S Avnet

Summary

Affiliation: Istituti Ortopedici Rizzoli
Country: Italy

Publications

  1. pmc Proton pump inhibitor chemosensitization in human osteosarcoma: from the bench to the patients' bed
    Stefano Ferrari
    Anti Tumour Drugs Section Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanita, Rome, Italy
    J Transl Med 11:268. 2013
  2. doi request reprint V-ATPase is a candidate therapeutic target for Ewing sarcoma
    Sofia Avnet
    Laboratory for Orthopaedic Pathophysiology and Regenerative Medicine, Istituto Ortopedico Rizzoli, Via Di Barbiano 1 10, 40136, Bologna, Italy
    Biochim Biophys Acta 1832:1105-16. 2013
  3. doi request reprint Sustained autocrine induction and impaired negative feedback of osteoclastogenesis in CD14(+) cells of giant cell tumor of bone
    Sofia Avnet
    Laboratory for Orthopaedic Pathophysiology and Regenerative Medicine, Istituto Ortopedico Rizzoli, 40136 Bologna, Italy
    Am J Pathol 182:1357-66. 2013
  4. ncbi request reprint Interferon-alpha inhibits in vitro osteoclast differentiation and renal cell carcinoma-induced angiogenesis
    S Avnet
    Laboratory for Pathophysiology of Orthopaedic Implants, Istituti Ortopedici Rizzoli, I 40136 Bologna, Italy
    Int J Oncol 30:469-76. 2007
  5. doi request reprint IGF2 derived from SH-SY5Y neuroblastoma cells induces the osteoclastogenesis of human monocytic precursors
    Sofia Avnet
    Laboratory for Orthopaedic Pathophysiology and Regenerative Medicine, Istituto Ortopedico Rizzoli, Bologna, Via Di Barbiano 1 10, Bologna, Italy
    Exp Cell Res 317:2147-58. 2011
  6. ncbi request reprint Increased osteoclast activity is associated with aggressiveness of osteosarcoma
    Sofia Avnet
    Laboratory for Pathophysiology, Istituti Ortopedici Rizzoli, 40136 Bologna, Italy
    Int J Oncol 33:1231-8. 2008
  7. doi request reprint Insulin receptor isoform A and insulin-like growth factor II as additional treatment targets in human osteosarcoma
    Sofia Avnet
    Laboratory for Pathophysiology, Rizzoli Orthopaedic Institute, Bologna, Italy
    Cancer Res 69:2443-52. 2009
  8. ncbi request reprint Effects of antisense mediated inhibition of cathepsin K on human osteoclasts obtained from peripheral blood
    Sofia Avnet
    Laboratory for Pathophysiology, Istituti Ortopedici Rizzoli, v di barbiano 1 10, 40136 Bologna, Italy
    J Orthop Res 24:1699-708. 2006
  9. ncbi request reprint Bone-targeted doxorubicin-loaded nanoparticles as a tool for the treatment of skeletal metastases
    M Salerno
    Laboratory for Orthopaedic Pathophysiology and Regenerative Medicine, Istituto Ortopedico Rizzoli, Bologna, Italy
    Curr Cancer Drug Targets 10:649-59. 2010
  10. ncbi request reprint The influence of alumina and ultra-high molecular weight polyethylene particles on osteoblast-osteoclast cooperation
    D Granchi
    Laboratory of Pathophysiology of Orthopaedic Implants, Istituti Ortopedici Rizzoli, Via Di Barbiano 1 10, Bologna 40136, Italy
    Biomaterials 25:4037-45. 2004

