Luca Di Tommaso

Summary

Affiliation: Istituto Clinico Humanitas
Country: Italy

Publications

  1. doi request reprint Advanced precancerous lesions in the liver
    Luca Di Tommaso
    Department of Medical Biotechnology and Translational Medicine and Unit of Pathology, University of Milan and Humanitas Clinical and Research Center, Via Manzoni 56, 20089 Rozzano, Milan, Italy
    Best Pract Res Clin Gastroenterol 27:269-84. 2013
  2. ncbi request reprint [Angiosarcoma of the nasal cavity. Report of a case and review of the literature]
    L Di Tommaso
    Department of Pathology, School of Medicine University of Milan, Humanitas Clinical Institute, Rozzano, Milan, Italy
    Pathologica 99:76-80. 2007
  3. ncbi request reprint [Well differentiated thyroid carcinoma: new perspectives and old dilemmas]
    Luca Di Tommaso
    Dipartimento di Patologia, Facolta di Medicina, Universita di Milano, Istituto Clinico Humanitas, Rozzano, Milano
    Ann Ital Chir 77:199-208. 2006
  4. doi request reprint Hepatic rosai-dorfman disease with coincidental lymphoma: report of a case
    Luca Di Tommaso
    Department of Pathology, IRCCS Istituto Clinico Humanitas of Rozzano, University of Milan School of Medicine, Milan, Italy
    Int J Surg Pathol 18:540-3. 2010
  5. doi request reprint Cracking spaces in Hashimoto Thyroiditis are lymphatic and prelymphatic vessels: a gift of immunohistochemistry for the centenary of Hashimoto's description
    Luca Di Tommaso
    Department of Pathology, University of Milan School of Medicine and IRCCS Humanitas Clinical Institute, Rozzano, Milan, Italy
    Am J Surg Pathol 34:1857-61. 2010
  6. ncbi request reprint A 3-D study of capsular invasion in follicular thyroid tumors. A novel approach to an old dilemma
    L Di Tommaso
    Department of Pathology, IRCCS Istituto Clinico Humanitas of Rozzano and University of Milan School of Medicine, Milan, Italy
    Pathologica 102:93-5. 2010
  7. pmc Soluble interleukin-2 receptors (sIL-2R) in Hodgkin's disease: outcome and clinical implications
    S Viviani
    Division of Medical Oncology A, Istituto Nazionale Tumori, Milano, Italy
    Br J Cancer 77:992-7. 1998
  8. doi request reprint Role of cMET expression in non-small-cell lung cancer patients treated with EGFR tyrosine kinase inhibitors
    P A Zucali
    Department of Medical Oncology and Hematology, Istituto Clinico Humanitas, Rozzano, Milan, Italy
    Ann Oncol 19:1605-12. 2008
  9. pmc Analysis of epidermal growth factor receptor expression as a predictive factor for response to gefitinib ('Iressa', ZD1839) in non-small-cell lung cancer
    H S Parra
    Department of Medical Oncology and Hematology, Istituto Clinico Humanitas, Via A Manzoni 56, Rozzano, Milan 20089, Italy
    Br J Cancer 91:208-12. 2004
  10. doi request reprint Molecular determinants of outcome in sorafenib-treated patients with hepatocellular carcinoma
    Nicola Personeni
    Department of Oncology Hematology, Humanitas Clinical and Research Center, Via Manzoni 56, 20089 Rozzano, MI, Italy
    J Cancer Res Clin Oncol 139:1179-87. 2013

Detail Information

Publications99

  1. doi request reprint Advanced precancerous lesions in the liver
    Luca Di Tommaso
    Department of Medical Biotechnology and Translational Medicine and Unit of Pathology, University of Milan and Humanitas Clinical and Research Center, Via Manzoni 56, 20089 Rozzano, Milan, Italy
    Best Pract Res Clin Gastroenterol 27:269-84. 2013
    ..The natural history of HG-DN is not predictable in individual cases and additional markers should be validated to increase the diagnostic accuracy and predict the behaviour. The treatment of HG-DN is under investigation. ..
  2. ncbi request reprint [Angiosarcoma of the nasal cavity. Report of a case and review of the literature]
    L Di Tommaso
    Department of Pathology, School of Medicine University of Milan, Humanitas Clinical Institute, Rozzano, Milan, Italy
    Pathologica 99:76-80. 2007
    ....
  3. ncbi request reprint [Well differentiated thyroid carcinoma: new perspectives and old dilemmas]
    Luca Di Tommaso
    Dipartimento di Patologia, Facolta di Medicina, Universita di Milano, Istituto Clinico Humanitas, Rozzano, Milano
    Ann Ital Chir 77:199-208. 2006
    ....
  4. doi request reprint Hepatic rosai-dorfman disease with coincidental lymphoma: report of a case
    Luca Di Tommaso
    Department of Pathology, IRCCS Istituto Clinico Humanitas of Rozzano, University of Milan School of Medicine, Milan, Italy
    Int J Surg Pathol 18:540-3. 2010
    ..The favorable outcome supports the belief that the prognosis of RDD is largely dependent on the number of extranodal sites involved, rather than on the specific sites themselves...
  5. doi request reprint Cracking spaces in Hashimoto Thyroiditis are lymphatic and prelymphatic vessels: a gift of immunohistochemistry for the centenary of Hashimoto's description
    Luca Di Tommaso
    Department of Pathology, University of Milan School of Medicine and IRCCS Humanitas Clinical Institute, Rozzano, Milan, Italy
    Am J Surg Pathol 34:1857-61. 2010
    ..Lymphatic vessels showed valves, perivascular lymphoid aggregates, and intravascular lymphocytes. The cracking spaces shown by Hashimoto are mainly lymphatic vessels and represent a characteristic feature of autoimmune thyroid diseases...
