Giovanni Di Zenzo

Summary

Affiliation: Istituto Dermopatico dell'Immacolata
Country: Italy

Publications

  1. doi request reprint Bullous pemphigoid: from the clinic to the bench
    Giovanni Di Zenzo
    Molecular and Cell Biology Laboratory, Istituto Dermopatico dell Immacolata, IDI IRCCS, Rome, Italy
    Clin Dermatol 30:3-16. 2012
  2. ncbi request reprint Bullous pemphigoid: physiopathology, clinical features and management
    Giovanni Di Zenzo
    Molecular and Cell Biology Laboratory, Istituto Dermopatico dell Immacolata, IDI IRCCS, Via Monti di Creta 104, 00167 Rome, Italy
    Adv Dermatol 23:257-88. 2007
  3. doi request reprint Multicenter prospective study of the humoral autoimmune response in bullous pemphigoid
    Giovanni Di Zenzo
    Istituto Dermopatico dell Immacolata, Molecular and Cell Biology Laboratory, IDI IRCCS, Rome, Italy
    Clin Immunol 128:415-26. 2008
  4. doi request reprint Sequential intramolecular epitope spreading of humoral responses to human BPAG2 in a transgenic model
    Giovanni Di Zenzo
    Laboratory of Molecular and Cell Biology, Istituto Dermopatico dell Immacolata, IDI IRCCS, Rome, Italy
    J Invest Dermatol 130:1040-7. 2010
  5. doi request reprint Demonstration of epitope-spreading phenomena in bullous pemphigoid: results of a prospective multicenter study
    Giovanni Di Zenzo
    Molecular and Cell Biology Laboratory, IDI IRCCS, Rome, Italy
    J Invest Dermatol 131:2271-80. 2011
  6. pmc Prevalence of collagen VII-specific autoantibodies in patients with autoimmune and inflammatory diseases
    Emilia Licarete
    Department of Dermatology, University of Freiburg, Hauptstr, 7, Freiburg 79104, Germany
    BMC Immunol 13:16. 2012
  7. ncbi request reprint The intracellular and extracellular domains of BP180 antigen comprise novel epitopes targeted by pemphigoid gestationis autoantibodies
    Giovanni Di Zenzo
    Molecular and Cell Biology Laboratory, Istituto Dermopatico dell Immacolata, IDI IRCCS, Rome, Italy
    J Invest Dermatol 127:864-73. 2007
  8. ncbi request reprint Characterization of the anti-BP180 autoantibody reactivity profile and epitope mapping in bullous pemphigoid patients
    Giovanni Di Zenzo
    Molecular and Cell Biology Laboratory, Istituto Dermopatico dell Immacolata, IDI IRCCS, Rome, Italy
    J Invest Dermatol 122:103-10. 2004
  9. ncbi request reprint Oral pemphigoid autoantibodies preferentially target BP180 ectodomain
    Valentina Calabresi
    Molecular and Cell Biology Laboratory, Istituto Dermopatico dell Immacolata, IDI IRCCS, Rome, Italy
    Clin Immunol 122:207-13. 2007
  10. pmc Pemphigus autoantibodies generated through somatic mutations target the desmoglein-3 cis-interface
    Giovanni Di Zenzo
    Molecular and Cell Biology Laboratory, Istituto Dermopatico dell Immacolata, IDI IRCCS, Rome, Italy
    J Clin Invest 122:3781-90. 2012