Collaborators

Detail Information

Publications22

  1. pmc Proton pump inhibitor chemosensitization in human osteosarcoma: from the bench to the patients' bed
    Stefano Ferrari
    Anti Tumour Drugs Section Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanita, Rome, Italy
    J Transl Med 11:268. 2013
    ..In this study, we investigated the effects of PPI in chemosensitizing osteosarcoma...
  2. doi request reprint V-ATPase is a candidate therapeutic target for Ewing sarcoma
    Sofia Avnet
    Laboratory for Orthopaedic Pathophysiology and Regenerative Medicine, Istituto Ortopedico Rizzoli, Via Di Barbiano 1 10, 40136, Bologna, Italy
    Biochim Biophys Acta 1832:1105-16. 2013
    ..In summary, glycolytic activity and activation of V-ATPase are crucial mechanisms of survival of ES cells and can be considered as promising selective targets for the treatment of this tumor...
  3. doi request reprint Sustained autocrine induction and impaired negative feedback of osteoclastogenesis in CD14(+) cells of giant cell tumor of bone
    Sofia Avnet
    Laboratory for Orthopaedic Pathophysiology and Regenerative Medicine, Istituto Ortopedico Rizzoli, 40136 Bologna, Italy
    Am J Pathol 182:1357-66. 2013
    ..These data demonstrate that CD14(+) cells of GCTs are abnormally stimulated to limitless differentiation into multinucleated giant cells and provide useful suggestions for the development of novel therapies...
  4. ncbi request reprint Interferon-alpha inhibits in vitro osteoclast differentiation and renal cell carcinoma-induced angiogenesis
    S Avnet
    Laboratory for Pathophysiology of Orthopaedic Implants, Istituti Ortopedici Rizzoli, I 40136 Bologna, Italy
    Int J Oncol 30:469-76. 2007
    ....
  5. doi request reprint IGF2 derived from SH-SY5Y neuroblastoma cells induces the osteoclastogenesis of human monocytic precursors
    Sofia Avnet
    Laboratory for Orthopaedic Pathophysiology and Regenerative Medicine, Istituto Ortopedico Rizzoli, Bologna, Via Di Barbiano 1 10, Bologna, Italy
    Exp Cell Res 317:2147-58. 2011
    ..Our findings suggest that in IGF2-producing osteolytic tumors IGF1R is a good candidate for targeted therapies in combination with conventional drugs...
  6. ncbi request reprint Increased osteoclast activity is associated with aggressiveness of osteosarcoma
    Sofia Avnet
    Laboratory for Pathophysiology, Istituti Ortopedici Rizzoli, 40136 Bologna, Italy
    Int J Oncol 33:1231-8. 2008
    ..0117). In conclusion, tumor-infiltrating osteoclasts are frequently found in OS and increased serum TRACP 5b levels and the presence of active osteoclast at primary sites were positively associated with tumor aggressiveness...
  7. doi request reprint Insulin receptor isoform A and insulin-like growth factor II as additional treatment targets in human osteosarcoma
    Sofia Avnet
    Laboratory for Pathophysiology, Rizzoli Orthopaedic Institute, Bologna, Italy
    Cancer Res 69:2443-52. 2009
    ..Cotargeting IGFIR and IR-A is more effective than targeting IGF-IR alone in inhibiting OS growth...
  8. ncbi request reprint Effects of antisense mediated inhibition of cathepsin K on human osteoclasts obtained from peripheral blood
    Sofia Avnet
    Laboratory for Pathophysiology, Istituti Ortopedici Rizzoli, v di barbiano 1 10, 40136 Bologna, Italy
    J Orthop Res 24:1699-708. 2006
    ..We demonstrated that antisense strategies against cathepsin K are selectively effective to inhibit resorption activity in human osteoclasts, like in animal models...
  9. ncbi request reprint Bone-targeted doxorubicin-loaded nanoparticles as a tool for the treatment of skeletal metastases
    M Salerno
    Laboratory for Orthopaedic Pathophysiology and Regenerative Medicine, Istituto Ortopedico Rizzoli, Bologna, Italy
    Curr Cancer Drug Targets 10:649-59. 2010
    ..014, P = 0.040, respectively), possibly as a consequence of alendronate activity. In summary, NP may act effectively as a delivery system of anticancer drugs to the bone, and deserve further evaluation for the treatment of bone tumors...
  10. ncbi request reprint The influence of alumina and ultra-high molecular weight polyethylene particles on osteoblast-osteoclast cooperation
    D Granchi
    Laboratory of Pathophysiology of Orthopaedic Implants, Istituti Ortopedici Rizzoli, Via Di Barbiano 1 10, Bologna 40136, Italy
    Biomaterials 25:4037-45. 2004
    ..With regard to the inductive effect on the osteoclastogenesis, our results show that the Al(2)O(3) wear debris are less active...
  11. doi request reprint Biocompatibility of poly(D,L-lactide-co-glycolide) nanoparticles conjugated with alendronate
    Elisabetta Cenni
    Laboratorio di Fisiopatologia degli Impianti Ortopedici, Istituti Ortopedici Rizzoli, Via Di Barbiano 1 10, 40136 Bologna, Italy