  6. ncbi request reprint A 3-D study of capsular invasion in follicular thyroid tumors. A novel approach to an old dilemma
    L Di Tommaso
    Department of Pathology, IRCCS Istituto Clinico Humanitas of Rozzano and University of Milan School of Medicine, Milan, Italy
    Pathologica 102:93-5. 2010
    ..Lesions with an intact shell are labeled as adenoma, those with capsular invasion are considered carcinoma and those with doubtful aspects are regarded as tumors of uncertain malignant potential...
  7. pmc Soluble interleukin-2 receptors (sIL-2R) in Hodgkin's disease: outcome and clinical implications
    S Viviani
    Division of Medical Oncology A, Istituto Nazionale Tumori, Milano, Italy
    Br J Cancer 77:992-7. 1998
    ....
  8. doi request reprint Role of cMET expression in non-small-cell lung cancer patients treated with EGFR tyrosine kinase inhibitors
    P A Zucali
    Department of Medical Oncology and Hematology, Istituto Clinico Humanitas, Rozzano, Milan, Italy
    Ann Oncol 19:1605-12. 2008
    ..However, resistance mechanisms are not well understood. We evaluated several potential biological markers of intrinsic EGFR-TKIs-resistance in NSCLC...
  9. pmc Analysis of epidermal growth factor receptor expression as a predictive factor for response to gefitinib ('Iressa', ZD1839) in non-small-cell lung cancer
    H S Parra
    Department of Medical Oncology and Hematology, Istituto Clinico Humanitas, Via A Manzoni 56, Rozzano, Milan 20089, Italy
    Br J Cancer 91:208-12. 2004
    ..Gefitinib demonstrated promising clinical activity in this group of patients with NSCLC. These results have also shown that EGFR expression is not a significant predictive factor for response to gefitinib...
  10. doi request reprint Molecular determinants of outcome in sorafenib-treated patients with hepatocellular carcinoma
    Nicola Personeni
    Department of Oncology Hematology, Humanitas Clinical and Research Center, Via Manzoni 56, 20089 Rozzano, MI, Italy
    J Cancer Res Clin Oncol 139:1179-87. 2013
    ..However, the determinants of sorafenib sensitivity in vivo remain largely unknown...
  11. doi request reprint Liver precancerous lesions and hepatocellular carcinoma: the histology report
    Massimo Roncalli
    Department of Pathology, University of Milan School of Medicine and Humanitas Clinical Institute, Rozzano, Milan, Italy
    Dig Liver Dis 43:S361-72. 2011
    ..The second part of the paper is devoted to the histopathology report of HCC on surgical specimens including explanted livers and on the differential diagnosis between HCC and liver metastasis...
  12. doi request reprint The application of markers (HSP70 GPC3 and GS) in liver biopsies is useful for detection of hepatocellular carcinoma
    Luca Di Tommaso
    Department of Pathology, University of Milan School of Medicine and IRCCS Humanitas Clinical Institute, Via Manzoni 56, 20089 Rozzano, Milan, Italy
    J Hepatol 50:746-54. 2009
    ....
  13. ncbi request reprint Fludarabine and cladribine in relapsed/refractory low-grade non-Hodgkin's lymphoma: a phase II randomized study
    C Tondini
    Division of Medical Oncology, Istituto Nazionale Tumori, Milan, Italy
    Ann Oncol 11:231-3. 2000
    ..It is unclear whether the purine analogs fludarabine (Flu) and cladribine (CdA) are non-resistant...
  14. ncbi request reprint Irinotecan and raltitrexed: an active combination in advanced colorectal cancer
    C Carnaghi
    Medical Oncology and Haematology Department, Istituto Clinico Humanitas, Milan, Italy
    Ann Oncol 13:1424-9. 2002
    ..The aim of our phase II trial was to assess the efficacy and tolerability of the combination of irinotecan and raltitrexed in patients with metastatic colorectal cancer untreated with chemotherapy...
  15. doi request reprint Morphophenotypic changes in human multistep hepatocarcinogenesis with translational implications
    Amedeo Sciarra
    Pathology Unit, Humanitas Clinical and Research Center, Rozzano, Milan, Italy Department of Medical Biotechnology and Translational Medicine BIOMETRA, University of Milan, School of Medicine, Milan, Italy
    J Hepatol 64:87-93. 2016
    ..The aim of this study was to investigate the morphophenotypical changes of this sequence and their potential translational significance...
  16. doi request reprint MicroRNA-425-3p predicts response to sorafenib therapy in patients with hepatocellular carcinoma
    Valentina Vaira
    Division of Pathology, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy
    Liver Int 35:1077-86. 2015
    ..In this study, we evaluated the predictive role of microRNAs (miRNAs) in this setting of patients...
  17. ncbi request reprint Hepatocellular dysplastic nodules
    Massimo Roncalli
    Department of Pathology, University of Milan, Istituto Clinico Humanitas of Rozzano, Milan, Italy
    Ann Ital Chir 79:81-9. 2008
    ....
  18. doi request reprint Phase I pharmacokinetic and pharmacodynamic study of lapatinib in combination with sorafenib in patients with advanced refractory solid tumors
    Matteo Simonelli
    Oncology and Hematology Unit, Humanitas Cancer Center, Istituto Clinico Humanitas, Rozzano, Italy
    Eur J Cancer 49:989-98. 2013
    ....
  19. doi request reprint Histopathological classification of hepatocellular carcinoma
    Massimo Roncalli
    Department of Pathology, University of Milan School of Medicine and IRCCS Istituto Clinico Humanitas, Rozzano, Milan, Italy
    Dig Liver Dis 42:S228-34. 2010
    ....