Collaborators

Detail Information

Publications16

  1. doi request reprint Bullous pemphigoid: from the clinic to the bench
    Giovanni Di Zenzo
    Molecular and Cell Biology Laboratory, Istituto Dermopatico dell Immacolata, IDI IRCCS, Rome, Italy
    Clin Dermatol 30:3-16. 2012
    ..Although potent topical steroids have emerged in the past decade as first-line treatment of BP, management of the disease may be challenging...
  2. ncbi request reprint Bullous pemphigoid: physiopathology, clinical features and management
    Giovanni Di Zenzo
    Molecular and Cell Biology Laboratory, Istituto Dermopatico dell Immacolata, IDI IRCCS, Via Monti di Creta 104, 00167 Rome, Italy
    Adv Dermatol 23:257-88. 2007
    ....
  3. doi request reprint Multicenter prospective study of the humoral autoimmune response in bullous pemphigoid
    Giovanni Di Zenzo
    Istituto Dermopatico dell Immacolata, Molecular and Cell Biology Laboratory, IDI IRCCS, Rome, Italy
    Clin Immunol 128:415-26. 2008
    ..These results demonstrate the usefulness of the combined ELISAs based on various BP180 and BP230 fragments in establishing the diagnosis of BP and support the concept that BP180 is the major autoantigen of BP...
  4. doi request reprint Sequential intramolecular epitope spreading of humoral responses to human BPAG2 in a transgenic model
    Giovanni Di Zenzo
    Laboratory of Molecular and Cell Biology, Istituto Dermopatico dell Immacolata, IDI IRCCS, Rome, Italy
    J Invest Dermatol 130:1040-7. 2010
    ..These studies provide a comprehensive and prospective characterization of the evolution of humoral immune responses to hBPAG2 in vivo...
  5. doi request reprint Demonstration of epitope-spreading phenomena in bullous pemphigoid: results of a prospective multicenter study
    Giovanni Di Zenzo
    Molecular and Cell Biology Laboratory, IDI IRCCS, Rome, Italy
    J Invest Dermatol 131:2271-80. 2011
    ..These findings support the idea that IgG recognition of the BP180 ectodomain is an early and crucial event in BP disease, followed by variable intra- and intermolecular ES events, which likely shape the individual course of BP...
  6. pmc Prevalence of collagen VII-specific autoantibodies in patients with autoimmune and inflammatory diseases
    Emilia Licarete
    Department of Dermatology, University of Freiburg, Hauptstr, 7, Freiburg 79104, Germany
    BMC Immunol 13:16. 2012
    ..The aim of our present study was to develop an accurate immunoassay for assessing the presence of autoantibodies against collagen VII in large cohorts of patients and healthy donors...
  7. ncbi request reprint The intracellular and extracellular domains of BP180 antigen comprise novel epitopes targeted by pemphigoid gestationis autoantibodies
    Giovanni Di Zenzo
    Molecular and Cell Biology Laboratory, Istituto Dermopatico dell Immacolata, IDI IRCCS, Rome, Italy
    J Invest Dermatol 127:864-73. 2007
    ..The identification and characterization of hitherto unrecognized epitopes targeted by PG patient autoantibodies provide novel insights into the pathophysiology of humoral immune response to BP180 in PG...
  8. ncbi request reprint Characterization of the anti-BP180 autoantibody reactivity profile and epitope mapping in bullous pemphigoid patients
    Giovanni Di Zenzo
    Molecular and Cell Biology Laboratory, Istituto Dermopatico dell Immacolata, IDI IRCCS, Rome, Italy
    J Invest Dermatol 122:103-10. 2004
    ..Our findings provide novel insights into the pathophysiology of bullous pemphigoid and show the potential of the utilized approach as a tool for a rapid diagnosis of bullous pemphigoid patients and their management...
  9. ncbi request reprint Oral pemphigoid autoantibodies preferentially target BP180 ectodomain
    Valentina Calabresi
    Molecular and Cell Biology Laboratory, Istituto Dermopatico dell Immacolata, IDI IRCCS, Rome, Italy
    Clin Immunol 122:207-13. 2007
    ..Finally, the combined use of sensitive techniques allowed the detection of circulating autoantibodies in 90% of OP patients, supporting the usefulness of this approach in the diagnosis of MMP disease...
  10. pmc Pemphigus autoantibodies generated through somatic mutations target the desmoglein-3 cis-interface
    Giovanni Di Zenzo
    Molecular and Cell Biology Laboratory, Istituto Dermopatico dell Immacolata, IDI IRCCS, Rome, Italy
    J Clin Invest 122:3781-90. 2012
    ....
  11. doi request reprint The pathogenic activity of anti-desmoglein autoantibodies parallels disease severity in rituximab-treated patients with pemphigus vulgaris
    Anna Sinistro
    Molecular and Cell Biology Laboratory, Istituto Dermopatico dell Immacolata IDI IRCCS, 00167 Rome, Italy
    Eur J Dermatol 25:578-85. 2015
    ..In a subset of rituximab-treated patients in remission, high ELISA index values have been reported; however, their significance remains so far unclear...
  12. doi request reprint Endemic pemphigus foliaceus: towards understanding autoimmune mechanisms of disease development
    Giovanni Di Zenzo
    Laboratory of Molecular and Cell Biology, Istituto Dermopatico dell Immacolata IDI IRCCS, Rome, Italy
    J Invest Dermatol 132:2499-502. 2012
    ..have investigated whether fogo selvagem patients and healthy individuals from endemic areas develop autoantibody responses against other desmosomal cadherins and E-cadherin...
  13. doi request reprint Pemphigoid Gestationis Complicating an Egg Donation Pregnancy
    Liliana Guerra
    Laboratory of Molecular and Cell Biology, Istituto Dermopatico dell Immacolata IDI IRCCS, 00167 Rome, Italy
    Acta Derm Venereol 96:695-6. 2016
    ..is missing (Short communication). ..
  14. doi request reprint Immune response in pemphigus and beyond: progresses and emerging concepts
    Giovanni Di Zenzo
    Laboratory of Molecular and Cell Biology, Istituto Dermopatico dell Immacolata, IDI IRCCS, Rome, Italy
    Semin Immunopathol 38:57-74. 2016
    ..These new insights not only highlight the key role of Dsgs in maintenance of tissue homeostasis but are expected to progressively change pemphigus management, paving the way for novel targeted immunologic and pharmacologic therapies. ..
  15. doi request reprint Clonal analysis of B-cell response in pemphigus course: toward more effective therapies
    Giovanni Di Zenzo
    Laboratory of Molecular and Cell Biology, Istituto Dermopatico dell Immacolata, IDI IRCCS, Rome, Italy
    J Invest Dermatol 135:651-4. 2015
    ..In addition, the disappearance of anti-Dsg3 B-cell clones in two patients during long-term rituximab-induced remission supports the therapeutic potential of rituximab...
  16. ncbi request reprint Mammalian cell transduction and internalization properties of lambda phages displaying the full-length adenoviral penton base or its central domain
    Stefania Piersanti
    Department of Genetics and Molecular Biology, University La Sapienza and Parco Scientifico Biomedico di Roma, S Raffaele, Rome, Italy
    J Mol Med (Berl) 82:467-76. 2004
    ..We show that lambda Pb and lambda Pb (286-393) can both mediate receptor-dependent transduction; while only lambda Pb is able to promote endosomal escape and proteasome resistance of phage particles...