N Baldini

Summary

Affiliation: Istituti Ortopedici Rizzoli
Country: Italy

Publications

  1. ncbi request reprint The combined use of mesenchymal stromal cells and scaffolds for bone repair
    Gabriela Ciapetti
    Istituto Ortopedico Rizzoli, Bologna, Italy
    Curr Pharm Des 18:1796-820. 2012
  2. pmc Proton pump inhibitor chemosensitization in human osteosarcoma: from the bench to the patients' bed
    Stefano Ferrari
    Anti Tumour Drugs Section Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanita, Rome, Italy
    J Transl Med 11:268. 2013
  3. ncbi request reprint P-glycoprotein expression in osteosarcoma: a basis for risk-adapted adjuvant chemotherapy
    N Baldini
    Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, University of Bologna, Italy
    J Orthop Res 17:629-32. 1999
  4. ncbi request reprint CD99 engagement: an effective therapeutic strategy for Ewing tumors
    K Scotlandi
    Laboratorio di Ricerca Oncologica, Istituti Ortopedici Rizzoli, Bologna, Italy
    Cancer Res 60:5134-42. 2000
  5. ncbi request reprint Expression of interleukin 15 (IL-15) in human rhabdomyosarcoma, osteosarcoma and Ewing's sarcoma
    P L Lollini
    Institute of Cancer Research, University of Bologna, Italy
    Int J Cancer 71:732-6. 1997
  6. ncbi request reprint Expression of functional CD40 on human osteosarcoma and Ewing's sarcoma cells
    P L Lollini
    Institute for Cancer Research, University of Bologna, Italy
    Clin Cancer Res 4:1843-9. 1998
  7. ncbi request reprint Identification of EWS/FLI-1 transcripts in giant-cell tumor of bone
    K Scotlandi
    Laboratorio di Ricerca Oncologica, Dipartimento Goidanich, Istituti Ortopedici Rizzoli, Bologna, Italy
    Int J Cancer 87:328-35. 2000
  8. ncbi request reprint Murine model for skeletal metastases of Ewing's sarcoma
    K Scotlandi
    Laboratorio di Ricerca Oncologica, Istituti Ortopedici Rizzoli, Universita degli Studi di Bologna, Italy
    J Orthop Res 18:959-66. 2000
  9. ncbi request reprint Predictive factors of histological response to primary chemotherapy in Ewing's sarcoma
    G Bacci
    Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy
    Acta Oncol 37:671-6. 1998
  10. ncbi request reprint Inhibition of insulin-like growth factor I receptor increases the antitumor activity of doxorubicin and vincristine against Ewing's sarcoma cells
    S Benini
    Laboratorio di Ricerca Oncologica, Istituti Ortopedici Rizzoli, 40136 Bologna, Italy
    Clin Cancer Res 7:1790-7. 2001

Collaborators

Detail Information

Publications43

  1. ncbi request reprint The combined use of mesenchymal stromal cells and scaffolds for bone repair
    Gabriela Ciapetti
    Istituto Ortopedico Rizzoli, Bologna, Italy
    Curr Pharm Des 18:1796-820. 2012
    ..The results from a wide array of in vitro and in vivo studies, as well as from some clinical trials, are expanding the range of clinical protocols for bone repair, that is the ultimate goal of orthopaedics...
  2. pmc Proton pump inhibitor chemosensitization in human osteosarcoma: from the bench to the patients' bed
    Stefano Ferrari
    Anti Tumour Drugs Section Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanita, Rome, Italy
    J Transl Med 11:268. 2013
    ..In this study, we investigated the effects of PPI in chemosensitizing osteosarcoma...
  3. ncbi request reprint P-glycoprotein expression in osteosarcoma: a basis for risk-adapted adjuvant chemotherapy
    N Baldini
    Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, University of Bologna, Italy
    J Orthop Res 17:629-32. 1999
    ..Standard programs are sufficient for P-glycoprotein-negative osteosarcomas, whereas P-glycoprotein-positive tumors may benefit from the use of more intensive therapeutic approaches...