  20. doi request reprint Toker cells of the breast. Morphological and immunohistochemical characterization of 40 cases
    Luca Di Tommaso
    Department of Pathology, University of Milan School of Medicine and IRCCS Humanitas Clinical Institute, Rozzano, Milan, Italy
    Hum Pathol 39:1295-300. 2008
    ..The combined use of CD138/p53 is very helpful in distinguishing these atypical Toker cells from those of Paget's disease...
  21. ncbi request reprint Diagnostic value of HSP70, glypican 3, and glutamine synthetase in hepatocellular nodules in cirrhosis
    Luca Di Tommaso
    Department of Pathology, University of Milan School of Medicine and IRCCS Humanitas Clinical Institute, Rozzano, Milan, Italy, and Institute of Pathology, University Hospital Basel, Switzerland
    Hepatology 45:725-34. 2007
    ..CONCLUSION: The adopted panel of 3 markers is very helpful in distinguishing eHCC-G1 from dysplastic nodules arising in cirrhosis...
  22. ncbi request reprint Reduced intensity conditioning regimen followed by glycosylated G-CSF mobilized PBSCT in patients with solid tumors and malignant lymphomas
    L Castagna
    Department of Medical Oncology and Hematology, Istituto Clinico Humanitas, Rozzano, Milan, Italy
    Bone Marrow Transplant 30:207-14. 2002
    ..Our study confirms that a low intensity conditioning regimen for allogeneic stem cell transplantation is feasible and effective in heavily pretreated patients...
  23. doi request reprint CYP1A2 is a predictor of HCC recurrence in HCV-related chronic liver disease: A retrospective multicentric validation study
    Amedeo Sciarra
    University of Milan School of Medicine, Milan, Italy
    Dig Liver Dis . 2016
    ..Several clinicopathological markers have been associated with HCC recurrence, but none has been validated. Extratumoral expression of cytochrome P4501A2 (CYP1A2) was recently proposed as predictor of HCC recurrence...
  24. doi request reprint Sinusal localization of nodal micrometastases is a prognostic factor in breast cancer
    G Masci
    Department of Oncology and Hematology, Istituto Clinico Humanitas IRCCS, Rozzano, Italy
    Ann Oncol 21:1228-32. 2010
    ..Despite this, their clinical relevance is still debated. The aim of this study is to investigate features that affect disease-free survival (DFS) and overall survival (OS) in patients with nodal micrometastases from breast cancer...
  25. pmc Primary resistance to cetuximab therapy in EGFR FISH-positive colorectal cancer patients
    F Cappuzzo
    Department of Medical Oncology, Istituto Clinico Humanitas IRCCS, Milan University, Rozzano, Italy
    Br J Cancer 99:83-9. 2008
    ..The rarity of MET and IGF1R gene amplification suggests a marginal role in primary resistance. The potential prognostic implication of IGF1R expression merits further evaluation...
  26. pmc Pemetrexed plus carboplatin in elderly patients with malignant pleural mesothelioma: combined analysis of two phase II trials
    G L Ceresoli
    Department of Oncology, Istituto Clinico Humanitas IRCCS, Rozzano, Milano, Italy
    Br J Cancer 99:51-6. 2008
    ..9 months, P=0.12). Apart from slightly worse haematological toxicity, there was no significant difference in outcome or toxicity between age groups. The PC regimen is effective and well tolerated in selected elderly patients with MPM...
  27. ncbi request reprint Surrogate predictive biomarkers for response to anti-EGFR agents: state of the art and challenges
    F Cappuzzo
    Department of Oncology Hematology, Istituto Clinico Humanitas IRCCS, Rozzano, Milan, Italy
    Int J Biol Markers 22:S10-23. 2007
    ....
  28. pmc MET increased gene copy number and primary resistance to gefitinib therapy in non-small-cell lung cancer patients
    F Cappuzzo
    Department of Oncology Hematology, Istituto Clinico Humanitas IRCCS, Rozzano, Italy
    Ann Oncol 20:298-304. 2009
    ..MET amplification has been detected in approximately 20% of non-small-cell lung cancer patients (NSCLC) with epidermal growth factor receptor (EGFR) mutations progressing after an initial response to tyrosine kinase inhibitor (TKI) therapy...
  29. ncbi request reprint IGEV regimen and a fixed dose of lenograstim: an effective mobilization regimen in pretreated Hodgkin's lymphoma patients
    M Magagnoli
    Department of Medical Oncology and Hematology, Istituto Clinico Humanitas, Rozzano, Milan, Italy
    Bone Marrow Transplant 40:1019-25. 2007
    ..Thirty-four patients received a single and 47 received tandem transplantation with rapid engraftment. These results confirm that the IGEV regimen with lenograstim support can be used successfully and safely to mobilize PBSCs...
  30. doi request reprint Outcome of T1N0M0 breast cancer in relation to St. Gallen risk assignment criteria for adjuvant therapy
    I Garassino
    Department of Oncology and Hematology, Istituto Clinico Humanitas IRCCS, 20089 Rozzano Milano, Italy
    Breast 18:263-6. 2009
    ....
  31. ncbi request reprint EGFR FISH assay predicts for response to cetuximab in chemotherapy refractory colorectal cancer patients
    F Cappuzzo
    Department of Medical Oncology, Istituto Clinico Humanitas IRCCS, Rozzano, Italy
    Ann Oncol 19:717-23. 2008
    ..Standardized conditions to distinguish subpopulations of colorectal cancer (CRC) patients more and less sensitive to cetuximab therapy remain undefined...
  32. ncbi request reprint Salvage chemotherapy in Hodgkin's disease. Results in patients relapsing more than twelve months after first complete remission
    S Viviani
    Division of Medical Oncology, Istituto Nazionale Tumori, Milan, Italy
    Ann Oncol 1:123-7. 1990
    ..Present findings indicate that about half of patients relapsing after a disease-free interval exceeding 12 months can remain alive and disease-free 5 years after starting salvage chemotherapy...
