening of new therapeutic strategies. ..
  8. pmc Clusterin Binds to Aβ1-42 Oligomers with High Affinity and Interferes with Peptide Aggregation by Inhibiting Primary and Secondary Nucleation
    Marten Beeg
    From the Department of Molecular Biochemistry and Pharmacology, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, 20156 Milan, Italy
    J Biol Chem 291:6958-66. 2016
    ..These data substantiate the interaction of clusterin with biologically active regions exposed on nuclei/oligomers of Aβ1-42, providing a molecular basis for the neuroprotective effects of the chaperone. ..
  9. ncbi request reprint Structural properties of Gerstmann-Straussler-Scheinker disease amyloid protein
    Mario Salmona
    Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milan, Italy
    J Biol Chem 278:48146-53. 2003
    ..These data indicate that the intrinsic properties of PrP-(82-146) are dependent upon the integrity of the C-terminal region and account for the massive deposition of PrP amyloid in GSS...
  10. pmc The efficacy of tetracyclines in peripheral and intracerebral prion infection
    Ada De Luigi
    Department of Molecular Biochemistry and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    PLoS ONE 3:e1888. 2008
    ..Median survival increased of 8.1% with doxycycline and 10% with minocycline. These data suggest that tetracyclines might have therapeutic potential for humans...
  11. doi request reprint Novel approaches for studying amyloidogenic peptides/proteins
    Marten Beeg
    Department of Biochemistry and Molecular Pharmacology, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, 20156 Milano, Italy
    Curr Opin Pharmacol 13:797-801. 2013
    ....
  12. pmc The Anti-Prion Antibody 15B3 Detects Toxic Amyloid-β Oligomers
    Matteo Stravalaci
    Department of Molecular Biochemistry and Pharmacology, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    J Alzheimers Dis 53:1485-97. 2016
    ..Thus this antibody binds to pathologically relevant forms of Aβ, and offers a potential research, diagnostic, and therapeutic tool for AD. ..
  13. ncbi request reprint ST1926, a novel and orally active retinoid-related molecule inducing apoptosis in myeloid leukemia cells: modulation of intracellular calcium homeostasis
    Enrico Garattini
    Laboratory of Molecular Biology, Centro Catullo e Daniela Borgomainerio, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    Blood 103:194-207. 2004
    ....
  14. pmc C. elegans expressing human β2-microglobulin: a novel model for studying the relationship between the molecular assembly and the toxic phenotype
    Luisa Diomede
    Department of Molecular Biochemistry and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    PLoS ONE 7:e52314. 2012
    ..Here we show that tetracyclines can correct this abnormality confirming that these compounds are able to protect a living organism from the proteotoxicity of human β(2)-m...
  15. doi request reprint Neuropathologic and biochemical changes during disease progression in liver X receptor beta-/- mice, a model of adult neuron disease
    Paolo Bigini
    Department of Molecular Biochemistry and Pharmacology, Mario Negri Institute for Pharmacological Research, Milan, Italy
    J Neuropathol Exp Neurol 69:593-605. 2010
    ....
  16. ncbi request reprint SPIRE, a modular pipeline for eQTL analysis of RNA-Seq data, reveals a regulatory hotspot controlling miRNA expression in C. elegans
    Ivan Kel
    Instituto di Tecnologie Biomediche Consiglio Nazionale delle Ricerche, Via F lli Cervi 93, 20090, Segrate, Milano, Italy
    Mol Biosyst 12:3447-3458. 2016
    ..elegans. SPIRE is publicly available as open source software at , together with some example data, a readme file, supplementary material and a short tutorial...
  17. ncbi request reprint Synthetic miniprion PrP106
    Valentina Bonetto
    Dulbecco Telethon Institute, Department of Molecular Biochemistry and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, Milan 20157, Italy
    J Biol Chem 277:31327-34. 2002
    ..These features are central properties of PrP(Sc) and make sPrP106 an excellent tool for investigating the molecular basis of the conformational conversion of PrP(C) into PrP(Sc) and prion disease pathogenesis...
  18. doi request reprint Soil quality in the Lomellina area using in vitro models and ecotoxicological assays
    Diego Baderna
    Laboratory of Environmental Chemistry and Toxicology, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Via Giuseppe La Masa 19, 20156 Milan, Italy Electronic address
    Environ Res 133:220-31. 2014
    ..Additional information on the carcinogenic potential of mixtures was provided by the cell transformation assay, strengthening the combined approach...