  4. ncbi request reprint CD99 engagement: an effective therapeutic strategy for Ewing tumors
    K Scotlandi
    Laboratorio di Ricerca Oncologica, Istituti Ortopedici Rizzoli, Bologna, Italy
    Cancer Res 60:5134-42. 2000
    ..These results provide a novel entry site for therapeutic intervention, which may have application in the care of patients with Ewing tumor, and warrant additional studies to clarify the molecular mechanisms activated by CD99 engagement...
  5. ncbi request reprint Expression of interleukin 15 (IL-15) in human rhabdomyosarcoma, osteosarcoma and Ewing's sarcoma
    P L Lollini
    Institute of Cancer Research, University of Bologna, Italy
    Int J Cancer 71:732-6. 1997
    ..ELISA assays showed IL-15 release in a subset of rhabdomyosarcomas and osteosarcomas, but not in Ewing's sarcoma. The highest production of IL-15, in the picogram/ml range, was found in rhabdomyosarcoma cell lines RH30 and RD...
  6. ncbi request reprint Expression of functional CD40 on human osteosarcoma and Ewing's sarcoma cells
    P L Lollini
    Institute for Cancer Research, University of Bologna, Italy
    Clin Cancer Res 4:1843-9. 1998
    ..The results indicate that in human osteosarcoma and Ewing's sarcoma, CD40 is a functional receptor whose engagement can have opposite effects on tumor cell survival and malignancy...
  7. ncbi request reprint Identification of EWS/FLI-1 transcripts in giant-cell tumor of bone
    K Scotlandi
    Laboratorio di Ricerca Oncologica, Dipartimento Goidanich, Istituti Ortopedici Rizzoli, Bologna, Italy
    Int J Cancer 87:328-35. 2000
    ..Detection of EWS/FLI-1 fusion transcripts in giant-cell tumor of bone provides a model for the study of the transforming mechanisms of the EWS/FLI-1 fusion gene in mesenchymal tumors...
  8. ncbi request reprint Murine model for skeletal metastases of Ewing's sarcoma
    K Scotlandi
    Laboratorio di Ricerca Oncologica, Istituti Ortopedici Rizzoli, Universita degli Studi di Bologna, Italy
    J Orthop Res 18:959-66. 2000
    ..This experimental model of bone metastasis of Ewing's sarcoma may be the basis for future studies aimed at understanding the pathophysiology and treatment of Ewing's sarcoma...
  9. ncbi request reprint Predictive factors of histological response to primary chemotherapy in Ewing's sarcoma
    G Bacci
    Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy
    Acta Oncol 37:671-6. 1998
    ..The analysis of event-free survival in 158 patients with a 4-year minimum follow-up confirmed that histological response to preoperative chemotherapy is a reliable predictor of outcome in Ewing's sarcoma...
  10. ncbi request reprint Inhibition of insulin-like growth factor I receptor increases the antitumor activity of doxorubicin and vincristine against Ewing's sarcoma cells
    S Benini
    Laboratorio di Ricerca Oncologica, Istituti Ortopedici Rizzoli, 40136 Bologna, Italy
    Clin Cancer Res 7:1790-7. 2001
    ..In conclusion, we showed that, in ES, the blockage of IGF-IR by a neutralizing MAb or by suramin may greatly potentiate the antitumor activity of conventional chemotherapeutic drugs...
  11. pmc Do ion levels in hip resurfacing differ from metal-on-metal THA at midterm?
    A Moroni
    Department II of Orthopaedics and Traumatology, Bologna University, Rizzoli Orthopaedic Institute, Via G C Pupilli 1, 40136 Bologna, Italy
    Clin Orthop Relat Res 469:180-7. 2011
    ..Metal-on-metal Birmingham hip resurfacing (MOM-BHR) is an alternative to metal-on-metal total hip arthroplasty (MOM-THA), especially for young and/or active patients. However, wear resulting in increased serum ion levels is a concern...