  33. pmc Insulin-like growth factor receptor 1 (IGF1R) expression and survival in surgically resected non-small-cell lung cancer (NSCLC) patients
    F Cappuzzo
    Department of Oncology Hematology, Istituto Clinico Humanitas Istituto di Ricerca a Carattere Scientifico IRCCS, Rozzano
    Ann Oncol 21:562-7. 2010
    ..Patients exposed to anti-epidermal growth factor receptor (EGFR) agents were excluded. IGF1R expression was evaluated by immunohistochemistry in tissue microarray sections...
  34. ncbi request reprint Combined regimen of cisplatin, doxorubicin, and alpha-2b interferon in the treatment of advanced malignant pleural mesothelioma: a Phase II multicenter trial of the Italian Group on Rare Tumors (GITR) and the Italian Lung Cancer Task Force (FONICAP)
    H S Parra
    Department of Medical Oncology and Hematology, Istituto Clinico Humanitas, Via Manzoni 56, 20089 Rozzano Milano, Italy
    Cancer 92:650-6. 2001
    ..Therefore, the combined chemoimmunotherapy regimen is an worthwhile approach to evaluate in a Phase II trial...
  35. ncbi request reprint Mobilizing potential of ifosfamide/vinorelbine-based chemotherapy in pretreated malignant lymphoma
    M Magagnoli
    Department of Medical Oncology and Hematology, Istituto Clinico Humanitas, Rozzano, Milan, Italy
    Bone Marrow Transplant 28:923-7. 2001
    ..These results confirm that ifosfamide and vinorelbine-based chemotherapy regimen with G-CSF support can be successfully and safely used to mobilize PBSCs...
  36. ncbi request reprint Clinical significance of neuroendocrine phenotype in non-small-cell lung cancer
    C Carnaghi
    Dipartimento di Scienze Onco Ematologiche, Istituto Clinico Humanitas, Rozzano, Milano, Italy
    Ann Oncol 12:S119-23. 2001
    ..In conclusion, there is no doubt that caution is required when interpreting the results of a number of studies questioning the clinical impact of the NE features of NSCLCs...
  37. ncbi request reprint Dose-escalation of CHOP in non-Hodgkin's lymphoma
    A Santoro
    Division of Medical Oncology, Istituto Nazionale Tumori, Milano, Italy
    Ann Oncol 10:519-25. 1999
    ..In order to determine the maximum tolerable dose of an intensified CHOP regimen, a dose-escalation study of CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) in patients with non-Hodgkin's lymphoma (NHL) was started...
  38. ncbi request reprint Activity of a specific inhibitor, gefitinib (Iressa, ZD1839), of epidermal growth factor receptor in refractory non-small-cell lung cancer
    A Santoro
    Department of Medical Oncology and Hematology, Istituto Clinico Humanitas, Rozzano, Milan, Italy
    Ann Oncol 15:33-7. 2004
    ..Therefore, we aimed to assess the antitumor activity and tolerability of gefitinib in a series of patients with previously treated, advanced NSCLC, as a part of a compassionate use program...
  39. ncbi request reprint Gemcitabine in the treatment of refractory Hodgkin's disease: results of a multicenter phase II study
    A Santoro
    Istituto Clinico Humanitas, Rozzano Milano, Italy
    J Clin Oncol 18:2615-9. 2000
    ..To explore the use of gemcitabine for the treatment of patients with relapsing or refractory Hodgkin's disease...
  40. ncbi request reprint Three-week versus four-week schedule of cisplatin and gemcitabine: results of a randomized phase II study
    H Soto Parra
    Department of Medical Oncology and Hematology and Division of Thoracic Surgery, Istituto Clinico Humanitas, Rozzano Milan, Italy
    Ann Oncol 13:1080-6. 2002
    ..We therefore started a randomized phase II trial to compare toxicity and dose intensity (DI) between these two GC schedules...
  41. ncbi request reprint Intensified CHOP regimen in aggressive lymphomas: maximal dose intensity and dose density of doxorubicin and cyclophosphamide
    M Balzarotti
    Department of Medical Oncology and Hematology, and Division of Pathology, Istituto Clinico Humanitas, Rozzano Milano, Italy
    Ann Oncol 13:1341-6. 2002
    ....
  42. pmc Increased SOX2 gene copy number is associated with FGFR1 and PIK3CA gene gain in non-small cell lung cancer and predicts improved survival in early stage disease
    Luca Toschi
    Division of Oncology and Hematology, Humanitas Clinical and Research Center, Rozzano, Milan, Italy
    PLoS ONE 9:e95303. 2014
    ..We aimed to investigate prevalence and prognostic role of SOX2, PIK3CA, FGFR1 and BRF2 gene gain in patients with surgically resected non-small cell lung cancer (NSCLC)...
  43. doi request reprint Detection of somatostatin receptor subtypes 2 and 5 by somatostatin receptor scintigraphy and immunohistochemistry: clinical implications in the diagnostic and therapeutic management of gastroenteropancreatic neuroendocrine tumors
    Francesco Sclafani
    Medical Oncology and Hematology Unit, Humanitas Cancer Center, Istituto Clinico Humanitas, IRCCS, Rozzano MI, Italy
    Tumori 97:620-8. 2011
    ..Immunohistochemistry (IHC) was reported as a reliable method for the detection of SSTRs with theoretically superior sensitivity over SRS...
  44. ncbi request reprint Thymic tumor with adenoid cystic carcinomalike features: a clinicopathologic study of 4 cases
    Luca Di Tommaso
    Department of Pathology, IRCCS Istituto Clinico Humanitas of Rozzano, University of Milan School of Medicine, Milan
    Am J Surg Pathol 31:1161-7. 2007
    ..We have interpreted them as a microscopic subtype of well-differentiated thymic carcinoma of low-grade malignancy, an impression supported by the admittedly limited follow-up information...