    Biomaterials 29:1400-11. 2008
    ..These results demonstrated that PLGA-ALE NPs had an acceptable degree of blood compatibility and were not cytotoxic; therefore, they may be considered suitable for intravenous administration...
  12. ncbi request reprint Sequence and TLR9 independent increase of TRACP expression by antisense DNA and siRNA molecules
    Pirkko Muhonen
    Institute of Biomedicine, Department of Anatomy, University of Turku, FIN 20520 Turku, Finland
    Biochem Biophys Res Commun 359:889-95. 2007
    ..In contrast, cells with increased TRACP activity showed decreased activity of tartrate-sensitive acid phosphatases...
  13. ncbi request reprint Inhibition of angiogenesis via FGF-2 blockage in primitive and bone metastatic renal cell carcinoma
    Elisabetta Cenni
    Laboratory for Pathophysiology of Orthopedic Implants, Istituti Ortopedici Rizzoli, Bologna, Italy
    Anticancer Res 27:315-9. 2007
    ..Fibroblast growth factor-2 (FGF-2) has a role in the angiogenesis induced by renal carcinoma...
  14. ncbi request reprint Isolation and characterization of a new cell line from a renal carcinoma bone metastasis
    Sofia Avnet
    Laboratory for Pathophysiology of Orthopedic Implants, Istituti Ortopedici Rizzoli, Bologna, Italy
    Anticancer Res 24:1705-11. 2004
    ..The use of cell lines isolated from metastases should enable the assessment of peculiar aspects of bone resorbing cytokine expression, as well as angiogenetic activity of renal carcinoma bone metastases...
  15. ncbi request reprint In vitro blockade of receptor activator of nuclear factor-kappaB ligand prevents osteoclastogenesis induced by neuroblastoma cells
    Donatella Granchi
    Laboratory of Pathophysiology, Istituti Ortopedici Rizzoli, Bologna, Italy
    Int J Cancer 111:829-38. 2004
    ..Moreover, our results suggest that RANKL could be a relevant target in the adjuvant therapy of bone metastatic neuroblastoma as proper neutralization revokes completely osteoclastic differentiation...
  16. ncbi request reprint Molecular basis of osteoclastogenesis induced by osteoblasts exposed to wear particles
    Donatella Granchi
    Laboratorio di Fisiopatologia degli Impianti Ortopedici, Istituti Ortopedici Rizzoli, Via Di Barbiano 1 10, 40136 Bologna, Italy
    Biomaterials 26:2371-9. 2005
    ..Moreover, they provide new insight into the molecular basis of particle-induced osteoclastogenesis, that is the starting point for planning mode-specific targeting of periprosthetic osteolysis...
  17. ncbi request reprint Inhibition of angiogenic activity of renal carcinoma by an antisense oligonucleotide targeting fibroblast growth factor-2
    Elisabetta Cenni
    Laboratory for Pathophysiology of Orthopedic Implants, Istituti Ortopedici Rizzoli, Bologna, Italy
    Anticancer Res 25:1109-13. 2005
    ..Fibroblast growth factor-2 (FGF-2) induces angiogenesis, critical for the growth and metastatic spread of tumors...
  18. ncbi request reprint MET overexpression turns human primary osteoblasts into osteosarcomas
    Salvatore Patanè
    Laboratory of Cancer Genetics, University of Turin School of Medicine, Candiolo Turin, Italy
    Cancer Res 66:4750-7. 2006
    ..These data show that MET overexpression is oncogenic and that it is essential for the maintenance of the cancer phenotype...
  19. ncbi request reprint Primitive and bone metastatic renal carcinoma cells promote osteoclastogenesis through endothelial cells
    Elisabetta Cenni
    Laboratorio di Fisiopatologia degli Impianti Ortopedici, Istituti Ortopedici Rizzoli, Bologna, Italy
    Anticancer Res 26:3065-9. 2006
    ..The contribution of angiogenesis to renal carcinoma bone metastases is virtually unknown...
  20. ncbi request reprint Expression of an IGF-I receptor dominant negative mutant induces apoptosis, inhibits tumorigenesis and enhances chemosensitivity in Ewing's sarcoma cells
    Katia Scotlandi
    Laboratorio di Ricerca Oncologica, Istituti Ortopedici Rizzoli, Bologna, Italy
    Int J Cancer 101:11-6. 2002
    ....
  21. pmc Histogenetic characterization of giant cell tumor of bone
    Manuela Salerno
    Laboratory for Pathophysiology, Istituto Ortopedico Rizzoli, 40136 Bologna, Italy
    Clin Orthop Relat Res 466:2081-91. 2008
    ..The increased number of giant cells in GCT may be secondary to an autocrine circuit mediated by the receptor activator of nuclear factor kB...
  22. doi request reprint Effects of prelamin A processing inhibitors on the differentiation and activity of human osteoclasts
    Nicoletta Zini
    IGM CNR Unit of Bologna c o IOR, Bologna, Italy
    J Cell Biochem 105:34-40. 2008
    ..This finding may help the understanding of the osteolytic and osteoporotic processes that characterize progeroid laminopathies...