  12. ncbi request reprint Orthopaedic research in italy: state of the art
    E Cenni
    Istituto Ortopedico Rizzoli, Bologna, Italy
    Int J Immunopathol Pharmacol 24:157-78. 2011
    ..The data presented in the following discussion is comparable with leading international results, highlighting Italian orthopaedic research excellemce as well as its shortcomings...
  13. ncbi request reprint Bone-targeted doxorubicin-loaded nanoparticles as a tool for the treatment of skeletal metastases
    M Salerno
    Laboratory for Orthopaedic Pathophysiology and Regenerative Medicine, Istituto Ortopedico Rizzoli, Bologna, Italy
    Curr Cancer Drug Targets 10:649-59. 2010
    ..014, P = 0.040, respectively), possibly as a consequence of alendronate activity. In summary, NP may act effectively as a delivery system of anticancer drugs to the bone, and deserve further evaluation for the treatment of bone tumors...
  14. doi request reprint The potential role of metal ion release as a marker of loosening in patients with total knee replacement: a cohort study
    L Savarino
    Laboratory for Orthopaedic Pathophysiology and Regenerative Medicine Istituto Ortopedico Rizzoli, Via Di Barbiano 1 10, 40136 Bologna, Italy
    J Bone Joint Surg Br 92:634-8. 2010
    ..Measurement of the serum level of Cr ions may be of value for detecting failure due to loosening when the diagnosis is in doubt. The other metal ions studies did not have any diagnostic value...
  15. doi request reprint Novel soybean/gelatine-based bioactive and injectable hydroxyapatite foam: material properties and cell response
    F Perut
    Laboratory for Orthopaedic Pathophysiology and Regenerative Medicine, Istituto Ortopedico Rizzoli, Bologna, Italy
    Acta Biomater 7:1780-7. 2011
    ..These findings suggest that injectable, porous and bioactive calcium phosphate cements can be produced for bone regeneration through minimally invasive surgery...
  16. ncbi request reprint c-erbB-2 over-expression in amplified and non-amplified breast carcinoma samples
    F Farabegoli
    Department of Experimental Pathology, University of Bologna, Italy
    Int J Cancer 84:273-7. 1999
    ..The combination of FISH and immuno-histochemistry may be helpful to achieve this aim...
  17. ncbi request reprint Differences in ion release after ceramic-on-ceramic and metal-on-metal total hip replacement. Medium-term follow-up
    L Savarino
    The Rizzoli Orthopaedic Institute, Bologna, Italy
    J Bone Joint Surg Br 88:472-6. 2006
    ..For this reason, the low corrosion level in a ceramic-on-ceramic coupling could be advantageous...
  18. ncbi request reprint In vivo study on the healing of bone defects treated with bone marrow stromal cells, platelet-rich plasma, and freeze-dried bone allografts, alone and in combination
    D Dallari
    VII Orthopaedic and Traumatology Division, Rizzoli Orthopaedic Institute, Via Pupilli 1, 40136 Bologna, Italy
    J Orthop Res 24:877-88. 2006
    ..05). These results showed that the combination of FDBA, BMSC and PRP permitted an acceleration in bone healing and bone remodeling processes...
  19. ncbi request reprint Potential of FeAlCr intermetallics reinforced with nanoparticles as new biomaterials for medical devices
    J L González-Carrasco
    Centro Nacional de Investigaciones Metalúrgicas, CENIM CSIC, Avda Gregorio del Amo 8, 28040 Madrid, Spain
    J Biomed Mater Res B Appl Biomater 80:201-10. 2007
    ..In this respect, ALUSI alloys hold the promise to be suitable substrate for bone integration. The finding of no cytotoxic effect in the presence of the alloy particles is a reliable proof of the absence of acute toxicity of the material...