  45. pmc Prognostic and predictive value of centrally reviewed Ki-67 labeling index in postmenopausal women with endocrine-responsive breast cancer: results from Breast International Group Trial 1-98 comparing adjuvant tamoxifen with letrozole
    Giuseppe Viale
    Division of Pathology and Laboratory Medicine, European Institute of Oncology, University of Milan, Milan, Italy
    J Clin Oncol 26:5569-75. 2008
    ..To evaluate the prognostic and predictive value of Ki-67 labeling index (LI) in a trial comparing letrozole (Let) with tamoxifen (Tam) as adjuvant therapy in postmenopausal women with early breast cancer...
  46. ncbi request reprint Pilot study with adriamycin and ifosfamide in small cell lung cancer
    P Bidoli
    Division of Medical Oncology, Istituto Nazionale Tumori, Milano, Italy
    Tumori 75:34-7. 1989
    ..However, the high response rate achieved after four cycles and the low incidence of marrow toxicity suggest the use of this regimen for a short period with increased dose levels...
  47. doi request reprint A phase II randomized multicenter trial of gefitinib plus FOLFIRI and FOLFIRI alone in patients with metastatic colorectal cancer
    A Santoro
    Unità Operativa di Oncologia e Ematologia, Istituto Clinico Humanitas, Rozzano, Italy
    Ann Oncol 19:1888-93. 2008
    ..This randomized phase II trial investigates the feasibility and efficacy of gefitinib and 5-fluorouracil, folinic acid, irinotecan (FOLFIRI) in patients with metastatic colorectal cancer...
  48. doi request reprint A prospective randomized study comparing 25-G and 22-G needles of a new platform for endoscopic ultrasound-guided fine needle aspiration of solid masses
    Silvia Carrara
    Digestive Endoscopy Unit, Division of Gastroenterology, Humanitas Research Hospital, Rozzano, Milan, Italy Electronic address
    Dig Liver Dis 48:49-54. 2016
    ..A new needle platform for endoscopic ultrasound-guided fine-needle aspiration biopsy has been developed that allows interchangeability of all needle sizes...
  49. doi request reprint TRIP: a pathological score for transarterial chemoembolization resistance individualized prediction in hepatocellular carcinoma
    Amedeo Sciarra
    Pathology Department, Humanitas clinical and Research Center and University of Milan School of Medicine, Milan, Italy
    Liver Int 35:2466-73. 2015
    ..The aim of this study was to identify tissue predictors of tumour resistance to TACE for use in clinical practice on pretreatment biopsies...
  50. pmc Multiple focal nodular hyperplasias induced by oxaliplatin-based chemotherapy
    Matteo Donadon
    Matteo Donadon, Guido Torzilli, Liver Surgery Unit, Department of General Surgery, University of Milan, Humanitas Clinical and Research Center, 20089 Rozzano, Milan, Italy
    World J Hepatol 5:340-4. 2013
    ..The value of the modern multidisciplinary management of patients with colorectal cancer relies also on the precise estimation of the risk/benefit for each patient. ..
  51. pmc Insulin-like growth factor-1 receptor and phosphorylated AKT-serine 473 expression in 132 resected thymomas and thymic carcinomas
    Paolo A Zucali
    Department of Oncology, Humanitas Clinical Institute, IRCCS, Rozzano, Milan, Italy
    Cancer 116:4686-95. 2010
    ..Thymic malignancies are rare tumors. The insulin-like growth factor-1 (IGF-1)/IGF-1 receptor (IGF-1R) system is involved in the development of the thymus. IGF-1R expression in thymic epithelial malignancies is unknown...
  52. ncbi request reprint Hepatocellular dysplastic nodules
    Massimo Roncalli
    Department of Pathology, University of Milan, IRCCS Istituto Clinico Humanitas, Rozzano MI, Italy
    Hepatol Res 37:S125-34. 2007
    ..These tools might allow a better understanding of the boundaries of the process going from high grade dysplasia to in situ HCC and from the latter to microinvasive HCC and advanced HCC, for proper clinical management and optimal therapy...
  53. ncbi request reprint Basal cell carcinoma adjacent to syringoma in periorbital skin: a case report
    Bethania De Sousa Fernandes
    Department of Pathology, School of Medicine, University of Milan, Italy
    Am J Dermatopathol 27:362-3. 2005
  54. ncbi request reprint The capillary lobule: a deceptively benign feature of post-radiation angiosarcoma of the skin: report of three cases
    Luca Di Tommaso
    Department of Pathology, University of Milan Medical School, Rozzano, Italy
    Am J Dermatopathol 27:301-5. 2005
    ..Therefore, the detection of capillary lobules in irradiated skin ought to be regarded with great suspicion, and other morphologic signs suggestive of angiosarcoma should be sought in the specimen...
  55. doi request reprint Diagnostic accuracy of clathrin heavy chain staining in a marker panel for the diagnosis of small hepatocellular carcinoma
    Luca Di Tommaso
    Department of Pathology, Istituto di Ricovero e Cura a Carattere Scientifico, Rozzano, Milan, Italy
    Hepatology 53:1549-57. 2011
    ..9% and 88.2%, respectively). In seven cases (including six small G1 HCCs), there was no staining with any of the markers. Cirrhotic control livers were stained for CHC in four cases (13.3%) and for GPC3 in one case (3.3%)...
  56. pmc Prospective study of high-dose chemotherapy and autologous peripheral stem cell transplantation in adult patients with advanced desmoplastic small round-cell tumour
    A Bertuzzi
    Department of Medical Oncology and Hematology, Istituto Clinico Humanitas, Via Manzoni 56, Rozzano, Milan 20089, Italy
    Br J Cancer 89:1159-61. 2003
    ..High-dose chemotherapy did not seem to change the results in desmoplastic small round-cell tumour...
  57. doi request reprint Pegfilgrastim versus filgrastim after high-dose chemotherapy and autologous peripheral blood stem cell support
    L Castagna
    Department of Oncology and Hematology, Istituto Clinico Humanitas, Rozzano, Milan, Italy
    Ann Oncol 21:1482-5. 2010
    ..This randomized trial aims to demonstrate the noninferiority of pegfilgrastim (PEG) compared with filgrastim (FIL) after HDC...
  58. doi request reprint Hepatic metastases from breast cancer
    Arianna Rubino
    Department of General Surgery I, IRCCS Istituto Clinico Humanitas, Rozzano, Milan, Italy
    Updates Surg 62:143-8. 2010
    ..Neoadjuvant treatment and preoperative diagnostic laparoscopy should be planned in future experience...
  59. pmc Clinicopathological and Immunohistochemical Characteristics in Male Breast Cancer: A Retrospective Case Series
    Giovanna Masci
    Humanitas Clinical and Research Hospital, Rozzano, Milan, Italy Humanitas Centro Catanese di Oncologia, Catania, Italy Humanitas Gavazzeni, Bergamo, Italy Humanitas Mater Domini, Castellanza, Italy
    Oncologist 20:586-92. 2015
    ..Due to its rarity, male breast cancer (mBC) remains an inadequately characterized disease, and current evidence for treatment derives from female breast cancer (FBC)...
  60. doi request reprint Primary pulmonary meningioma: report of a case and review of the literature
    Matteo Incarbone
    Department of Thoracic Surgery, Istituto Clinico Humanitas, Via Manzoni 56, 20089 Rozzano Milan, Italy
    Lung Cancer 62:401-7. 2008
    ..When feasible, pulmonary wedge resection by video-assisted thoracic surgery (VATS) including intra-operative histological examination is the most suitable approach to determine the diagnosis and the volume of pulmonary resection...
  61. ncbi request reprint Cutaneous melanoma metastatic to uterine adenomyoma: report of a case
    Luca Di Tommaso
    Department of Pathology, School of Medicine University of Milan, Humanitas Clinical Institute, Rozzano, Italy
    Int J Surg Pathol 13:223-5. 2005
    ..Pathologists should be aware of this possibility in order to look carefully for metastatic implants in similar lesions. It is proposed that chemokine profile of neoplastic cells can be a useful tool in predicting metastatic targets...
  62. pmc Cytogenetic study in therapy-related myelodysplastic syndromes (t-MDS) and acute non-lymphocytic leukaemia (t-ANLL)
    G Sozzi
    Istituto Nazionale Tumori, Milan, Italy
    Br J Cancer 61:425-8. 1990
    ..In the other 15 cases, the presence of a normal karyotype together with the morphological and immunophenotypical characterisation was consistent with a diagnosis of non-neoplastic specimens...
  63. ncbi request reprint The kidney in hepatorenal syndrome (I Part)
    A Santoro
    Nephrology and Dialysis Unit, Policlinico Sant Orsola Malpighi, Bologna, Italy
    Int J Artif Organs 27:95-103. 2004
  64. doi request reprint First-line bevacizumab combined with reduced dose interferon-alpha2a is active in patients with metastatic renal cell carcinoma
    B Melichar
    Charles University Medical School and Teaching Hospital, Hradec Kralove, Czech Republic
    Ann Oncol 19:1470-6. 2008
    ..In this hypothesis-generating study, subgroup analysis was carried out to determine the effect of IFN dose reduction...
  65. ncbi request reprint An open-label, single-arm study assessing safety and efficacy of panitumumab in patients with metastatic colorectal cancer refractory to standard chemotherapy
    E Van Cutsem
    Digestive Oncology Unit, University Hospital Gasthuisberg, Leuven, Belgium
    Ann Oncol 19:92-8. 2008
    ....
  66. ncbi request reprint Combined epirubicin and interleukin-2 regimen in the treatment of malignant mesothelioma: a multicenter phase II study of the Italian Group on Rare Tumors
    S Bretti
    Divisione di Oncologia Medica, Ospedale Oncologico S. Giovanni A.S, Torino, Italy
    Tumori 84:558-61. 1998
    ..Toxicity was relevant and caused treatment discontinuation in many patients. These results do not support the use of such a combination in the management of malignant mesothelioma...
  67. ncbi request reprint A randomised phase II study on neo-adjuvant chemotherapy for 'high-risk' adult soft-tissue sarcoma
    E Gortzak
    The Netherlands Cancer Institute/Antoni van Leeuwenhoekhuis, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands
    Eur J Cancer 37:1096-103. 2001
    ..Although not powered to draw definitive conclusions on benefit, but with an at least 7 year median follow-up, the results render it less likely that major survival benefits will be achieved with this type of chemotherapy...
  68. doi request reprint Sorafenib in advanced hepatocellular carcinoma
    Josep M Llovet
    Barcelona Clinic Liver Cancer Group, Institut d Investigacions Biomediques August Pi i Sunyer, Centro de Investigaciones en Red de Enfermedades Hepáticas y Digestivas Hospital Clínic Barcelona, Barcelona
    N Engl J Med 359:378-90. 2008
    ..A preliminary study suggested that sorafenib, an oral multikinase inhibitor of the vascular endothelial growth factor receptor, the platelet-derived growth factor receptor, and Raf may be effective in hepatocellular carcinoma...