  20. ncbi request reprint Human bone marrow stromal cells: In vitro expansion and differentiation for bone engineering
    G Ciapetti
    Laboratory for Pathophysiology of Orthopaedic Implants, Istituti Ortopedici Rizzoli, University of Bologna, Via Di Barbiano 1 10, 40136 Bologna, Italy
    Biomaterials 27:6150-60. 2006
    ....
  21. ncbi request reprint Improved osteogenic differentiation of human marrow stromal cells cultured on ion-induced chemically structured poly-epsilon-caprolactone
    G Marletta
    Laboratory for Molecular Surfaces and Nanotechnology, Dipartimento di Scienze Chimiche and CSGI, University of Catania, V le A Doria 6, 95125 Catania, Italy
    Biomaterials 28:1132-40. 2007
    ..In conclusion, the change of PCL surface properties induced by ion beam irradiation is confirmed to enhance the adhesion of MSC and support their differentiation...
  22. ncbi request reprint The performance of poly-epsilon-caprolactone scaffolds in a rabbit femur model with and without autologous stromal cells and BMP4
    L Savarino
    Laboratory for Pathophysiology of Orthopaedic Implants, Istituti Ortopedici Rizzoli, Via Di Barbiano 1 10, 40136, Bologna, Italy
    Biomaterials 28:3101-9. 2007
    ..Finally, the BMP4-expressing BMSCs strongly favoured osteoinductivity of cellular constructs, as demonstrated by a more extensive bone/scaffold contact...
  23. ncbi request reprint Enhanced tibial osteotomy healing with use of bone grafts supplemented with platelet gel or platelet gel and bone marrow stromal cells
    D Dallari
    Seventh Division, Istituti Ortopedici Rizzoli, Via Di Barbiano 1 10, 40136 Bologna, Italy
    J Bone Joint Surg Am 89:2413-20. 2007
    ..We compared the osteogenic potential of lyophilized bone chips combined with platelet gel, or with platelet gel and bone marrow stromal cells, with that of lyophilized bone chips alone in the healing of a high tibial osteotomy...
  24. ncbi request reprint Metal ion release from fracture fixation devices: a potential marker of implant failure
    L Savarino
    Laboratory for Pathophysiology of Orthopaedic Implants, Rizzoli Orthopaedic Institute, Bologna, Italy
    J Biomed Mater Res B Appl Biomater 86:389-95. 2008
    ....
  25. ncbi request reprint Interferon-alpha inhibits in vitro osteoclast differentiation and renal cell carcinoma-induced angiogenesis
    S Avnet
    Laboratory for Pathophysiology of Orthopaedic Implants, Istituti Ortopedici Rizzoli, I 40136 Bologna, Italy
    Int J Oncol 30:469-76. 2007
    ....
  26. ncbi request reprint Poly-epsilon-caprolactone/hydroxyapatite composites for bone regeneration: in vitro characterization and human osteoblast response
    F Causa
    Institute of Composite and Biomedical Materials IMCB CNR and Interdisciplinary Research Centre in Biomaterials, University of Naples Federico II, Piazzale Tecchio 80, 80125 Naples, Italy
    J Biomed Mater Res A 76:151-62. 2006
    ..The results indicated that PCL represents a potential candidate as an efficient substrate for bone substitution through an accurate balance between structural/ mechanical properties of polymer and biological activities...
  27. ncbi request reprint Evaluation of bone healing enhancement by lyophilized bone grafts supplemented with platelet gel: a standardized methodology in patients with tibial osteotomy for genu varus
    L Savarino
    Laboratory for Pathophysiology of Orthopaedic Implants, Istituti Ortopedici Rizzoli, Via Di Barbiano 1 10, 40136 Bologna, Italy
    J Biomed Mater Res B Appl Biomater 76:364-72. 2006
    ..The completion of the study and the evaluation of the ultimate clinical outcome are necessary in order to verify PG in vivo effects in orthopedic surgery...