  69. ncbi request reprint Insulin-like growth factor receptor 1 (IGFR-1) is significantly associated with longer survival in non-small-cell lung cancer patients treated with gefitinib
    F Cappuzzo
    University of Colorado Cancer Center, Department of Medicine Medical Oncology and Pathology, Aurora, USA
    Ann Oncol 17:1120-7. 2006
    ..The aim of the study was to assess whether loss of PTEN and expression of insulin-like growth factor receptor 1 (IGFR-1) could be responsible for intrinsic resistance to the tyrosine kinase inhibitor (TKI) gefitinib...
  70. ncbi request reprint Vinorelbine and prednisone in frail elderly patients with intermediate-high grade non-Hodgkin's lymphomas
    U Tirelli
    Ann Oncol 17:533. 2006
  71. ncbi request reprint Early restaging positron emission tomography with 18F-fluorodeoxyglucose in aggressive non-Hodgkin's lymphomas: is it too easy to be true?
    M Balzarotti
    Ann Oncol 14:1155-6. 2003
  72. pmc Primary chemotherapy with gemcitabine, epirubicin and taxol (GET) in operable breast cancer: a phase II study
    P F Conte
    Department of Medical Oncology and Hematology, University of Modena and Reggio Emilia, Italy
    Br J Cancer 93:406-11. 2005
    ..The gemcitabine, epirubicin, taxol regimen is active and well tolerated as PCT for operable breast cancer. This combination allows the administration of full doses of active agents with a low incidence of febrile neutropenia...
  73. ncbi request reprint BBR 3438, a novel 9-aza-anthrapyrazole, in patients with advanced gastric cancer: a phase II study group trial of the Central European Society of Anticancer-Drug Research (CESAR)
    R D Hofheinz
    Onkologisches Zentrum, III Medizinische Klinik, Fakultät für Klinische Medizin Mannheim, Universitat Heidelberg, Germany
    Invest New Drugs 23:363-8. 2005
    ..In terms of antitumor activity, BBR 3438 was found to be ineffective in the treatment of gastric cancer...
  74. ncbi request reprint A critical reappraisal of MIB-1 labelling index significance in a large series of pituitary tumours: secreting versus non-secreting adenomas
    M L Jaffrain-Rea
    Department of Experimental Medicine, Universita degli Studi di L Aquila, Via Vetoio, Coppito 2, 67100 L Aquila AQ, Italy
    Endocr Relat Cancer 9:103-13. 2002
    ..LI should be interpreted according to hormone secretion and pre-operative treatment. Unusually high LI values deserve particular attention...
  75. ncbi request reprint Reduced cardiotoxicity and comparable efficacy in a phase III trial of pegylated liposomal doxorubicin HCl (CAELYX/Doxil) versus conventional doxorubicin for first-line treatment of metastatic breast cancer
    M E R O'Brien
    Kent Cancer Center, Maidstone, UK
    Ann Oncol 15:440-9. 2004
    ....
  76. ncbi request reprint Human pituitary tumours express the bHLH transcription factors NeuroD1 and ASH1
    E Ferretti
    Department of Experimental Medicine, University of L Aquila, L Aquila, Italy
    J Endocrinol Invest 26:957-65. 2003
    ....
  77. ncbi request reprint Metastatic colorectal cancer: integrating irinotecan into combination and sequential chemotherapy
    J Y Douillard
    Centre R Gauducheau, Nantes, France
    Ann Oncol 14:ii7-12. 2003
    ..Infusional regimens have a better risk/benefit ratio than bolus regimens. However, the adverse event profile with both approaches is manageable, and irinotecan plus 5-FU/FA can be considered one standard of care in metastatic CRC...
  78. ncbi request reprint Minidose warfarin is associated with a high incidence of International Normalized Ratio elevation during chemotherapy with FOLFOX regimen
    M Magagnoli
    Ann Oncol 14:959-60. 2003
  79. ncbi request reprint High rate of remission and low rate of disease recurrence in patients with multiple myeloma allografted with PBSC from their HLA-identical sibling donors
    I Majolino
    Hematology and Bone Marrow Transplantation Unit, Azienda Ospedaliera S Camillo Forlanini, Roma, Italy
    Bone Marrow Transplant 31:767-73. 2003
    ..PBSC allograft can induce long remissions, because of profound suppression of the neoplastic clone that is probably linked to the antitumor effect of cGVHD...
  80. ncbi request reprint [The hyperplasia-adenoma sequence: a case supporting this hypothesis]
    V Villanacci
    2o Servizio di Anatomia ed Istologia Patologica, Universita degli Studi di Brescia, Spedali Civili di Brescia, P le Spedali Civili 1 I 25100 Brescia, Italia
    Pathologica 94:234-7. 2002
    ..The description is focused on the capability of a hyperplastic polyp to evolve into adenomatous tissue through different modalities...
  81. ncbi request reprint Brain metastasis from hepatocellular carcinoma associated with hepatitis B virus
    A Frati
    Dept of Neurosurgery, IRCCS Neuromed Is, Rome, Italy
    J Exp Clin Cancer Res 21:321-7. 2002
    ..We also suggest that HBV and its X protein (HBX) might play an important role in such aggressive behavior of the neoplasia...
  82. ncbi request reprint Metabolism of adenosine in human colorectal tumour
    D Vannoni
    Department Medicina Interna, Sc Endocrino Metaboliche e Biochimica, University of Siena, Italy
    Nucleosides Nucleotides Nucleic Acids 23:1455-7. 2004
    ..The results show that the activities of the enzymes are markedly higher in tumour in comparison to normal mucosa to coope with the accelerated purine metabolism in cancerous tissues...
  83. ncbi request reprint Atypical tentorial meningioma 30 years after radiotherapy for a pituitary adenoma
    A Santoro
    Neurosurgery Unit I, Department of Neurological Sciences, La Sapienza University of Rome, , Italy
    Neurol Sci 22:463-7. 2002
    ....