  28. ncbi request reprint In vitro testing of the potential for orthopedic bone cements to cause apoptosis of osteoblast-like cells
    G Ciapetti
    Laboratorio di Fisiopatologia degli Impianti Ortopedici, Istituti Ortopedici Rizzoli, Bologna, Italy
    Biomaterials 23:617-27. 2002
    ..This study helps to gain more insight into the mechanism of cell death induced by PMMA-based cements and suggests apoptosis of osteoblasts as a part of the tissue reaction around cemented prostheses...
  29. ncbi request reprint Ion release in patients with metal-on-metal hip bearings in total joint replacement: a comparison with metal-on-polyethylene bearings
    L Savarino
    Laboratorio di Fisiopatologia degli Impianti Ortopedici, Istituti Ortopedici Rizzoli, Bologna, Italy
    J Biomed Mater Res 63:467-74. 2002
    ..In such a way a risk-to-benefit ratio for the patient could be established...
  30. ncbi request reprint Osteoblast growth and function in porous poly epsilon -caprolactone matrices for bone repair: a preliminary study
    G Ciapetti
    Laboratorio di Fisiopatologia degli Impianti Ortopedici, Istituto Ortopedico Rizzoli, Via Di Barbiano 1 10, 40139, Bologna, Italy
    Biomaterials 24:3815-24. 2003
    ..It can be concluded that PCL is a promising material for three-dimensional scaffold for bone formation, and the presence of bone-like components improves osteoblast activity...
  31. ncbi request reprint Ion release in stable hip arthroplasties using metal-on-metal articulating surfaces: a comparison between short- and medium-term results
    L Savarino
    Laboratorio di Fisiopatologia degli Impianti Ortopedici, Istituti Ortopedici Rizzoli, Bologna, Italy
    J Biomed Mater Res A 66:450-6. 2003
    ..This exposure should be carefully monitored, in order to clarify the biologic effects of ion dissemination and, consequently, to identify risks concerning long-term toxicity of metals...
  32. ncbi request reprint Biologic effects of surface roughness and fluorhydroxyapatite coating on osteointegration in external fixation systems: an in vivo experimental study
    L Savarino
    Laboratorio di Fisiopatologia degli Impianti Ortopedici, Istituti Ortopedici Rizzoli, Bologna and Università di Bologna, Via Di Barbiano 1 10, 40136 Bologna, Italy
    J Biomed Mater Res A 66:652-61. 2003
    ..The authors emphasize the necessity for simultaneous evaluation of surface topography and chemistry as well as an improvement in plasma-spraying and post-processing techniques and in standard procedures for materials characterization...
  33. ncbi request reprint The influence of alumina and ultra-high molecular weight polyethylene particles on osteoblast-osteoclast cooperation
    D Granchi
    Laboratory of Pathophysiology of Orthopaedic Implants, Istituti Ortopedici Rizzoli, Via Di Barbiano 1 10, Bologna 40136, Italy
    Biomaterials 25:4037-45. 2004
    ..With regard to the inductive effect on the osteoclastogenesis, our results show that the Al(2)O(3) wear debris are less active...
  34. ncbi request reprint Diagnosis of infection after total hip replacement
    L Savarino
    Laboratory for Pathophysiology of Orthopaedic Implants, and 7th Division of Orthopaedic Surgery, Istituti Ortopedici Rizzoli, Via Di Barbiano 1 10, 40136 Bologna, Italy
    J Biomed Mater Res B Appl Biomater 70:139-45. 2004
    ..The inflammatory response to wear debris and the presence of superimposed, slowly growing bacteria could act synergically, both contributing to the pathogenesis of periprosthetic osteolysis...
  35. ncbi request reprint Quantitative assessment of the response of osteoblast- and macrophage-like cells to particles of Ni-free Fe-base alloys
    G Ciapetti
    Laboratorio di Fisiopatologia degli Impianti Ortopedici, Istituti Ortopedici Rizzoli, Bologna, Italy
    Biomaterials 26:849-59. 2005
    ..In vitro mineralisation was achieved by osteoblasts in due time. The new alloys are well tolerated in in vitro systems, and, due to their chemical and mechanical characteristics, they are under development for surgical implants...
  36. ncbi request reprint Evaluation of mechanical properties and biological response of an alumina-forming Ni-free ferritic alloy
    J L González-Carrasco
    Physical Metallurgy Department, Centro Nacional de Investigaciones Metalúrgicas, CENIM CSIC, Avda Gregorio del Amo 8, 28040 Madrid, Spain
    Biomaterials 26:3861-71. 2005
    ..Results from this study suggest that the resulting alumina/alloy system combines the good mechanical properties of the alloy with the superior biocompatibility of the alpha-alumina, for which there is very good clinical experience...
  37. ncbi request reprint Systemic cross-linked N-terminal telopeptide and procollagen I C-terminal extension peptide as markers of bone turnover after total hip arthroplasty
    L Savarino
    Laboratory for Pathophysiology of Orthopaedic Implants, Istituti Ortopedici Rizzoli, Via Di Barbiano 1 10, 40136 Bologna, Italy
    J Bone Joint Surg Br 87:571-6. 2005
    ..The NTx level could be used to indicate stability of the implant. However, further prospective, larger studies are necessary...
  38. ncbi request reprint Effects of activated platelet concentrates on human primary cultures of fibroblasts and osteoblasts
    E Cenni
    Laboratory for Pathophysiology of Orthopedic Implants, Rizzoli Orthopedic Institute, Bologna, Italy
    J Periodontol 76:323-8. 2005
    ..The aim of this research was to assess the effect of platelet concentrates activated with thrombin on human gingival fibroblasts and human osteoblasts from trabecular bone...
  39. ncbi request reprint A preliminary in vitro and in vivo study of the effects of new anthraquinones on neutrophils and bone remodeling
    L Savarino
    Laboratory for Pathophysiology of Orthopaedic Implants, Istituti Ortopedici Rizzoli, Via Di Barbiano 1 10, 40136 Bologna, Italy
    J Biomed Mater Res A 75:324-32. 2005
    ..If it will be confirmed, they could be proposed in a variety of bone diseases, in particular, when acute inflammation is associated to osteolytic processes and, eventually, in the prevention and treatment of periprosthetic osteolysis...
  40. ncbi request reprint Reversal of multidrug-resistance using Valspodar (PSC 833) and doxorubicin in osteosarcoma
    E Cagliero
    Istituto per la Ricerca e la Cura del Cancro I R C C, 10060 Candiolo, Italy
    Oncol Rep 12:1023-31. 2004
    ..The high incidence of Pgp expression in osteosarcoma confers to the study a rationale for an effective regimen based on down-modulation of MDR...
  41. ncbi request reprint Radio-induced sarcomas in survivors of Ewing's sarcoma
    S Boriani
    1st Orthopaeidic Clinic, University of Bologna, Italia
    Tumori 74:543-51. 1988
    ..Theoretical and statistical analyses were carried out considering different modalities of local treatment. Statistically, the only significant factor was related to the irradiation dose. Surgical resection seems to prevent RIS...
  42. pmc Normal human IgG prevents endothelial cell activation induced by TNFalpha and oxidized low-density lipoprotein atherogenic stimuli
    N Ronda
    Department of Clinical Medicine, University of Parma, Parma, Italy
    Clin Exp Immunol 133:219-26. 2003
    ..These findings point to a regulatory role for specific antibodies included in circulating normal IgG towards proinflammatory responses of endothelial cells in atherogenesis and suggest possible development of new therapeutic strategies...
  43. ncbi request reprint Simultaneous paired analysis of numerical chromosomal aberrations and DNA content in osteosarcoma
    M Serra
    Laboratorio di Ricerca OncologicaIstituti Ortopedici Rizzoli, Bologna, Italy
    Mod Pathol 14:710-6. 2001
    ....