  84. ncbi request reprint Surgical treatment and clinical outcome of GH-secreting adenomas in elderly patients
    G Minniti
    Division of Neurosurgery, IRCCS NEUROMED University of Rome, Pozzilli, Italy
    Acta Neurochir (Wien) 143:1205-11. 2001
    ..We conclude that transsphenoidal surgery, if well planned and carefully performed, is safe and able to induce a significant cardiovascular and metabolic improvement even in elderly acromegalic patients...
  85. ncbi request reprint Lung resection as salvage treatment for metastatic osteosarcoma
    U Pastorino
    Division of Thoracic Surgery, Istituto Nazionale Tumori, Milan
    Tumori 74:201-6. 1988
    ..These data support the concept of pulmonary metastasectomy as effective salvage therapy for metastatic osteosarcomas whose distant spread is confined in the lungs...
  86. ncbi request reprint Intermediate-dose melphalan with stem-cell support in platinum-refractory ovarian cancer
    M Magagnoli
    Bone Marrow Transplant 33:1261-2. 2004
  87. ncbi request reprint Role of intensive therapy in liver transplant recipients: experience in blood purification and biosynthetic techniques
    S Faenza
    Department of Surgery, University of Bologna, Bologna, Italy
    Transplant Proc 36:555-7. 2004
    ..The aim of this work was to provide a summary of our clinical findings and current methods in extracorporeal liver support with the goal of improving the clinical status potential transplant patients...
  88. ncbi request reprint Single-agent high-dose melphalan followed by peripheral blood stem cell (PBSC) in lymphoma patients: an effective, and well-tolerated conditioning regimen
    M Magagnoli
    Bone Marrow Transplant 33:1067-8. 2004
  89. ncbi request reprint [Suitability to the specific task of drivers suffering from hypertension]
    A Santoro
    Istituto di Medicina del Lavoro, Universita Cattolica Sacro Cuore, Roma
    G Ital Med Lav Ergon 29:505-7. 2007
    ....
  90. ncbi request reprint [Italian Registry of Dialysis and Transplantation: 1996-2001 experience]
    F Conte
    G Ital Nefrol 21:561-7. 2004
    ..The gross mortality rate in dialyzed patients was stable during this period, at approximately 14%, the main causes of death being cardiovascular diseases and cachexia...
  91. ncbi request reprint Online convective therapies: results from a hemofiltration trial
    A Santoro
    UO Nefrologia e Dialisi Malpighi, Policlinico S Orsola Malpighi, Bologna, Italy
    Contrib Nephrol 149:51-7. 2005
    ..By the end of the protocol, patients in HF showed a 2.5% incidence of acute dialysis hypotension, while patients in BD had 23%...
  92. ncbi request reprint Allogeneic peripheral stem-cell transplantation with reduced-intensity conditioning regimen in refractory primary B-cell prolymphocytic leukemia: a long-term follow-up
    L Castagna
    Bone Marrow Transplant 35:1225. 2005
  93. ncbi request reprint [Guidelines on water and solutions for dialysis. Italian Society of Nephrology]
    S Alloatti
    Center for Nephrology and Dialysis of Aosta, Italian Society of Nephrology, Aosta, Italy
    G Ital Nefrol 22:246-73. 2005
    ..Suggestions and questions concerning these guidelines are welcome to nefrologia@sin-italy.org...
  94. ncbi request reprint High incidence of INR alteration in gastrointestinal cancer patients treated with mini-dose warfarin and 5-fluorouracil-based regimens
    M Magagnoli
    Ann Oncol 17:174-6. 2006
  95. ncbi request reprint High-dose chemotherapy as adjuvant treatment for high-risk primary breast cancer patients
    A Bertuzzi
    Ann Oncol 17:719-20. 2006
  96. ncbi request reprint [Census 2004 of the Italian Renal and Dialysis Units. Emilia-Romagna, Toscana]
    T Lusenti
    UO di Nefrologia e Dialisi, Ospedale S Maria Nuova, Reggio Emilia, Italy
    G Ital Nefrol 23:203-11. 2006
    ..7 and 3.3 dialysis patients. E) Activity: hospital admissions 1572, 1769 pmp; renal biopsies 115 and 166 pmp...
  97. ncbi request reprint Chronic expanding intracerebral hematoma treated by mini-invasive ultrasonography-guided needle aspiration
    E Passacantilli
    Department of Neuroscience Neurosurgery, University of Rome La Sapienza, Rome, Italy
    J Neurosurg Sci 50:67-70. 2006
    ..US-guided aspiration is a low cost, not time consuming technique, that allows an intraoperative real-time control of the lesion and seems to be an effective alternative to open surgery in cases of CEIHs with a thin capsule...
  98. ncbi request reprint Circulating gastrin and ghrelin levels in patients with colorectal cancer: correlation with tumour stage, Helicobacter pylori infection and BMI
    V D'Onghia
    Dip Di Medicina Interna, Sc Endocrino Metaboliche e Biochimica, Sez di Biochimica, Universita di Siena, Via A Moro 2, 53100 Siena, Italy
    Biomed Pharmacother 61:137-41. 2007
    ..Additional studies are necessary to ascertain the significance of gastrin and ghrelin opposite behaviour in colon cancer probably linked with interferences in endocrine pathways involving other gut peptides in this compromised condition...
  99. doi request reprint Efficacy and (pharmaco)kinetics of one single dose of rasburicase in patients with chronic kidney disease
    E Sestigiani
    Department of Nephrology, Dialysis and Hypertension, Malpighi Hospital, Bologna, Italy
    Nephron Clin Pract 108:c265-71. 2008
    ..We studied the pharmacokinetics and metabolism of rasburicase in the treatment of chronic asymptomatic hyperuricemia in chronic kidney disease (CKD) patients...